Chemical: Drug
sodium lauryl sulfate

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Overview

Generic Names
  • Dodecyl alcohol, hydrogen sulfate, sodium salt
  • Dodecyl sodium sulfate
  • Dodecyl sulfate sodium
  • Dodecyl sulfate sodium salt
  • Dodecyl sulfate, sodium salt
  • Lauryl sodium sulfate
  • Lauryl sulfate sodium
  • Lauryl sulfate sodium salt
  • Lauryl sulfate, sodium salt
  • Laurylsiran sodny [czech]
  • Lauyl sodium sulfate
  • Monododecyl sodium sulfate
  • N-dodecyl sulfate sodium
  • NADDS
  • NALS
  • Natrium laurylsulfuricum
  • Natriumlaurylsulfat
  • Sodium dodecyl sulfate
  • Sodium lauryl sulphate
  • Sodium monododecyl sulfate
  • Sodium monolauryl sulfate
  • Sodium n-dodecyl sulfate
  • Sodiumlauryl ether sulfate
  • Sulfuric acid dodecyl ester sodium salt
  • Sulfuric acid monododecyl ester sodium salt
  • Sulfuric acid, monododecyl ester, sodium salt
  • sds
Trade Names
  • Adeka Hope LS 35
  • Adeka Hope LS 90
  • Akyposal NLS
  • Akyposal SDS
  • Alscoap LN 40A
  • Alscoap LN 90
  • Alscoap MP 90N
  • Alscoap SP 40
  • Alscoap-LN 90P
  • Anticerumen
  • Aquarex me
  • Aquarex methyl
  • Avirol 101
  • Avirol 118 conc
  • Avirol SL 2010
  • Berol 452
  • Bio-Soft SDBS 60
  • Calfoam ES 303
  • Calfoam SLS 30
  • Carsonol SLS
  • Carsonol SLS paste b
  • Carsonol SLS special
  • Carsonol SLS-s
  • Caswell No. 779
  • Conco sulfate WA-1200
  • Conco sulfate WA-1245
  • Conco sulfate WAG
  • Conco sulfate WAN
  • Conco sulfate WAS
  • Conco sulfate WN
  • Conco sulfate wa
  • Cycloryl 21
  • Cycloryl 21LS
  • Cycloryl 31
  • Cycloryl 580
  • Cycloryl 585N
  • Dehydag sulfate GL
  • Dehydag sulfate GL emulsion
  • Dehydag sulphate GL emulsion
  • Dehydrag sulfate GL emulsion
  • Dermacide
  • Detergent 66
  • Dreft
  • Dupanol waq
  • Duponal
  • Duponal waqe
  • Duponol
  • Duponol ME
  • Duponol QC
  • Duponol QX
  • Duponol WA
  • Duponol WA DRY
  • Duponol WAQ
  • Duponol c
  • Duponol methyl
  • Duponol waqa
  • Duponol waqe
  • Duponol waqm
  • Emal 10
  • Emal 10 Needle
  • Emal 10 Powder
  • Emal 2F
  • Emal 2F Needle
  • Emal 2F30
  • Emal o
  • Emal os
  • Emersal 6400
  • Empicol 0303
  • Empicol 0303VA
  • Empicol BSD 70
  • Empicol LPZ
  • Empicol LS 30
  • Empicol LX 2
  • Empicol LX 28
  • Empicol LX 28R
  • Empicol LX 42
  • Empicol LXSV 938U
  • Empicol LXV
  • Empicol LY 28S
  • Empicol LZ/D
  • Empimin SDS
  • Emulsogen LS
  • Equex S
  • Equex SP
  • Finasol OSR 2
  • Finasol OSR2
  • Finasol osr(sub 2)
  • Fongrapol LSS
  • Gardinol
  • Gardinol type detergent
  • Genapol LSS
  • Hexamol SLS
  • Incronol SLS
  • Irium
  • Jordanol SL-300
  • K 12 (surfactant)
  • Lanette wax s
  • Lanette wax-s
  • Maprobix neu
  • Maprofix 563
  • Maprofix LK
  • Maprofix neu
  • Maprofix wac
  • Maprofix wac-la
  • Melanol CL
  • Melanol CL 30
  • Monagen Y 100
  • Monogen LH
  • Monogen Y 100
  • Monogen Y 500
  • Montopol LA paste
  • Needle 10
  • Neutrazyme
  • Nikkol SLS
  • Nissan Sintrex L 100
  • Nissan persoft SP
  • Odoripon Al 95
  • Orvus WA
  • Orvus WA paste
  • Perklankrol ESD 60
  • Perlandrol L
  • Perlankrol E.S.D. 60
  • Perlankrol L
  • Pionin A 21
  • Polystep B 3
  • Polystep B 5
  • Quolac ex-ub
  • Rewopol NLS 28
  • Rewopol NLS 30
  • Rhodapon LCP
  • Rhodapon LSB
  • Rhodapon SB
  • Rhodapon SB 8208S
  • Rhodapon SM
  • Rhodapon UB
  • Richonol A
  • Richonol AF
  • Richonol C
  • Rolpon LS
  • Rosulfan L 1
  • Sandet ona
  • Silipon RN 6031
  • Sinnopon LS 100
  • Sinnopon LS 95
  • Sinolin 90TK-N
  • Sintapon l
  • Sintrex L 100
  • Sipex SB
  • Sipex SD
  • Sipex SP
  • Sipex op
  • Sipex ub
  • Sipon LCS 98
  • Sipon LS
  • Sipon LS 100
  • Sipon LSB
  • Sipon PD
  • Sipon WD
  • Sipon ub
  • Solsol needles
  • Sorpol 5029O
  • Sorpol 8070
  • Standapol 112 conc
  • Standapol WA-AC
  • Standapol WAQ
  • Standapol WAQ special
  • Standapol WAQ-LC
  • Standapol WAS 100
  • Stanfax 234
  • Steinapol NLS
  • Steinapol NLS 90
  • Stepanal WAC
  • Stepanol ME
  • Stepanol ME DRY
  • Stepanol ME DRY AW
  • Stepanol ME DRY SLS
  • Stepanol T 28
  • Stepanol WA
  • Stepanol WA 100
  • Stepanol WA extra
  • Stepanol WA paste
  • Stepanol WA special
  • Stepanol WA-100
  • Stepanol WAC
  • Stepanol WAQ
  • Stepanol methyl
  • Stepanol methyl DRY AW
  • Sterling WA paste
  • Sterling waq-CH
  • Sterling waq-cosmetic
  • Sulfetal L 95
  • Sulfochem SLS
  • Sulfolyser
  • Sulfopon T 30
  • Sulfopon WA 1
  • Sulfopon WA 1 Special
  • Sulfopon WA 2
  • Sulfopon WA 3
  • Sulfopon WA1 Special
  • Sulfopon WA2
  • Sulfopon WA3
  • Sulfotex WA
  • Sulfotex wala
  • Sunnol LM 1130
  • Supralate C
  • Surfactant K12
  • Surfax 220
  • Swascol 1P
  • Swascol 3L
  • Swascol 4L
  • Syntapon L
  • Tarapon K 12
  • Texapon DL conc.
  • Texapon K 12
  • Texapon K 1296
  • Texapon K 1298
  • Texapon K 12G
  • Texapon K12
  • Texapon K1296
  • Texapon L 100
  • Texapon V HC
  • Texapon V HC powder
  • Texapon Z high conc. needles
  • Texapon ZHC
  • Trepenol WA
  • Ufarol AM 30
  • Ufarol TCL 92
  • Ultra sulfate SL-1
  • WAQE
  • Witcolate A
Brand Mixture Names
  • For sope (sodium lauryl sulfate + stearic acid)
  • Plax anti-plaque den rinse peppermint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
  • Plax anti-plaque dent rinse soft mint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
  • Plax anti-plaque dental rinse (sodium benzoate + sodium lauryl sulfate + sodium salicylate)

