Disease:
heart valve replacement

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP2C9 *1 N/A N/A N/A
No VIP available No VIP available VA CYP2C9 *3 N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs10517 NC_000016.10:g.69709857A>G, NC_000016.9:g.69743760A>G, NG_011504.1:g.21774T>C, NM_000903.2:c.*1119T>C, NM_001025433.1:c.*1119T>C, NM_001025434.1:c.*1119T>C, NM_001286137.1:c.*1119T>C, XM_005255830.1:c.*1119T>C, rs1131357, rs3191227, rs386514164, rs60683463
A > G
SNP
No VIP available No Clinical Annotations available VA
rs1057868 NC_000007.13:g.75615006C>T, NC_000007.14:g.75985688C>T, NG_008930.1:g.75587C>T, NM_000941.2:c.1508C>T, NP_000932.3:p.Ala503Val, NW_003871064.1:g.3514924C>T, XM_005250459.1:c.1508C>T, XM_005250460.1:c.1205C>T, XM_005250461.1:c.932C>T, XM_005277600.1:c.1508C>T, XM_005277601.1:c.1205C>T, XM_005277602.1:c.932C>T, XP_005250516.1:p.Ala503Val, XP_005250517.1:p.Ala402Val, XP_005250518.1:p.Ala311Val, XP_005277657.1:p.Ala503Val, XP_005277658.1:p.Ala402Val, XP_005277659.1:p.Ala311Val, rs17840495, rs17846082, rs17859083, rs3198400, rs57699079
C > T
SNP
A503V
No VIP available No Clinical Annotations available VA
rs1057910 NC_000010.10:g.96741053A=, NC_000010.10:g.96741053A>C, NC_000010.11:g.94981296A=, NC_000010.11:g.94981296A>C, NG_008385.1:g.47639A=, NG_008385.1:g.47639A>C, NM_000771.3:c.1075A=, NM_000771.3:c.1075A>C, NP_000762.2:p.Ile359=, NP_000762.2:p.Ile359Leu, XM_005269575.1:c.1075A=, XM_005269575.1:c.1075A>C, XP_005269632.1:p.Ile359=, XP_005269632.1:p.Ile359Leu, rs17847042, rs3198471, rs61212474
A > C
SNP
I359L
No VIP available No Clinical Annotations available VA
rs12065184 NC_000001.10:g.161278677A>C, NC_000001.11:g.161308887A>C, NG_008055.1:g.6086T>G, NM_000530.6:c.67+952T>G, NM_000530.7:c.67+952T>G, NM_001315491.1:c.67+952T>G, rs52829536, rs59221238
A > C
SNP
No VIP available No Clinical Annotations available VA
rs12714145 NC_000002.11:g.85787341C>T, NC_000002.12:g.85560218C>T, NG_011811.2:g.6317G>A, NM_000821.6:c.214+597G>A, NM_001142269.3:c.44-1143G>A, NM_001311312.1:c.214+597G>A, XM_005264259.1:c.214+597G>A, XM_005264259.3:c.214+597G>A, XM_011532764.1:c.-445+597G>A, XM_011532765.1:c.-444-1143G>A, XR_939677.1:n.279+597G>A, rs59983638
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1415774 NC_000020.10:g.33765616A>G, NC_000020.11:g.35177813A>G, NG_032899.1:g.10843A>G, NM_006404.4:c.*1000A>G, XM_005260251.1:c.601+1367A>G, XM_011528496.1:c.601+1367A>G, rs17321460, rs58892463, rs60278957
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2069514 NC_000015.10:g.74745879G>A, NC_000015.9:g.75038220G>A, NG_008431.1:g.28338G>A
G > A
SNP
No VIP available No Clinical Annotations available VA
rs2108622 NC_000019.10:g.15879621C>T, NC_000019.9:g.15990431C>T, NG_007971.2:g.23454G>A, NM_001082.4:c.1297G>A, NP_001073.3:p.Val433Met, rs116975254, rs52819608, rs57319528
C > T
SNP
V433M
No VIP available No Clinical Annotations available VA
rs2189784 NC_000019.10:g.15848390G>A, NC_000019.9:g.15959200G>A, rs60426306
G > A
SNP
No VIP available No Clinical Annotations available VA
rs2260863 NC_000001.10:g.226019774G>C, NC_000001.11:g.225832073G>C, NG_009776.1:g.26978G>C, NM_000120.3:c.364+114G>C, NM_001136018.3:c.364+114G>C, NM_001291163.1:c.364+114G>C, XM_005273085.1:c.364+114G>C, rs57978216
G > C
SNP
No VIP available No Clinical Annotations available VA
