Chemical: Drug
nevirapine
PharmGKB contains no dosing guidelines for this . To report known genotypebased dosing guidelines, or if you are interested in developing guidelines, click here.
1. FDA Label for nevirapine
Genes and/or phenotypes found in this label

Epidermal Necrolysis, Toxic
 Warnings section, Adverse reactions section
 source: PHONT

Leukemia
 Warnings section, Adverse reactions section
 source: PHONT

Toxic liver disease
 Warnings section, Adverse reactions section
 source: PHONT
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peerreviewed literature available at the time they are written and are intended only to assist clinicians in decisionmaking and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the healthcare provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variantdrug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Gene" column lead to PharmGKB Gene Pages.
List of all variant annotations for nevirapine
Gene ? 
Variant?
(147) 
Alternate Names ?  Chemicals ? 
Alleles
?
(+ chr strand) 
Function ? 
Amino Acid?
Translation 


VA  CYP2B6  *1  N/A  N/A  N/A  
VA  CYP2B6  *6  N/A  N/A  N/A  
VA  CYP2B6  *18  N/A  N/A  N/A  
VA  HLAA  *24:07  N/A  N/A  N/A  
VA  HLAB  *14:02:01  N/A  N/A  N/A  
VA  HLAB  *15:10:01  N/A  N/A  N/A  
CA VA  HLAB  *35:01:01:01  N/A  N/A  N/A  
CA VA  HLAB  *35:05:01  N/A  N/A  N/A  
VA  HLAB  *38:02:01  N/A  N/A  N/A  
VA  HLAB  *40:01:01  N/A  N/A  N/A  
VA  HLAB  *58:01  N/A  N/A  N/A  
VA  HLAB  *58:02  N/A  N/A  N/A  
VA  HLAC  *02:10  N/A  N/A  N/A  
VA  HLAC  *03:02  N/A  N/A  N/A  
VA  HLAC  *04:01:01:01  N/A  N/A  N/A  
VA  HLAC  *07:02:01:01  N/A  N/A  N/A  
VA  HLAC  *08:01  N/A  N/A  N/A  
VA  HLAC  *08:01:01  N/A  N/A  N/A  
VA  HLAC  *08:02:01  N/A  N/A  N/A  
VA  HLADQB1  *02:01:01  N/A  N/A  N/A  
VA  HLADQB1  *03:02:01  N/A  N/A  N/A  
CA VA  HLADQB1  *05:01:01:01  N/A  N/A  N/A  
VA  HLADQB1  *06:09  N/A  N/A  N/A  
VA  HLADQB1  *06:02:01  N/A  N/A  N/A  
VA  HLADQB1  *06:03:01  N/A  N/A  N/A  
CA VA  HLADRB1  *01:01:01  N/A  N/A  N/A  
VA  HLADRB1  *01:02:01  N/A  N/A  N/A  
VA  HLADRB1  *12:02:01  N/A  N/A  N/A  
VA  HLADRB1  *15:01:01:01  N/A  N/A  N/A  
VA  HLADRB1  *15:03:01:01  N/A  N/A  N/A  
rs10276036  NC_000007.13:g.87180198C>T, NC_000007.14:g.87550882C>T, NG_011513.1:g.167367G>A, NM_000927.4:c.100044G>A, rs10488634, rs111193439, rs17276942, rs57688958, rs58206924 
C > A
C > T

SNP  
rs1045642  NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664 
A > G

SNP 
I1145I


rs1128503  NC_000007.13:g.87179601A>G, NC_000007.14:g.87550285A>G, NG_011513.1:g.167964T>C, NM_000927.4:c.1236T>C, NP_000918.2:p.Gly412=, rs116989428, rs17276907, rs2032587, rs2229105, rs28365046, rs386518005, rs58257317 
A > G

