Disease:
Abnormalities, Drug-Induced
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
| Gene ? |
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|---|
| rs2306283 | NC_000012.11:g.21329738A>G, NC_000012.12:g.21176804A>G, NG_011745.1:g.50611A>G, NM_006446.4:c.388A>G, NP_006437.3:p.Asn130Asp, rs17389242, rs52832430, rs60767041 |
A > G
|
SNP |
N130D
|
|||
| rs4149056 | NC_000012.11:g.21331549T>C, NC_000012.12:g.21178615T>C, NG_011745.1:g.52422T>C, NM_006446.4:c.521T>C, NP_006437.3:p.Val174Ala, rs52816141, rs60037639 |
T > C
|
SNP |
V174A
|
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147
Overview
| Alternate Names: |
|
|---|---|
| PharmGKB Accession Id: | PA443224 |
| External Vocabularies |
|
Curated Information ?
| Evidence | Drug Class |
|---|---|
| hmg coa reductase inhibitors |
Relationships from National Drug File - Reference Terminology (NDF-RT)
May Treat
- benztropine may treat Abnormalities, Drug-Induced
- bethanechol may treat Abnormalities, Drug-Induced
- edrophonium may treat Abnormalities, Drug-Induced
- glycopyrrolate may treat Abnormalities, Drug-Induced
- hyoscyamine may treat Abnormalities, Drug-Induced
- neostigmine may treat Abnormalities, Drug-Induced
- physostigmine may treat Abnormalities, Drug-Induced
- phytonadione may treat Abnormalities, Drug-Induced
- pyridostigmine may treat Abnormalities, Drug-Induced
- trihexyphenidyl may treat Abnormalities, Drug-Induced
May Prevent
- digoxin immune fab may prevent Abnormalities, Drug-Induced
Publications related to Abnormalities, Drug-Induced: 5
Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study. Clinical pharmacology and therapeutics. 2010. Donnelly L A, et al.
|
|
|
Drug-induced liver injury: past, present and future. Pharmacogenomics. 2010. Daly Ann K.
|
|
|
Drug-induced autoimmunity. Current opinion in rheumatology. 2009. Dedeoglu Fatma.
|
|
|
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nature genetics. 2009. Newton-Cheh Christopher, et al.
|
|
|
Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins. American journal of medical genetics. Part A. 2004. Edison Robin J, et al.
|