rs2290228 NC_000007.13:g.128388648G>A, NC_000007.14:g.128748594G>A, NG_033110.1:g.14303G>A, NM_001130674.2:c.11G>A, NM_001199671.1:c.35G>A, NM_001199672.1:c.35G>A, NM_001199673.1:c.11G>A, NM_001219.4:c.11G>A, NP_001124146.1:p.Arg4Gln, NP_001186600.1:p.Arg12Gln, NP_001186601.1:p.Arg12Gln, NP_001186602.1:p.Arg4Gln, NP_001210.1:p.Arg4Gln, NR_074086.1:n.141+9162G>A, XM_011516588.1:c.-406G>A, rs10399443, rs11545532, rs61408000
G > A
SNP
R4Q
No VIP available CA VA
rs2304429
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2501873 NC_000001.10:g.161204538C>T, NC_000001.11:g.161234748C>T, NG_029113.1:g.8463G>A, NM_001077469.2:c.238+1099G>A, NM_001077470.2:c.151+1099G>A, NM_001077471.2:c.238+1099G>A, NM_001077472.2:c.151+1099G>A, NM_001077473.2:c.151+1099G>A, NM_001077474.2:c.238+1099G>A, NM_001077475.2:c.151+1099G>A, NM_001077476.2:c.151+1099G>A, NM_001077477.2:c.151+1099G>A, NM_001077478.2:c.238+1099G>A, NM_001077479.2:c.151+1099G>A, NM_001077480.2:c.238+1099G>A, NM_001077481.2:c.238+1099G>A, NM_001077482.2:c.238+1099G>A, NM_005122.4:c.238+1099G>A, XM_005245693.1:c.454+1099G>A, XM_005245693.3:c.454+1099G>A, XM_005245694.1:c.454+1099G>A, XM_005245694.3:c.454+1099G>A, XM_005245695.1:c.454+1099G>A, XM_005245696.1:c.454+1099G>A, XM_005245697.1:c.238+1099G>A, XM_005245697.3:c.238+1099G>A, XM_005245698.1:c.454+1099G>A, XM_005245699.1:c.454+1099G>A, XM_011510237.1:c.454+1099G>A, rs57345476, rs74230383
C > T
SNP
No VIP available No Clinical Annotations available VA
rs28371759 NC_000007.13:g.99361626A>G, NC_000007.14:g.99764003A>G, NG_008421.1:g.25183T>C, NM_001202855.2:c.875T>C, NM_017460.5:c.878T>C, NP_001189784.1:p.Leu292Pro, NP_059488.2:p.Leu293Pro, XM_011515841.1:c.878T>C, XM_011515842.1:c.875T>C, XP_011514143.1:p.Leu293Pro, XP_011514144.1:p.Leu292Pro, rs386574775, rs60608883
A > G
SNP
L292P
No VIP available No Clinical Annotations available VA
rs2868177 NC_000007.13:g.75589903A>G, NC_000007.14:g.75960585A>G, NG_008930.1:g.50484A>G, NM_000941.2:c.188+6405A>G, NW_003871064.1:g.3489821A>G, XM_005250459.1:c.188+6405A>G, XM_005250461.1:c.-264+6405A>G, XM_005277600.1:c.188+6405A>G, XM_005277602.1:c.-264+6405A>G, rs10375158, rs59093849, rs61116122
A > G
SNP
No VIP available No Clinical Annotations available VA
rs3093105 NC_000019.10:g.15897578A>C, NC_000019.9:g.16008388A>C, NG_007971.2:g.5497T>G, NM_001082.4:c.34T>G, NP_001073.3:p.Trp12Gly, rs117322022
A > C
SNP
W12G
No VIP available No Clinical Annotations available VA
rs3093158 NC_000019.10:g.15889356C>T, NC_000019.9:g.16000166C>T, NG_007971.2:g.13719G>A, NM_001082.4:c.918+67G>A, rs58337631
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3136516 NC_000011.10:g.46739206G>A, NC_000011.9:g.46760756G>A, NG_008953.1:g.25014G>A, NM_000506.4:c.1726-59G>A, NM_001311257.1:c.1678-59G>A, XR_428840.2:n.1588-59G>A, rs17847084, rs587776431
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3212198 NC_000020.10:g.43044362C>T, NC_000020.11:g.44415722C>T, NG_009818.1:g.64922C>T, NM_000457.4:c.648+1060C>T, NM_001030003.2:c.582+1060C>T, NM_001030004.2:c.582+1060C>T, NM_001258355.1:c.627+1060C>T, NM_001287182.1:c.573+1060C>T, NM_001287183.1:c.573+1060C>T, NM_001287184.1:c.573+1060C>T, NM_175914.4:c.582+1060C>T, NM_178849.2:c.648+1060C>T, NM_178850.2:c.648+1060C>T, XM_005260407.1:c.765+1060C>T, XM_005260407.2:c.765+1060C>T, XM_011528797.1:c.696+1060C>T, XM_011528798.1:c.696+1060C>T, rs3787357, rs57374331
C > T
SNP
No VIP available No Clinical Annotations available VA