SNP 
G412G


rs1265112  NC_000006.11:g.31118019T=, NC_000006.11:g.31118019T>C, NC_000006.12:g.31150242T=, NC_000006.12:g.31150242T>C, NM_001105563.1:c.110527A>G, NM_001105563.1:c.110527G>A, NM_001105564.1:c.121327A>G, NM_001105564.1:c.121327G>A, NM_019052.3:c.94627A>G, NM_019052.3:c.94627G>A, NT_113891.3:g.2632659C=, NT_113891.3:g.2632659C>T, NT_167245.2:g.2409550C=, NT_167245.2:g.2409550C>T, NT_167246.2:g.2460749T=, NT_167246.2:g.2460749T>C, NT_167247.2:g.2494363T=, NT_167247.2:g.2494363T>C, NT_167248.2:g.2408256T=, NT_167248.2:g.2408256T>C, XM_005272832.1:c.94627A>G, XM_005272832.1:c.94627G>A, XM_005272833.1:c.94627A>G, XM_005272833.1:c.94627G>A, XM_005272833.3:c.94627A>G, XM_005272833.3:c.94627G>A, XM_005272834.1:c.94627A>G, XM_005272834.1:c.94627G>A, XM_005272835.1:c.94627A>G, XM_005272835.1:c.94627G>A, XM_005272836.1:c.94627A>G, XM_005272836.1:c.94627G>A, XM_005272837.1:c.94627A>G, XM_005272837.1:c.94627G>A, XM_005272838.1:c.83827A>G, XM_005272838.1:c.83827G>A, XM_005272839.1:c.11827A>G, XM_005272839.1:c.11827G>A, XM_005272840.1:c.11827A>G, XM_005272840.1:c.11827G>A, XM_005274987.1:c.94627A>G, XM_005274987.1:c.94627G>A, XM_005274988.1:c.94627A>G, XM_005274988.1:c.94627G>A, XM_005274988.3:c.94627A>G, XM_005274988.3:c.94627G>A, XM_005274989.1:c.94627A>G, XM_005274989.1:c.94627G>A, XM_005274990.1:c.94627A>G, XM_005274990.1:c.94627G>A, XM_005274991.1:c.94627A>G, XM_005274991.1:c.94627G>A, XM_005274992.1:c.94627A>G, XM_005274992.1:c.94627G>A, XM_005274993.1:c.83827A>G, XM_005274993.1:c.83827G>A, XM_005274994.1:c.11827A>G, XM_005274994.1:c.11827G>A, XM_005274995.1:c.11827A>G, XM_005274995.1:c.11827G>A, XM_005275137.1:c.94627A>G, XM_005275137.1:c.94627G>A, XM_005275138.1:c.94627A>G, XM_005275138.1:c.94627G>A, XM_005275139.1:c.94627A>G, XM_005275139.1:c.94627G>A, XM_005275140.1:c.11827A>G, XM_005275140.1:c.11827G>A, XM_005275265.1:c.94627A>G, XM_005275265.1:c.94627G>A, XM_005275266.1:c.94627A>G, XM_005275266.1:c.94627G>A, XM_005275267.1:c.94627A>G, XM_005275267.1:c.94627G>A, XM_005275268.1:c.83827A>G, XM_005275268.1:c.83827G>A, XM_005275269.1:c.11827A>G, XM_005275269.1:c.11827G>A, XM_005275422.1:c.121327A>G, XM_005275422.1:c.121327G>A, XM_005275423.1:c.94627A>G, XM_005275423.1:c.94627G>A, XM_005275424.1:c.94627A>G, XM_005275424.1:c.94627G>A, XM_006725488.1:c.94627A>G, XM_006725488.1:c.94627G>A, XM_006725702.1:c.94627A>G, XM_006725702.1:c.94627G>A, XM_006726004.1:c.94627A>G, XM_006726004.1:c.94627G>A, XM_011514702.1:c.113227A>G, XM_011514702.1:c.113227G>A, XM_011514703.1:c.94627A>G, XM_011514703.1:c.94627G>A, XM_011514704.1:c.83827A>G, XM_011514704.1:c.83827G>A, XM_011514705.1:c.83827A>G, XM_011514705.1:c.83827G>A, XM_011514706.1:c.94627A>G, XM_011514706.1:c.94627G>A, XM_011547254.1:c.94627A>G, XM_011547254.1:c.94627G>A, XM_011547255.1:c.94627A>G, XM_011547255.1:c.94627G>A, XM_011547256.1:c.94627A>G, XM_011547256.1:c.94627G>A, XM_011547257.1:c.83827A>G, XM_011547257.1:c.83827G>A, XM_011547258.1:c.83827A>G, XM_011547258.1:c.83827G>A, XM_011547259.1:c.94627A>G, XM_011547259.1:c.94627G>A, XM_011547260.1:c.11827A>G, XM_011547260.1:c.11827G>A, XM_011547657.1:c.94627A>G, XM_011547657.1:c.94627G>A, XM_011547658.1:c.94627A>G, XM_011547658.1:c.94627G>A, XM_011547659.1:c.94627A>G, XM_011547659.1:c.94627G>A, XM_011547660.1:c.83827A>G, XM_011547660.1:c.83827G>A, XM_011547661.1:c.83827A>G, XM_011547661.1:c.83827G>A, XM_011547662.1:c.94627A>G, XM_011547662.1:c.94627G>A, XM_011547663.1:c.11827A>G, XM_011547663.1:c.11827G>A, XM_011547889.1:c.94627A>G, XM_011547889.1:c.94627G>A, XM_011547890.1:c.94627A>G, XM_011547890.1:c.94627G>A, XM_011547891.1:c.94627A>G, XM_011547891.1:c.94627G>A, XM_011547892.1:c.94627A>G, XM_011547892.1:c.94627G>A, XM_011547893.1:c.94627A>G, XM_011547893.1:c.94627G>A, XM_011547894.1:c.83827A>G, XM_011547894.1:c.83827G>A, XM_011547895.1:c.83827A>G, XM_011547895.1:c.83827G>A, XM_011548055.1:c.94627A>G, XM_011548055.1:c.94627G>A, XM_011548056.1:c.94627A>G, XM_011548056.1:c.94627G>A, XM_011548057.1:c.94627A>G, XM_011548057.1:c.94627G>A, XM_011548058.1:c.94627A>G, XM_011548058.1:c.94627G>A, XM_011548059.1:c.94627A>G, XM_011548059.1:c.94627G>A, XM_011548060.1:c.83827A>G, XM_011548060.1:c.83827G>A, XM_011548061.1:c.83827A>G, XM_011548061.1:c.83827G>A, XM_011548245.1:c.124027A>G, XM_011548245.1:c.124027G>A, XM_011548246.1:c.124027A>G, XM_011548246.1:c.124027G>A, XM_011548247.1:c.113227A>G, XM_011548247.1:c.113227G>A, XM_011548248.1:c.94627A>G, XM_011548248.1:c.94627G>A, XM_011548249.1:c.94627A>G, XM_011548249.1:c.94627G>A, XM_011548250.1:c.83827A>G, XM_011548250.1:c.83827G>A, XM_011548251.1:c.11827A>G, XM_011548251.1:c.11827G>A, XR_247374.1:n.124027A>G, XR_247374.1:n.124027G>A, XR_247390.1:n.124027A>G, XR_247390.1:n.124027G>A, XR_952828.1:n.149027A>G, XR_952828.1:n.149027G>A, XR_952829.1:n.149027A>G, XR_952829.1:n.149027G>A, XR_952943.1:n.149027A>G, XR_952943.1:n.149027G>A, XR_952944.1:n.149027A>G, XR_952944.1:n.149027G>A, XR_953005.1:n.144027A>G, XR_953005.1:n.144027G>A, XR_953006.1:n.144027A>G, XR_953006.1:n.144027G>A, rs116151586, rs117335190, rs61111094 
T > C

