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2D structure from PubChem
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Generic Names
  • Difenidol
  • Difenidol HCl
  • Difenidol hydrochloride
  • Difenidolo [DCIT]
  • Difenidolum [INN-Latin]
  • Diphenidol HCl
  • Diphenidol hydrochloride
Trade Names
  • Ansmin
  • Avomol
  • Celmidol
  • Cephadol
  • Cerrosa
  • Maniol
  • Nometic
  • Satanolon
  • Verterge
  • Vontrol
  • Yesdol
Brand Mixture Names

PharmGKB Accession Id:


Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.

Source: Drug Bank


For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Diphenidol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.

Source: Drug Bank


Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


Well absorbed from gastrointestinal tract following oral administration.

Source: Drug Bank


4 hours

Source: Drug Bank


Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: Drug Bank


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank


KEGG Compound:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Therapeutic Targets Database:

Clinical Trials

These are trials that mention diphenidol and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.