Gene:
CHRNA3
cholinergic receptor, nicotinic, alpha 3 (neuronal)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for CHRNA3

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs1051730 NC_000015.10:g.78601997G>A, NC_000015.9:g.78894339G>A, NG_016143.1:g.24299C>T, NM_000743.4:c.645C>T, NM_001166694.1:c.645C>T, NP_000734.2:p.Tyr215=, NP_001160166.1:p.Tyr215=, NR_046313.1:n.1146C>T, XM_006720382.1:c.444C>T, XM_011521173.1:c.564C>T, XP_006720445.1:p.Tyr148=, XP_011519475.1:p.Tyr188=, rs117683679, rs17486992, rs386514167, rs59313803
G > A
SNP
Y215Y
No VIP available No Clinical Annotations available VA
rs16969968 NC_000015.10:g.78590583G>A, NC_000015.9:g.78882925G>A, NG_023328.1:g.30064G>A, NM_000745.3:c.1192G>A, NM_001307945.1:c.458+734G>A, NP_000736.2:p.Asp398Asn, XM_005254142.1:c.707+485G>A, XM_005254142.2:c.707+485G>A, XM_011521174.1:c.458+734G>A, rs17486705, rs386541574, rs52821477
G > A
SNP
D398N
No VIP available CA VA
rs3743078 NC_000015.10:g.78602417C>G, NC_000015.9:g.78894759C>G, NG_016143.1:g.23879G>C, NM_000743.4:c.378-153G>C, NM_001166694.1:c.378-153G>C, NR_046313.1:n.879-153G>C, XM_006720382.1:c.177-153G>C, XM_011521173.1:c.297-153G>C
C > G
SNP
No VIP available CA VA
rs578776 NC_000015.10:g.78596058G>A, NC_000015.9:g.78888400G>A, NG_016143.1:g.30238C>T, NG_023328.1:g.35539G>A, NM_000743.4:c.*546C>T, NM_001166694.1:c.1390-2867C>T, NR_046313.1:n.2083+482C>T, XM_006720382.1:c.*546C>T, XM_011521173.1:c.*546C>T, rs386599954, rs57549958
G > A
SNP
No VIP available CA VA
rs7170068 NC_000015.10:g.78620601G>A, NC_000015.9:g.78912943G>A, NG_016143.1:g.5695C>T, NM_000743.4:c.82+112C>T, NM_001166694.1:c.82+112C>T, NR_046313.1:n.583+112C>T, XM_006720382.1:c.-984C>T, XM_011521173.1:c.-1175C>T
G > A
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  acetylcholine receptor, nicotinic, alpha 3 (neuronal)
Alternate Symbols:  None
PharmGKB Accession Id: PA113

Details

Cytogenetic Location: chr15 : q25.1 - q25.1
GP mRNA Boundary: chr15 : 78885394 - 78913637
GP Gene Boundary: chr15 : 78882394 - 78923637
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Nicotine Pathway (Chromaffin Cell), Pharmacodynamics
    Representation of genes involved in nicotine effects in chromaffin cells.
  1. Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Representation of genes involved in nicotine effects in dopaminergic neurons.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CHRNA5

Curated Information ?

Curated Information ?

Publications related to CHRNA3: 34

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. Scientific reports. 2016. Ware Jennifer J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Dissecting ancestry genomic background in substance dependence genome-wide association studies. Pharmacogenomics. 2015. Polimanti Renato, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking. PloS one. 2015. Tyndale Rachel F, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
CHRNA3 and CYP3A5*3 genotype, lung function and chronic obstructive pulmonary disease in the general population. Pharmacogenetics and genomics. 2014. Kaur-Knudsen Diljit, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska-Native tobacco users. Addiction (Abingdon, England). 2013. Zhu Andy Z X, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenetics and genomics. 2013. Bergen Andrew W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. International journal of molecular sciences. 2013. Wassenaar Catherine A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Interplay of Genetic Risk Factors (CHRNA5-CHRNA3-CHRNB4) and Cessation Treatments in Smoking Cessation Success. The American journal of psychiatry. 2012. Chen Li-Shiun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. Human genetics. 2012. Gold Allison B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. Journal of the National Cancer Institute. 2011. Wassenaar Catherine A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. The pharmacogenomics journal. 2011. Swan G E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms With Smoking Rate Among Treatment-Seeking Smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2011. Falcone Mary, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2010. Winterer Georg, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Breaking Barriers in the Genomics and Pharmacogenetics of Drug Addiction. Clinical pharmacology and therapeutics. 2010. Ho M K, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. Human genetics. 2010. Erlich Porat M, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010. Sherva Richard, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. Pharmacogenomics. 2010. De Ruyck Kim, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proceedings of the National Academy of Sciences of the United States of America. 2010. Hong L Elliot, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. Lung cancer (Amsterdam, Netherlands). 2010. Carcereny Enric, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2010. Li Ming D, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009. Chen Xiangning, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Human molecular genetics. 2009. Keskitalo Kaisu, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer research. 2009. Saccone Nancy L, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Human molecular genetics. 2009. Freathy Rachel M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Chronic obstructive pulmonary disease: towards pharmacogenetics. Genome medicine. 2009. Wood Alice M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Inherited susceptibility to common cancers. The New England journal of medicine. 2008. Foulkes William D. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS genetics. 2008. Weiss Robert B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nature genetics. 2008. Amos Christopher I, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008. Hung Rayjean J, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008. Thorgeirsson Thorgeir E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors. Molecular pharmacology. 2006. Mihalak Karla B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. 2003. West Kip A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Nicotinic acetylcholine receptors in autonomic ganglia. Autonomic neuroscience : basic & clinical. 2002. Skok Vladimir I. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia. Brain research bulletin. 2002. Tassonyi Edömer, et al. PubMed

LinkOuts

NCBI Gene:
1136
OMIM:
118503
612052
UCSC Genome Browser:
NM_000743
RefSeq RNA:
NM_000743
NM_001166694
RefSeq Protein:
NP_000734
NP_001160166
RefSeq DNA:
NG_016143
NT_010194
UniProtKB:
ACHA3_HUMAN (P32297)
Ensembl:
ENSG00000080644
GenAtlas:
CHRNA3
GeneCard:
CHRNA3
MutDB:
CHRNA3
ALFRED:
LO036567B
HuGE:
CHRNA3
Comparative Toxicogenomics Database:
1136
ModBase:
P32297
HumanCyc Gene:
HS01365
IUPHAR Receptor:
α3 (464)
HGNC:
1957

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