Chemical: Drug
olanzapine

last updated 02/07/2014

1. DPWG Guideline for olanzapine and CYP2D6

Summary

There are currently no dosing recommendations for olanzapine based on CYP2D6 genotype.

Annotation

The Royal Dutch Pharmacists Association - Pharmacogenetics Working Group has evaluated therapeutic dose recommendations for olanzapine based on CYP2D6 genotype [Article:21412232]. They do not provide dosing recommendations at this time.

Phenotype (Genotype)Therapeutic Dose RecommendationLevel of EvidenceClinical Relevance
PM (2 inactive alleles)None.Published controlled studies of moderate quality* relating to phenotyped and/or genotyped patients or healthy volunteers, and having relevant pharmacokinetic or clinical endpoints.Clinical effect (NS). Kinetic effect (NS).
IM (2 decreased activity alleles, or 1 active and 1 inactive allele, or 1 decreased activity and 1 inactive allele)None.Published controlled studies of moderate quality* relating to phenotyped and/or genotyped patients or healthy volunteers, and having relevant pharmacokinetic or clinical endpoints.Clinical effect (NS). Kinetic effect (NS).
UM (gene duplication in absence of inactive or decreased activity alleles)None.None.None.
Allele TypeAlleles
active*1, *2, *33, *35
decreased activity*9, *10, *17, *29, *36, *41
inactive*3-*8, *11-*16, *19-*21, *38, *40, *42
  • * See Methods or PMID: 18253145 for definition of "moderate" quality.
  • NS: not statistically significant difference.


Annotated Labels

  1. FDA Label for fluoxetine,olanzapine and CYP2D6
  2. EMA Label for olanzapine and CYP1A2,CYP2D6

last updated 12/17/2013

1. FDA Label for fluoxetine,olanzapine and CYP2D6

Informative PGx

Summary

Symbyax, a drug mixture of fluoxetine and olanzapine, is used for the treatment of bipolar disorder and treatment resistant depression and, due to its potent CYP2D6 inhibition as a result of fluoxetine, exhibits drug interactions with other medications also metabolized by CYP2D6. Coadministration with other drugs that are metabolized by CYP2D6 should be approached with caution.

Annotation

Symbyax is a drug mixture of fluoxetine and olanzapine used for the treatment of bipolar disorder and treatment resistant depression. Fluoxetine is a selective serotonin reuptake inhibitor and is metabolized by several cytochrome P450 enzymes with CYP2D6 being a major contributor (see Fluoxetine Pathway and CYP2D6 VIP for more details). Olanzapine is an atypical antipsychotic metabolized by CYP1A2. Clearance of olanzapine is influenced by smoking (see CYP1A2 VIP for additional information).

Excerpt from the Fluoxetine and Olanzapine (Symbyax) drug label:

A subset (about 7%) of the population has reduced activity of the drug metabolizing enzyme CYP2D6. Such individuals are referred to as "poor metabolizers" of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants (TCAs). In a study involving labeled and unlabeled enantiomers administered as a racemate, these individuals metabolized S-fluoxetine at a slower rate and thus achieved higher concentrations of S-fluoxetine. Consequently, concentrations of S-norfluoxetine at steady state were lower.

Because the metabolism of fluoxetine, like that of a number of other compounds including TCAs and other selective serotonin antidepressants, involves the CYP2D6 system, concomitant therapy with drugs also metabolized by this enzyme system (such as the TCAs) may lead to drug interactions.

Fluoxetine inhibits the activity of CYP2D6 and may make individuals with normal CYP2D6 metabolic activity resemble a poor metabolizer. Coadministration of fluoxetine with other drugs that are metabolized by CYP2D6... should be approached with caution.

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the Fluoxetine and Olanzapine drug label.

*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.

Full label available at DailyMed

Genes and/or phenotypes found in this label

  • Bipolar Disorder
    • Indications & usage section, Dosage & administration section, Adverse reactions section, Clinical studies section, Use in specific populations section, Warnings and precautions section
    • source: U.S. Food and Drug Administration
  • Depression
    • Indications & usage section, Dosage & administration section, Adverse reactions section, Clinical studies section, Use in specific populations section, Warnings and precautions section
    • source: U.S. Food and Drug Administration
  • CYP1A2
    • dosage, metabolism/PK, Drug interactions section, Clinical pharmacology section
    • source: U.S. Food and Drug Administration
  • CYP2D6
    • dosage, metabolism/PK, Contraindications section, Drug interactions section, Clinical pharmacology section, Warnings and precautions section
    • source: U.S. Food and Drug Administration
  • CYP3A
    • metabolism/PK, Drug interactions section
    • source: U.S. Food and Drug Administration

last updated 10/27/2013

2. EMA Label for olanzapine and CYP1A2,CYP2D6

Informative PGx

Summary

The EMA European Public Assessment Report (EPAR) for olanzapine (Zalasta) contains information regarding the metabolism of the drug by the enzymes CYP1A2 and CYP2D6: factors that induce or inhibit CYP1A2 may alter the concentration of olanzapine and thus may require dosage monitoring. The EPAR does not mention pharmacogenetics or testing of genetic variants in these genes.

Annotation

The CYP2D6 inhibitor fluoxetine is noted not to have a significant effect on olanzapine pharmacokinetics.

Excerpts from the olanzapine (Zalasta) EPAR:

Inhibition of CYP1A2 Fluvoxamine, a specific CYP 1A2 inhibitor, has been shown to significantly inhibit the metabolism of olanzapine. The mean increase in olanzapine Cmax following fluvoxamine was 54% in female non-smokers and 77% in male smokers. The mean increase in olanzapine AUC was 52% and 108% respectively. A lower starting dose of olanzapine should be considered in patients who are using fluvoxamine or any other CYP1A2 inhibitors, such as ciprofloxacin. A decrease in the dose of olanzapine should be considered if treatment with an inhibitor of CYP 1A2 is initiated.


Fluoxetine (a CYP2D6 inhibitor), single doses of antacid (aluminium, magnesium) or cimetidine have not been found to significantly affect the pharmacokinetics of olanzapine.

This information is highlighted in the following sections:
Interaction with other medicinal products and other forms of interaction, pharmacokinetic properties.

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the olanzapine EMA drug label.

*Disclaimer: The contents of this page have not been endorsed by the EMA and are the sole responsibility of PharmGKB.


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Clinical Annotation for rs1800497 (ANKK1, DRD2), antipsychotics, clozapine, olanzapine, risperidone, Hyperprolactinemia, tardive dyskinesia and Weight gain (level 2B Toxicity/ADR)

Level of Evidence
Level 2B
Type
Toxicity/ADR
Variant
rs1800497
Genes
ANKK1, DRD2
Phenotypes
Hyperprolactinemia, tardive dyskinesia, Weight gain
OMB Race
Mixed Population
Race Notes
Whites, Mixed, one has note that association is more significant in males and caucasians

To see the rest of this clinical annotation please register or sign in.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for olanzapine

