Chemical: Drug
succinylcholine

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.


Annotated Labels

  1. FDA Label for succinylcholine and BCHE,CACNA1S,RYR1
  2. HCSC Label for succinylcholine and BCHE

last updated 08/07/2014

1. FDA Label for succinylcholine and BCHE,CACNA1S,RYR1

Actionable PGx

Summary

Succinylcholine is rapid acting, depolarizing skeletal muscle relaxant indicated as an adjunct to general anesthesia, to facilitate tracheal intubation and mechanical ventilation.

Annotation

The FDA-approved label warns that individuals who are carriers of the atypical variant of the plasma cholinesterase gene (BCHE) are at risk of prolonged apnea if administered succinylcholine. Patients with genetic mutations that cause Duchene's or Becker's muscular dystrophy who are given succinylcholine are also at increased risk of rhabdomyolysis, hyperkalemia and cardiac arrest. Finally, patients with a family history of malignant hyperthermia who are given succinylcholine have an elevated risk of developing malignant hyperthermia.

Specific variants in the RYR1 and CACNA1S genes are associated with risk of malignant hyperthermia in individuals administered succinylcholine.
Although the succinylcholine chloride (Anectine) drug label does not specifically mention genetic testing, the FDA-approved label contraindicates succinylcholine for individuals carrying one of many genetic variants known to increase the risk of malignant hyperthermia or hyperkalemia, and that succinylcholine should be administered with caution, if at all, in patients who are homozygous for the atypical-variant of plasma cholinesterase.

Excerpts from the succinylcholine chloride (Anectine) drug label:


RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest, and death after the administration of succinylcholine to apparently healthy children who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular dystrophy.

Succinylcholine is contraindicated in persons with personal or familial history of malignant hyperthermia, skeletal muscle myopathies, and known hypersensitivity to the drug.

WARNINGS
SUCCINYLCHOLINE IS METABOLIZED BY PLASMA CHOLINESTERASE AND SHOULD BE USED WITH CAUTION, IF AT ALL, IN PATIENTS KNOWN TO BE OR SUSPECTED OF BEING HOMOZYGOUS FOR THE ATYPICAL PLASMA CHOLINESTERASE GENE.

Patients homozygous for atypical plasma cholinesterase gene (1 in 2500 patients) are extremely sensitive to the neuromuscular blocking effect of succinylcholine. In these patients, a 5- to 10-mg test dose of succinylcholine may be administered to evaluate sensitivity to succinylcholine, or neuromuscular blockade may be produced by the cautious administration of a 1-mg/mL solution of succinylcholine by slow IV infusion. Apnea or prolonged muscle paralysis should be treated with controlled respiration.

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the succinylcholine chloride drug label.

*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.

Full label available at DailyMed

Genes and/or phenotypes found in this label

  • Apnea
    • other, Warnings section, Pediatric use section, Adverse reactions section, Precautions section
    • source: U.S. Food and Drug Administration
  • Hyperkalemia
    • other, Boxed warning section, Contraindications section, Pediatric use section, Adverse reactions section, Warnings and precautions section
    • source: U.S. Food and Drug Administration
  • Malignant Hyperthermia
    • other, Boxed warning section, Contraindications section, Warnings section, Pediatric use section, Adverse reactions section
    • source: U.S. Food and Drug Administration
  • BCHE
    • other, Adverse reactions section, Warnings and precautions section
    • source: U.S. Food and Drug Administration

last updated 06/08/2015

2. HCSC Label for succinylcholine and BCHE

Actionable PGx

Summary

The product monograph for succinylcholine notes that it should be used with caution, if at all, in patients know or suspected of being homozygous for the atypical plasma cholinesterase gene (BCHE), due to the risk for prolonged muscle paralysis.

Annotation

Succinylcholine is a neuromuscular blocking agent indicated as an adjunct to general anesthesia. Excerpts from the succinylcholine product monograph:

Succinylcholine is metabolized by plasma cholinesterase and should be used with caution, if at all, in patients known to be or suspected of being homozygous for the atypical plasma cholinesterase gene.

Patients homozygous for atypical plasma cholinesterase gene (1 in 2500 patients) are extremely sensitive to the neuromuscular blocking effect of succinylcholine. In these patients, a 5 to 10 mg test dose of succinylcholine may be administered, or neuromuscular blockade may be produced by the cautious administration of a 1 mg/mL solution of succinylcholine by intravenous drip. Apnea or prolonged muscle paralysis should be treated with controlled respiration.

For the complete product monograph text with sections containing pharmacogenetic information highlighted, see the succinylcholine product monograph.

*Disclaimer: The contents of this page have not been endorsed by HCSC and are the sole responsibility of PharmGKB.