SNP  
rs12721646  NC_000019.10:g.41009202C>T, NC_000019.9:g.41515107C>T, NG_007929.1:g.22904C>T, NM_000767.4:c.64617C>T, XM_005258569.1:c.64617C>T, XM_005258569.3:c.64617C>T, XM_005258570.1:c.64617C>T, XM_005258571.1:c.3653096C>T, XM_006723050.2:c.64617C>T, XM_011526546.1:c.64617C>T, XM_011526547.1:c.64617C>T, XM_011526548.1:c.4853096C>T, XM_011526549.1:c.5517C>T, XM_011526550.1:c.3653096C>T, rs148630516, rs28399495 
C > G
C > T

SNP  
rs12721655  NC_000019.10:g.41004377A>G, NC_000019.9:g.41510282A>G, NG_007929.1:g.18079A>G, NM_000767.4:c.415A>G, NP_000758.1:p.Lys139Glu, XM_005258569.1:c.415A>G, XM_005258569.3:c.415A>G, XM_005258570.1:c.415A>G, XM_005258571.1:c.295A>G, XM_006723050.2:c.415A>G, XM_011526546.1:c.415A>G, XM_011526547.1:c.415A>G, XM_011526548.1:c.415A>G, XM_011526549.1:c.145A>G, XM_011526550.1:c.295A>G, XP_005258626.1:p.Lys139Glu, XP_005258627.1:p.Lys139Glu, XP_005258628.1:p.Lys99Glu, XP_006723113.1:p.Lys139Glu, XP_011524848.1:p.Lys139Glu, XP_011524849.1:p.Lys139Glu, XP_011524850.1:p.Lys139Glu, XP_011524852.1:p.Lys99Glu, rs56006122 
A > G

SNP 
K139E


rs12768009  NC_000010.10:g.96525865G>A, NC_000010.11:g.94766108G>A, NG_008384.2:g.8403G>A, NG_032466.1:g.8621C>T, NM_000769.1:c.168+3235G>A, NM_000769.2:c.168+3235G>A 
G > A