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP1A2 *1A N/A N/A N/A
No VIP available No VIP available VA CYP1A2 *1C N/A N/A N/A
No VIP available No VIP available VA CYP1A2 *1F N/A N/A N/A
No VIP available CA VA CYP2C9 *1 N/A N/A N/A
No VIP available CA VA CYP2C9 *2 N/A N/A N/A
No VIP available CA VA CYP2C9 *3 N/A N/A N/A
No VIP available CA VA CYP2C9 *6 N/A N/A N/A
No VIP available CA VA CYP2D6 *1 N/A N/A N/A
No VIP available CA VA CYP2D6 *3 N/A N/A N/A
No VIP available CA VA CYP2D6 *4 N/A N/A N/A
No VIP available No VIP available VA CYP2D6 *10 N/A N/A N/A
No VIP available No VIP available VA CYP3A4 *1 N/A N/A N/A
No VIP available No VIP available VA CYP3A4 *1B N/A N/A N/A
No VIP available CA VA CYP3A5 *1A N/A N/A N/A
No VIP available CA VA CYP3A5 *3A N/A N/A N/A
No VIP available No VIP available VA HTR2C 2--1--1 N/A N/A N/A
No VIP available CA VA SLC6A4 HTTLPR long form (L allele) N/A N/A N/A
No VIP available CA VA SLC6A4 HTTLPR short form (S allele) N/A N/A N/A
No VIP available CA VA TPMT *1 N/A N/A N/A
No VIP available CA VA TPMT *3A N/A N/A N/A
No VIP available CA VA TPMT *3C N/A N/A N/A
No VIP available CA VA UGT1A1 *1 N/A N/A N/A
No VIP available CA VA UGT1A1 *28 N/A N/A N/A
No VIP available No Clinical Annotations available VA
CYP2D6 poor metabolizer N/A N/A N/A
No VIP available CA VA
rs10042486 NC_000005.10:g.63965502C>T, NC_000005.9:g.63261329C>T, NG_032816.1:g.1791G>A
C > T
SNP
No VIP available No Clinical Annotations available VA
rs10214163 NC_000005.10:g.75998585C>T, NC_000005.9:g.75294410C>T, rs386511075, rs58502419, rs61727521, rs74290936
C > T
SNP
No VIP available CA VA
rs10423928 NC_000019.10:g.45679046T>A, NC_000019.9:g.46182304T>A, NM_000164.3:c.1152+820T>A, NM_001308418.1:c.1044+820T>A, XM_005258733.1:c.1044+820T>A, XM_011526709.1:c.1278+820T>A, XM_011526710.1:c.1278+820T>A, XM_011526711.1:c.1170+820T>A, XM_011526712.1:c.1044+820T>A, XM_011526713.1:c.1029+820T>A, XM_011526714.1:c.861+820T>A, XM_011526715.1:c.861+820T>A, XR_935791.1:n.1171+820T>A
T > A
SNP
No VIP available CA VA
rs1045642 NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664
A > G
SNP
I1145I
No VIP available No Clinical Annotations available VA
rs10458360 NC_000001.10:g.172633975G>C, NC_000001.11:g.172664835G>C, NG_007269.1:g.10791G>C, NM_000639.1:c.451+445G>C, NM_000639.2:c.451+445G>C, NM_001302746.1:c.*21+445G>C, rs17279462, rs60231082
G > C
SNP
No VIP available CA VA
rs1049353 NC_000006.11:g.88853635C>T, NC_000006.12:g.88143916C>T, NM_001160226.1:c.1359G>A, NM_001160258.1:c.1359G>A, NM_001160259.1:c.1359G>A, NM_016083.4:c.1359G>A, NM_033181.3:c.1260G>A, NP_001153698.1:p.Thr453=, NP_001153730.1:p.Thr453=, NP_001153731.1:p.Thr453=, NP_057167.2:p.Thr453=, NP_149421.2:p.Thr420=, XM_005248649.1:c.1359G>A, XM_005248650.1:c.1359G>A, XM_005248650.3:c.1359G>A, XM_005248651.1:c.1260G>A, XM_005248652.1:c.1176G>A, XM_006715330.2:c.1359G>A, XM_011535424.1:c.1359G>A, XM_011535425.1:c.1359G>A, XM_011535426.1:c.1359G>A, XM_011535427.1:c.1359G>A, XM_011535428.1:c.1359G>A, XP_005248706.1:p.Thr453=, XP_005248707.1:p.Thr453=, XP_005248708.1:p.Thr420=, XP_005248709.1:p.Thr392=, XP_006715393.1:p.Thr453=, XP_011533726.1:p.Thr453=, XP_011533727.1:p.Thr453=, XP_011533728.1:p.Thr453=, XP_011533729.1:p.Thr453=, XP_011533730.1:p.Thr453=, rs17264339, rs3173203, rs386513644, rs56973242
C > T
SNP
T453T
No VIP available CA VA
rs1076560 NC_000011.10:g.113412966C>A, NC_000011.9:g.113283688C>A, NG_008841.1:g.67314G>T, NM_000795.3:c.811-83G>T, NM_016574.3:c.724-83G>T, XM_005271425.1:c.811-83G>T, XM_005271426.1:c.808-83G>T, rs1800500
C > A
SNP
No VIP available CA VA
rs1079598 NC_000011.10:g.113425552A>G, NC_000011.9:g.113296274A>G, NG_008841.1:g.54728T>C, NM_000795.3:c.-31-870T>C, NM_016574.3:c.-31-870T>C, XM_005271425.1:c.-31-870T>C, XM_005271426.1:c.-901T>C, rs4134628, rs4986924, rs61553796
A > G
SNP
No VIP available No Clinical Annotations available VA
rs10848635 NC_000012.11:g.2316195T>A, NC_000012.12:g.2207029T>A, NG_008801.2:g.241244T>A, NM_000719.6:c.477+86599T>A, NM_001129827.1:c.477+86599T>A, NM_001129829.1:c.477+86599T>A, NM_001129830.1:c.477+86599T>A, NM_001129830.2:c.477+86599T>A, NM_001129831.1:c.477+86599T>A, NM_001129832.1:c.477+86599T>A, NM_001129833.1:c.477+86599T>A, NM_001129834.1:c.477+86599T>A, NM_001129835.1:c.477+86599T>A, NM_001129836.1:c.477+86599T>A, NM_001129837.1:c.477+86599T>A, NM_001129838.1:c.477+86599T>A, NM_001129839.1:c.477+86599T>A, NM_001129840.1:c.477+86599T>A, NM_001129841.1:c.477+86599T>A, NM_001129842.1:c.477+86599T>A, NM_001129843.1:c.477+86599T>A, NM_001129844.1:c.477+86599T>A, NM_001129846.1:c.477+86599T>A, NM_001167623.1:c.477+86599T>A, NM_001167624.2:c.477+86599T>A, NM_001167625.1:c.477+86599T>A, NM_199460.3:c.477+86599T>A, XM_005253765.1:c.567+86599T>A, XM_005253766.1:c.486+86599T>A, XM_005253767.1:c.486+86599T>A, XM_005253768.1:c.486+86599T>A, XM_005253769.1:c.486+86599T>A, XM_005253770.1:c.486+86599T>A, XM_005253771.1:c.486+86599T>A, XM_005253772.1:c.486+86599T>A, XM_005253773.1:c.486+86599T>A, XM_005253774.1:c.486+86599T>A, XM_005253775.1:c.486+86599T>A, XM_005253776.1:c.486+86599T>A, XM_005253777.1:c.486+86599T>A, XM_005253778.1:c.486+86599T>A, XM_005253779.1:c.486+86599T>A, XM_005253780.1:c.486+86599T>A, XM_005253781.1:c.486+86599T>A, XM_005253782.1:c.486+86599T>A, XM_005253783.1:c.486+86599T>A, XM_005253784.1:c.486+86599T>A, XM_005253785.1:c.486+86599T>A, XM_005253786.1:c.486+86599T>A, XM_005253787.1:c.486+86599T>A, XM_006719017.1:c.567+86599T>A, XM_011521018.1:c.-642+86599T>A, XM_011521020.1:c.567+86599T>A, XM_011521021.1:c.477+86599T>A, XM_011521022.1:c.477+86599T>A, XM_011521023.1:c.477+86599T>A, rs60528912
T > A
SNP
No VIP available No Clinical Annotations available VA
rs11111201 NC_000012.11:g.102588475G>A, NC_000012.12:g.102194697G>A, NM_001319988.1:c.1495-615G>A, NM_001319993.1:c.1021-615G>A, NM_001319994.1:c.1021-615G>A, NM_017915.4:c.1264-615G>A, NR_135123.1:n.599-1254G>A, XM_005268992.1:c.1495-615G>A, XM_005268993.1:c.1021-615G>A, XM_011538506.1:c.1276-615G>A, XM_011538507.1:c.1105-615G>A, XM_011538508.1:c.1042-615G>A, XM_011538509.1:c.1030-615G>A, XM_011538510.1:c.1021-615G>A, XM_011538511.1:c.1018-615G>A, XM_011538512.1:c.913-615G>A, XM_011538513.1:c.1276-1254G>A, XM_011538514.1:c.1021-615G>A, XM_011538515.1:c.613-615G>A, XM_011538516.1:c.1018-1254G>A, XM_011538517.1:c.913-1254G>A, XM_011538518.1:c.834-1254G>A, XM_011538519.1:c.409-615G>A, XM_011538520.1:c.409-615G>A, rs17438953
G > A
SNP
No VIP available No Clinical Annotations available VA
rs11240594 NC_000001.10:g.205896235G>A, NC_000001.11:g.205927107G>A, NM_052934.3:c.1293+104C>T, NM_134325.2:c.1293+104C>T, XM_011509121.1:c.1026+104C>T, XM_011509122.1:c.801+104C>T, XM_011509123.1:c.1293+104C>T, XM_011509124.1:c.1293+104C>T, XR_921737.1:n.1419+104C>T, rs56626684, rs57200172
G > A
SNP
No VIP available CA VA
rs1124493 NC_000011.10:g.113411573T>G, NC_000011.9:g.113282295T>G, NG_008841.1:g.68707A>C, NM_000795.3:c.1139-653A>C, NM_016574.3:c.1052-653A>C, XM_005271425.1:c.1139-653A>C, XM_005271426.1:c.1136-653A>C
T > G
SNP
No VIP available No Clinical Annotations available VA
rs11631682 NC_000015.10:g.74764017G>A, NC_000015.9:g.75056358G>A, rs59785721
G > A
SNP
No VIP available CA VA
rs11677416 NC_000002.11:g.113529240T>C, NC_000002.12:g.112771663T>C, rs111174737, rs56427039, rs60563797
T > C
SNP
No VIP available CA VA
rs11872992 NC_000018.10:g.60373354G>A, NC_000018.9:g.58040587G>A, NG_016441.1:g.4415C>T, NM_005912.2:c.-1005C>T, rs60275201
G > A
SNP
No VIP available CA VA
rs11960832 NC_000005.10:g.76219161C>T, NC_000005.9:g.75514986C>T, NM_001297716.1:c.913+9274C>T, NM_014979.3:c.913+9274C>T, XM_005248470.1:c.913+9274C>T, XM_011543281.1:c.913+9274C>T, XM_011543282.1:c.160+9274C>T, rs58899392, rs60969535
C > T
SNP
No VIP available No Clinical Annotations available VA
rs12535293 NC_000007.13:g.99455104G>A, NC_000007.14:g.99857481G>A, NG_007935.1:g.34469G>A, NM_001278921.1:c.535+582G>A, NM_022820.4:c.865+582G>A, NM_057095.2:c.865+582G>A, NM_057096.3:c.865+582G>A, NR_103868.1:n.825+582G>A, NR_103869.1:n.1089+582G>A, XM_011516493.1:c.865+582G>A, XM_011516494.1:c.445+582G>A, rs58902366, rs59965354
G > A
SNP
No VIP available CA VA
rs12720462 NC_000001.10:g.171217691C>A, NC_000001.11:g.171248552C>A, NM_001282693.1:c.-78C>A, NM_001282694.1:c.-78C>A, NM_002021.2:c.-69C>A, XM_005245034.1:c.-78C>A, XM_005245035.1:c.-78C>A, XM_005245038.1:c.-78C>A, XM_005245038.2:c.-78C>A, XM_006711241.2:c.-78C>A, XM_006711242.2:c.-78C>A, XR_922278.1:n.361-825G>T, rs16864229, rs17550689, rs58198621, rs59345966
C > A
SNP
No VIP available CA VA
rs13429709 NC_000002.11:g.162997960T>C, NC_000002.12:g.162141450T>C, NR_110255.1:n.93-20320T>C, XR_241339.1:n.93-20320T>C
T > C
SNP
No VIP available CA VA
rs1414334 NC_000023.10:g.114138144C>G, NC_000023.11:g.114903581C>G, NG_012082.2:g.324497C>G, NM_000868.3:c.551-3008C>G, NM_001256760.2:c.551-3008C>G, NM_001256761.2:c.456-3008C>G, NW_004070891.1:g.572383C>G, rs59611151