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for succinylcholine

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA RYR1 571I;3366R;3933Y N/A N/A N/A
No VIP available No VIP available VA RYR1 571V;3366H;3933C N/A N/A N/A
No VIP available No Clinical Annotations available VA
BCHE deficiency N/A N/A N/A
rs111888148 NC_000019.10:g.38455463G>A, NC_000019.10:g.38455463G>T, NC_000019.9:g.38946103G>A, NC_000019.9:g.38946103G>T, NG_008866.1:g.26764G>A, NG_008866.1:g.26764G>T, NM_000540.2:c.1589G>A, NM_000540.2:c.1589G>T, NM_001042723.1:c.1589G>A, NM_001042723.1:c.1589G>T, NP_000531.2:p.Arg530His, NP_000531.2:p.Arg530Leu, NP_001036188.1:p.Arg530His, NP_001036188.1:p.Arg530Leu, XM_006723317.1:c.1589G>A, XM_006723317.1:c.1589G>T, XM_006723319.1:c.1589G>A, XM_006723319.1:c.1589G>T, XM_011527204.1:c.1586G>A, XM_011527204.1:c.1586G>T, XM_011527205.1:c.1589G>A, XM_011527205.1:c.1589G>T, XP_006723380.1:p.Arg530His, XP_006723380.1:p.Arg530Leu, XP_006723382.1:p.Arg530His, XP_006723382.1:p.Arg530Leu, XP_011525506.1:p.Arg529His, XP_011525506.1:p.Arg529Leu, XP_011525507.1:p.Arg530His, XP_011525507.1:p.Arg530Leu
G > A
SNP
R530H
rs112563513 NC_000019.10:g.38499223G>A, NC_000019.9:g.38989863G>A, NG_008866.1:g.70524G>A, NM_000540.2:c.7007G>A, NM_001042723.1:c.7007G>A, NP_000531.2:p.Arg2336His, NP_001036188.1:p.Arg2336His, XM_006723317.1:c.7007G>A, XM_006723319.1:c.7007G>A, XM_011527204.1:c.7004G>A, XM_011527205.1:c.7007G>A, XP_006723380.1:p.Arg2336His, XP_006723382.1:p.Arg2336His, XP_011525506.1:p.Arg2335His, XP_011525507.1:p.Arg2336His
G > A
SNP
R2336H
VIP No Clinical Annotations available No Variant Annotations available
rs118192116 NC_000019.10:g.38451850C>G, NC_000019.9:g.38942490C>G, NG_008866.1:g.23151C>G, NM_000540.2:c.1209C>G, NM_001042723.1:c.1209C>G, NP_000531.2:p.Ile403Met, NP_001036188.1:p.Ile403Met, XM_006723317.1:c.1209C>G, XM_006723319.1:c.1209C>G, XM_011527204.1:c.1206C>G, XM_011527205.1:c.1209C>G, XP_006723380.1:p.Ile403Met, XP_006723382.1:p.Ile403Met, XP_011525506.1:p.Ile402Met, XP_011525507.1:p.Ile403Met
C > G
SNP
I403M
rs118192122 NC_000019.10:g.38500643G>A, NC_000019.9:g.38991283G>A, NG_008866.1:g.71944G>A, NM_000540.2:c.7361G>A, NM_001042723.1:c.7361G>A, NP_000531.2:p.Arg2454His, NP_001036188.1:p.Arg2454His, XM_006723317.1:c.7361G>A, XM_006723319.1:c.7361G>A, XM_011527204.1:c.7358G>A, XM_011527205.1:c.7361G>A, XP_006723380.1:p.Arg2454His, XP_006723382.1:p.Arg2454His, XP_011525506.1:p.Arg2453His, XP_011525507.1:p.Arg2454His
G > A
SNP
R2454H
No VIP available CA VA
rs118192124 NC_000019.10:g.38500636C>T, NC_000019.9:g.38991276C>T, NG_008866.1:g.71937C>T, NM_000540.2:c.7354C>T, NM_001042723.1:c.7354C>T, NP_000531.2:p.Arg2452Trp, NP_001036188.1:p.Arg2452Trp, XM_006723317.1:c.7354C>T, XM_006723319.1:c.7354C>T, XM_011527204.1:c.7351C>T, XM_011527205.1:c.7354C>T, XP_006723380.1:p.Arg2452Trp, XP_006723382.1:p.Arg2452Trp, XP_011525506.1:p.Arg2451Trp, XP_011525507.1:p.Arg2452Trp
C > T
SNP
R2452W
rs118192161 NC_000019.10:g.38444211C>T, NC_000019.9:g.38934851C>T, NG_008866.1:g.15512C>T, NM_000540.2:c.487C>T, NM_001042723.1:c.487C>T, NP_000531.2:p.Arg163Cys, NP_001036188.1:p.Arg163Cys, XM_006723317.1:c.487C>T, XM_006723319.1:c.487C>T, XM_011527204.1:c.487C>T, XM_011527205.1:c.487C>T, XP_006723380.1:p.Arg163Cys, XP_006723382.1:p.Arg163Cys, XP_011525506.1:p.Arg163Cys, XP_011525507.1:p.Arg163Cys
C > T
SNP
R163C
rs118192162 NC_000019.10:g.38455359A>C, NC_000019.10:g.38455359A>G, NC_000019.9:g.38945999A>C, NC_000019.9:g.38945999A>G, NG_008866.1:g.26660A>C, NG_008866.1:g.26660A>G, NM_000540.2:c.1565A>C, NM_000540.2:c.1565A>G, NM_001042723.1:c.1565A>C, NM_001042723.1:c.1565A>G, NP_000531.2:p.Tyr522Cys, NP_000531.2:p.Tyr522Ser, NP_001036188.1:p.Tyr522Cys, NP_001036188.1:p.Tyr522Ser, XM_006723317.1:c.1565A>C, XM_006723317.1:c.1565A>G, XM_006723319.1:c.1565A>C, XM_006723319.1:c.1565A>G, XM_011527204.1:c.1562A>C, XM_011527204.1:c.1562A>G, XM_011527205.1:c.1565A>C, XM_011527205.1:c.1565A>G, XP_006723380.1:p.Tyr522Cys, XP_006723380.1:p.Tyr522Ser, XP_006723382.1:p.Tyr522Cys, XP_006723382.1:p.Tyr522Ser, XP_011525506.1:p.Tyr521Cys, XP_011525506.1:p.Tyr521Ser, XP_011525507.1:p.Tyr522Cys, XP_011525507.1:p.Tyr522Ser
A > C
SNP
Y522S
rs118192163 NC_000019.10:g.38494565G>A, NC_000019.10:g.38494565G>C, NC_000019.9:g.38985205G>A, NC_000019.9:g.38985205G>C, NG_008866.1:g.65866G>A, NG_008866.1:g.65866G>C, NM_000540.2:c.6488G>A, NM_000540.2:c.6488G>C, NM_001042723.1:c.6488G>A, NM_001042723.1:c.6488G>C, NP_000531.2:p.Arg2163His, NP_000531.2:p.Arg2163Pro, NP_001036188.1:p.Arg2163His, NP_001036188.1:p.Arg2163Pro, XM_006723317.1:c.6488G>A, XM_006723317.1:c.6488G>C, XM_006723319.1:c.6488G>A, XM_006723319.1:c.6488G>C, XM_011527204.1:c.6485G>A, XM_011527204.1:c.6485G>C, XM_011527205.1:c.6488G>A, XM_011527205.1:c.6488G>C, XP_006723380.1:p.Arg2163His, XP_006723380.1:p.Arg2163Pro, XP_006723382.1:p.Arg2163His, XP_006723382.1:p.Arg2163Pro, XP_011525506.1:p.Arg2162His, XP_011525506.1:p.Arg2162Pro, XP_011525507.1:p.Arg2163His, XP_011525507.1:p.Arg2163Pro, rs28933999
G > A
SNP
R2163H
rs118192167 NC_000019.10:g.38580004A>G, NC_000019.9:g.39070644A>G, NG_008866.1:g.151305A>G, NM_000540.2:c.14387A>G, NM_001042723.1:c.14372A>G, NP_000531.2:p.Tyr4796Cys, NP_001036188.1:p.Tyr4791Cys, XM_006723317.1:c.14369A>G, XM_006723319.1:c.14354A>G, XM_011527204.1:c.14384A>G, XM_011527205.1:c.14300A>G, XP_006723380.1:p.Tyr4790Cys, XP_006723382.1:p.Tyr4785Cys, XP_011525506.1:p.Tyr4795Cys, XP_011525507.1:p.Tyr4767Cys
A > G
SNP
Y4796C
