Gene:
TPH2
tryptophan hydroxylase 2

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for TPH2

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs10879346 NC_000012.11:g.72351835C>T, NC_000012.12:g.71958055C>T, NG_008279.1:g.24210C>T, NM_173353.3:c.608+8400C>T, XM_005268642.1:c.626+8400C>T, XM_011537899.1:c.14+8400C>T, XR_245894.1:n.613-3498C>T, XR_245894.2:n.709-3498C>T, rs59716601
C > T
SNP
rs1386494 NC_000012.11:g.72352543T>C, NC_000012.12:g.71958763T>C, NG_008279.1:g.24918T>C, NM_173353.3:c.608+9108T>C, XM_005268642.1:c.626+9108T>C, XM_011537899.1:c.14+9108T>C, XR_245894.1:n.613-2790T>C, XR_245894.2:n.709-2790T>C, rs58409378
T > C
SNP
rs1487278 NC_000012.11:g.72400851T>C, NC_000012.12:g.72007071T>C, NG_008279.1:g.73226T>C, NM_173353.3:c.1068+12506T>C, XM_005268642.1:c.1086+12506T>C, XM_011537899.1:c.474+12506T>C, rs61103738
T > C
SNP
rs1843809 NC_000012.11:g.72348698G>T, NC_000012.12:g.71954918G>T, NG_008279.1:g.21073G>T, NM_173353.3:c.608+5263G>T, XM_005268642.1:c.626+5263G>T, XM_011537899.1:c.14+5263G>T, XR_245894.1:n.612+5263G>T, XR_245894.2:n.708+5263G>T, rs61293102
G > T
SNP
rs4290270 NC_000012.11:g.72416235A>T, NC_000012.12:g.72022455A>T, NG_008279.1:g.88610A>T, NM_173353.3:c.1125A>T, NP_775489.2:p.Ala375=, XM_005268642.1:c.1143A>T, XM_011537899.1:c.531A>T, XP_005268699.1:p.Ala381=, XP_011536201.1:p.Ala177=, rs57072898
A > T
SNP
A375A
rs4570625 NC_000012.11:g.72331923G>T, NC_000012.12:g.71938143G>T, NG_008279.1:g.4298G>T, NM_173353.3:c.-844G>T, XM_005268642.1:c.-844G>T, XR_245894.1:n.-840G>T, XR_245894.2:n.-744G>T, rs60080807
G > T
SNP
rs7305115 NC_000012.11:g.72372862A>G, NC_000012.12:g.71979082A>G, NG_008279.1:g.45237A>G, NM_173353.3:c.936A>G, NP_775489.2:p.Pro312=, XM_005268642.1:c.954A>G, XM_011537899.1:c.342A>G, XP_005268699.1:p.Pro318=, XP_011536201.1:p.Pro114=, rs58909855
A > G
SNP
P312P
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  FLJ37295; NTPH
PharmGKB Accession Id: PA128747823

Details

Cytogenetic Location: chr12 : q21.1 - q21.1
GP mRNA Boundary: chr12 : 72332626 - 72426221
GP Gene Boundary: chr12 : 72322626 - 72429221
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Genes involved in serotonin synthesis, release, reuptake, and in mediation of the antidepressant effect of selective serotonin reuptake inhibitors (SSRI) in human brain.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to TPH2: 22

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenetic study focused on fluoxetine pharmacodynamics in children and adolescent patients: impact of the serotonin pathway. Pharmacogenetics and genomics. 2016. Mas Sergi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms. Neuroscience letters. 2015. Plemenitaš Anja, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 2015. Bauer Isabelle E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Serotonin pathway polymorphisms and the treatment of major depressive disorder and anxiety disorders. Pharmacogenomics. 2015. Helton Sarah G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. Pharmacogenomics. 2015. Levran Orna, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Understanding the pharmacogenetics of selective serotonin reuptake inhibitors. Expert opinion on drug metabolism & toxicology. 2014. Fabbri Chiara, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders. Journal of child and adolescent psychopharmacology. 2013. Rotberg Benyamin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
No significant association between genetic variants in 7 candidate genes and response to methylphenidate treatment in adult patients with ADHD. Journal of clinical psychopharmacology. 2012. Contini Ver├┤nica, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics. 2012. Narasimhan Sneha, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Clinical pharmacology and therapeutics. 2011. Sadee W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Breaking Barriers in the Genomics and Pharmacogenetics of Drug Addiction. Clinical pharmacology and therapeutics. 2010. Ho M K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressive treatment. European archives of psychiatry and clinical neuroscience. 2010. Zobel Astrid, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular psychiatry. 2010. Kloiber S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals. Molecular psychiatry. 2009. Baehne C G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009. Perroud Nader, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. 2009. Illi Ari, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenetics and genomics. 2009. Peters Eric J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. 2009. Tsai Shih-Jen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of selective serotonin reuptake inhibitors in pediatric depression and anxiety. Pharmacogenomics. 2008. Kronenberg Sefi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Mutations in human monoamine-related neurotransmitter pathway genes. Human mutation. 2008. Haavik Jan, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenetics and genomics. 2008. Tzvetkov Mladen Vassilev, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Archives of general psychiatry. 2007. Lin Yi-Mei J, et al. PubMed

LinkOuts

NCBI Gene:
121278
OMIM:
607478
608516
613003
UCSC Genome Browser:
NM_173353
RefSeq RNA:
NM_173353
RefSeq Protein:
NP_775489
RefSeq DNA:
NG_008279
NT_029419
UniProtKB:
TPH2_HUMAN (Q8IWU9)
Ensembl:
ENSG00000139287
GeneCard:
TPH2
ALFRED:
LO007366W
HuGE:
TPH2
Comparative Toxicogenomics Database:
121278
ModBase:
Q8IWU9
HumanCyc Gene:
HS06603
HGNC:
20692

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