rs339097 NC_000007.13:g.128399224A>G, NC_000007.14:g.128759170A>G, NG_033110.1:g.24879A>G, NM_001130674.2:c.582+133A>G, NM_001199671.1:c.606+133A>G, NM_001199672.1:c.606+133A>G, NM_001199673.1:c.582+133A>G, NM_001219.4:c.582+133A>G, NR_074086.1:n.308+133A>G, XM_011516588.1:c.360+133A>G, rs1668425, rs386582001, rs56844598
A > G
SNP
No VIP available No Clinical Annotations available VA
rs3756009 NC_000004.11:g.187186111A>G, NC_000004.12:g.186264957A>G, NG_008051.1:g.3994A>G, NM_000128.3:c.-1340A>G, XM_005262821.1:c.-1340A>G, XM_005262821.2:c.-1340A>G, XM_005262822.1:c.-1340A>G, XM_005262822.2:c.-1340A>G, XM_005262823.1:c.-1340A>G, XM_005262823.2:c.-1340A>G, XM_005262824.1:c.-1340A>G, XM_005262825.1:c.-1340A>G, XM_005262826.1:c.-1340A>G, XM_006714137.1:c.-1340A>G, XR_938706.1:n.-988A>G, XR_938707.1:n.-988A>G, rs17507427
A > G
SNP
No VIP available CA VA
rs3826041
A > C
SNP
No VIP available No Clinical Annotations available VA
rs4124874 NC_000002.11:g.234665659T>G, NC_000002.12:g.233757013T>G, NG_002601.2:g.172270T>G, NG_033238.1:g.1741T>G, NM_001072.3:c.862-10021T>G, NM_007120.2:c.868-10021T>G, NM_019075.2:c.856-10021T>G, NM_019076.4:c.856-10021T>G, NM_019077.2:c.856-10021T>G, NM_019078.1:c.868-10021T>G, NM_019093.2:c.868-10021T>G, NM_021027.2:c.856-10021T>G, NM_205862.1:c.61-10021T>G, NR_037694.1:n.-1668A>C, NR_037695.1:n.-1668A>C, NR_037696.1:n.-1668A>C, XR_241238.1:n.924-10021T>G, XR_241240.1:n.1023-10021T>G, XR_241241.1:n.942-10021T>G, rs57409706
T > G
SNP
No VIP available No Clinical Annotations available VA
rs4148323 NC_000002.11:g.234669144G>A, NC_000002.12:g.233760498G>A, NG_002601.2:g.175755G>A, NG_033238.1:g.5226G>A, NM_000463.2:c.211G>A, NM_001072.3:c.862-6536G>A, NM_007120.2:c.868-6536G>A, NM_019075.2:c.856-6536G>A, NM_019076.4:c.856-6536G>A, NM_019077.2:c.856-6536G>A, NM_019078.1:c.868-6536G>A, NM_019093.2:c.868-6536G>A, NM_021027.2:c.856-6536G>A, NM_205862.1:c.61-6536G>A, NP_000454.1:p.Gly71Arg, XR_241238.1:n.924-6536G>A, XR_241239.1:n.233G>A, XR_241240.1:n.1023-6536G>A, XR_241241.1:n.942-6536G>A, rs113525835, rs34360183, rs58105808, rs58585123
G > A
SNP
G71R
No VIP available No Clinical Annotations available VA
rs4244285 NC_000010.10:g.96541616G>A, NC_000010.11:g.94781859G>A, NG_008384.2:g.24154G>A, NM_000769.1:c.681G>A, NM_000769.2:c.681G>A, NP_000760.1:p.Pro227=, rs116940633, rs17879456, rs60361278
G > A
SNP
P227P
No VIP available No Clinical Annotations available VA
rs4645943 NC_000008.10:g.128747471C>T, NC_000008.11:g.127735225C>T, NG_007161.1:g.4156C>T, NM_002467.4:c.-1369C>T, NR_117101.1:n.-1258G>A, NR_117102.1:n.-1258G>A, XM_005250922.1:c.-1411C>T, XR_242431.1:n.-1261G>A, rs57894328
C > T
SNP
No VIP available No Clinical Annotations available VA
rs4645962 NC_000008.10:g.128751326T>C, NC_000008.11:g.127739080T>C, NG_007161.1:g.8011T>C, NM_002467.4:c.802+61T>C, XM_005250922.1:c.757+61T>C
T > C
SNP
No VIP available No Clinical Annotations available VA
rs4645974 NC_000008.10:g.128754689C>T, NC_000008.11:g.127742443C>T, NG_007161.1:g.11374C>T, rs56434981, rs59670569
C > T
SNP
No VIP available No Clinical Annotations available VA
rs4653436 NC_000001.10:g.225995211G>A, NC_000001.11:g.225807509G>A, NG_009776.1:g.2415G>A, rs57171465
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4917639 NC_000010.10:g.96725535A>C, NC_000010.11:g.94965778A>C, NG_008385.1:g.32121A>C, NM_000771.3:c.820-6326A>C, XM_005269575.1:c.820-6326A>C, rs17429632, rs56870279
A > C
SNP