rs118192170 NC_000019.10:g.38584989T>C, NC_000019.9:g.39075629T>C, NG_008866.1:g.156290T>C, NM_000540.2:c.14693T>C, NM_001042723.1:c.14678T>C, NP_000531.2:p.Ile4898Thr, NP_001036188.1:p.Ile4893Thr, XM_006723317.1:c.14675T>C, XM_006723319.1:c.14660T>C, XM_011527204.1:c.14690T>C, XM_011527205.1:c.14606T>C, XP_006723380.1:p.Ile4892Thr, XP_006723382.1:p.Ile4887Thr, XP_011525506.1:p.Ile4897Thr, XP_011525507.1:p.Ile4869Thr
T > C
SNP
I4898T
rs118192172 NC_000019.10:g.38457545C>T, NC_000019.9:g.38948185C>T, NG_008866.1:g.28846C>T, NM_000540.2:c.1840C>T, NM_001042723.1:c.1840C>T, NP_000531.2:p.Arg614Cys, NP_001036188.1:p.Arg614Cys, XM_006723317.1:c.1840C>T, XM_006723319.1:c.1840C>T, XM_011527204.1:c.1837C>T, XM_011527205.1:c.1840C>T, XP_006723380.1:p.Arg614Cys, XP_006723382.1:p.Arg614Cys, XP_011525506.1:p.Arg613Cys, XP_011525507.1:p.Arg614Cys, rs28933996
C > T
SNP
R614C
rs118192175 NC_000019.10:g.38494564C>T, NC_000019.9:g.38985204C>T, NG_008866.1:g.65865C>T, NM_000540.2:c.6487C>T, NM_001042723.1:c.6487C>T, NP_000531.2:p.Arg2163Cys, NP_001036188.1:p.Arg2163Cys, XM_006723317.1:c.6487C>T, XM_006723319.1:c.6487C>T, XM_011527204.1:c.6484C>T, XM_011527205.1:c.6487C>T, XP_006723380.1:p.Arg2163Cys, XP_006723382.1:p.Arg2163Cys, XP_011525506.1:p.Arg2162Cys, XP_011525507.1:p.Arg2163Cys, rs28933998
C > T
SNP
R2163C
rs118192176 NC_000019.10:g.38494579G>A, NC_000019.9:g.38985219G>A, NG_008866.1:g.65880G>A, NM_000540.2:c.6502G>A, NM_001042723.1:c.6502G>A, NP_000531.2:p.Val2168Met, NP_001036188.1:p.Val2168Met, XM_006723317.1:c.6502G>A, XM_006723319.1:c.6502G>A, XM_011527204.1:c.6499G>A, XM_011527205.1:c.6502G>A, XP_006723380.1:p.Val2168Met, XP_006723382.1:p.Val2168Met, XP_011525506.1:p.Val2167Met, XP_011525507.1:p.Val2168Met
G > A
SNP
V2168M
rs118192177 NC_000019.10:g.38496283C>G, NC_000019.10:g.38496283C>T, NC_000019.9:g.38986923C>G, NC_000019.9:g.38986923C>T, NG_008866.1:g.67584C>G, NG_008866.1:g.67584C>T, NM_000540.2:c.6617C>G, NM_000540.2:c.6617C>T, NM_001042723.1:c.6617C>G, NM_001042723.1:c.6617C>T, NP_000531.2:p.Thr2206Arg, NP_000531.2:p.Thr2206Met, NP_001036188.1:p.Thr2206Arg, NP_001036188.1:p.Thr2206Met, XM_006723317.1:c.6617C>G, XM_006723317.1:c.6617C>T, XM_006723319.1:c.6617C>G, XM_006723319.1:c.6617C>T, XM_011527204.1:c.6614C>G, XM_011527204.1:c.6614C>T, XM_011527205.1:c.6617C>G, XM_011527205.1:c.6617C>T, XP_006723380.1:p.Thr2206Arg, XP_006723380.1:p.Thr2206Met, XP_006723382.1:p.Thr2206Arg, XP_006723382.1:p.Thr2206Met, XP_011525506.1:p.Thr2205Arg, XP_011525506.1:p.Thr2205Met, XP_011525507.1:p.Thr2206Arg, XP_011525507.1:p.Thr2206Met, rs28934000
C > G
C > T
SNP
T2206M/R
rs118192178 NC_000019.10:g.38500898C>G, NC_000019.10:g.38500898C>T, NC_000019.9:g.38991538C>G, NC_000019.9:g.38991538C>T, NG_008866.1:g.72199C>G, NG_008866.1:g.72199C>T, NM_000540.2:c.7522C>G, NM_000540.2:c.7522C>T, NM_001042723.1:c.7522C>G, NM_001042723.1:c.7522C>T, NP_000531.2:p.Arg2508Cys, NP_000531.2:p.Arg2508Gly, NP_001036188.1:p.Arg2508Cys, NP_001036188.1:p.Arg2508Gly, XM_006723317.1:c.7522C>G, XM_006723317.1:c.7522C>T, XM_006723319.1:c.7522C>G, XM_006723319.1:c.7522C>T, XM_011527204.1:c.7519C>G, XM_011527204.1:c.7519C>T, XM_011527205.1:c.7522C>G, XM_011527205.1:c.7522C>T, XP_006723380.1:p.Arg2508Cys, XP_006723380.1:p.Arg2508Gly, XP_006723382.1:p.Arg2508Cys, XP_006723382.1:p.Arg2508Gly, XP_011525506.1:p.Arg2507Cys, XP_011525506.1:p.Arg2507Gly, XP_011525507.1:p.Arg2508Cys, XP_011525507.1:p.Arg2508Gly
C > T
SNP
R2508C
No VIP available CA No Variant Annotations available
rs118204423 NC_000019.10:g.38457539G>C, NC_000019.9:g.38948179G>C, NG_008866.1:g.28840G>C, NM_000540.2:c.1834G>C, NM_001042723.1:c.1834G>C, NP_000531.2:p.Ala612Pro, NP_001036188.1:p.Ala612Pro, XM_006723317.1:c.1834G>C, XM_006723319.1:c.1834G>C, XM_011527204.1:c.1831G>C, XM_011527205.1:c.1834G>C, XP_006723380.1:p.Ala612Pro, XP_006723382.1:p.Ala612Pro, XP_011525506.1:p.Ala611Pro, XP_011525507.1:p.Ala612Pro
G > C
SNP
A612P
rs121918592 NC_000019.10:g.38448712G>A, NC_000019.10:g.38448712G>C, NC_000019.9:g.38939352G>A, NC_000019.9:g.38939352G>C, NG_008866.1:g.20013G>A, NG_008866.1:g.20013G>C, NM_000540.2:c.1021G>A, NM_000540.2:c.1021G>C, NM_001042723.1:c.1021G>A, NM_001042723.1:c.1021G>C, NP_000531.2:p.Gly341Arg, NP_001036188.1:p.Gly341Arg, XM_006723317.1:c.1021G>A, XM_006723317.1:c.1021G>C, XM_006723319.1:c.1021G>A, XM_006723319.1:c.1021G>C, XM_011527204.1:c.1018G>A, XM_011527204.1:c.1018G>C, XM_011527205.1:c.1021G>A, XM_011527205.1:c.1021G>C, XP_006723380.1:p.Gly341Arg, XP_006723382.1:p.Gly341Arg, XP_011525506.1:p.Gly340Arg, XP_011525507.1:p.Gly341Arg, rs28933997
G > A
G > C
SNP
G341R
rs121918593 NC_000019.10:g.38499993G>A, NC_000019.9:g.38990633G>A, NG_008866.1:g.71294G>A, NM_000540.2:c.7300G>A, NM_001042723.1:c.7300G>A, NP_000531.2:p.Gly2434Arg, NP_001036188.1:p.Gly2434Arg, XM_006723317.1:c.7300G>A, XM_006723319.1:c.7300G>A, XM_011527204.1:c.7297G>A, XM_011527205.1:c.7300G>A, XP_006723380.1:p.Gly2434Arg, XP_006723382.1:p.Gly2434Arg, XP_011525506.1:p.Gly2433Arg, XP_011525507.1:p.Gly2434Arg
G > A
SNP
G2434R
rs121918594 NC_000019.10:g.38500655G>A, NC_000019.9:g.38991295G>A, NG_008866.1:g.71956G>A, NM_000540.2:c.7373G>A, NM_001042723.1:c.7373G>A, NP_000531.2:p.Arg2458His, NP_001036188.1:p.Arg2458His, XM_006723317.1:c.7373G>A, XM_006723319.1:c.7373G>A, XM_011527204.1:c.7370G>A, XM_011527205.1:c.7373G>A, XP_006723380.1:p.Arg2458His, XP_006723382.1:p.Arg2458His, XP_011525506.1:p.Arg2457His, XP_011525507.1:p.Arg2458His
G > A
SNP
R2458H
rs121918595 NC_000019.10:g.38580094C>T, NC_000019.9:g.39070734C>T, NG_008866.1:g.151395C>T, NM_000540.2:c.14477C>T, NM_001042723.1:c.14462C>T, NP_000531.2:p.Thr4826Ile, NP_001036188.1:p.Thr4821Ile, XM_006723317.1:c.14459C>T, XM_006723319.1:c.14444C>T, XM_011527204.1:c.14474C>T, XM_011527205.1:c.14390C>T, XP_006723380.1:p.Thr4820Ile, XP_006723382.1:p.Thr4815Ile, XP_011525506.1:p.Thr4825Ile, XP_011525507.1:p.Thr4797Ile
