Disease:
Pain, Postoperative

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP2D6 *1 N/A N/A N/A
No VIP available No VIP available VA CYP2D6 *10 N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs1045642 NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664
A > G
SNP
I1145I
No VIP available CA VA
rs11959113 NC_000005.10:g.148848933G>A, NC_000005.9:g.148228496G>A, XM_005268382.1:c.1175-14764G>A, XM_005268383.1:c.1174+20928G>A, rs61232536, rs74294119
G > A
SNP
No VIP available CA VA
rs1799971 NC_000006.11:g.154360797A>G, NC_000006.12:g.154039662A>G, NG_021208.1:g.34162A>G, NM_000914.4:c.118A>G, NM_001008503.2:c.118A>G, NM_001008504.3:c.118A>G, NM_001008505.2:c.118A>G, NM_001145279.3:c.397A>G, NM_001145280.3:c.-11+28644A>G, NM_001145281.2:c.47+29103A>G, NM_001145282.2:c.118A>G, NM_001145283.2:c.118A>G, NM_001145284.3:c.118A>G, NM_001145285.2:c.118A>G, NM_001145286.2:c.118A>G, NM_001285522.1:c.118A>G, NM_001285523.1:c.118A>G, NM_001285524.1:c.397A>G, NP_000905.3:p.Asn40Asp, NP_001008503.2:p.Asn40Asp, NP_001008504.2:p.Asn40Asp, NP_001008505.2:p.Asn40Asp, NP_001138751.1:p.Asn133Asp, NP_001138754.1:p.Asn40Asp, NP_001138755.1:p.Asn40Asp, NP_001138756.1:p.Asn40Asp, NP_001138757.1:p.Asn40Asp, NP_001138758.1:p.Asn40Asp, NP_001272451.1:p.Asn40Asp, NP_001272452.1:p.Asn40Asp, NP_001272453.1:p.Asn133Asp, NR_104348.1:n.252A>G, NR_104349.1:n.252A>G, NR_104350.1:n.252A>G, NR_104351.1:n.252A>G, XM_005267002.1:c.304A>G, XM_006715497.2:c.304A>G, XM_011535849.1:c.397A>G, XP_005267059.1:p.Asn102Asp, XP_006715560.1:p.Asn102Asp, XP_011534151.1:p.Asn133Asp, XR_245534.1:n.304A>G, XR_245535.1:n.304A>G, XR_245536.1:n.304A>G, XR_245537.1:n.304A>G, rs17181017, rs52818856, rs61596185
A > G
SNP
N40D
No VIP available No Clinical Annotations available VA
rs2032582 NC_000007.13:g.87160618A>C, NC_000007.13:g.87160618A>T, NC_000007.14:g.87531302A>C, NC_000007.14:g.87531302A>T, NG_011513.1:g.186947T>A, NG_011513.1:g.186947T>G, NM_000927.4:c.2677T>A, NM_000927.4:c.2677T>G, NP_000918.2:p.Ser893Ala, NP_000918.2:p.Ser893Thr, rs10228331, rs2229106, rs386553610, rs57135550, rs9641018
A > C
SNP
S893A
No VIP available No Clinical Annotations available VA
rs2076222 NC_000001.10:g.209791929G>T, NC_000001.11:g.209618584G>T, NG_007116.1:g.38892C>A, NM_000228.2:c.2777C>A, NM_001017402.1:c.2777C>A, NM_001127641.1:c.2777C>A, NP_000219.2:p.Ala926Asp, NP_001017402.1:p.Ala926Asp, NP_001121113.1:p.Ala926Asp, XM_005273124.1:c.2777C>A, XM_005273124.3:c.2777C>A, XP_005273181.1:p.Ala926Asp, rs58828090
G > T
SNP
A926D
No VIP available CA VA
rs2835859 NC_000021.8:g.39018162T>C, NC_000021.9:g.37645860T>C, NG_029892.2:g.275534A>G, NM_002240.4:c.947-20376A>G, XM_011529558.1:c.947-20376A>G, XM_011529559.1:c.947-20376A>G, rs57686640
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2952768 NC_000002.11:g.208494234T>C, NC_000002.12:g.207629510T>C, rs57113745, rs74270034
T > C
SNP
No VIP available No Clinical Annotations available VA
rs3845446 NC_000001.10:g.181766437T>C, NC_000001.11:g.181797301T>C, NM_000721.3:c.6270+443T>C, NM_001205293.1:c.6399+443T>C, NM_001205294.1:c.6213+443T>C, XM_005245477.1:c.6258+443T>C, XM_011509971.1:c.6342+443T>C, rs386587547, rs60661707
T > C
SNP
No VIP available CA VA
rs9384179 NC_000006.11:g.154421057G>A, NC_000006.12:g.154099922G>A, NG_021208.1:g.94422G>A, NM_000914.4:c.1164+8450G>A, NM_001008503.2:c.1164+8450G>A, NM_001145279.3:c.1443+8450G>A, NM_001145280.3:c.864+8450G>A, NM_001145281.2:c.921+8450G>A, NM_001145282.2:c.1164+8450G>A, NM_001145283.2:c.1165-8094G>A, NM_001145284.3:c.1165-7826G>A, NM_001145285.2:c.1165-7694G>A, NM_001145286.2:c.1165-7543G>A, NM_001145287.2:c.864+8450G>A, NM_001285522.1:c.291-18761G>A, NM_001285524.1:c.1443+8450G>A, NM_001285526.1:c.864+8450G>A, NR_104348.1:n.1407+5604G>A, NR_104349.1:n.1407+5604G>A, NR_104350.1:n.945+8450G>A, NR_104351.1:n.1407+5604G>A, XM_005267003.1:c.864+8450G>A, XM_011535849.1:c.1443+8450G>A, XM_011535859.1:c.864+8450G>A, XM_011535860.1:c.864+8450G>A, XM_011535861.1:c.864+8450G>A, XR_245534.1:n.1459+5604G>A, XR_245535.1:n.1459+5604G>A, XR_245536.1:n.1459+5604G>A, XR_245537.1:n.997+8450G>A
G > A
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names: 
Synonym
Postoperative Pain; Postoperative Pains; Postoperative pain
PharmGKB Accession Id: PA445210
External Vocabularies