C > G
SNP
No VIP available CA VA
rs1415744 NC_000006.11:g.146022531T>C, NC_000006.12:g.145701395T>C, NG_012832.1:g.39461A>G, NM_001018041.1:c.302-15099A>G, NM_005670.3:c.302-15099A>G, XM_005267139.1:c.302-15099A>G, XM_006715564.2:c.302-15099A>G, XM_011536113.1:c.302-15099A>G, XM_011536114.1:c.302-15099A>G, XM_011536115.1:c.302-15099A>G, rs56685907
T > C
SNP
No VIP available No Clinical Annotations available VA
rs1492899 NC_000001.10:g.172615395C>T, NC_000001.11:g.172646255C>T, rs17279336, rs57968838
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1695 NC_000011.10:g.67585218A>G, NC_000011.9:g.67352689A>G, NG_012075.1:g.6624A>G, NM_000852.3:c.313A>G, NP_000843.1:p.Ile105Val, XM_005273958.1:c.313A>G, XP_005274015.1:p.Ile105Val, rs1138257, rs11553891, rs17353321, rs17856342, rs2230827, rs4609, rs56971933, rs947894
A > G
SNP
I105V
No VIP available No Clinical Annotations available VA
rs17070785 NC_000008.10:g.4467528A>G, NC_000008.11:g.4610006A>G, NM_033225.5:c.302+27336T>C, XM_011534752.1:c.302+27336T>C, rs59334064
A > G
SNP
No VIP available No Clinical Annotations available VA
rs17161981 NC_000007.13:g.99460445G>A, NC_000007.14:g.99862822G>A, NG_007935.1:g.39810G>A, NM_001278921.1:c.924-715G>A, NM_022820.4:c.1254-712G>A, NM_057095.2:c.1254-715G>A, NM_057096.3:c.1253+983G>A, NR_103868.1:n.1213+983G>A, NR_103869.1:n.1478-715G>A, XM_011516493.1:c.1254-36G>A, XM_011516494.1:c.833+983G>A, rs56519387, rs57347575, rs58640471
G > A
SNP
No VIP available No Clinical Annotations available VA
rs17161983 NC_000007.13:g.99463818A>G, NC_000007.14:g.99866195A>G, NG_007935.1:g.43183A>G, NM_001278921.1:c.*194A>G, NM_022820.4:c.*194A>G, NM_057095.2:c.*194A>G, NM_057096.3:c.*280A>G, NR_103868.1:n.1503A>G, NR_103869.1:n.1930A>G, XM_011516493.1:c.*194A>G, XM_011516494.1:c.*280A>G, rs57853943, rs59438728
A > G
SNP
No VIP available No Clinical Annotations available VA
rs17782313 NC_000018.10:g.60183864T>C, NC_000018.9:g.57851097T>C, rs59090733, rs59781239
T > C
SNP
No VIP available CA VA
rs1799732 NC_000011.10:g.113475529_113475530insG, NC_000011.9:g.113346251_113346252insG, NG_008841.1:g.4750_4751insC, NM_000795.3:c.-486_-485insC, NM_016574.3:c.-486_-485insC, XM_005271425.1:c.-32+128_-32+129insC, XR_948023.1:n.528_529insC, rs143987432, rs144707848, rs72523179, rs72566141
- > G
indel
No VIP available CA VA
rs1799735 unknown
No VIP available CA VA
rs1799978 NC_000011.10:g.113475629T>C, NC_000011.9:g.113346351T>C, NG_008841.1:g.4651A>G, NM_000795.3:c.-585A>G, NM_016574.3:c.-585A>G, XM_005271425.1:c.-32+29A>G, XR_948023.1:n.429A>G, rs386545565, rs4986916, rs61293607
T > C
SNP
No VIP available CA VA
rs1800497 NC_000011.10:g.113400106G>A, NC_000011.9:g.113270828G>A, NG_012976.1:g.17316G>A, NM_178510.1:c.2137G>A, NP_848605.1:p.Glu713Lys, XM_011542736.1:c.2170G>A, XM_011542737.1:c.2140G>A, XM_011542738.1:c.1948G>A, XP_011541038.1:p.Glu724Lys, XP_011541039.1:p.Glu714Lys, XP_011541040.1:p.Glu650Lys, rs117686243, rs4134623, rs4245144, rs59538675
G > A
SNP
E713K
No VIP available No Clinical Annotations available VA
rs1801028 NC_000011.10:g.113412762G>C, NC_000011.9:g.113283484G>C, NG_008841.1:g.67518C>G, NM_000795.3:c.932C>G, NM_016574.3:c.845C>G, NP_000786.1:p.Ser311Cys, NP_057658.2:p.Ser282Cys, XM_005271425.1:c.932C>G, XM_005271426.1:c.929C>G, XP_005271482.1:p.Ser311Cys, XP_005271483.1:p.Ser310Cys, rs4134622
G > C
SNP
S311C
No VIP available CA VA
rs1801131 NC_000001.10:g.11854476T>G, NC_000001.11:g.11794419T>G, NG_013351.1:g.16685A>C, NM_005957.4:c.1286A>C, NP_005948.3:p.Glu429Ala, XM_005263458.1:c.1409A>C, XM_005263458.2:c.1409A>C, XM_005263459.1:c.1355A>C, XM_005263460.1:c.1286A>C, XM_005263460.3:c.1286A>C, XM_005263461.1:c.1286A>C, XM_005263461.3:c.1286A>C, XM_005263462.1:c.1286A>C, XM_005263462.3:c.1286A>C, XM_005263463.1:c.1040A>C, XM_005263463.2:c.1040A>C, XM_011541495.1:c.1406A>C, XM_011541496.1:c.1409A>C, XP_005263515.1:p.Glu470Ala, XP_005263516.1:p.Glu452Ala, XP_005263517.1:p.Glu429Ala, XP_005263518.1:p.Glu429Ala, XP_005263519.1:p.Glu429Ala, XP_005263520.1:p.Glu347Ala, XP_011539797.1:p.Glu469Ala, XP_011539798.1:p.Glu470Ala, rs17367365, rs17857426, rs4134712
T > G
SNP
E429A
No VIP available CA VA
rs1801282 NC_000003.11:g.12393125C>G, NC_000003.12:g.12351626C>G, NG_011749.1:g.68777C>G, NM_005037.5:c.-2-28078C>G, NM_015869.4:c.34C>G, NM_138711.3:c.-2-28078C>G, NM_138712.3:c.-2-28078C>G, NP_056953.2:p.Pro12Ala, XM_011533840.1:c.-2-28078C>G, XM_011533841.1:c.-2-28078C>G, XM_011533842.1:c.34C>G, XM_011533843.1:c.34C>G, XM_011533844.1:c.-2-28078C>G, XP_011532144.1:p.Pro12Ala, XP_011532145.1:p.Pro12Ala, rs17241090, rs17749580, rs36206375, rs56460253, rs57327233
C > G
SNP
P12A
No VIP available CA VA
rs1880676 NC_000010.10:g.50824117G>A, NC_000010.11:g.49616071G>A, NG_011797.1:g.11977G>A, NM_001142929.1:c.-68-431G>A, NM_001142933.1:c.19G>A, NM_001142934.1:c.-90G>A, NM_020549.4:c.287-431G>A, NM_020984.3:c.-68-431G>A, NM_020985.3:c.-68-431G>A, NM_020986.3:c.-68-431G>A, NP_001136405.1:p.Asp7Asn, rs56499801, rs59491670
G > A
SNP
D7N
No VIP available No Clinical Annotations available VA
rs1995381 NC_000005.10:g.76274833A>G, NC_000005.9:g.75570658A>G, NM_001297716.1:c.914-10329A>G, NM_014979.3:c.914-10329A>G, XM_005248470.1:c.914-10329A>G, XM_011543281.1:c.914-10329A>G, XM_011543282.1:c.161-10329A>G, rs61306801
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2011425 NC_000002.11:g.234627608T>G, NC_000002.12:g.233718962T>G, NG_002601.2:g.134219T>G, NM_001072.3:c.861+25097T>G, NM_007120.2:c.142T>G, NM_019075.2:c.856-48072T>G, NM_019076.4:c.856-48072T>G, NM_019077.2:c.855+36170T>G, NM_019078.1:c.867+5104T>G, NM_021027.2:c.855+46173T>G, NM_205862.1:c.60+25097T>G, NP_009051.1:p.Leu48Val, XR_241238.1:n.198T>G, XR_241240.1:n.1022+25097T>G, XR_241241.1:n.941+46173T>G, rs16849670, rs17866635, rs58554624
T > G
SNP
L48V
No VIP available No Clinical Annotations available VA
rs2069522 NC_000015.10:g.74746892T>C, NC_000015.9:g.75039233T>C, NG_008431.1:g.29351T>C, NM_000761.4:c.-2015T>C, rs17690443, rs61436425
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2069526 NC_000015.10:g.74749000T>G, NC_000015.9:g.75041341T>G, NG_008431.1:g.31459T>G, NM_000761.3:c.-10+103T>G, NM_000761.4:c.-10+103T>G, rs17861148, rs57601484, rs61709032
T > G
SNP
No VIP available No Clinical Annotations available VA
rs2112865 NC_000005.10:g.76133778A>G, NC_000005.9:g.75429603A>G, NM_001297716.1:c.580+1448A>G, NM_014979.3:c.580+1448A>G, XM_005248470.1:c.580+1448A>G, XM_011543281.1:c.580+1448A>G, XM_011543282.1:c.8+1448A>G, rs61088038
A > G
SNP
No VIP available No Clinical Annotations available VA
rs221253 NC_000007.13:g.157332172T>C, NC_000007.14:g.157539478T>C, NG_029966.1:g.1053311A>G, NM_001308267.1:c.*1236A>G, NM_001308268.1:c.*1236A>G, NM_002847.4:c.*1236A>G, NM_130842.3:c.*1236A>G, NM_130843.3:c.*1236A>G, XM_005249553.1:c.*1236A>G, XM_011516445.1:c.*1236A>G, rs117742956, rs1639770, rs3735206, rs59330973
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2213712 NC_000001.10:g.172599878G>C, NC_000001.11:g.172630738G>C, rs60221615
G > C
SNP
No VIP available No Clinical Annotations available VA
rs2228622 NC_000009.11:g.4564432G>A, NC_000009.12:g.4564432G>A, NG_017044.1:g.79006G>A, NM_004170.5:c.414G>A, NP_004161.4:p.Thr138=, XM_011518007.1:c.483G>A, XM_011518008.1:c.423G>A, XM_011518009.1:c.354G>A, XM_011518010.1:c.273G>A, XP_011516309.1:p.Thr161=, XP_011516310.1:p.Thr141=, XP_011516311.1:p.Thr118=, XP_011516312.1:p.Thr91=, XR_242510.1:n.1480-10044C>T, rs17768809, rs2273899, rs386561697, rs7856209
G > A
SNP
T138T
No VIP available No Clinical Annotations available VA
rs2247408 NC_000006.11:g.144278262T>C, NC_000006.12:g.143957125T>C, NG_009384.1:g.112474A>G, NM_001080951.2:c.-325+3344A>G, NM_001080952.2:c.-325+3344A>G, NM_001080953.2:c.-325+3344A>G, NM_001080954.2:c.-325+3344A>G, NM_001080955.2:c.-5+3344A>G, NM_001080956.2:c.-5+3344A>G, NM_001289037.1:c.-5+3344A>G, NM_001289038.1:c.-5+3344A>G, NM_001289039.1:c.-5+7662A>G, NM_001289040.1:c.-5+3344A>G, NM_001289041.1:c.-5+3344A>G, NM_001289042.1:c.-325+7662A>G, NM_001289043.1:c.-325+3344A>G, NM_001289044.1:c.-325+3344A>G, NM_001289045.1:c.-325+3344A>G, NM_001289046.1:c.-325+3344A>G, NM_001289047.1:c.-324-8665A>G, NM_001289048.1:c.-325+3344A>G, NM_001289049.1:c.-325+3344A>G, NM_001317156.1:c.-325+3344A>G, NM_001317157.1:c.-325+3344A>G, NM_001317158.1:c.-5+3344A>G, NM_001317159.1:c.-325+3344A>G, NM_001317160.1:c.-5+3344A>G, NM_001317161.1:c.-325+3344A>G, NM_001317162.1:c.-325+3344A>G, NM_002656.3:c.-5+3344A>G, NM_006718.4:c.-325+3344A>G, XM_005267020.1:c.-325+3344A>G, XM_005267021.1:c.-325+3344A>G, XM_005267022.1:c.-325+3344A>G, XM_005267023.1:c.-5+3344A>G, XM_005267024.1:c.-5+3344A>G, XM_005267025.1:c.-5+3344A>G, XM_005267026.1:c.-5+7662A>G, XM_005267027.1:c.-5+3344A>G, XM_005267028.1:c.-5+3344A>G, XM_005267029.1:c.-5+3344A>G, XM_005267030.1:c.-5+3344A>G, XM_005267031.1:c.-5+3344A>G, XM_005267032.1:c.-5+3344A>G, XM_005267033.1:c.-5+7662A>G, XM_005267034.1:c.-5+7662A>G