C > T
SNP
T4826I
No VIP available CA VA
rs1799807 NC_000003.11:g.165548529T>C, NC_000003.12:g.165830741T>C, NG_009031.1:g.11725A>G, NM_000055.2:c.293A>G, NP_000046.1:p.Asp98Gly, XM_005247685.1:c.416A>G, XP_005247742.1:p.Asp139Gly, rs386545549, rs52796585, rs56541123
T > C
SNP
D98G
No VIP available CA VA
rs1800559 NC_000001.10:g.201029943C>A, NC_000001.10:g.201029943C>T, NC_000001.11:g.201060815C>A, NC_000001.11:g.201060815C>T, NG_009816.1:g.56752G>A, NG_009816.1:g.56752G>T, NM_000069.2:c.3257G>A, NM_000069.2:c.3257G>T, NP_000060.2:p.Arg1086His, NP_000060.2:p.Arg1086Leu, XM_005245478.1:c.3257G>A, XM_005245478.1:c.3257G>T, XM_005245478.2:c.3257G>A, XM_005245478.2:c.3257G>T, XP_005245535.1:p.Arg1086His, XP_005245535.1:p.Arg1086Leu, rs28931587, rs80338783
C > A
C > T
SNP
R1086H/L
rs1801086 NC_000019.10:g.38446710G>A, NC_000019.10:g.38446710G>C, NC_000019.10:g.38446710G>T, NC_000019.9:g.38937350G>A, NC_000019.9:g.38937350G>C, NC_000019.9:g.38937350G>T, NG_008866.1:g.18011G>A, NG_008866.1:g.18011G>C, NG_008866.1:g.18011G>T, NM_000540.2:c.742G>A, NM_000540.2:c.742G>C, NM_000540.2:c.742G>T, NM_001042723.1:c.742G>A, NM_001042723.1:c.742G>C, NM_001042723.1:c.742G>T, NP_000531.2:p.Gly248Arg, NP_000531.2:p.Gly248Trp, NP_001036188.1:p.Gly248Arg, NP_001036188.1:p.Gly248Trp, XM_006723317.1:c.742G>A, XM_006723317.1:c.742G>C, XM_006723317.1:c.742G>T, XM_006723319.1:c.742G>A, XM_006723319.1:c.742G>C, XM_006723319.1:c.742G>T, XM_011527204.1:c.742G>A, XM_011527204.1:c.742G>C, XM_011527204.1:c.742G>T, XM_011527205.1:c.742G>A, XM_011527205.1:c.742G>C, XM_011527205.1:c.742G>T, XP_006723380.1:p.Gly248Arg, XP_006723380.1:p.Gly248Trp, XP_006723382.1:p.Gly248Arg, XP_006723382.1:p.Gly248Trp, XP_011525506.1:p.Gly248Arg, XP_011525506.1:p.Gly248Trp, XP_011525507.1:p.Gly248Arg, XP_011525507.1:p.Gly248Trp
G > A
G > C
G > T
SNP
G248R/W
No VIP available CA VA
rs1803274 NC_000003.11:g.165491280C>T, NC_000003.12:g.165773492C>T, NG_009031.1:g.68974G>A, NM_000055.2:c.1699G>A, NP_000046.1:p.Ala567Thr, XM_005247685.1:c.1822G>A, XP_005247742.1:p.Ala608Thr, rs17713328, rs17846898, rs3773869, rs52816414, rs60242395
C > T
SNP
A567T
No VIP available CA VA
rs193922747 NC_000019.10:g.38440802T>C, NC_000019.9:g.38931442T>C, NG_008866.1:g.12103T>C, NM_000540.2:c.103T>C, NM_001042723.1:c.103T>C, NP_000531.2:p.Cys35Arg, NP_001036188.1:p.Cys35Arg, XM_006723317.1:c.103T>C, XM_006723319.1:c.103T>C, XM_011527204.1:c.103T>C, XM_011527205.1:c.103T>C, XP_006723380.1:p.Cys35Arg, XP_006723382.1:p.Cys35Arg, XP_011525506.1:p.Cys35Arg, XP_011525507.1:p.Cys35Arg
T > C
SNP
C35R
No VIP available CA No Variant Annotations available
rs193922753 NC_000019.10:g.38444212G>A, NC_000019.10:g.38444212G>T, NC_000019.9:g.38934852G>A, NC_000019.9:g.38934852G>T, NG_008866.1:g.15513G>A, NG_008866.1:g.15513G>T, NM_000540.2:c.488G>A, NM_000540.2:c.488G>T, NM_001042723.1:c.488G>A, NM_001042723.1:c.488G>T, NP_000531.2:p.Arg163His, NP_000531.2:p.Arg163Leu, NP_001036188.1:p.Arg163His, NP_001036188.1:p.Arg163Leu, XM_006723317.1:c.488G>A, XM_006723317.1:c.488G>T, XM_006723319.1:c.488G>A, XM_006723319.1:c.488G>T, XM_011527204.1:c.488G>A, XM_011527204.1:c.488G>T, XM_011527205.1:c.488G>A, XM_011527205.1:c.488G>T, XP_006723380.1:p.Arg163His, XP_006723380.1:p.Arg163Leu, XP_006723382.1:p.Arg163His, XP_006723382.1:p.Arg163Leu, XP_011525506.1:p.Arg163His, XP_011525506.1:p.Arg163Leu, XP_011525507.1:p.Arg163His, XP_011525507.1:p.Arg163Leu
G > A
G > T
SNP
R163H/L
rs193922770 NC_000019.10:g.38455528C>T, NC_000019.9:g.38946168C>T, NG_008866.1:g.26829C>T, NM_000540.2:c.1654C>T, NM_001042723.1:c.1654C>T, NP_000531.2:p.Arg552Trp, NP_001036188.1:p.Arg552Trp, XM_006723317.1:c.1654C>T, XM_006723319.1:c.1654C>T, XM_011527204.1:c.1651C>T, XM_011527205.1:c.1654C>T, XP_006723380.1:p.Arg552Trp, XP_006723382.1:p.Arg552Trp, XP_011525506.1:p.Arg551Trp, XP_011525507.1:p.Arg552Trp
C > T
SNP
R552W
rs193922772 NC_000019.10:g.38457546G>A, NC_000019.10:g.38457546G>T, NC_000019.9:g.38948186G>A, NC_000019.9:g.38948186G>T, NG_008866.1:g.28847G>A, NG_008866.1:g.28847G>T, NM_000540.2:c.1841G>A, NM_000540.2:c.1841G>T, NM_001042723.1:c.1841G>A, NM_001042723.1:c.1841G>T, NP_000531.2:p.Arg614His, NP_000531.2:p.Arg614Leu, NP_001036188.1:p.Arg614His, NP_001036188.1:p.Arg614Leu, XM_006723317.1:c.1841G>A, XM_006723317.1:c.1841G>T, XM_006723319.1:c.1841G>A, XM_006723319.1:c.1841G>T, XM_011527204.1:c.1838G>A, XM_011527204.1:c.1838G>T, XM_011527205.1:c.1841G>A, XM_011527205.1:c.1841G>T, XP_006723380.1:p.Arg614His, XP_006723380.1:p.Arg614Leu, XP_006723382.1:p.Arg614His, XP_006723382.1:p.Arg614Leu, XP_011525506.1:p.Arg613His, XP_011525506.1:p.Arg613Leu, XP_011525507.1:p.Arg614His, XP_011525507.1:p.Arg614Leu
G > A
G > T
SNP
R614H/L
rs193922802 NC_000019.10:g.38499655G>A, NC_000019.9:g.38990295G>A, NG_008866.1:g.70956G>A, NM_000540.2:c.7048G>A, NM_001042723.1:c.7048G>A, NP_000531.2:p.Ala2350Thr, NP_001036188.1:p.Ala2350Thr, XM_006723317.1:c.7048G>A, XM_006723319.1:c.7048G>A, XM_011527204.1:c.7045G>A, XM_011527205.1:c.7048G>A, XP_006723380.1:p.Ala2350Thr, XP_006723382.1:p.Ala2350Thr, XP_011525506.1:p.Ala2349Thr, XP_011525507.1:p.Ala2350Thr
G > A
SNP
A2350T
No VIP available CA VA
rs193922803 NC_000019.10:g.38499670C>T, NC_000019.9:g.38990310C>T, NG_008866.1:g.70971C>T, NM_000540.2:c.7063C>T, NM_001042723.1:c.7063C>T, NP_000531.2:p.Arg2355Trp, NP_001036188.1:p.Arg2355Trp, XM_006723317.1:c.7063C>T, XM_006723319.1:c.7063C>T, XM_011527204.1:c.7060C>T, XM_011527205.1:c.7063C>T, XP_006723380.1:p.Arg2355Trp, XP_006723382.1:p.Arg2355Trp, XP_011525506.1:p.Arg2354Trp, XP_011525507.1:p.Arg2355Trp