Curated Information ?

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
No related diseases are available

Publications related to Pain, Postoperative: 19

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. Pharmacogenomics. 2015. Mieda Tsutomu, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Effect of the CYP2D6 gene polymorphism on postoperative analgesia of tramadol in Han nationality nephrectomy patients. European journal of clinical pharmacology. 2015. Dong Hong, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial. JAMA psychiatry. 2015. Oslin David W, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
OPRM1 genotype and naltrexone response in depressed alcohol-dependent patients. Pharmacogenetics and genomics. 2015. Foulds James A, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity. British journal of clinical pharmacology. 2014. Mouly S, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PloS one. 2015. Yoshida Kaori, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents. The pharmacogenomics journal. 2014. Chidambaran V, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics. 2014. Matic Maja, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. JAMA : the journal of the American Medical Association. 2013. Wachman Elisha M, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy. Cancer. 2012. Liu Yu-Chang, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients. Pharmacogenomics. 2011. Hung Chin-Chuan, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Lack of Association of OPRM1 and ABCB1 Single-Nucleotide Polymorphisms to Oxycodone Response in Postoperative Pain. Journal of clinical pharmacology. 2011. Zwisler Stine T, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva anestesiologica. 2011. Zhang W, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009. Fukuda Kenichi, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study. British journal of anaesthesia. 2009. Ginosar Y, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain. 2008. Landau Ruth, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clinical pharmacology and therapeutics. 2008. Campa D, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Archives of general psychiatry. 2008. Anton Raymond F, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 2007. Reyes-Gibby Cielito C, et al. PubMed