T > C
SNP
No VIP available CA VA
rs2266780 NC_000001.10:g.171083242A>G, NC_000001.11:g.171114102A>G, NG_012690.1:g.28225A>G, NM_001002294.2:c.923A>G, NM_001319173.1:c.863A>G, NM_001319174.1:c.734A>G, NM_006894.5:c.923A>G, NP_001002294.1:p.Glu308Gly, NP_001306102.1:p.Glu288Gly, NP_001306103.1:p.Glu245Gly, NP_008825.4:p.Glu308Gly, XM_005245043.1:c.863A>G, XM_005245044.1:c.734A>G, XM_011509345.1:c.863A>G, XM_011509346.1:c.863A>G, XP_005245100.1:p.Glu288Gly, XP_005245101.1:p.Glu245Gly, XP_011507647.1:p.Glu288Gly, XP_011507648.1:p.Glu288Gly, rs17564742, rs57076237, rs57860801, rs80356549
A > G
SNP
E308G
No VIP available CA VA
rs2268639 NC_000006.11:g.39050622T>A, NC_000006.12:g.39082846T>A, NM_002062.3:c.1224+2107T>A, XR_241888.1:n.1284+2107T>A, XR_241889.1:n.1284+2107T>A, XR_926153.1:n.1284+2107T>A, XR_926154.1:n.1284+2107T>A, XR_926155.1:n.1284+2107T>A, rs59254920
T > A
SNP
No VIP available No Clinical Annotations available VA
rs2270927 NC_000005.10:g.76295885C>G, NC_000005.9:g.75591710C>G, NM_001297716.1:c.1445C>G, NM_014979.3:c.1445C>G, NP_001284645.1:p.Thr482Ser, NP_055794.3:p.Thr482Ser, XM_005248470.1:c.1445C>G, XM_011543281.1:c.1445C>G, XM_011543282.1:c.692C>G, XP_005248527.1:p.Thr482Ser, XP_011541583.1:p.Thr482Ser, XP_011541584.1:p.Thr231Ser, XR_948491.1:n.355-41G>C, rs17674646, rs52802028
C > G
SNP
T482S
No VIP available No Clinical Annotations available VA
rs2283271 NC_000012.11:g.2182298T>A, NC_000012.12:g.2073132T>A, NG_008801.2:g.107347T>A, NM_000719.6:c.49+19521T>A, NM_001129827.1:c.49+19521T>A, NM_001129829.1:c.49+19521T>A, NM_001129830.1:c.49+19521T>A, NM_001129830.2:c.49+19521T>A, NM_001129831.1:c.49+19521T>A, NM_001129832.1:c.49+19521T>A, NM_001129833.1:c.49+19521T>A, NM_001129834.1:c.49+19521T>A, NM_001129835.1:c.49+19521T>A, NM_001129836.1:c.49+19521T>A, NM_001129837.1:c.49+19521T>A, NM_001129838.1:c.49+19521T>A, NM_001129839.1:c.49+19521T>A, NM_001129840.1:c.49+19521T>A, NM_001129841.1:c.49+19521T>A, NM_001129842.1:c.49+19521T>A, NM_001129843.1:c.49+19521T>A, NM_001129844.1:c.49+19521T>A, NM_001129846.1:c.49+19521T>A, NM_001167623.1:c.49+19521T>A, NM_001167624.2:c.49+19521T>A, NM_001167625.1:c.49+19521T>A, NM_199460.3:c.49+19521T>A, XM_005253765.1:c.140-42092T>A, XM_005253766.1:c.49+19521T>A, XM_005253767.1:c.49+19521T>A, XM_005253768.1:c.49+19521T>A, XM_005253769.1:c.49+19521T>A, XM_005253770.1:c.49+19521T>A, XM_005253771.1:c.49+19521T>A, XM_005253772.1:c.49+19521T>A, XM_005253773.1:c.49+19521T>A, XM_005253774.1:c.49+19521T>A, XM_005253775.1:c.49+19521T>A, XM_005253776.1:c.49+19521T>A, XM_005253777.1:c.49+19521T>A, XM_005253778.1:c.49+19521T>A, XM_005253779.1:c.49+19521T>A, XM_005253780.1:c.49+19521T>A, XM_005253781.1:c.49+19521T>A, XM_005253782.1:c.49+19521T>A, XM_005253783.1:c.49+19521T>A, XM_005253784.1:c.49+19521T>A, XM_005253785.1:c.49+19521T>A, XM_005253786.1:c.49+19521T>A, XM_005253787.1:c.49+19521T>A, XM_006719017.1:c.140-42092T>A, XM_011521018.1:c.-1070+19521T>A, XM_011521020.1:c.140-42092T>A, XM_011521021.1:c.49+19521T>A, XM_011521022.1:c.49+19521T>A, XM_011521023.1:c.49+19521T>A, rs17801062, rs57218195
T > A
SNP
No VIP available CA VA
rs2412459 NC_000015.10:g.40003758C>T, NC_000015.9:g.40295959C>T, NG_034053.1:g.74635C>T, NM_001013703.3:c.3357+444C>T, XM_005254392.1:c.3357+444C>T, XM_005254393.1:c.3357+444C>T, XM_011521599.1:c.3357+444C>T, XM_011521600.1:c.3357+444C>T, rs57614854
C > T
SNP
No VIP available CA VA
rs2440390 NC_000011.10:g.113416156T>C, NC_000011.9:g.113286878T>C, NG_008841.1:g.64124A>G, NM_000795.3:c.533-545A>G, NM_016574.3:c.533-545A>G, XM_005271425.1:c.533-545A>G, XM_005271426.1:c.530-545A>G, rs58573085
T > C
SNP
No VIP available CA VA
rs2472297 NC_000015.10:g.74735539C>T, NC_000015.9:g.75027880C>T, NG_008431.1:g.17998C>T, rs17334285, rs57326042
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2472300 NC_000015.10:g.74741568A>G, NC_000015.9:g.75033909A>G, NG_008431.1:g.24027A>G, rs17861136, rs59966254
A > G
SNP
No VIP available CA VA
rs2497538 NC_000023.10:g.113968341C=, NC_000023.10:g.113968341C>A, NC_000023.11:g.114733932A>C, NG_012082.2:g.154848A=, NG_012082.2:g.154848A>C, NM_000868.3:c.349+2325A>C, NM_000868.3:c.349+2325C>A, NM_001256760.2:c.349+2325A>C, NM_001256760.2:c.349+2325C>A, NM_001256761.2:c.349+2325A>C, NM_001256761.2:c.349+2325C>A, NW_004070891.1:g.402734A=, NW_004070891.1:g.402734A>C, XR_944300.1:n.209-3156T>G, XR_944301.1:n.209-3156T>G, rs59596828
C > A
SNP
No VIP available No Clinical Annotations available VA
rs2525557 NC_000007.13:g.99578199A>G, NC_000007.14:g.99980576A>G, NR_036679.1:n.-186A>G, rs11496118, rs41503246, rs58424061, rs59194580
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2527887 NC_000007.13:g.99550954T>A, NC_000007.14:g.99953331T>A, rs56661816
T > A
SNP
No VIP available No Clinical Annotations available VA
rs2527894 NC_000007.13:g.99538841A>G, NC_000007.14:g.99941218A>G, rs58847795, rs59498304
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2527927 NC_000007.13:g.99477426G>A, NC_000007.14:g.99879803G>A, rs17211590, rs57487098
G > A
SNP
No VIP available No Clinical Annotations available VA
rs25531 NC_000017.10:g.28564346T>C, NC_000017.11:g.30237328T>C, NG_011747.2:g.3609A>G, NM_001045.5:c.-1936A>G, XM_005258025.1:c.-1810A>G, XR_934652.1:n.-225T>C, XR_934653.1:n.-225T>C, XR_934654.1:n.165+258T>C, XR_934655.1:n.-225T>C, rs2020931, rs35593448
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2572023 NC_000007.13:g.99474427A>G, NC_000007.14:g.99876804A>G, NM_001005276.1:c.230T>C, NP_001005276.1:p.Ile77Thr, rs17277317, rs58768647
A > G
SNP
I77T
No VIP available CA VA
rs2734841 NC_000011.10:g.113411054A>C, NC_000011.9:g.113281776A>C, NG_008841.1:g.69226T>G, NM_000795.3:c.1139-134T>G, NM_016574.3:c.1052-134T>G, XM_005271425.1:c.1139-134T>G, XM_005271426.1:c.1136-134T>G, rs12802428, rs17115519, rs58907051
A > C
SNP
No VIP available CA VA
rs2734842 NC_000011.10:g.113409552G>C, NC_000011.9:g.113280274G>C, NG_008841.1:g.70728C>G, NM_000795.3:c.*1175C>G, NM_016574.3:c.*1175C>G, XM_005271425.1:c.*1175C>G, XM_005271426.1:c.*1175C>G, rs12794936
G > C
SNP
No VIP available CA VA
rs2842030 NC_000001.10:g.163040495G>T, NC_000001.11:g.163070705G>T, NG_023312.1:g.7100G>T, NM_001102445.2:c.335+1177G>T, NM_001113380.1:c.-1449G>T, NM_001113381.1:c.44+1177G>T, NM_005613.5:c.44+1177G>T
G > T
SNP
No VIP available No Clinical Annotations available VA
rs2859228 NC_000001.10:g.172613241A>G, NC_000001.11:g.172644101A>G, rs60700418
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2859229 NC_000001.10:g.172615017C>T, NC_000001.11:g.172645877C>T, rs57571990
C > T
SNP
No VIP available CA VA
rs324420 NC_000001.10:g.46870761C>A, NC_000001.11:g.46405089C>A, NG_012195.1:g.15823C>A, NM_001441.2:c.385C>A, NP_001432.2:p.Pro129Thr, XM_005270624.1:c.385C>A, XM_005270625.1:c.385C>A, XP_005270681.1:p.Pro129Thr, XP_005270682.1:p.Pro129Thr, XR_246250.1:n.463C>A, rs57947754
C > A
SNP
P129T
No VIP available No Clinical Annotations available VA
rs3780412 NC_000009.11:g.4572480T>C, NC_000009.12:g.4572480T>C, NG_017044.1:g.87054T>C, NM_004170.5:c.767+92T>C, XM_011518007.1:c.836+92T>C, XM_011518008.1:c.776+92T>C, XM_011518009.1:c.707+92T>C, XM_011518010.1:c.626+92T>C, XR_242510.1:n.1480-18092A>G, rs58061521
T > C
SNP
No VIP available No Clinical Annotations available VA
rs3780413 NC_000009.11:g.4567353C>G, NC_000009.12:g.4567353C>G, NG_017044.1:g.81927C>G, NM_004170.5:c.484-316C>G, XM_011518007.1:c.553-316C>G, XM_011518008.1:c.493-316C>G, XM_011518009.1:c.424-316C>G, XM_011518010.1:c.343-316C>G, XR_242510.1:n.1480-12965G>C, rs13296335
C > G
SNP
No VIP available CA VA
rs3810950 NC_000010.10:g.50824619G>A, NC_000010.11:g.49616573G>A, NG_011797.1:g.12479G>A, NM_001142929.1:c.4G>A, NM_001142933.1:c.112G>A, NM_001142934.1:c.4G>A, NM_020549.4:c.358G>A, NM_020984.3:c.4G>A, NM_020985.3:c.4G>A, NM_020986.3:c.4G>A, NP_001136401.1:p.Ala2Thr, NP_001136405.1:p.Ala38Thr, NP_001136406.1:p.Ala2Thr, NP_065574.3:p.Ala120Thr, NP_066264.3:p.Ala2Thr, NP_066265.3:p.Ala2Thr, NP_066266.3:p.Ala2Thr, rs17775591, rs60084580
G > A
SNP
A2T
No VIP available No Clinical Annotations available VA
rs3813928 NC_000023.10:g.113818282G>A, NC_000023.11:g.114583809G>A, NG_012082.2:g.4725G>A, NM_000868.3:c.-997G>A, NM_001256760.2:c.-1088G>A, NM_001256761.2:c.-997G>A, NW_004070891.1:g.252611G>A, rs17260544, rs56468477, rs58438880
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3813929 NC_000023.10:g.113818520C>T, NC_000023.11:g.114584047C>T, NG_012082.2:g.4963C>T, NM_000868.3:c.-759C>T, NM_001256760.2:c.-850C>T, NM_001256761.2:c.-759C>T, NW_004070891.1:g.252849C>T, rs17326402