No VIP available No Clinical Annotations available VA
rs4986893 NC_000010.10:g.96540410G>A, NC_000010.11:g.94780653G>A, NG_008384.2:g.22948G>A, NM_000769.2:c.636G>A, NP_000760.1:p.Trp212Ter, rs52827375, rs57081121
G > A
SNP
W212*
No VIP available No Clinical Annotations available VA
rs699664 NC_000002.11:g.85780536C>T, NC_000002.12:g.85553413C>T, NG_011811.2:g.13122G>A, NM_000821.6:c.974G>A, NM_001142269.3:c.803G>A, NP_000812.2:p.Arg325Gln, NP_001135741.1:p.Arg268Gln, XM_005264259.1:c.974G>A, XM_005264259.3:c.974G>A, XM_011532764.1:c.152G>A, XM_011532765.1:c.152G>A, XP_005264316.1:p.Arg325Gln, XP_011531066.1:p.Arg51Gln, XP_011531067.1:p.Arg51Gln, XR_939677.1:n.1039G>A, rs116926260, rs17617541, rs386606475, rs52835631
C > T
SNP
R325Q
No VIP available CA VA
rs72800847
G > A
SNP
No VIP available No Clinical Annotations available VA
rs7294 NC_000016.10:g.31091000C>T, NC_000016.9:g.31102321C>T, NG_011564.1:g.8956G>A, NM_001311311.1:c.*134G>A, NM_024006.5:c.*134G>A, NM_206824.2:c.*237G>A, XM_005255568.1:c.*134G>A, XM_011545816.1:c.-2191G>A, XM_011545817.1:c.-2191G>A, XM_011545818.1:c.-2191G>A, XM_011545819.1:c.-2191G>A, XM_011545820.1:c.-2191G>A, XM_011545943.1:c.*134G>A, XM_011545944.1:c.*134G>A, XM_011545945.1:c.*237G>A, XR_243303.1:n.1175G>A, XR_950848.1:n.1414G>A, rs17880624, rs59098562
C > T
SNP
No VIP available No Clinical Annotations available VA
rs7412 NC_000019.10:g.44908822C>T, NC_000019.9:g.45412079C>T, NG_007084.2:g.8041C>T, NM_000041.3:c.526C>T, NM_001302688.1:c.604C>T, NM_001302689.1:c.526C>T, NM_001302690.1:c.526C>T, NM_001302691.1:c.526C>T, NP_000032.1:p.Arg176Cys, NP_001289617.1:p.Arg202Cys, NP_001289618.1:p.Arg176Cys, NP_001289619.1:p.Arg176Cys, NP_001289620.1:p.Arg176Cys, XM_005258867.1:c.604C>T, XM_005258868.1:c.526C>T, XP_005258924.1:p.Arg202Cys, XP_005258925.1:p.Arg176Cys, rs3200542
C > T
SNP
R176C
No VIP available No Clinical Annotations available VA
rs7542281 NC_000001.10:g.169536439C>T, NC_000001.11:g.169567201C>T, NG_011806.1:g.24331G>A, NM_000130.4:c.373+5020G>A, rs9332558
C > T
SNP
No VIP available CA VA
rs887829 NC_000002.11:g.234668570C>T, NC_000002.12:g.233759924C>T, NG_002601.2:g.175181C>T, NG_033238.1:g.4652C>T, NM_000463.2:c.-364C>T, NM_001072.3:c.862-7110C>T, NM_007120.2:c.868-7110C>T, NM_019075.2:c.856-7110C>T, NM_019076.4:c.856-7110C>T, NM_019077.2:c.856-7110C>T, NM_019078.1:c.868-7110C>T, NM_019093.2:c.868-7110C>T, NM_021027.2:c.856-7110C>T, NM_205862.1:c.61-7110C>T, XR_241238.1:n.924-7110C>T, XR_241239.1:n.-342C>T, XR_241240.1:n.1023-7110C>T, XR_241241.1:n.942-7110C>T, rs12990609, rs34790730, rs36207722, rs386619532, rs61315639
C > T
SNP
No VIP available No Clinical Annotations available VA
rs9332127 NC_000010.10:g.96707471G>C, NC_000010.11:g.94947714G>C, NG_008385.1:g.14057G>C, NM_000771.3:c.482-65G>C, XM_005269575.1:c.482-65G>C, rs17847038, rs58304507
G > C
SNP
No VIP available No Clinical Annotations available VA
rs9923231 NC_000016.10:g.31096368C=, NC_000016.10:g.31096368C>T, NC_000016.9:g.31107689C=, NC_000016.9:g.31107689C>T, NG_011564.1:g.3588G=, NG_011564.1:g.3588G>A, NM_001311311.1:c.-1639G=, NM_001311311.1:c.-1639G>A, NM_024006.5:c.-1639G=, NM_024006.5:c.-1639G>A, NM_206824.2:c.-1639G=, NM_206824.2:c.-1639G>A, XM_005255568.1:c.-1639G=, XM_005255568.1:c.-1639G>A, XM_011545943.1:c.-1639G=, XM_011545943.1:c.-1639G>A, XM_011545944.1:c.-1252G=, XM_011545944.1:c.-1252G>A, XM_011545945.1:c.-1252G=, XM_011545945.1:c.-1252G>A, XR_243303.1:n.-990G=, XR_243303.1:n.-990G>A, XR_950848.1:n.-31G=, XR_950848.1:n.-31G>A, rs117572127, rs17878363, rs60511154
