Disease:
Acquired Immunodeficiency Syndrome
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
| Gene ? |
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|---|
CA
|
GSTM1 | non-null | N/A | N/A | N/A | ||
|
CA
VA
|
GSTM1 | null | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *5A | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *5B | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *6A | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *6B | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *7A | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *7B | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *14A | N/A | N/A | N/A | ||
|
VA
|
NAT2 | *14B | N/A | N/A | N/A | ||
| rs1045642 | NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664 |
A > G
|
SNP |
I1145I
|
|||
| rs2233945 | NC_000006.11:g.31107361C=, NC_000006.11:g.31107361C>A, NC_000006.12:g.31139584C=, NC_000006.12:g.31139584C>A, NG_021348.1:g.29754C=, NG_021348.1:g.29754C>A, NM_014068.2:c.168-57A>C, NM_014068.2:c.168-57C>A, NM_014069.2:c.-558G>T, NM_014069.2:c.-558T>G, NT_113891.2:g.2622083C=, NT_113891.2:g.2622083C>A, NT_113891.3:g.2621977C=, NT_113891.3:g.2621977C>A, NT_167245.1:g.2404499C=, NT_167245.1:g.2404499C>A, NT_167245.2:g.2398914C=, NT_167245.2:g.2398914C>A, NT_167246.1:g.2455729C=, NT_167246.1:g.2455729C>A, NT_167246.2:g.2450109C=, NT_167246.2:g.2450109C>A, NT_167247.1:g.2489306C=, NT_167247.1:g.2489306C>A, NT_167247.2:g.2483721C=, NT_167247.2:g.2483721C>A, NT_167248.1:g.2403206A=, NT_167248.1:g.2403206A>C, NT_167248.2:g.2397610A=, NT_167248.2:g.2397610A>C, XM_011547844.1:c.*33A>C, XM_011547844.1:c.*33C>A, XM_011547845.1:c.*33A>C, XM_011547845.1:c.*33C>A, rs112468750, rs114324939, rs117539914 |
C > A
|
SNP | ||||
| rs2472677 | NC_000003.11:g.119518417C>T, NC_000003.12:g.119799570C>T, NG_011856.1:g.24087C>T, NM_003889.3:c.-22-7659C>T, NM_022002.2:c.96-7659C>T, NM_033013.2:c.-22-7659C>T, XM_005247866.1:c.-187-7659C>T, rs57813967 |
C > T
|
SNP | ||||
| rs3099844 | NC_000006.11:g.31448976C=, NC_000006.11:g.31448976C>A, NC_000006.12:g.31481199C=, NC_000006.12:g.31481199C>A, NT_113891.2:g.2958634A=, NT_113891.2:g.2958634A>C, NT_113891.3:g.2958528A=, NT_113891.3:g.2958528A>C, NT_167244.1:g.2763686C=, NT_167244.1:g.2763686C>A, NT_167244.2:g.2813770C=, NT_167244.2:g.2813770C>A, NT_167245.1:g.2734310C=, NT_167245.1:g.2734310C>A, NT_167245.2:g.2728725C=, NT_167245.2:g.2728725C>A, NT_167247.1:g.2828760C=, NT_167247.1:g.2828760C>A, NT_167247.2:g.2823175C=, NT_167247.2:g.2823175C>A, NT_167248.1:g.2742682C=, NT_167248.1:g.2742682C>A, NT_167248.2:g.2737086C=, NT_167248.2:g.2737086C>A, NT_167249.1:g.2779748C=, NT_167249.1:g.2779748C>A, NT_167249.2:g.2780450C=, NT_167249.2:g.2780450C>A, XR_926693.1:n.701G=, XR_926693.1:n.701G>T, XR_953042.1:n.531G=, XR_953042.1:n.531G>T, rs116662199, rs116841198, rs58471066, rs7757186 |
C > A
|
SNP | ||||
| rs72554665 | NC_000023.10:g.153760484C>A, NC_000023.10:g.153760484C>G, NC_000023.11:g.154532269C>A, NC_000023.11:g.154532269C>G, NG_009015.2:g.20304G>C, NG_009015.2:g.20304G>T, NM_000402.4:c.1466G>C, NM_000402.4:c.1466G>T, NM_001042351.2:c.1376G>C, NM_001042351.2:c.1376G>T, NP_000393.4:p.Arg489Leu, NP_000393.4:p.Arg489Pro, NP_001035810.1:p.Arg459Leu, NP_001035810.1:p.Arg459Pro, NW_003871103.3:g.1966248C>A, NW_003871103.3:g.1966248C>G, XM_005274657.1:c.1469G>C, XM_005274657.1:c.1469G>T, XM_005274657.2:c.1469G>C, XM_005274657.2:c.1469G>T, XM_005274658.1:c.1379G>C, XM_005274658.1:c.1379G>T, XM_005274658.2:c.1379G>C, XM_005274658.2:c.1379G>T, XM_005277833.1:c.1469G>C, XM_005277833.1:c.1469G>T, XM_005277834.1:c.1379G>C, XM_005277834.1:c.1379G>T, XM_011531132.1:c.*498G>C, XM_011531132.1:c.*498G>T, XP_005274714.1:p.Arg490Leu, XP_005274714.1:p.Arg490Pro, XP_005274715.1:p.Arg460Leu, XP_005274715.1:p.Arg460Pro, XP_005277890.1:p.Arg490Leu, XP_005277890.1:p.Arg490Pro, XP_005277891.1:p.Arg460Leu, XP_005277891.1:p.Arg460Pro |
C > A
|
SNP |
R489L
|
|||
| rs8175347 |
(TA)6 > (TA)5
(TA)6 > (TA)7
(TA)6 > (TA)8
|
microsatellite |
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147
Overview
| Alternate Names: |
|
|---|---|
| PharmGKB Accession Id: | PA443250 |
| External Vocabularies |
|
Curated Information ?
| Evidence | Drug |
|---|---|
| atazanavir | |
| efavirenz | |
| nevirapine | |
| sulfamethoxazole | |
| trimethoprim |
Relationships from National Drug File - Reference Terminology (NDF-RT)
May Treat
- abacavir may treat Acquired Immunodeficiency Syndrome
- amprenavir may treat Acquired Immunodeficiency Syndrome
- delavirdine may treat Acquired Immunodeficiency Syndrome
- didanosine may treat Acquired Immunodeficiency Syndrome
- efavirenz may treat Acquired Immunodeficiency Syndrome
- enfuvirtide may treat Acquired Immunodeficiency Syndrome
- indinavir may treat Acquired Immunodeficiency Syndrome
- lamivudine may treat Acquired Immunodeficiency Syndrome
- lopinavir may treat Acquired Immunodeficiency Syndrome
- nelfinavir may treat Acquired Immunodeficiency Syndrome
- nevirapine may treat Acquired Immunodeficiency Syndrome
- ritonavir may treat Acquired Immunodeficiency Syndrome
- saquinavir may treat Acquired Immunodeficiency Syndrome
- stavudine may treat Acquired Immunodeficiency Syndrome
- tenofovir may treat Acquired Immunodeficiency Syndrome
- zalcitabine may treat Acquired Immunodeficiency Syndrome
- zidovudine may treat Acquired Immunodeficiency Syndrome