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3819811 NC_000006.11:g.144280529A>G, NC_000006.12:g.143959392A>G, NG_009384.1:g.110207T>C, NM_001080951.2:c.-325+1077T>C, NM_001080952.2:c.-325+1077T>C, NM_001080953.2:c.-325+1077T>C, NM_001080954.2:c.-325+1077T>C, NM_001080955.2:c.-5+1077T>C, NM_001080956.2:c.-5+1077T>C, NM_001289037.1:c.-5+1077T>C, NM_001289038.1:c.-5+1077T>C, NM_001289039.1:c.-5+5395T>C, NM_001289040.1:c.-5+1077T>C, NM_001289041.1:c.-5+1077T>C, NM_001289042.1:c.-325+5395T>C, NM_001289043.1:c.-325+1077T>C, NM_001289044.1:c.-325+1077T>C, NM_001289045.1:c.-325+1077T>C, NM_001289046.1:c.-325+1077T>C, NM_001289047.1:c.-325+9515T>C, NM_001289048.1:c.-325+1077T>C, NM_001289049.1:c.-325+1077T>C, NM_001317156.1:c.-325+1077T>C, NM_001317157.1:c.-325+1077T>C, NM_001317158.1:c.-5+1077T>C, NM_001317159.1:c.-325+1077T>C, NM_001317160.1:c.-5+1077T>C, NM_001317161.1:c.-325+1077T>C, NM_001317162.1:c.-325+1077T>C, NM_002656.3:c.-5+1077T>C, NM_006718.4:c.-325+1077T>C, XM_005267020.1:c.-325+1077T>C, XM_005267021.1:c.-325+1077T>C, XM_005267022.1:c.-325+1077T>C, XM_005267023.1:c.-5+1077T>C, XM_005267024.1:c.-5+1077T>C, XM_005267025.1:c.-5+1077T>C, XM_005267026.1:c.-5+5395T>C, XM_005267027.1:c.-5+1077T>C, XM_005267028.1:c.-5+1077T>C, XM_005267029.1:c.-5+1077T>C, XM_005267030.1:c.-5+1077T>C, XM_005267031.1:c.-5+1077T>C, XM_005267032.1:c.-5+1077T>C, XM_005267033.1:c.-5+5395T>C, XM_005267034.1:c.-5+5395T>C
A > G
SNP
No VIP available CA VA
rs4410790 NC_000007.13:g.17284577T>C, NC_000007.14:g.17244953T>C, rs59310321
T > C
SNP
No VIP available CA VA
rs4436578 NC_000011.10:g.113436043C>T, NC_000011.9:g.113306765C>T, NG_008841.1:g.44237G>A, NM_000795.3:c.-31-11361G>A, NM_016574.3:c.-31-11361G>A, XM_005271425.1:c.-31-11361G>A, rs58376220
C > T
SNP
No VIP available No Clinical Annotations available VA
rs4580760 NC_000005.10:g.76144530A>C, NC_000005.9:g.75440355A>C, NM_001297716.1:c.580+12200A>C, NM_014979.3:c.580+12200A>C, XM_005248470.1:c.580+12200A>C, XM_011543281.1:c.580+12200A>C, XM_011543282.1:c.8+12200A>C, rs58034436, rs58555659
A > C
SNP
No VIP available No Clinical Annotations available VA
rs4646425 NC_000015.10:g.74750940C>T, NC_000015.9:g.75043281C>T, NG_008431.1:g.33399C>T, NM_000761.3:c.832-249C>T, NM_000761.4:c.832-249C>T, rs17861156, rs60834094
C > T
SNP
VIP No Clinical Annotations available No Variant Annotations available
rs4680 NC_000022.10:g.19951271G>A, NC_000022.11:g.19963748G>A, NG_011526.1:g.27009G>A, NM_000754.3:c.472G>A, NM_001135161.1:c.472G>A, NM_001135162.1:c.472G>A, NM_007310.2:c.322G>A, NP_000745.1:p.Val158Met, NP_001128633.1:p.Val158Met, NP_001128634.1:p.Val158Met, NP_009294.1:p.Val108Met, NR_039918.1:n.-5G>A, XM_005261229.1:c.472G>A, XM_011529885.1:c.586G>A, XM_011529886.1:c.586G>A, XM_011529887.1:c.472G>A, XM_011529888.1:c.472G>A, XM_011529889.1:c.472G>A, XM_011529890.1:c.472G>A, XM_011529891.1:c.472G>A, XP_005261286.1:p.Val158Met, XP_011528187.1:p.Val196Met, XP_011528188.1:p.Val196Met, XP_011528189.1:p.Val158Met, XP_011528190.1:p.Val158Met, XP_011528191.1:p.Val158Met, XP_011528192.1:p.Val158Met, XP_011528193.1:p.Val158Met, rs1131157, rs11544671, rs165688, rs17295216, rs17349704, rs17818178, rs17849308, rs17850006, rs2070104, rs3177905, rs3190784, rs3747070, rs58002978
G > A
SNP
V158M
No VIP available CA VA
rs472660 NC_000007.13:g.99460107G>A, NC_000007.14:g.99862484G>A, NG_007935.1:g.39472G>A, NM_001278921.1:c.923+645G>A, NM_022820.4:c.1253+645G>A, NM_057095.2:c.1253+645G>A, NM_057096.3:c.1253+645G>A, NR_103868.1:n.1213+645G>A, NR_103869.1:n.1477+645G>A, XM_011516493.1:c.1254-374G>A, XM_011516494.1:c.833+645G>A, rs10356653, rs57847390
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4729562 NC_000007.13:g.99583650G>A, NC_000007.14:g.99986027G>A, rs41437447, rs56460152, rs60441031
G > A
SNP
No VIP available CA VA
rs4731426 NC_000007.13:g.127882070G>C, NC_000007.14:g.128242017G>C, NG_007450.1:g.5740G>C, NM_000230.2:c.-29+711G>C, XM_005250340.1:c.-29+711G>C, XM_005250340.3:c.-29+711G>C, rs17533479, rs58681052
G > C
SNP
No VIP available CA VA
rs489693 NC_000018.10:g.60215554C>A, NC_000018.9:g.57882787C>A, rs1673474
C > A
SNP
No VIP available CA VA
rs4994 NC_000008.10:g.37823798A>G, NC_000008.11:g.37966280A>G, NG_011936.1:g.5387T>C, NM_000025.2:c.190T>C, NP_000016.1:p.Trp64Arg, rs117258787, rs17025
A > G
SNP
W64R
No VIP available CA VA
rs518147 NC_000023.10:g.113818582G=, NC_000023.10:g.113818582G>C, NC_000023.11:g.114584109C>G, NG_012082.2:g.5025C=, NG_012082.2:g.5025C>G, NM_000868.3:c.-697C=, NM_000868.3:c.-697C>G, NM_001256760.2:c.-788C=, NM_001256760.2:c.-788C>G, NM_001256761.2:c.-697C=, NM_001256761.2:c.-697C>G, NW_004070891.1:g.252911C=, NW_004070891.1:g.252911C>G, rs17326409, rs3813930
G > G
SNP
No VIP available CA VA
rs5443 NC_000012.11:g.6954875C>T, NC_000012.12:g.6845711C>T, NG_009100.1:g.10501C>T, NM_001297571.1:c.822C>T, NM_002075.3:c.825C>T, NP_001284500.1:p.Ser274=, NP_002066.1:p.Ser275=, NW_003871083.2:g.47295C>T, XM_005253679.1:c.825C>T, XM_005253680.1:c.822C>T, XM_005253681.1:c.702-6C>T, XM_005277751.1:c.825C>T, XM_005277752.1:c.822C>T, XM_005277753.1:c.702-6C>T, XM_011520953.1:c.825C>T, XM_011520954.1:c.822C>T, XM_011521027.1:c.*1818G>A, XM_011521028.1:c.*1818G>A, XM_011521029.1:c.*2036G>A, XM_011521030.1:c.*1969G>A, XP_005253736.1:p.Ser275=, XP_005253737.1:p.Ser274=, XP_005277808.1:p.Ser275=, XP_005277809.1:p.Ser274=, XP_011519255.1:p.Ser275=, XP_011519256.1:p.Ser274=, rs2230334, rs3138516, rs57419337, rs6489738
C > T
SNP
S274S
No VIP available No Clinical Annotations available VA
rs6002616 NC_000022.10:g.42504679A>G, NC_000022.11:g.42108675A>G, NG_001589.4:g.535T>C, NR_034118.2:n.668-15372A>G, NR_034118.2:n.668-15373A>G, NT_187682.1:g.31020A>G, NW_003315971.2:g.31020A>G, NW_004504305.1:g.31020A>G, NW_009646207.1:g.23637A>G, rs17383128, rs56835692, rs8141053
A > G
SNP
No VIP available CA VA
rs6265 NC_000011.10:g.27658369C>T, NC_000011.9:g.27679916C>T, NG_011794.1:g.68690G>A, NM_001143805.1:c.196G>A, NM_001143806.1:c.196G>A, NM_001143807.1:c.196G>A, NM_001143808.1:c.196G>A, NM_001143809.1:c.283G>A, NM_001143810.1:c.442G>A, NM_001143811.1:c.196G>A, NM_001143812.1:c.196G>A, NM_001143813.1:c.196G>A, NM_001143814.1:c.196G>A, NM_001143816.1:c.196G>A, NM_001709.4:c.196G>A, NM_170731.4:c.220G>A, NM_170732.4:c.196G>A, NM_170733.3:c.196G>A, NM_170734.3:c.241G>A, NM_170735.5:c.196G>A, NP_001137277.1:p.Val66Met, NP_001137278.1:p.Val66Met, NP_001137279.1:p.Val66Met, NP_001137280.1:p.Val66Met, NP_001137281.1:p.Val95Met, NP_001137282.1:p.Val148Met, NP_001137283.1:p.Val66Met, NP_001137284.1:p.Val66Met, NP_001137285.1:p.Val66Met, NP_001137286.1:p.Val66Met, NP_001137288.1:p.Val66Met, NP_001700.2:p.Val66Met, NP_733927.1:p.Val74Met, NP_733928.1:p.Val66Met, NP_733929.1:p.Val66Met, NP_733930.1:p.Val81Met, NP_733931.1:p.Val66Met, NR_002832.2:n.503C>T, NR_033312.1:n.434C>T, NR_033313.1:n.434C>T, NR_033314.1:n.503C>T, NR_033315.1:n.434C>T, XM_005253060.1:c.442G>A, XM_011520280.1:c.442G>A, XP_005253117.1:p.Val148Met, XP_011518582.1:p.Val148Met, XR_242807.1:n.355C>T, XR_242808.1:n.352C>T, XR_242809.1:n.224-802C>T, rs16917222, rs17855547, rs3829232, rs386602118, rs60760775
C > -
C > A
SNP
V66M
No VIP available CA VA
rs6275 NC_000011.10:g.113412755A>G, NC_000011.9:g.113283477A>G, NG_008841.1:g.67525T>C, NM_000795.3:c.939T>C, NM_016574.3:c.852T>C, NP_000786.1:p.His313=, NP_057658.2:p.His284=, XM_005271425.1:c.939T>C, XM_005271426.1:c.936T>C, XP_005271482.1:p.His313=, XP_005271483.1:p.His312=, rs1130352, rs12791267, rs17115547, rs3189087, rs386602147, rs61689984
A > G
SNP
H313H
No VIP available CA VA
rs6277 NC_000011.10:g.113412737G>A, NC_000011.9:g.113283459G>A, NG_008841.1:g.67543C>T, NM_000795.3:c.957C>T, NM_016574.3:c.870C>T, NP_000786.1:p.Pro319=, NP_057658.2:p.Pro290=, XM_005271425.1:c.957C>T, XM_005271426.1:c.954C>T, XP_005271482.1:p.Pro319=, XP_005271483.1:p.Pro318=, rs1071576, rs1075651, rs17413837, rs3189090
G > A
SNP
P319P
No VIP available CA VA
rs6279 NC_000011.10:g.113410351G>C, NC_000011.9:g.113281073G>C, NG_008841.1:g.69929C>G, NM_000795.3:c.*376C>G, NM_016574.3:c.*376C>G, XM_005271425.1:c.*376C>G, XM_005271426.1:c.*376C>G, rs12796734, rs17115505, rs60748172
G > C
SNP
No VIP available CA VA
rs6280 NC_000003.11:g.113890815C>T, NC_000003.12:g.114171968C>T, NG_008842.2:g.32440G>A, NM_000796.5:c.25G>A, NM_001282563.2:c.25G>A, NM_001290809.1:c.25G>A, NM_033663.5:c.25G>A, NP_000787.2:p.Gly9Ser, NP_001269492.1:p.Gly9Ser, NP_001277738.1:p.Gly9Ser, NP_387512.3:p.Gly9Ser, XM_005247170.1:c.25G>A, XM_005247171.1:c.25G>A, XM_011512510.1:c.25G>A, XM_011512511.1:c.25G>A, XM_011512512.1:c.25G>A, XP_005247227.1:p.Gly9Ser, XP_005247228.1:p.Gly9Ser, XP_011510812.1:p.Gly9Ser, XP_011510813.1:p.Gly9Ser, XP_011510814.1:p.Gly9Ser, rs117481259, rs324025, rs52792556, rs59703514
C > T
SNP
G9S
No VIP available CA VA
rs6313 NC_000013.10:g.47469940G>A, NC_000013.11:g.46895805G>A, NG_013011.1:g.6230C>T, NM_000621.4:c.102C>T, NM_001165947.2:c.160+869C>T, NP_000612.1:p.Ser34=, rs17367493, rs3742280, rs386602276, rs57425741