C > T
SNP
R2355W
rs193922807 NC_000019.10:g.38499731G>C, NC_000019.9:g.38990371G>C, NG_008866.1:g.71032G>C, NM_000540.2:c.7124G>C, NM_001042723.1:c.7124G>C, NP_000531.2:p.Gly2375Ala, NP_001036188.1:p.Gly2375Ala, XM_006723317.1:c.7124G>C, XM_006723319.1:c.7124G>C, XM_011527204.1:c.7121G>C, XM_011527205.1:c.7124G>C, XP_006723380.1:p.Gly2375Ala, XP_006723382.1:p.Gly2375Ala, XP_011525506.1:p.Gly2374Ala, XP_011525507.1:p.Gly2375Ala
G > C
SNP
G2375A
rs193922809 NC_000019.10:g.38499975G>A, NC_000019.9:g.38990615G>A, NG_008866.1:g.71276G>A, NM_000540.2:c.7282G>A, NM_001042723.1:c.7282G>A, NP_000531.2:p.Ala2428Thr, NP_001036188.1:p.Ala2428Thr, XM_006723317.1:c.7282G>A, XM_006723319.1:c.7282G>A, XM_011527204.1:c.7279G>A, XM_011527205.1:c.7282G>A, XP_006723380.1:p.Ala2428Thr, XP_006723382.1:p.Ala2428Thr, XP_011525506.1:p.Ala2427Thr, XP_011525507.1:p.Ala2428Thr
G > A
SNP
A2428T
rs193922816 NC_000019.10:g.38500642C>T, NC_000019.9:g.38991282C>T, NG_008866.1:g.71943C>T, NM_000540.2:c.7360C>T, NM_001042723.1:c.7360C>T, NP_000531.2:p.Arg2454Cys, NP_001036188.1:p.Arg2454Cys, XM_006723317.1:c.7360C>T, XM_006723319.1:c.7360C>T, XM_011527204.1:c.7357C>T, XM_011527205.1:c.7360C>T, XP_006723380.1:p.Arg2454Cys, XP_006723382.1:p.Arg2454Cys, XP_011525506.1:p.Arg2453Cys, XP_011525507.1:p.Arg2454Cys
C > T
SNP
R2454C
No VIP available CA No Variant Annotations available
rs193922818 NC_000019.10:g.38500899G>A, NC_000019.9:g.38991539G>A, NG_008866.1:g.72200G>A, NM_000540.2:c.7523G>A, NM_001042723.1:c.7523G>A, NP_000531.2:p.Arg2508His, NP_001036188.1:p.Arg2508His, XM_006723317.1:c.7523G>A, XM_006723319.1:c.7523G>A, XM_011527204.1:c.7520G>A, XM_011527205.1:c.7523G>A, XP_006723380.1:p.Arg2508His, XP_006723382.1:p.Arg2508His, XP_011525506.1:p.Arg2507His, XP_011525507.1:p.Arg2508His
G > A
SNP
R2508H
rs193922876 NC_000019.10:g.38580114C>T, NC_000019.9:g.39070754C>T, NG_008866.1:g.151415C>T, NM_000540.2:c.14497C>T, NM_001042723.1:c.14482C>T, NP_000531.2:p.His4833Tyr, NP_001036188.1:p.His4828Tyr, XM_006723317.1:c.14479C>T, XM_006723319.1:c.14464C>T, XM_011527204.1:c.14494C>T, XM_011527205.1:c.14410C>T, XP_006723380.1:p.His4827Tyr, XP_006723382.1:p.His4822Tyr, XP_011525506.1:p.His4832Tyr, XP_011525507.1:p.His4804Tyr
C > T
SNP
H4833Y
rs193922878 NC_000019.10:g.38580370C>G, NC_000019.9:g.39071010C>G, NG_008866.1:g.151671C>G, NM_000540.2:c.14512C>G, NM_001042723.1:c.14497C>G, NP_000531.2:p.Leu4838Val, NP_001036188.1:p.Leu4833Val, XM_006723317.1:c.14494C>G, XM_006723319.1:c.14479C>G, XM_011527204.1:c.14509C>G, XM_011527205.1:c.14425C>G, XP_006723380.1:p.Leu4832Val, XP_006723382.1:p.Leu4827Val, XP_011525506.1:p.Leu4837Val, XP_011525507.1:p.Leu4809Val
C > G
SNP
L4838V
No VIP available CA VA
rs28933389 NC_000003.11:g.165548010G>A, NC_000003.12:g.165830222G>A, NG_009031.1:g.12244C>T, NM_000055.2:c.812C>T, NP_000046.1:p.Thr271Met, XM_005247685.1:c.935C>T, XP_005247742.1:p.Thr312Met
G > A
SNP
T271M
No VIP available CA VA
rs28933390 NC_000003.11:g.165547569C>A, NC_000003.12:g.165829781C>A, NG_009031.1:g.12685G>T, NM_000055.2:c.1253G>T, NP_000046.1:p.Gly418Val, XM_005247685.1:c.1376G>T, XP_005247742.1:p.Gly459Val
C > A
SNP
G418V
rs28933396 NC_000019.10:g.38499997G>A, NC_000019.10:g.38499997G>T, NC_000019.9:g.38990637G>A, NC_000019.9:g.38990637G>T, NG_008866.1:g.71298G>A, NG_008866.1:g.71298G>T, NM_000540.2:c.7304G>A, NM_000540.2:c.7304G>T, NM_001042723.1:c.7304G>A, NM_001042723.1:c.7304G>T, NP_000531.2:p.Arg2435His, NP_000531.2:p.Arg2435Leu, NP_001036188.1:p.Arg2435His, NP_001036188.1:p.Arg2435Leu, XM_006723317.1:c.7304G>A, XM_006723317.1:c.7304G>T, XM_006723319.1:c.7304G>A, XM_006723319.1:c.7304G>T, XM_011527204.1:c.7301G>A, XM_011527204.1:c.7301G>T, XM_011527205.1:c.7304G>A, XM_011527205.1:c.7304G>T, XP_006723380.1:p.Arg2435His, XP_006723380.1:p.Arg2435Leu, XP_006723382.1:p.Arg2435His, XP_006723382.1:p.Arg2435Leu, XP_011525506.1:p.Arg2434His, XP_011525506.1:p.Arg2434Leu, XP_011525507.1:p.Arg2435His, XP_011525507.1:p.Arg2435Leu
G > A
SNP
R2435H
rs28933397 NC_000019.10:g.38500654C>T, NC_000019.9:g.38991294C>T, NG_008866.1:g.71955C>T, NM_000540.2:c.7372C>T, NM_001042723.1:c.7372C>T, NP_000531.2:p.Arg2458Cys, NP_001036188.1:p.Arg2458Cys, XM_006723317.1:c.7372C>T, XM_006723319.1:c.7372C>T, XM_011527204.1:c.7369C>T, XM_011527205.1:c.7372C>T, XP_006723380.1:p.Arg2458Cys, XP_006723382.1:p.Arg2458Cys, XP_011525506.1:p.Arg2457Cys, XP_011525507.1:p.Arg2458Cys
C > T
SNP
R2458C
rs63749869 NC_000019.10:g.38580440G>A, NC_000019.9:g.39071080G>A, NG_008866.1:g.151741G>A, NM_000540.2:c.14582G>A, NM_001042723.1:c.14567G>A, NP_000531.2:p.Arg4861His, NP_001036188.1:p.Arg4856His, XM_006723317.1:c.14564G>A, XM_006723319.1:c.14549G>A, XM_011527204.1:c.14579G>A, XM_011527205.1:c.14495G>A, XP_006723380.1:p.Arg4855His, XP_006723382.1:p.Arg4850His, XP_011525506.1:p.Arg4860His, XP_011525507.1:p.Arg4832His
G > A
SNP
R4861H
No VIP available No Clinical Annotations available VA
rs772226819 NC_000001.10:g.201061121G>A, NC_000001.11:g.201091993G>A, NG_009816.1:g.25574C>T, NM_000069.2:c.520C>T, NP_000060.2:p.Arg174Trp, XM_005245478.1:c.520C>T, XM_005245478.2:c.520C>T, XP_005245535.1:p.Arg174Trp
G > A
SNP
R174W
No VIP available No Clinical Annotations available VA
rs772583466
C > T
SNP
G467S
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • Scoline
  • Succinylcholine Chloride
  • Suxamethonium chloride
  • succinyldicholine
Trade Names
  • Anectine
  • Quelicin
  • Quelicin Preservative Free
  • Sucostrin
Brand Mixture Names