PharmGKB Accession Id

PA451398

Type(s):

Drug

Description

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.

Source: Drug Bank

Indication

SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Like other surfactants, SLS is amphiphilic. It thus migrates to the surface of liquids, where its alignment and aggregation with other SLS molecules lowers the surface tension. This allows for easier spreading and mixing of the liquid. SLS has potent protein denaturing activity and inhibits the infectivity of viruses by by solubilizing the viral envelope and/or by denaturing envelope and/or capsid proteins.

Source: Drug Bank

Pharmacology

SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Toxicity

Oral (LD50): Acute: 1288 mg/kg Rat

Source: Drug Bank

Chemical Properties

Chemical Formula

C12H25NaO4S

Source: Drug Bank

Isomeric SMILES

CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]

Source: OpenEye

Canonical SMILES

[Na+].CCCCCCCCCCCCOS([O-]

Source: Drug Bank

Average Molecular Weight

288.379

Source: Drug Bank

Monoisotopic Molecular Weight

288.137124653

Source: Drug Bank

SMILES

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

Source: Drug Bank

InChI String

InChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

Source: Drug Bank

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00815
ChEBI:
8984
KEGG Compound:
C11166
KEGG Drug:
D01045
PubChem Compound:
9028
PubChem Substance:
13348
Therapeutic Targets Database:
DAP001227

Clinical Trials

These are trials that mention sodium lauryl sulfate and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

Common Searches

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Sources for PharmGKB drug information: DrugBank, PubChem.