G > A
SNP
S34S
No VIP available CA VA
rs6314 NC_000013.10:g.47409034G>A, NC_000013.11:g.46834899G>A, NG_013011.1:g.67136C>T, NM_000621.4:c.1354C>T, NM_001165947.2:c.1102C>T, NP_000612.1:p.His452Tyr, NP_001159419.1:p.His368Tyr, rs17286902, rs386602280, rs52815111, rs57559933
G > A
SNP
H452Y
No VIP available CA VA
rs6318 NC_000023.10:g.113965735G=, NC_000023.10:g.113965735G>C, NC_000023.11:g.114731326C=, NC_000023.11:g.114731326C>G, NG_012082.2:g.152242G=, NG_012082.2:g.152242G>C, NM_000868.3:c.68G=, NM_000868.3:c.68G>C, NM_001256760.2:c.68G=, NM_001256760.2:c.68G>C, NM_001256761.2:c.68G=, NM_001256761.2:c.68G>C, NP_000859.1:p.Cys23=, NP_000859.1:p.Cys23Ser, NP_001243689.1:p.Cys23=, NP_001243689.1:p.Cys23Ser, NP_001243690.1:p.Cys23=, NP_001243690.1:p.Cys23Ser, NW_004070891.1:g.400128C=, NW_004070891.1:g.400128C>G, XR_944300.1:n.209-550C>G, XR_944300.1:n.209-550G>C, XR_944301.1:n.209-550C>G, XR_944301.1:n.209-550G>C
G > C
SNP
C23S
No VIP available No Clinical Annotations available VA
rs651430 NC_000007.13:g.99429843A>G, NC_000007.14:g.99832220A>G, NG_007935.1:g.9208A>G, NM_001278921.1:c.71+4034A>G, NM_022820.4:c.71+4034A>G, NM_057095.2:c.71+4034A>G, NM_057096.3:c.71+4034A>G, NR_103868.1:n.174+4034A>G, NR_103869.1:n.174+4034A>G, XM_011516493.1:c.71+4034A>G, rs10383541, rs59625562
A > G
SNP
No VIP available No Clinical Annotations available VA
rs6874435 NC_000005.10:g.76279030A>G, NC_000005.9:g.75574855A>G, NM_001297716.1:c.914-6132A>G, NM_014979.3:c.914-6132A>G, XM_005248470.1:c.914-6132A>G, XM_011543281.1:c.914-6132A>G, XM_011543282.1:c.161-6132A>G, rs58758616
A > G
SNP
No VIP available No Clinical Annotations available VA
rs6960542 NC_000007.13:g.99583219C>T, NC_000007.14:g.99985596C>T, rs59390909, rs59705549
C > T
SNP
No VIP available No Clinical Annotations available VA
rs723672 NC_000012.11:g.2161561C>T, NC_000012.12:g.2052395C>T, NG_008801.2:g.86610C>T, NM_000719.6:c.-1168C>T, NM_001129827.1:c.-1168C>T, NM_001129829.1:c.-1168C>T, NM_001129830.2:c.-1168C>T, NM_001129831.1:c.-1168C>T, NM_001129832.1:c.-1168C>T, NM_001129833.1:c.-1168C>T, NM_001129834.1:c.-1168C>T, NM_001129835.1:c.-1168C>T, NM_001129836.1:c.-1168C>T, NM_001129837.1:c.-1168C>T, NM_001129838.1:c.-1168C>T, NM_001129839.1:c.-1168C>T, NM_001129840.1:c.-1168C>T, NM_001129841.1:c.-1168C>T, NM_001129842.1:c.-1168C>T, NM_001129843.1:c.-1168C>T, NM_001129844.1:c.-1168C>T, NM_001129846.1:c.-1168C>T, NM_001167623.1:c.-1168C>T, NM_001167624.2:c.-1168C>T, NM_001167625.1:c.-1168C>T, NM_199460.3:c.-1168C>T, XM_005253765.1:c.140-62829C>T, XM_005253766.1:c.-1168C>T, XM_005253767.1:c.-1168C>T, XM_005253768.1:c.-1168C>T, XM_005253769.1:c.-1168C>T, XM_005253770.1:c.-1168C>T, XM_005253771.1:c.-1168C>T, XM_005253772.1:c.-1168C>T, XM_005253773.1:c.-1168C>T, XM_005253774.1:c.-1168C>T, XM_005253775.1:c.-1168C>T, XM_005253776.1:c.-1168C>T, XM_005253777.1:c.-1168C>T, XM_005253778.1:c.-1168C>T, XM_005253779.1:c.-1168C>T, XM_005253780.1:c.-1168C>T, XM_005253781.1:c.-1168C>T, XM_005253782.1:c.-1168C>T, XM_005253783.1:c.-1168C>T, XM_005253784.1:c.-1168C>T, XM_005253785.1:c.-1168C>T, XM_005253786.1:c.-1168C>T, XM_005253787.1:c.-1168C>T, XM_006719017.1:c.140-62829C>T, XM_011521018.1:c.-2286C>T, XM_011521020.1:c.140-62829C>T, XM_011521021.1:c.-1168C>T, XM_011521022.1:c.-1168C>T, XM_011521023.1:c.-1168C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs758723 NC_000012.11:g.2220405T>A, NC_000012.12:g.2111239T>A, NG_008801.2:g.145454T>A, NM_000719.6:c.50-3985T>A, NM_001129827.1:c.50-3985T>A, NM_001129829.1:c.50-3985T>A, NM_001129830.1:c.50-3985T>A, NM_001129830.2:c.50-3985T>A, NM_001129831.1:c.50-3985T>A, NM_001129832.1:c.50-3985T>A, NM_001129833.1:c.50-3985T>A, NM_001129834.1:c.50-3985T>A, NM_001129835.1:c.50-3985T>A, NM_001129836.1:c.50-3985T>A, NM_001129837.1:c.50-3985T>A, NM_001129838.1:c.50-3985T>A, NM_001129839.1:c.50-3985T>A, NM_001129840.1:c.50-3985T>A, NM_001129841.1:c.50-3985T>A, NM_001129842.1:c.50-3985T>A, NM_001129843.1:c.50-3985T>A, NM_001129844.1:c.50-3985T>A, NM_001129846.1:c.50-3985T>A, NM_001167623.1:c.50-3985T>A, NM_001167624.2:c.50-3985T>A, NM_001167625.1:c.50-3985T>A, NM_199460.3:c.50-3985T>A, XM_005253765.1:c.140-3985T>A, XM_005253766.1:c.50-3985T>A, XM_005253767.1:c.50-3985T>A, XM_005253768.1:c.50-3985T>A, XM_005253769.1:c.50-3985T>A, XM_005253770.1:c.50-3985T>A, XM_005253771.1:c.50-3985T>A, XM_005253772.1:c.50-3985T>A, XM_005253773.1:c.50-3985T>A, XM_005253774.1:c.50-3985T>A, XM_005253775.1:c.50-3985T>A, XM_005253776.1:c.50-3985T>A, XM_005253777.1:c.50-3985T>A, XM_005253778.1:c.50-3985T>A, XM_005253779.1:c.50-3985T>A, XM_005253780.1:c.50-3985T>A, XM_005253781.1:c.50-3985T>A, XM_005253782.1:c.50-3985T>A, XM_005253783.1:c.50-3985T>A, XM_005253784.1:c.50-3985T>A, XM_005253785.1:c.50-3985T>A, XM_005253786.1:c.50-3985T>A, XM_005253787.1:c.50-3985T>A, XM_006719017.1:c.140-3985T>A, XM_011521018.1:c.-1069-3985T>A, XM_011521020.1:c.140-3985T>A, XM_011521021.1:c.50-3985T>A, XM_011521022.1:c.50-3985T>A, XM_011521023.1:c.50-3985T>A
T > A
SNP
rs762551 NC_000015.10:g.74749576C>A, NC_000015.9:g.75041917C>A, NG_008431.1:g.32035C>A, NM_000761.3:c.-9-154C>A, NM_000761.4:c.-9-154C>A, rs17861151, rs57172993
C > A
SNP
No VIP available CA VA
rs7877 NC_000001.10:g.171254890C>T, NC_000001.11:g.171285751C>T, NM_001282692.1:c.*207C>T, NM_001282693.1:c.*207C>T, NM_001282694.1:c.*207C>T, NM_002021.2:c.*207C>T, XM_005245034.1:c.*207C>T, XM_005245035.1:c.*207C>T, XM_005245036.1:c.*207C>T, XM_005245037.1:c.*207C>T, XM_005245037.2:c.*207C>T, XM_005245038.1:c.*497C>T, XM_005245038.2:c.*497C>T, XM_006711241.2:c.*207C>T, rs2076321, rs3181904, rs57922066
C > T
SNP
No VIP available CA VA
rs7912580 NC_000010.10:g.63915972G>A, NC_000010.11:g.62156213G>A, rs57222647
G > A
SNP
No VIP available CA VA
rs7973796 NC_000012.11:g.102596123G>A, NC_000012.12:g.102202345G>A, rs17421550
G > A
SNP
No VIP available CA VA
rs7997012 NC_000013.10:g.47411985A>G, NC_000013.11:g.46837850A>G, NG_013011.1:g.64185T>C, NM_000621.4:c.614-2211T>C, NM_001165947.2:c.362-2211T>C, rs60567994
A > G
SNP
No VIP available CA VA
rs806378 NC_000006.11:g.88859551C>T, NC_000006.12:g.88149832C>T, NM_001160226.1:c.-206-2026G>A, NM_001160258.1:c.-206-2026G>A, NM_001160259.1:c.-63-4495G>A, NM_016083.4:c.-63-4495G>A, XM_005248649.1:c.-63-4495G>A, XM_005248650.3:c.-255+651G>A, XM_005248651.1:c.-63-4495G>A, XM_005248652.1:c.-79-4495G>A, XM_006715330.2:c.-63-4495G>A, XM_011535424.1:c.-254-2026G>A, XM_011535425.1:c.-254-2026G>A, XM_011535426.1:c.-255+651G>A, XM_011535427.1:c.-255+651G>A, XM_011535428.1:c.-63-4495G>A, rs1744433
C > T
SNP
No VIP available No Clinical Annotations available VA
rs929087 NC_000001.10:g.172632057A>G, NC_000001.11:g.172662917A>G, NG_007269.1:g.8873A>G, NM_000639.1:c.395-1417A>G, NM_000639.2:c.395-1417A>G, NM_001302746.1:c.349-1417A>G, rs3820655, rs59072814
A > G
SNP
No VIP available No Clinical Annotations available VA
rs9306356 NC_000022.10:g.42567090T>C, NC_000022.11:g.42171084T>C, NG_028982.1:g.49356A>G, NG_028982.3:g.177533A>G, NM_005650.2:c.5750-1188A>G, NM_005650.3:c.5750-1188A>G, NM_181492.2:c.5750-1188A>G, NT_187682.1:g.93429T>C, NW_003315971.2:g.81267T>C, NW_009646207.1:g.73888T>C, NW_009646208.1:g.70353T>C, XM_005261722.1:c.5750-1188A>G, XM_005261722.2:c.5750-1188A>G, XM_005261723.1:c.5750-1188A>G, XM_005261724.1:c.5750-1188A>G, XM_005276955.1:c.5750-1179A>G, XM_005276956.1:c.5750-1179A>G, XM_005276957.1:c.5750-1179A>G, XM_006724313.2:c.5750-1188A>G, XM_011530352.1:c.5750-1188A>G, XM_011530353.1:c.5750-1188A>G, XM_011530354.1:c.5750-1188A>G, XM_011530355.1:c.5750-1188A>G, XM_011547035.1:c.5750-1179A>G, XM_011547036.1:c.5750-1179A>G, XM_011547752.1:c.5750-1188A>G, XM_011547753.1:c.5750-1188A>G, XM_011548817.1:c.5750-1188A>G, XM_011548818.1:c.5750-1188A>G, XM_011548820.1:c.5750-1189A>G, XM_011548821.1:c.5750-1189A>G
T > C
SNP
No VIP available CA VA
rs951439 NC_000001.10:g.163033691C>T, NC_000001.11:g.163063901C>T, NG_023312.1:g.296C>T, rs36214199, rs386623110, rs52799590, rs57153444
C > T
SNP
No VIP available CA VA
rs9852 NC_000004.11:g.38139024C>T, NC_000004.12:g.38137403C>T, NM_001253912.1:c.*68C>T, NM_001253913.1:c.*68C>T, NM_001253914.1:c.*68C>T, NM_001253915.1:c.*68C>T, NM_015173.3:c.*68C>T, XM_005262646.1:c.*68C>T, XM_005262647.1:c.*68C>T, XM_005262648.1:c.*68C>T, XM_005262649.1:c.*68C>T, XM_005262650.1:c.*68C>T, XM_005262651.1:c.*68C>T, XM_006714001.1:c.*68C>T, XM_011513659.1:c.*68C>T, XM_011513660.1:c.*68C>T, XM_011513661.1:c.*68C>T, XM_011513662.1:c.*68C>T, XM_011513663.1:c.*68C>T, XM_011513664.1:c.*68C>T, XM_011513665.1:c.*68C>T, XM_011513666.1:c.*68C>T, XM_011513667.1:c.*68C>T, XM_011513669.1:c.*68C>T, XM_011513670.1:c.*68C>T, rs17580009, rs3186425, rs61627288
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • olanzapine
Trade Names
  • Olansek
  • Symbyax
  • Zalasta
  • Zydis
  • Zyprexa
  • Zyprexa Intramuscular
  • Zyprexa Zydis
Brand Mixture Names