PharmGKB Accession Id

PA451522

Type(s):

Drug

Description

A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.

Source: Drug Bank

Indication

Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The mechanism of action of Succinylcholine involves what appears to be a "persistent" depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.

Source: Drug Bank

Pharmacology

Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

By pseudocholinesterase, to succinylmonocholine and choline.

Source: Drug Bank

Route of Elimination

About 10% of the drug is excreted unchanged in the urine.

Source: Drug Bank

Chemical Properties

Chemical Formula

C14H30N2O4

Source: Drug Bank

Canonical SMILES

C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+]

Source: Drug Bank

Average Molecular Weight

290.399

Source: Drug Bank

Monoisotopic Molecular Weight

290.220557458

Source: Drug Bank

SMILES

C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

Source: Drug Bank

InChI String

InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2

Source: Drug Bank

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this drug. To report a pathway, click here.

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
BCHE
No Dosing Guideline available DL CA VA No VIP available No VIP available
CACNA1S
RYR1

Drug Targets

Gene Description
CHRM1 (source: Drug Bank)
CHRM2 (source: Drug Bank)
CHRM3 (source: Drug Bank)
CHRNA10 (source: Drug Bank)

Drug Interactions

Interaction Description
amikacin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
clindamycin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
clindamycin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
echothiophate iodide - succinylcholine Echothiophate iodide may increase the effect of succinylcholine. (source: Drug Bank)
gentamicin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
gentamicin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
lincomycin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
metoclopramide - succinylcholine The agent increases the effect of succinylcholine (source: Drug Bank)
metoclopramide - succinylcholine The agent increases the effect of succinylcholine (source: Drug Bank)
netilmicin - succinylcholine The agent increases the effect of muscle relaxant (source: Drug Bank)
piperacillin - succinylcholine The agent increases the effect of the muscle relaxant (source: Drug Bank)
piperacillin - succinylcholine The agent increases the effect of the muscle relaxant (source: Drug Bank)
pyridostigmine - succinylcholine The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank)
quinidine - succinylcholine The quinine derivative increases the effect of the muscle relaxant (source: Drug Bank)
quinidine - succinylcholine The quinine derivative increases the effect of the muscle relaxant (source: Drug Bank)
quinine - succinylcholine The quinine derivative increases the effect of the muscle relaxant (source: Drug Bank)
quinine - succinylcholine The quinine derivative increases the effect of the muscle relaxant (source: Drug Bank)
tacrine - succinylcholine Tacrine may increase the effects of Succinylcholine. Monitor Succinylcholine therapy for increased effects. (source: Drug Bank)