SNP  
rs130072  NC_000006.11:g.31112484C>T, NC_000006.12:g.31144707C>T, NM_001105563.1:c.2039G>A, NM_001105564.1:c.2147G>A, NM_019052.3:c.1880G>A, NP_001099033.1:p.Arg680Gln, NP_001099034.1:p.Arg716Gln, NP_061925.2:p.Arg627Gln, NT_113891.3:g.2627138C>T, NT_167245.2:g.2404029C>T, NT_167246.2:g.2455222C>T, NT_167247.2:g.2488835C>T, NT_167248.2:g.2402725C>T, XM_005272832.1:c.1880G>A, XM_005272833.1:c.1880G>A, XM_005272833.3:c.1880G>A, XM_005272834.1:c.1880G>A, XM_005272835.1:c.1880G>A, XM_005272836.1:c.1880G>A, XM_005272837.1:c.1880G>A, XM_005272838.1:c.1772G>A, XM_005272839.1:c.1052G>A, XM_005272840.1:c.1052G>A, XM_005274987.1:c.1880G>A, XM_005274988.1:c.1880G>A, XM_005274988.3:c.1880G>A, XM_005274989.1:c.1880G>A, XM_005274990.1:c.1880G>A, XM_005274991.1:c.1880G>A, XM_005274992.1:c.1880G>A, XM_005274993.1:c.1772G>A, XM_005274994.1:c.1052G>A, XM_005274995.1:c.1052G>A, XM_005275137.1:c.1880G>A, XM_005275138.1:c.1880G>A, XM_005275139.1:c.1798+178G>A, XM_005275140.1:c.1052G>A, XM_005275265.1:c.1880G>A, XM_005275266.1:c.1880G>A, XM_005275267.1:c.1798+178G>A, XM_005275268.1:c.1772G>A, XM_005275269.1:c.1052G>A, XM_005275422.1:c.2065+178G>A, XM_005275423.1:c.1880G>A, XM_005275424.1:c.1880G>A, XM_006725488.1:c.1880G>A, XM_006725702.1:c.1880G>A, XM_006726004.1:c.1880G>A, XM_011514702.1:c.2066G>A, XM_011514703.1:c.1880G>A, XM_011514704.1:c.1772G>A, XM_011514705.1:c.1772G>A, XM_011514706.1:c.*343G>A, XM_011547254.1:c.1880G>A, XM_011547255.1:c.1880G>A, XM_011547256.1:c.1880G>A, XM_011547257.1:c.1772G>A, XM_011547258.1:c.1772G>A, XM_011547259.1:c.*343G>A, XM_011547260.1:c.1052G>A, XM_011547657.1:c.1880G>A, XM_011547658.1:c.1880G>A, XM_011547659.1:c.1880G>A, XM_011547660.1:c.1772G>A, XM_011547661.1:c.1772G>A, XM_011547662.1:c.*343G>A, XM_011547663.1:c.1052G>A, XM_011547889.1:c.1880G>A, XM_011547890.1:c.1880G>A, XM_011547891.1:c.1880G>A, XM_011547892.1:c.1880G>A, XM_011547893.1:c.1880G>A, XM_011547894.1:c.1772G>A, XM_011547895.1:c.1772G>A, XM_011548055.1:c.1880G>A, XM_011548056.1:c.1880G>A, XM_011548057.1:c.1880G>A, XM_011548058.1:c.1880G>A, XM_011548059.1:c.1880G>A, XM_011548060.1:c.1772G>A, XM_011548061.1:c.1772G>A, XM_011548245.1:c.2174G>A, XM_011548246.1:c.2174G>A, XM_011548247.1:c.2066G>A, XM_011548248.1:c.1880G>A, XM_011548249.1:c.1880G>A, XM_011548250.1:c.1772G>A, XM_011548251.1:c.1052G>A, XP_005272889.1:p.Arg627Gln, XP_005272890.1:p.Arg627Gln, XP_005272891.1:p.Arg627Gln, XP_005272892.1:p.Arg627Gln, XP_005272893.1:p.Arg627Gln, XP_005272894.1:p.Arg627Gln, XP_005272895.1:p.Arg591Gln, XP_005272896.1:p.Arg351Gln, XP_005272897.1:p.Arg351Gln, XP_005275044.1:p.Arg627Gln, XP_005275045.1:p.Arg627Gln, XP_005275046.1:p.Arg627Gln, XP_005275047.1:p.Arg627Gln, XP_005275048.1:p.Arg627Gln, XP_005275049.1:p.Arg627Gln, XP_005275050.1:p.Arg591Gln, XP_005275051.1:p.Arg351Gln, XP_005275052.1:p.Arg351Gln, XP_005275194.1:p.Arg627Gln, XP_005275195.1:p.Arg627Gln, XP_005275197.1:p.Arg351Gln, XP_005275322.1:p.Arg627Gln, XP_005275323.1:p.Arg627Gln, XP_005275325.1:p.Arg591Gln, XP_005275326.1:p.Arg351Gln, XP_005275480.1:p.Arg627Gln, XP_005275481.1:p.Arg627Gln, XP_006725551.1:p.Arg627Gln, XP_006725765.1:p.Arg627Gln, XP_006726067.1:p.Arg627Gln, XP_011513004.1:p.Arg689Gln, XP_011513005.1:p.Arg627Gln, XP_011513006.1:p.Arg591Gln, XP_011513007.1:p.Arg591Gln, XP_011545556.1:p.Arg627Gln, XP_011545557.1:p.Arg627Gln, XP_011545558.1:p.Arg627Gln, XP_011545559.1:p.Arg591Gln, XP_011545560.1:p.Arg591Gln, XP_011545562.1:p.Arg351Gln, XP_011545959.1:p.Arg627Gln, XP_011545960.1:p.Arg627Gln, XP_011545961.1:p.Arg627Gln, XP_011545962.1:p.Arg591Gln, XP_011545963.1:p.Arg591Gln, XP_011545965.1:p.Arg351Gln, XP_011546191.1:p.Arg627Gln, XP_011546192.1:p.Arg627Gln, XP_011546193.1:p.Arg627Gln, XP_011546194.1:p.Arg627Gln, XP_011546195.1:p.Arg627Gln, XP_011546196.1:p.Arg591Gln, XP_011546197.1:p.Arg591Gln, XP_011546357.1:p.Arg627Gln, XP_011546358.1:p.Arg627Gln, XP_011546359.1:p.Arg627Gln, XP_011546360.1:p.Arg627Gln, XP_011546361.1:p.Arg627Gln, XP_011546362.1:p.Arg591Gln, XP_011546363.1:p.Arg591Gln, XP_011546547.1:p.Arg725Gln, XP_011546548.1:p.Arg725Gln, XP_011546549.1:p.Arg689Gln, XP_011546550.1:p.Arg627Gln, XP_011546551.1:p.Arg627Gln, XP_011546552.1:p.Arg591Gln, XP_011546553.1:p.Arg351Gln, XR_247374.1:n.2174G>A, XR_247390.1:n.2174G>A, XR_952828.1:n.2424G>A, XR_952829.1:n.2402G>A, XR_952943.1:n.2424G>A, XR_952944.1:n.2402G>A, XR_953005.1:n.2374G>A, XR_953006.1:n.2352G>A, rs11540820, rs116682468, rs118078470, rs17516353, rs59465152 
C > T