PharmGKB Accession Id

PA450688

Type(s):

Drug

Description

Olanzapine is an atypical antipsychotic, approved by the FDA in 1996. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company, whose patent for olanzapine proper ends in 2011.

Source: Drug Bank

Pharmacogenetics

Pharmacokinetics

Olanzapine is metabolized primarily by direct glucuronidation and CYP1A2 and to a lesser extent by CYP2D6 and CYP3A4 [Article:18537577]. Further support for an in vivo role of CYP1A2 is found in a study, which observed that smokers had lower serum levels and higher clearance rates of olanzapine than nonsmokers [Article:10511917]. 10-N-glucuronide is the most abundant metabolite [Article:10511917]. 4- N-glucuronides and 4-N-desmethylolanzapine are other minor metabolites of olanzapine [Article:10511917].

Pharmacodynamics

Olanzapine is a second-generation antipsychotics and has a range of receptor affinities for serotonin receptors HTR2A and HTR2C, dopaminergic receptors (DRD1-DRD4), histamine H1 receptor (HRH1), alpha1 adrenergic receptors and muscarinic receptors (CHRM1- CHRM5) [Article:10511917]. In vitro studies using luciferase reporter gene assays and western blot analysis found that olanzapine up-regulated brain-derived neurotrophic factor (BDNF) transcription linked with enhancement of CREB-mediated transcription [Article:20546816]. Further cell based experiments showed that olanzapine induced the activation of the JAK-STAT pathway and signal transducer and activator of transcription 3 (STAT3) binding to the regulator of G-protein signaling 7 (RGS7) gene may underlie the increase in RGS7 mRNA [Article:18976543]. Second-generation antipsychotics, like olanzapine, often produce undesirable side effects, among which are weight gain and other elements of metabolic syndrome [Article:20570665]. Olanzapine therapy is also usually associated with a significant increase in plasma triacylglyceride levels PMID: 20333360].

Cases of torsade de pointes have been reported with the use of antipsychotics like olanzapine and a large trial is ongoing to evaluate the cardiac risk profile of ziprazidone and olanzapine [Article:20210726]. Blockage of human ether-a-go-go-related gene (KCNH2) potassium channel seems to be related to adverse cardiac effects [Article:20210726]. Compared to other antipsychotics, olanzapine displayed the greatest selectivity for DRD2 and HTR2A receptor binding (100-1000-fold) compared to its KCNH2 channel IC(50) [Article:12176106]. Another KCNH2 binding study concluded that olanzapine possesses direct cardiac electrophysiological effects [Article:17092964].

Pharmacogenomics

Carriers of the 142T>G variant in the UDP glucuronosyltransferase 1 family, polypeptide A4 (UGT1A4) gene were found to be predisposed to reduced olanzapine exposure [Article:20143052]. Olanzapine appears to have moderate affinity for P-glycoprotein (ABCB1) [Articles:12031686, 16810505].

Three variants in the acetyl-coenzyme A carboxylase alpha (ACACA) gene were significantly associated with hypertriglyceridemia in patients taking olanzapine, quetiapine, chlorpromazine or mirtazapine, but not in controls [Article:19846279]. Variants in apolipoprotein C3 (APOC3), apolipoprotein A5 (APOA5) and lipoprotein lipase (LPL) genes are found to have an influence on serum lipids in patients with schizophrenia [Article:17726453]. A small study in 49 patients indicated that variations in the HTR2A gene are associated with metabolic abnormalities like C-peptide and insulin elevations during clozapine and olanzapine treatment [Article:20521326]. Further variants in DRD2 gene, insulin induced gene 2 (INSIG2) gene, peroxisome proliferator-activated receptor gamma (PPARG) gene, HTR2C gene, flavin-containing monooxygenase 3 (FMO3) gene, guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene, beta3 adrenergic receptor (ADRB3) gene, HTR2A gene, leptin (LEP) gene, leptin receptor (LEPR) gene, pro-melanin-concentrating hormone (PMCH) gene, apolipoprotein E (APOE) gene, apolipoprotein A4 (APOA4) gene, scavenger receptor class B member 1 (SCARB1) gene, alpha2A adrenergic receptor (ADRA2A) gene, and cannabinoid receptor 1 (CNR1) gene were studied in association with body weight change induced by olanzapine and other atypical antipsychotics treatment [Articles:20375926, 20373477, 19622037, 19434072, 19356079, 19193342, 19142110, 18681781, 17285096, 17541984, 17199131, 16583406, 20107430]. The regulator of G-protein signaling 2 (RGS2) gene was investigated in association with antipsychotic-induced parkinsonism in patients receiving risperidone, olanzapine or clozapine [Article:18347610]. Significant associations were observed between serotonin transporter (SLC6A4) LPR variant and early negative symptom response among first-episode patients with psychosis treated with haloperidol, olanzapine or risperidone [Article:20031235]. Functional polymorphisms in genes encoding neuroreceptor drug targets like HTR2A, DRD4, DRD3, DRD2 as well as variants in the norepinephrine transporter (SLC6A2) gene, SLC6A4 gene, interleukin-1 receptor antagonist (IL1RN) gene, glutamate metabotropic receptor 3 (GRM3) gene, catechol O-methyltransferase (COMT) gene, choline acetyltransferase (CHAT) gene, and synaptosomal-associated protein of 25 kDa (SNAP25) gene were investigated in association with interindividual differences in olanzapine and other atypical antipsychotics response and tolerability [Articles:20097665, 19000940, 18320559, 18086475, 18085566, 17092963, 16921503, 15913960, 15465976, 17503482, 15823421]. In a genome-wide pharmacogenomic analysis polymorphisms in the ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B) and in the contactin-associated protein-like 5 (CNTNAP5) genes, which mediated the effects of olanzapine and risperidone on negative symptoms, were very close to the studies threshold for declaring significance [Article:19721433].

See also PGx Research tab for olanzapine.

Source: PharmGKB

Indication

For the acute and maintenance treatment of schizophrenia and related psychotic disorders, as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Olanzapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.

Source: Drug Bank

Pharmacology

Olanzapine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, olanzapine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT 2) receptors.

Source: Drug Bank

Food Interaction

Avoid alcohol.|Take without regard to meals.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic

Source: Drug Bank

Protein Binding

93%

Source: Drug Bank

Absorption

Well absorbed, with approximately 40% of the dose metabolized before reaching the systemic circulation.

Source: Drug Bank

Half-Life

21 to 54 hours

Source: Drug Bank

Toxicity

Symptoms of an overdose include tachycardia, agitation, dysarthria, decreased consciousness and coma. Death has been reported after an acute overdose of 0.45g, but also survival after an acute overdose of 1500g.

Source: Drug Bank

Clearance

  • 12 to 47 L/h

Source: Drug Bank

Route of Elimination

It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Following a single oral dose of 14C labeled olanzapine, 7% of the dose of olanzapine was recovered in the urine as unchanged drug, indicating that olanzapine is highly metabolized.

Source: Drug Bank

Volume of Distribution

  • 1000 L

Source: Drug Bank

Chemical Properties

Chemical Formula

C17H20N4S

Source: Drug Bank

Isomeric SMILES

Cc1cc2c(s1)Nc3ccccc3N=C2N4CCN(CC4)C

Source: OpenEye

Canonical SMILES

CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2

Source: Drug Bank

Average Molecular Weight

312.432

Source: Drug Bank

Monoisotopic Molecular Weight

312.14086735

Source: Drug Bank

SMILES

CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2

Source: Drug Bank

InChI String

InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ADRA1A (source: Drug Bank)
ADRA1B (source: Drug Bank)
ADRA2A (source: Drug Bank)
ADRA2B (source: Drug Bank)
ADRA2C (source: Drug Bank)
CHRM1 (source: Drug Bank)
CHRM2 (source: Drug Bank)
CHRM3 (source: Drug Bank)
CHRM4 (source: Drug Bank)
CHRM5 (source: Drug Bank)
DRD1 (source: Drug Bank)
DRD2 (source: Drug Bank)
DRD3 (source: Drug Bank)
DRD4 (source: Drug Bank)
DRD5 (source: Drug Bank)
HRH1 (source: Drug Bank)
HTR1A (source: Drug Bank)
HTR1B (source: Drug Bank)
HTR1D (source: Drug Bank)
HTR1E (source: Drug Bank)
HTR2A (source: Drug Bank)
HTR2C (source: Drug Bank)
HTR3A (source: Drug Bank)
HTR6 (source: Drug Bank)
HTR7 (source: Drug Bank)

Drug Interactions

Interaction Description
donepezil - olanzapine Possible antagonism of action (source: Drug Bank)
donepezil - olanzapine Possible antagonism of action (source: Drug Bank)
galantamine - olanzapine Possible antagonism of action (source: Drug Bank)
galantamine - olanzapine Possible antagonism of action (source: Drug Bank)
olanzapine - donepezil Possible antagonism of action (source: Drug Bank)
olanzapine - donepezil Possible antagonism of action (source: Drug Bank)
olanzapine - fluvoxamine Fluvoxamine increases the effect and toxicity of olanzapine (source: Drug Bank)
olanzapine - fluvoxamine Fluvoxamine increases the effect and toxicity of olanzapine (source: Drug Bank)
olanzapine - galantamine Possible antagonism of action (source: Drug Bank)
olanzapine - galantamine Possible antagonism of action (source: Drug Bank)
olanzapine - ritonavir Ritonavir decreases the effect of olanzapine (source: Drug Bank)
olanzapine - ritonavir Ritonavir decreases the effect of olanzapine (source: Drug Bank)
olanzapine - rivastigmine Possible antagonism of action (source: Drug Bank)
olanzapine - rivastigmine Possible antagonism of action (source: Drug Bank)
tacrine - olanzapine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Olanzapine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents. (source: Drug Bank)
tacrine - olanzapine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Olanzapine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents. (source: Drug Bank)
tetrabenazine - olanzapine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. (source: Drug Bank)
trimethobenzamide - olanzapine Trimethobenzamide and Olanzapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects. (source: Drug Bank)
triprolidine - olanzapine Triprolidine and Olanzapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects. (source: Drug Bank)
triprolidine - olanzapine Triprolidine and Olanzapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects. (source: Drug Bank)
trospium - olanzapine Trospium and Olanzapine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects. (source: Drug Bank)

Curated Information ?