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

Induces
Contraindicated With

Publications related to succinylcholine: 133

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Neuromuscular conditions associated with malignant hyperthermia in paediatric patients: A 25-year retrospective study. Neuromuscular disorders : NMD. 2016. Bamaga Ahmed K, et al. PubMed
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Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene. Pharmacogenetics and genomics. 2016. Wichmann Sine, et al. PubMed
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PharmGKB Summary: very important pharmacogene information for RYR1. Pharmacogenetics and genomics. 2015. Alvarellos Maria L, et al. PubMed
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Several Ryanodine Receptor Type 1 Gene Mutations of p.Arg2508 Are Potential Sources of Malignant Hyperthermia. Anesthesia and analgesia. 2015. Miyoshi Hirotsugu, et al. PubMed
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PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics. Pharmacogenetics and genomics. 2015. Alvarellos Maria L, et al. PubMed
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European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility. British journal of anaesthesia. 2015. Hopkins P M, et al. PubMed
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RYR1-related myopathies: a wide spectrum of phenotypes throughout life. European journal of neurology. 2015. Snoeck M, et al. PubMed
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Malignant hyperthermia, a Scandinavian update. Acta anaesthesiologica Scandinavica. 2015. Broman M, et al. PubMed
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Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness. Anesthesiology. 2015. Fiszer Dorota, et al. PubMed
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Compound RYR1 heterozygosity resulting in a complex phenotype of malignant hyperthermia susceptibility and a core myopathy. Neuromuscular disorders : NMD. 2015. Kraeva N, et al. PubMed
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Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families. Anaesthesia and intensive care. 2015. Gillies R L, et al. PubMed
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RYR1-related malignant hyperthermia with marked cerebellar involvement - a paradigm of heat-induced CNS injury?. Neuromuscular disorders : NMD. 2015. Forrest Katharine M L, et al. PubMed
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Malignant hyperthermia: a review. Orphanet journal of rare diseases. 2015. Rosenberg Henry, et al. PubMed
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Pediatric malignant hyperthermia: risk factors, morbidity, and mortality identified from the Nationwide Inpatient Sample and Kids' Inpatient Database. Paediatric anaesthesia. 2014. Salazar Jose H, et al. PubMed
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Functional characterisation of the R2452W ryanodine receptor variant associated with malignant hyperthermia susceptibility. Cell calcium. 2014. Roesl Cornelia, et al. PubMed
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Improving awareness of nonanesthesia-related malignant hyperthermia presentations: a tale of two brothers. A & A case reports. 2014. Potts Lauren E, et al. PubMed
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Functional characterization of 2 known ryanodine receptor mutations causing malignant hyperthermia. Anesthesia and analgesia. 2014. Schiemann Anja H, et al. PubMed
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Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study. Orphanet journal of rare diseases. 2014. Klingler Werner, et al. PubMed
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Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium. PloS one. 2014. Delacour Herve, et al. PubMed
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Using exome data to identify malignant hyperthermia susceptibility mutations. Anesthesiology. 2013. Gonsalves Stephen G, et al. PubMed
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Difficult diagnosis of malignant hyperthermia during laparoscopic surgery. European journal of anaesthesiology. 2013. Freiermuth David, et al. PubMed
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Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis. Neuromuscular disorders : NMD. 2013. Dlamini N, et al. PubMed
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Ryanodine receptor type 1 gene variants in the malignant hyperthermia-susceptible population of the United States. Anesthesia and analgesia. 2013. Brandom Barbara W, et al. PubMed
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Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013. Eltit José M, et al. PubMed
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Estimate of the relative risk of succinylcholine for triggering malignant hyperthermia. Anesthesia and analgesia. 2013. Dexter Franklin, et al. PubMed
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Novel double and single ryanodine receptor 1 variants in two Austrian malignant hyperthermia families. Anesthesia and analgesia. 2012. Kaufmann Alexius, et al. PubMed
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A study of a family with the skeletal muscle RYR1 mutation (c.7354C>T) associated with central core myopathy and malignant hyperthermia susceptibility. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2012. Taylor A, et al. PubMed
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Screening of the ryanodine 1 gene for malignant hyperthermia causative mutations by high resolution melt curve analysis. Anesthesia and analgesia. 2011. Broman Marcus, et al. PubMed
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Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population. Canadian journal of anaesthesia = Journal canadien d'anesthésie. 2011. Kraeva Natasha, et al. PubMed
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Novel missense mutations and unexpected multiple changes of RYR1 gene in 75 malignant hyperthermia families. Clinical genetics. 2011. Tammaro A, et al. PubMed
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Concordance of butyrylcholinesterase phenotype with genotype: implications for biochemical reporting. American journal of clinical pathology. 2011. Parnas M Laura, et al. PubMed
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RYR1-related central core myopathy in a Chinese adolescent boy. Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine. 2011. Chan B, et al. PubMed
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Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy. Acta anaesthesiologica Scandinavica. 2011. Mollerup H M, et al. PubMed
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Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine. Genetics and molecular biology. 2011. Garcia Daniel Fantozzi, et al. PubMed
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Prolonged apnea during electroconvulsive therapy in monozygotic twins: case reports. Annals of general psychiatry. 2011. Zavorotnyy Maxim, et al. PubMed
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Genetic variation in RYR1 and malignant hyperthermia phenotypes. British journal of anaesthesia. 2009. Carpenter D, et al. PubMed
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Mutation screening of the RYR1-cDNA from peripheral B-lymphocytes in 15 Swedish malignant hyperthermia index cases. British journal of anaesthesia. 2009. Broman M, et al. PubMed
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Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes. Human mutation. 2009. Zullo Alberto, et al. PubMed
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Increasing the number of diagnostic mutations in malignant hyperthermia. Human mutation. 2009. Levano Soledad, et al. PubMed
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Analysis of RYR1 haplotype profile in patients with malignant hyperthermia. Annals of human genetics. 2009. Carpenter D, et al. PubMed
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A fulminant malignant hyperthermia episode in a patient with ryanodine receptor gene mutation p.Tyr522Ser. Anesthesia and analgesia. 2008. Girard Thierry, et al. PubMed
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The role of CACNA1S in predisposition to malignant hyperthermia. BMC medical genetics. 2009. Carpenter Danielle, et al. PubMed
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Mild clinical and histopathological features in patients who carry the frequent and causative malignant hyperthermia RyR1 mutation p.Thr2206Met. Clinical neuropathology. 2009. Rueffert H, et al. PubMed
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Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47. Journal of anesthesia. 2009. Migita Takako, et al. PubMed
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A double mutation of the ryanodine receptor type 1 gene in a malignant hyperthermia family with multiminicore myopathy. Journal of clinical neurology (Seoul, Korea). 2008. Jeong Seul-Ki, et al. PubMed
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Identification of genetic mutations in Australian malignant hyperthermia families using sequencing of RYR1 hotspots. Anaesthesia and intensive care. 2008. Gillies R L, et al. PubMed
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Molecular genetic testing to diagnose malignant hyperthermia susceptibility. Journal of clinical anesthesia. 2008. Girard Thierry, et al. PubMed
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Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population. Pharmacogenetics and genomics. 2008. Mikami Liya R, et al. PubMed
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Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia. Anesthesiology. 2008. Anderson Ayuk A, et al. PubMed
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Malignant hyperthermia susceptibility diagnosed with a family-specific ryanodine receptor gene type 1 mutation. Journal of anesthesia. 2008. Tanabe Takahiro, et al. PubMed
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Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. Pharmacogenetics and genomics. 2007. Gätke Mona R, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient. Anesthesiology. 2007. Newmark Jordan L, et al. PubMed
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Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies. Brain : a journal of neurology. 2007. Zhou Haiyan, et al. PubMed
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Central core disease due to recessive mutations in RYR1 gene: is it more common than described?. Muscle & nerve. 2007. Kossugue Patrícia M, et al. PubMed
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Malignant hyperthermia and central core disease causative mutations in Swedish patients. Acta anaesthesiologica Scandinavica. 2007. Broman M, et al. PubMed
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Molecular genetic detection of susceptibility to malignant hyperthermia in Belgian families. Acta anaesthesiologica Belgica. 2007. Heytens L. PubMed
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Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology. 2006. Yang Tianzhong, et al. PubMed
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Mutations in RYR1 in malignant hyperthermia and central core disease. Human mutation. 2006. Robinson Rachel, et al. PubMed
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Frequency and localization of mutations in the 106 exons of the RYR1 gene in 50 individuals with malignant hyperthermia. Human mutation. 2006. Galli Lucia, et al. PubMed
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Malignant hyperthermia in Japan: mutation screening of the entire ryanodine receptor type 1 gene coding region by direct sequencing. Anesthesiology. 2006. Ibarra M Carlos A, et al. PubMed
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Perinatal diagnosis of malignant hyperthermia susceptibility. Anesthesiology. 2006. Girard Thierry, et al. PubMed
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Central core disease is due to RYR1 mutations in more than 90% of patients. Brain : a journal of neurology. 2006. Wu Shiwen, et al. PubMed
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Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006. Chelu Mihail G, et al. PubMed
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Denaturing high performance liquid chromatography screening of ryanodine receptor type 1 gene in patients with malignant hyperthermia in Taiwan and identification of a novel mutation (Y522C). Anesthesia and analgesia. 2005. Yeh Huei-Ming, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility. Human mutation. 2005. Monnier Nicole, et al. PubMed
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Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine. Anesthesiology. 2005. Levano Soledad, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Screening of the entire ryanodine receptor type 1 coding region for sequence variants associated with malignant hyperthermia susceptibility in the north american population. Anesthesiology. 2005. Sambuughin Nyamkhishig, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Malignant hyperthermia in North America: genetic screening of the three hot spots in the type I ryanodine receptor gene. Anesthesiology. 2004. Sei Yoshitatsu, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
