Gene:
CCL2
chemokine (C-C motif) ligand 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for CCL2

Variant?
(144)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs2857657 32583132G>C, 5837G>C, 7320126G>C, 77-109G>C
G > C
Intronic
No VIP available CA VA
rs4586 105T>C, 32583269T>C, 5974T>C, 7320263T>C, Cys35=
T > C
Synonymous
Cys35Cys
No VIP available CA VA
rs4795893 32574448G>A, 7311442G>A
G > A
Not Available
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 144

Overview

Alternate Names:  SCYA2; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1, homologous to mouse Sig-je; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys-Cys), member 2
Alternate Symbols:  GDCF-2; HC11; MCAF; MCP-1; MCP1; MGC9434; SMC-CF
PharmGKB Accession Id: PA130413151

Details

Cytogenetic Location: chr17 : q11.2 - q12
GP mRNA Boundary: chr17 : 32582296 - 32584222
GP Gene Boundary: chr17 : 32572296 - 32587222
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
    Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.

External Pathways

Links to non-PharmGKB pathways.

  1. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  2. pertussis toxin-insensitive ccr5 signaling in macrophage - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
risperidone

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Schizophrenia

Publications related to CCL2: 5

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. 2014. Xiong Yuyu, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Clinica chimica acta; international journal of clinical chemistry. 2009. RuaƱo Gualberto, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Prednisolone mediated suppression of HIV-1 viral load strongly correlates with C-C chemokine CCL2: In vivo and in vitro findings. Clinical immunology (Orlando, Fla.). 2007. Ansari Abdul Wahid, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide expression studies of atherosclerosis: critical issues in methodology, analysis, interpretation of transcriptomics data. Arteriosclerosis, thrombosis, and vascular biology. 2006. Bijnens A P J J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. American journal of respiratory cell and molecular biology. 1999. Pype J L, et al. PubMed

LinkOuts

Entrez Gene:
6347
OMIM:
158105
182940
607948
609423
UCSC Genome Browser:
NM_002982
RefSeq RNA:
NM_002982
RefSeq Protein:
NP_002973
ALFRED:
LO024538W
HuGE:
CCL2
Comparative Toxicogenomics Database:
6347
ModBase:
P13500
HumanCyc Gene:
HS03144
HGNC:
10618

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