SNP 
R680Q


rs1517618  NC_000015.10:g.92104415G>C, NC_000015.9:g.92647645G>C, NM_001145044.1:c.882G>C, NM_013272.3:c.882G>C, NP_001138516.1:p.Glu294Asp, NP_037404.2:p.Glu294Asp, XM_005254889.1:c.882G>C, XM_005254890.1:c.708G>C, XM_005254891.1:c.537G>C, XM_011521456.1:c.708G>C, XM_011521457.1:c.882G>C, XP_005254946.1:p.Glu294Asp, XP_005254947.1:p.Glu236Asp, XP_005254948.1:p.Glu179Asp, XP_011519758.1:p.Glu236Asp, XP_011519759.1:p.Glu294Asp, XR_429450.2:n.802G>C, XR_931795.1:n.972G>C, XR_931796.1:n.972G>C, rs17519193, rs17844850, rs17857564, rs52834221, rs60307785 
G > C

SNP 
E294D


rs1523130  NC_000003.11:g.119499507T>C, NC_000003.12:g.119780660T>C, NG_011856.1:g.5177T>C, NM_003889.3:c.1663T>C, NM_033013.2:c.1663T>C, XM_005247866.1:c.1828T>C, rs118196528, rs3814054, rs59854583, rs61314694 
T > C

SNP  
rs2032582  NC_000007.13:g.87160618A>C, NC_000007.13:g.87160618A>T, NC_000007.14:g.87531302A>C, NC_000007.14:g.87531302A>T, NG_011513.1:g.186947T>A, NG_011513.1:g.186947T>G, NM_000927.4:c.2677T>A, NM_000927.4:c.2677T>G, NP_000918.2:p.Ser893Ala, NP_000918.2:p.Ser893Thr, rs10228331, rs2229106, rs386553610, rs57135550, rs9641018 
A > C