RYR1 mutations in UK central core disease patients: more than just the C-terminal transmembrane region of the RYR1 gene. Journal of medical genetics. 2004. Shepherd S, et al. PubMed
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Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population. Clinical chemistry. 2003. Yen Tina, et al. PubMed
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Scanning for mutations of the ryanodine receptor (RYR1) gene by denaturing HPLC: detection of three novel malignant hyperthermia alleles. Clinical chemistry. 2003. Tammaro Angela, et al. PubMed
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Frequency of butyrylcholinesterase gene mutations in individuals with abnormal inhibition numbers: an Italian-population study. Pharmacogenetics. 2003. Lando Giuliana, et al. PubMed
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Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala. Genetic testing. 2003. Wehner M, et al. PubMed
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Screening for mutations in the RYR1 gene in families with malignant hyperthermia. Journal of molecular neuroscience : MN. 2003. Muniz Viviane P, et al. PubMed
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Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes. Anesthesiology. 2002. Sei Yoshitatsu, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility. Anesthesiology. 2002. Monnier Nicole, et al. PubMed
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[Current aspects of the diagnosis of malignant hyperthermia]. Der Anaesthesist. 2002. Rüffert H, et al. PubMed
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Evidence for a spontaneous C1840-T mutation in the RYR1 gene after DNA fingerprinting in a malignant hyperthermia susceptible family. Naunyn-Schmiedeberg's archives of pharmacology. 2002. Steinfath Markus, et al. PubMed
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Mutations in the RYR1 gene in Italian patients at risk for malignant hyperthermia: evidence for a cluster of novel mutations in the C-terminal region. Cell calcium. 2002. Galli L, et al. PubMed
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Results of contracture tests with halothane, caffeine, and ryanodine depend on different malignant hyperthermia-associated ryanodine receptor gene mutations. Anesthesiology. 2002. Fiege Marko, et al. PubMed
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Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation. Clinical genetics. 2002. Wehner M, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
RYR1 mutations causing central core disease are associated with more severe malignant hyperthermia in vitro contracture test phenotypes. Human mutation. 2002. Robinson Rachel L, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Mutation screening in the ryanodine receptor 1 gene (RYR1) in patients susceptible to malignant hyperthermia who show definite IVCT results: identification of three novel mutations. Acta anaesthesiologica Scandinavica. 2002. Rueffert Henrik, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Novel mutations in C-terminal channel region of the ryanodine receptor in malignant hyperthermia patients. Japanese journal of pharmacology. 2002. Oyamada Hideto, et al. PubMed
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Genotype-phenotype comparison of the Swiss malignant hyperthermia population. Human mutation. 2001. Girard T, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
North American malignant hyperthermia population: screening of the ryanodine receptor gene and identification of novel mutations. Anesthesiology. 2001. Sambuughin N, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Identification and functional characterization of a novel ryanodine receptor mutation causing malignant hyperthermia in North American and South American families. Neuromuscular disorders : NMD. 2001. Sambuughin N, et al. PubMed
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Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family. British journal of anaesthesia. 2001. Rueffert H, et al. PubMed
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Determination of a positive malignant hyperthermia (MH) disposition without the in vitro contracture test in families carrying the RYR1 Arg614Cys mutation. Clinical genetics. 2001. Rueffert H, et al. PubMed
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Malignant hyperthermia and apparent heat stroke. JAMA. 2001. Tobin J R, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia. Clinical genetics. 2001. Stewart S L, et al. PubMed
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An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor. Human molecular genetics. 2000. Monnier N, et al. PubMed
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A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree. Human molecular genetics. 2000. Brown R L, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Malignant hyperthermia in infancy and identification of novel RYR1 mutation. British journal of anaesthesia. 2000. Chamley D, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
[Preliminary report: first identification of known mutation in the ryanodine receptor gene in a Japanese malignant hyperthermia pedigree]. Masui. The Japanese journal of anesthesiology. 2000. Ichihara Y, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Novel mutation in the RYR1 gene (R2454C) in a patient with malignant hyperthermia. Human mutation. 2000. Gencik M, et al. PubMed
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Malignant hyperthermia causing Gly2435Arg mutation of the ryanodine receptor facilitates ryanodine-induced calcium release in myotubes. British journal of anaesthesia. 1999. Brinkmeier H, et al. PubMed
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Screening of the ryanodine receptor gene in 105 malignant hyperthermia families: novel mutations and concordance with the in vitro contracture test. Human molecular genetics. 1999. Brandt A, et al. PubMed
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Genetic analysis with calcium-induced calcium release test in Japanese malignant hyperthermia susceptible (MHS) families. Hiroshima journal of medical sciences. 1999. Maehara Y, et al. PubMed
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A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease. Proceedings of the National Academy of Sciences of the United States of America. 1999. Lynch P J, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Mutation screening of the RYR1 gene and identification of two novel mutations in Italian malignant hyperthermia families. Journal of medical genetics. 1999. Barone V, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
A case of discordance between genotype and phenotype in a malignant hyperthermia family. European journal of human genetics : EJHG. 1999. Fortunato G, et al. PubMed
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Identification of novel mutations in the ryanodine-receptor gene (RYR1) in malignant hyperthermia: genotype-phenotype correlation. American journal of human genetics. 1998. Manning B M, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Gly341Arg mutation indicating malignant hyperthermia susceptibility: specific cause of chronically elevated serum creatine kinase activity. Journal of the neurological sciences. 1998. Monsieurs K G, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation. Clinical genetics. 1997. Fagerlund T H, et al. PubMed
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Novel mutations at a CpG dinucleotide in the ryanodine receptor in malignant hyperthermia. Human mutation. 1998. Manning B M, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease. The Journal of biological chemistry. 1997. Tong J, et al. PubMed
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Detection of a novel mutation at amino acid position 614 in the ryanodine receptor in malignant hyperthermia. British journal of anaesthesia. 1997. Quane K A, et al. PubMed
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Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle. American journal of human genetics. 1997. Monnier N, et al. PubMed
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The G1021A substitution in the RYR1 gene does not cosegregate with malignant hyperthermia susceptibility in a British pedigree. American journal of human genetics. 1997. Adeokun A M, et al. PubMed
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Detection of a novel mutation in the ryanodine receptor gene in an Irish malignant hyperthermia pedigree: correlation of the IVCT response with the affected and unaffected haplotypes. Journal of medical genetics. 1997. Keating K E, et al. PubMed
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Identification of heterozygous and homozygous individuals with the novel RYR1 mutation Cys35Arg in a large kindred. Anesthesiology. 1997. Lynch P J, et al. PubMed
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Malignant hyperthermia susceptibility in a patient with concomitant motor neuron disease. Journal of the neurological sciences. 1996. Monsieurs K G, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
RYR mutation G1021A (Gly341Arg) is not frequent in Danish and Swedish families with malignant hyperthermia susceptibility. Clinical genetics. 1996. Fagerlund T, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Comparison of the segregation of the RYR1 C1840T mutation with segregation of the caffeine/halothane contracture test results for malignant hyperthermia susceptibility in a large Manitoba Mennonite family. Anesthesiology. 1996. Serfas K D, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree. Journal of medical genetics. 1996. Healy J M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Creatine kinase alterations after acute malignant hyperthermia episodes and common surgical procedures. Anesthesia and analgesia. 1995. Antognini J F. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia. Journal of medical genetics. 1995. O'Brien R O, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genotype and phenotype relationships for mutations in the ryanodine receptor in patients referred for diagnosis of malignant hyperthermia. British journal of anaesthesia. 1995. Fletcher J E, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A search for three known RYR1 gene mutations in 41 Swedish families with predisposition to malignant hyperthermia. Clinical genetics. 1995. Fagerlund T H, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Discordance, in a malignant hyperthermia pedigree, between in vitro contracture-test phenotypes and haplotypes for the MHS1 region on chromosome 19q12-13.2, comprising the C1840T transition in the RYR1 gene. American journal of human genetics. 1995. Deufel T, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Ryanodine receptor gene point mutation and malignant hyperthermia susceptibility. Journal of neurology. 1995. Moroni I, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
C1840-T mutation in the human skeletal muscle ryanodine receptor gene: frequency in northern German families susceptible to malignant hyperthermia and the relationship to in vitro contracture response. Journal of molecular medicine (Berlin, Germany). 1995. Steinfath M, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Search for three known mutations in the RYR1 gene in 48 Danish families with malignant hyperthermia. Clinical genetics. 1994. Fagerlund T, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores. Genomics. 1994. Quane K A, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies. Human molecular genetics. 1994. Quane K A, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia. Nature genetics. 1993. Quane K A, et al. PubMed
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Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase. American journal of human genetics. 1992. Nogueira C P, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A cysteine-for-arginine substitution (R614C) in the human skeletal muscle calcium release channel cosegregates with malignant hyperthermia. Anesthesia and analgesia. 1992. Hogan K, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia. Genomics. 1992. Gillard E F, et al. PubMed
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A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. Genomics. 1991. Gillard E F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. Pharmacology & therapeutics. 1990. Lockridge O. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. Proceedings of the National Academy of Sciences of the United States of America. 1989. McGuire M C, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0781-3009-95
DrugBank:
DB00202
ChEBI:
45652
KEGG Compound:
C07546
PubChem Compound:
5314
PubChem Substance:
46506023
9749
Drugs Product Database (DPD):
2062232
ChemSpider:
5123
Therapeutic Targets Database:
DAP001132
FDA Drug Label at DailyMed:
579ff759-3099-45f5-befe-c4b79106c87e

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