Gene:
CHEK1
checkpoint kinase 1

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  CHK1
PharmGKB Accession Id: PA110

Details

Cytogenetic Location: chr11 : q24.2 - q24.2
GP mRNA Boundary: chr11 : 125495031 - 125546150
GP Gene Boundary: chr11 : 125485031 - 125549150
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics
    Representation of the metabolism of gemtuzumab ozogamicin and its physiological effects.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ATM
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ATR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
CCNB1

Curated Information ?

Curated Information ?

Publications related to CHEK1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. The pharmacogenomics journal. 2010. Ho-Pun-Cheung A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping. Blood. 2008. Johnson David C, et al. PubMed

LinkOuts

NCBI Gene:
1111
OMIM:
603078
UCSC Genome Browser:
NM_001274
RefSeq RNA:
NM_001114121
NM_001114122
NM_001274
RefSeq Protein:
NP_001107593
NP_001107594
NP_001265
RefSeq DNA:
NT_033899
UniProtKB:
CHK1_HUMAN (O14757)
Ensembl:
ENSG00000149554
GenAtlas:
CHEK1
GeneCard:
CHEK1
MutDB:
CHEK1
ALFRED:
LO011659W
HuGE:
CHEK1
Comparative Toxicogenomics Database:
1111
ModBase:
O14757
HumanCyc Gene:
HS07626
HGNC:
1925

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