SNP 
S893A


rs2054675  NC_000019.10:g.40989850T>C, NC_000019.9:g.41495755T>C, NG_007929.1:g.3552T>C, NM_000767.4:c.1456T>C, XM_005258569.1:c.1456T>C, XM_005258569.3:c.1456T>C, XM_005258570.1:c.1456T>C, XM_006723050.2:c.1456T>C, XM_011526546.1:c.1456T>C, XM_011526547.1:c.1456T>C, XM_011526548.1:c.1456T>C, rs3760658, rs61672187 
T > C

SNP  
rs2073724  NC_000006.11:g.31129707C>T, NC_000006.12:g.31161930C>T, NM_001077511.1:c.722C>T, NM_001318908.1:c.722C>T, NM_007109.2:c.722C>T, NP_001070979.1:p.Pro241Leu, NP_001305837.1:p.Pro241Leu, NP_009040.2:p.Pro241Leu, NT_113891.3:g.2644353C>T, NT_167245.2:g.2421245C>T, NT_167246.2:g.2472430C>T, NT_167247.2:g.2506044C>T, NT_167248.2:g.2419962C>T, NT_167249.2:g.2465345C>T, XM_005249334.1:c.722C>T, XM_005249334.2:c.722C>T, XM_005249335.1:c.722C>T, XM_005249336.1:c.722C>T, XM_005272865.1:c.722C>T, XM_005272866.1:c.722C>T, XM_005272867.1:c.722C>T, XM_005272868.1:c.722C>T, XM_005275018.1:c.722C>T, XM_005275019.1:c.722C>T, XM_005275020.1:c.722C>T, XM_005275155.1:c.722C>T, XM_005275156.1:c.722C>T, XM_005275157.1:c.722C>T, XM_005275287.1:c.722C>T, XM_005275288.1:c.722C>T, XM_005275289.1:c.722C>T, XM_005275449.1:c.722C>T, XM_005275449.2:c.722C>T, XM_005275450.1:c.722C>T, XM_005275451.1:c.722C>T, XM_005275588.1:c.722C>T, XM_005275589.1:c.722C>T, XM_011514829.1:c.722C>T, XM_011547277.1:c.722C>T, XM_011547278.1:c.722C>T, XM_011547680.1:c.722C>T, XM_011547900.1:c.722C>T, XM_011548078.1:c.722C>T, XM_011548461.1:c.722C>T, XP_005249391.1:p.Pro241Leu, XP_005249392.1:p.Pro241Leu, XP_005249393.1:p.Pro241Leu, XP_005272922.1:p.Pro241Leu, XP_005272923.1:p.Pro241Leu, XP_005272924.1:p.Pro241Leu, XP_005272925.1:p.Pro241Leu, XP_005275075.1:p.Pro241Leu, XP_005275076.1:p.Pro241Leu, XP_005275077.1:p.Pro241Leu, XP_005275212.1:p.Pro241Leu, XP_005275213.1:p.Pro241Leu, XP_005275214.1:p.Pro241Leu, XP_005275344.1:p.Pro241Leu, XP_005275345.1:p.Pro241Leu, XP_005275346.1:p.Pro241Leu, XP_005275506.1:p.Pro241Leu, XP_005275507.1:p.Pro241Leu, XP_005275508.1:p.Pro241Leu, XP_005275645.1:p.Pro241Leu, XP_005275646.1:p.Pro241Leu, XP_011513131.1:p.Pro241Leu, XP_011545579.1:p.Pro241Leu, XP_011545580.1:p.Pro241Leu, XP_011545982.1:p.Pro241Leu, XP_011546202.1:p.Pro241Leu, XP_011546380.1:p.Pro241Leu, XP_011546763.1:p.Pro241Leu, rs115538919, rs117671247, rs17457224, rs17853160, rs17857685, rs58398878 
C > T