EvidenceDisease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Acquired Long QT Syndrome (aLQTS)
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Alzheimer Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Arrhythmias, Cardiac
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Arthritis, Rheumatoid
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Atrial Fibrillation
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Attention Deficit Disorder with Hyperactivity
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Autism Spectrum Disorder
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Bipolar Disorder
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Body Weight Changes
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Breast Neoplasms
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Carcinoma, Non-Small-Cell Lung
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Carcinoma, Renal Cell
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Colorectal Neoplasms
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Crigler-Najjar Syndrome
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Crohn Disease
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Death
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Depression
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Dizziness
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Drug Toxicity
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dry mouth
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Epilepsy
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Esophagitis
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Fatigue
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Gastrointestinal Stromal Tumors
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gastrointestinal toxicity
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Gilbert's syndrome
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Headache
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Heart Failure
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HIV Infections
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Hyperbilirubinemia, Hereditary
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Hypercholesterolemia
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Hypereosinophilic Syndrome
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Hyperinsulinism
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Hyperlipidemias
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Hyperlipoproteinemia Type II
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Hyperprolactinemia
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Hypertension
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Hypotension
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Inflammatory Bowel Diseases
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Leukemia, Lymphocytic, Chronic, B-Cell
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Leukemia, Myeloid, Acute
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Leukemia, Nonlymphocytic, Acute
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Leukemia, Promyelocytic, Acute
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Malaria
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Mental Disorders
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Metabolic Diseases
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metabolic syndrome
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Metabolic Syndrome X
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Mood Disorders
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Mycoses
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Myelodysplastic Syndromes
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Neoplasm Metastasis
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Neurobehavioral Manifestations
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Obsessive-Compulsive Disorder
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Ocular Hypertension
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Pain
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Parkinson Disease
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Personality Disorders
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Psychotic Disorders
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Pulmonary Disease, Chronic Obstructive
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Pulmonary Fibrosis
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Rhabdomyolysis
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schizoaffective disorder
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Schizophrenia
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Sjogren's Syndrome
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Stroke
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Syncope
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tardive dyskinesia
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Thromboembolism
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Tuberculosis, Pulmonary
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Tumor Lysis Syndrome
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Urinary Incontinence
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Weight gain

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to olanzapine: 107

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PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control and Pharmacogenetics Study. Neuropsychobiology. 2016. Porcelli Stefano, et al. PubMed
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Impact of Pharmacogenetic Markers of CYP2D6 and DRD2 on Prolactin Response in Risperidone-Treated Thai Children and Adolescents With Autism Spectrum Disorders. Journal of clinical psychopharmacology. 2016. Sukasem Chonlaphat, et al. PubMed
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CACNA1C gene and schizophrenia: a case-control and pharmacogenetic study. Psychiatric genetics. 2015. Porcelli Stefano, et al. PubMed
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Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015. Blasi Giuseppe, et al. PubMed
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Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: a systematic review and meta-analysis. British journal of clinical pharmacology. 2015. Ruxton Kimberley, et al. PubMed
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Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children. Pharmacogenomics. 2015. Devlin Angela M, et al. PubMed
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GIPR Gene Polymorphism and Weight Gain in Patients With Schizophrenia Treated With Olanzapine. The Journal of neuropsychiatry and clinical neurosciences. 2015. Ono Shin, et al. PubMed
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Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients. Psychopharmacology. 2014. Nikolac Perkovic Matea, et al. PubMed
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Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances. Journal of psychiatric research. 2014. Kao A C C, et al. PubMed
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Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment. Pharmacogenetics and genomics. 2014. Drago Antonio, et al. PubMed
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Use of magnetic resonance imaging in pharmacogenomics. British journal of clinical pharmacology. 2014. Viviani Roberto, et al. PubMed
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No influence of CYP3A43 rs472660G>A on steady-state serum olanzapine concentrations in White psychiatric patients. Pharmacogenetics and genomics. 2014. Söderberg Mao M, et al. PubMed
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Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain. Pharmacogenomics. 2014. Brandl Eva J, et al. PubMed
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Towards the clinical implementation of pharmacogenetics in bipolar disorder. BMC medicine. 2014. Salloum Naji C, et al. PubMed
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MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2013. Czerwensky Fabian, et al. PubMed
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Pharmacogenetics of olanzapine metabolism. Pharmacogenomics. 2013. Söderberg Mao Mao, et al. PubMed
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The effect of the Taq1A variant in the dopamine D2 receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys. Pharmacogenetics and genomics. 2013. Roke Yvette, et al. PubMed
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Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers. Pharmacogenomics. 2013. López-Rodríguez Rosario, et al. PubMed
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Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE Study. Schizophrenia research. 2013. Ramsey Timothy L, et al. PubMed
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Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects. Human psychopharmacology. 2013. Cabaleiro Teresa, et al. PubMed
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Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure. Pharmacogenetics and genomics. 2013. Söderberg Mao M, et al. PubMed
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Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain. Human psychopharmacology. 2013. Brandl Eva J, et al. PubMed
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Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Translational psychiatry. 2013. Nurmi E L, et al. PubMed
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Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients. The pharmacogenomics journal. 2012. Söderberg M M, et al. PubMed
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Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Archives of general psychiatry. 2012. Malhotra Anil K, et al. PubMed
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The AmpliChip® CYP450 test and response to treatment in schizophrenia and obsessive compulsive disorder: a pilot study and focus on cases with abnormal CYP2D6 drug metabolism. Genetic testing and molecular biomarkers. 2012. Müller Daniel J, et al. PubMed
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Targeted pharmacogenetic analysis of antipsychotic response in the CATIE study. Pharmacogenomics. 2012. Liu Qian, et al. PubMed
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Pharmacogenomic associations with weight gain in olanzapine treatment of patients without schizophrenia. The Journal of clinical psychiatry. 2012. Houston John P, et al. PubMed
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UGT1A4*3 Encodes Significantly Increased Glucuronidation of Olanzapine in Patients on Maintenance Treatment and in Recombinant Systems. Clinical pharmacology and therapeutics. 2012. Haslemo T, et al. PubMed
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Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics. European archives of psychiatry and clinical neuroscience. 2012. Crisafulli Concetta, et al. PubMed
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Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene. The pharmacogenomics journal. 2012. Chowdhury N I, et al. PubMed
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Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population. The pharmacogenomics journal. 2012. Almoguera B, et al. PubMed
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Pharmacogenetic testing to predict antipsychotic-induced weight gain: a systematic review. Pharmacogenomics. 2011. Risselada Arne J, et al. PubMed
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Sexual dysfunction in male schizophrenia: influence of antipsychotic drugs, prolactin and polymorphisms of the dopamine D2 receptor genes. Pharmacogenomics. 2011. Zhang Xiang Rong, et al. PubMed
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011. Kido Yasuto, et al. PubMed
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Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine. The pharmacogenomics journal. 2011. Ono S, et al. PubMed
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Genetic variation in CYP3A43 explains racial difference in olanzapine clearance. Molecular psychiatry. 2011. Bigos K L, et al. PubMed
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Polymorphisms of the LEP, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting. Pharmacogenomics. 2011. Gregoor Jochem G, et al. PubMed
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Receptor targets for antidepressant therapy in bipolar disorder: An overview. Journal of affective disorders. 2011. Fountoulakis Konstantinos N, et al. PubMed
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Association of DRD2 and ANKK1 polymorphisms with prolactin increase in olanzapine-treated women. Psychiatry research. 2011. Houston John, et al. PubMed
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Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011. McClay Joseph L, et al. PubMed
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Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia. The pharmacogenomics journal. 2011. Kuzman M R, et al. PubMed
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KCNH2 pharmacogenomics summary. Pharmacogenetics and genomics. 2010. Oshiro Connie, et al. PubMed
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Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia. The pharmacogenomics journal. 2010. Liu W, et al. PubMed
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Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis. Pharmacogenomics. 2010. Sicard Michelle N, et al. PubMed
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Systematic review of pharmacoeconomic studies of pharmacogenomic tests. Pharmacogenomics. 2010. Beaulieu Mathieu, et al. PubMed
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Genome-wide association study of antipsychotic-induced QTc interval prolongation. The pharmacogenomics journal. 2010. Aberg K, et al. PubMed
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Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-beta. The pharmacogenomics journal. 2010. Pavan C, et al. PubMed
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DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia. Pharmacogenetics and genomics. 2010. Lencz Todd, et al. PubMed
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Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics. The pharmacogenomics journal. 2010. Liou Y-J, et al. PubMed
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Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. Journal of clinical psychopharmacology. 2010. Monteleone Palmiero, et al. PubMed
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Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. The pharmacogenomics journal. 2010. Müller D J, et al. PubMed
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D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. The American journal of psychiatry. 2010. Zhang Jian-Ping, et al. PubMed
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Coprescription of tamoxifen and medications that inhibit CYP2D6. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010. Sideras Kostandinos, et al. PubMed
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Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenetics and genomics. 2010. Hong Chen-Jee, et al. PubMed
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A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010. Tiwari Arun K, et al. PubMed
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Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis. Psychiatry research. 2010. Vázquez-Bourgon Javier, et al. PubMed
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Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome. The pharmacogenomics journal. 2010. Laika B, et al. PubMed
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Metabolic side effects of antipsychotic drug treatment--pharmacological mechanisms. Pharmacology & therapeutics. 2010. Reynolds Gavin P, et al. PubMed
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Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive symptoms. Archives of general psychiatry. 2009. Kwon Jun Soo, et al. PubMed
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The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia. DNA and cell biology. 2009. Herken Hasan, et al. PubMed
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Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. The pharmacogenomics journal. 2009. Godlewska B R, et al. PubMed
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Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans. Pharmacogenomics. 2009. Sickert Laertes, et al. PubMed
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Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study. Journal of Alzheimer's disease : JAD. 2009. Angelucci Francesco, et al. PubMed
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Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents. Pharmacogenetics and genomics. 2009. Calarge Chadi A, et al. PubMed
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Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3'-untranslated region. The pharmacogenomics journal. 2009. Greenbaum L, et al. PubMed
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Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients. Journal of psychiatric research. 2009. Shen Yu-Chih, et al. PubMed
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DRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain. The pharmacogenomics journal. 2009. Popp J, et al. PubMed
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Correlates of response to Olanzapine in a North Indian Schizophrenia sample. Psychiatry research. 2008. Thomas Pramod, et al. PubMed
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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed
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Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting. Journal of psychiatric research. 2008. Alenius Malin, et al. PubMed
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Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. The Journal of clinical psychiatry. 2008. Ujike Hiroshi, et al. PubMed
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Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes. Pharmacogenomics. 2008. Srivastava Vibhuti, et al. PubMed
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Association between dopamine-related polymorphisms and plasma concentrations of prolactin during risperidone treatment in schizophrenic patients. Progress in neuro-psychopharmacology & biological psychiatry. 2008. Yasui-Furukori Norio, et al. PubMed
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Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder. Human psychopharmacology. 2008. Adams David H, et al. PubMed
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Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia. The pharmacogenomics journal. 2008. Smith R C, et al. PubMed
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The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP). Therapeutic drug monitoring. 2008. Nozawa Motohiro, et al. PubMed
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Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. Biological psychiatry. 2008. Campbell Daniel B, et al. PubMed
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Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophrenia research. 2008. de Leon Jose, et al. PubMed
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Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2007. Chagnon Y C, et al. PubMed
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Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2007. Mancama D, et al. PubMed
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HTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysis. Human psychopharmacology. 2007. De Luca Vincenzo, et al. PubMed
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The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2007. Xing Qinghe, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism. The pharmacogenomics journal. 2007. Tiwari A K, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia. Journal of clinical psychopharmacology. 2007. Mulder Hans, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation. The pharmacogenomics journal. 2007. Theisen F M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Molecular psychiatry. 2007. Ruaño G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A clinical study of the association of antipsychotics with hyperlipidemia. Schizophrenia research. 2007. de Leon Jose, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Risk of extrapyramidal syndrome in schizophrenic patients treated with antipsychotics: a population-based study. Clinical pharmacology and therapeutics. 2007. Yang S-Y, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia. Therapeutic drug monitoring. 2006. Lin Ying-Chi, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. The American journal of psychiatry. 2006. Lencz Todd, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. Schizophrenia research. 2005. Bishop Jeffrey R, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations. Psychopharmacology. 2005. Hwang Rudi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2005. Ellingrod Vicki L, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neuroscience letters. 2005. Wu Shengnan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications. Biological psychiatry. 2004. Weickert Thomas W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. The American journal of psychiatry. 2004. Bertolino Alessandro, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine. Journal of clinical psychopharmacology. 2003. Carrillo Juan Antonio, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
5-HT2A receptor promoter polymorphism, -1438G/A and negative symptom response to olanzapine in schizophrenia. Psychopharmacology bulletin. 2003. Ellingrod Vicki L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. European journal of pharmacology. 2002. Kongsamut Sathapana, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
CYP2D6 polymorphisms and atypical antipsychotic weight gain. Psychiatric genetics. 2002. Ellingrod Vicki L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes. European journal of clinical pharmacology. 2001. Hägg S, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients. Pharmacogenetics. 2001. Suzuki A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Science, medicine, and the future: Pharmacogenetics. BMJ (Clinical research ed.). 2000. Wolf C R, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response. Pharmacogenetics. 1998. Arranz M J, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry research. 1998. Ohara K, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0002-4112-30
DrugBank:
DB00334
ChEBI:
7735
KEGG Compound:
C07322
KEGG Drug:
D00454
PubChem Compound:
4585
PubChem Substance:
197059
IUPHAR Ligand:
47
Drugs Product Database (DPD):
2247099
BindingDB:
35254
Therapeutic Targets Database:
DAP000022
FDA Drug Label at DailyMed:
d5051fbc-846b-4946-82df-341fb1216341

Clinical Trials

These are trials that mention olanzapine and are related to either pharmacogenetics or pharmacogenomics.

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