C > A
C > G
C > T
SNP
No VIP available No Clinical Annotations available VA
rs9934438 NC_000016.10:g.31093557G>A, NC_000016.9:g.31104878G>A, NG_011564.1:g.6399C>T, NM_001311311.1:c.174-136C>T, NM_024006.5:c.174-136C>T, NM_206824.2:c.173+1000C>T, XM_005255568.1:c.174-136C>T, XM_011545943.1:c.174-136C>T, XM_011545944.1:c.174-136C>T, XM_011545945.1:c.173+1000C>T, XR_243303.1:n.823-236C>T, XR_950848.1:n.962-136C>T, rs17641219
G > A
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names: 
PharmGKB Accession Id: PA166123431
External Vocabularies

Curated Information ?

Curated Information ?

Evidence Drug
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acenocoumarol
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
warfarin
No related diseases are available

Publications related to heart valve replacement: 12

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Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population. Pharmacogenomics. 2017. Tong Hoi Y, et al. PubMed
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The impact of non-genetic and genetic factors on a stable warfarin dose in Thai patients. European journal of clinical pharmacology. 2017. Wattanachai Nitsupa, et al. PubMed
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The association between GGCX, miR-133 genetic polymorphisms and warfarin stable dosage in Han Chinese patients with mechanical heart valve replacement. Journal of clinical pharmacy and therapeutics. 2017. Tang X-Y, et al. PubMed
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Clinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement. Medicine. 2017. Liu Rui, et al. PubMed
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Genetic polymorphisms of patients on stable warfarin maintenance therapy in a Ghanaian population. BMC research notes. 2016. Kudzi William, et al. PubMed
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Identification of Novel Variants Associated with Warfarin Stable Dosage Using a Two-stage Extreme Phenotype Strategy. Journal of thrombosis and haemostasis : JTH. 2016. Luo Zhiying, et al. PubMed
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Influence of UDP-Glucuronosyltransferase Polymorphisms on Stable Warfarin Doses in Patients with Mechanical Cardiac Valves. Cardiovascular therapeutics. 2015. An Sook Hee, et al. PubMed
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A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population. PloS one. 2016. Tong Hoi Y, et al. PubMed
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Effects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements. Pharmacogenomics. 2015. Lee Kyung E, et al. PubMed
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Warfarin dosage response related pharmacogenetics in chinese population. PloS one. 2015. Li Siyue, et al. PubMed
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Combined effects of hepatocyte nuclear factor 4alpha and constitutive androstane receptor on stable warfarin doses. Pharmacogenetics and genomics. 2014. Moon Jung Yeon, et al. PubMed
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A pharmacogenetics-based warfarin maintenance dosing algorithm from northern chinese patients. PloS one. 2014. Chen Jinxing, et al. PubMed