SNP 
P241L


rs2125739  NC_000006.11:g.43412865T>C, NC_000006.12:g.43445127T>C, NM_001198934.1:c.2843T>C, NM_033450.2:c.2759T>C, NP_001185863.1:p.Ile948Thr, NP_258261.2:p.Ile920Thr, XM_005249465.1:c.2843T>C, XM_005249466.1:c.2843T>C, XM_005249467.1:c.2843T>C, XM_005249468.1:c.2843T>C, XM_005249469.1:c.890T>C, XM_005249470.1:c.*370T>C, XM_011514974.1:c.2843T>C, XM_011514975.1:c.2843T>C, XM_011514976.1:c.2843T>C, XM_011514977.1:c.2843T>C, XM_011514978.1:c.2726T>C, XM_011514979.1:c.2843T>C, XM_011514980.1:c.2843T>C, XM_011514981.1:c.2843T>C, XM_011514982.1:c.1511T>C, XM_011514983.1:c.1511T>C, XM_011514984.1:c.*370T>C, XM_011514985.1:c.890T>C, XM_011514986.1:c.890T>C, XP_005249522.1:p.Ile948Thr, XP_005249523.1:p.Ile948Thr, XP_005249524.1:p.Ile948Thr, XP_005249525.1:p.Ile948Thr, XP_005249526.1:p.Ile297Thr, XP_011513276.1:p.Ile948Thr, XP_011513277.1:p.Ile948Thr, XP_011513278.1:p.Ile948Thr, XP_011513279.1:p.Ile948Thr, XP_011513280.1:p.Ile909Thr, XP_011513281.1:p.Ile948Thr, XP_011513282.1:p.Ile948Thr, XP_011513283.1:p.Ile948Thr, XP_011513284.1:p.Ile504Thr, XP_011513285.1:p.Ile504Thr, XP_011513287.1:p.Ile297Thr, XP_011513288.1:p.Ile297Thr, XR_926334.1:n.2988T>C, rs59156345 
T > C

SNP 
I948T


rs2229107  NC_000007.13:g.87138659A>T, NC_000007.14:g.87509343A>T, NG_011513.1:g.208906T>A, NM_000927.4:c.3421T>A, NP_000918.2:p.Ser1141Thr, rs17149694, rs56650970, rs59426833 
A > T

SNP 
S1141T


rs2233945  NC_000006.11:g.31107361C=, NC_000006.11:g.31107361C>A, NC_000006.12:g.31139584C=, NC_000006.12:g.31139584C>A, NG_021348.1:g.29754C=, NG_021348.1:g.29754C>A, NM_014068.2:c.16857A>C, NM_014068.2:c.16857C>A, NM_014069.2:c.558G>T, NM_014069.2:c.558T>G, NT_113891.2:g.2622083C=, NT_113891.2:g.2622083C>A, NT_113891.3:g.2621977C=, NT_113891.3:g.2621977C>A, NT_167245.1:g.2404499C=, NT_167245.1:g.2404499C>A, NT_167245.2:g.2398914C=, NT_167245.2:g.2398914C>A, NT_167246.1:g.2455729C=, NT_167246.1:g.2455729C>A, NT_167246.2:g.2450109C=, NT_167246.2:g.2450109C>A, NT_167247.1:g.2489306C=, NT_167247.1:g.2489306C>A, NT_167247.2:g.2483721C=, NT_167247.2:g.2483721C>A, NT_167248.1:g.2403206A=, NT_167248.1:g.2403206A>C, NT_167248.2:g.2397610A=, NT_167248.2:g.2397610A>C, XM_011547844.1:c.*33A>C, XM_011547844.1:c.*33C>A, XM_011547845.1:c.*33A>C, XM_011547845.1:c.*33C>A, rs112468750, rs114324939, rs117539914 
C > A

SNP  
rs2279343  NC_000019.10:g.41009358A>G, NC_000019.9:g.41515263A>G, NG_007929.1:g.23060A>G, NM_000767.4:c.785A>G, NP_000758.1:p.Lys262Arg, XM_005258569.1:c.785A>G, XM_005258569.3:c.785A>G, XM_005258570.1:c.785A>G, XM_005258571.1:c.3652940A>G, XM_006723050.2:c.785A>G, XM_011526546.1:c.785A>G, XM_011526547.1:c.785A>G, XM_011526548.1:c.4852940A>G, XM_011526549.1:c.194A>G, XM_011526550.1:c.3652940A>G, XP_005258626.1:p.Lys262Arg, XP_005258627.1:p.Lys262Arg, XP_006723113.1:p.Lys262Arg, XP_011524848.1:p.Lys262Arg, XP_011524849.1:p.Lys262Arg, XP_011524851.1:p.Lys65Arg 
A > G

SNP 
K262R


rs2472677  NC_000003.11:g.119518417C>T, NC_000003.12:g.119799570C>T, NG_011856.1:g.24087C>T, NM_003889.3:c.227659C>T, NM_022002.2:c.967659C>T, NM_033013.2:c.227659C>T, XM_005247866.1:c.1877659C>T, rs57813967 
C > T

SNP  
rs2562519  NC_000005.10:g.90485154C>T, NC_000005.9:g.89780971C>T, NM_006467.2:c.43371C>T, XM_005248404.1:c.33381C>T, XM_005248404.2:c.33381C>T, XM_005248405.1:c.43371C>T, XM_005248406.1:c.43371C>T, XM_005248407.1:c.33381C>T, XM_006714519.2:c.43371C>T, XM_006714520.2:c.33381C>T, XM_011543100.1:c.43371C>T, XM_011543101.1:c.33381C>T, XM_011543102.1:c.33381C>T, XM_011543103.1:c.43371C>T, XM_011543104.1:c.33381C>T, XM_011543105.1:c.1224C>T, XM_011543106.1:c.43371C>T, rs57639746 
C > T

SNP  
rs2740574  NC_000007.13:g.99382096C>T, NC_000007.14:g.99784473C>T, NG_008421.1:g.4713G>A, NM_001202855.2:c.392G>A, NM_017460.5:c.392G>A, XM_011515841.1:c.392G>A, XM_011515842.1:c.392G>A, rs3176920, rs36231114, rs59393892 
C > T

SNP  
rs28371706  NC_000022.10:g.42525772G>A, NC_000022.11:g.42129770G>A, NG_008376.3:g.5222C>T, NM_000106.5:c.320C>T, NM_001025161.2:c.320C>T, NP_000097.3:p.Thr107Ile, NP_001020332.2:p.Thr107Ile, NT_187682.1:g.52111G>A, NW_004504305.1:g.52097G>A, NW_009646208.1:g.15336G>A, XM_005278353.1:c.320C>T, XM_005278354.1:c.532C>T, XM_005278354.3:c.532C>T, XM_011529966.1:c.320C>T, XM_011529967.1:c.320C>T, XM_011529968.1:c.320C>T, XM_011529969.1:c.177C>T, XM_011529970.1:c.320C>T, XM_011529971.1:c.177C>T, XM_011529972.1:c.320C>T, XM_011547541.1:c.532C>T, XM_011547750.1:c.177C>T, XM_011547751.1:c.192C>T, XM_011547756.1:c.265G>A, XM_011548819.1:c.532C>T, XP_005278410.1:p.Thr107Ile, XP_011528268.1:p.Thr107Ile, XP_011528269.1:p.Thr107Ile, XP_011528270.1:p.Thr107Ile, XP_011528271.1:p.His59=, XP_011528272.1:p.Thr107Ile, XP_011528273.1:p.His59=, XP_011528274.1:p.Thr107Ile, XP_011546052.1:p.His59=, XR_430455.2:n.101G>A, XR_952745.1:n.1477C>T, rs587777915, rs59604033 
G > A

SNP 
T107I


rs28399454  NC_000019.10:g.40845362C>T, NC_000019.9:g.41351267C>T, NG_008377.1:g.10086G>A, NM_000762.5:c.1093G>A, NP_000753.3:p.Val365Met, XM_005258568.1:c.940G>A, XP_005258625.1:p.Val314Met, rs57673794 
C > T

SNP 
V365M


rs28399499  NC_000019.10:g.41012316T>C, NC_000019.9:g.41518221T>C, NG_007929.1:g.26018T>C, NM_000767.4:c.983T>C, NP_000758.1:p.Ile328Thr, XM_005258569.1:c.983T>C, XM_005258569.3:c.983T>C, XM_005258570.1:c.983T>C, XM_005258571.1:c.383T>C, XM_006723050.2:c.983T>C, XM_011526546.1:c.983T>C, XM_011526547.1:c.983T>C, XM_011526548.1:c.503T>C, XM_011526549.1:c.392T>C, XM_011526550.1:c.383T>C, XP_005258626.1:p.Ile328Thr, XP_005258627.1:p.Ile328Thr, XP_005258628.1:p.Ile128Thr, XP_006723113.1:p.Ile328Thr, XP_011524848.1:p.Ile328Thr, XP_011524849.1:p.Ile328Thr, XP_011524850.1:p.Ile168Thr, XP_011524851.1:p.Ile131Thr, XP_011524852.1:p.Ile128Thr 
T > C

SNP 
I328T


rs3099844  NC_000006.11:g.31448976C=, NC_000006.11:g.31448976C>A, NC_000006.12:g.31481199C=, NC_000006.12:g.31481199C>A, NT_113891.2:g.2958634A=, NT_113891.2:g.2958634A>C, NT_113891.3:g.2958528A=, NT_113891.3:g.2958528A>C, NT_167244.1:g.2763686C=, NT_167244.1:g.2763686C>A, NT_167244.2:g.2813770C=, NT_167244.2:g.2813770C>A, NT_167245.1:g.2734310C=, NT_167245.1:g.2734310C>A, NT_167245.2:g.2728725C=, NT_167245.2:g.2728725C>A, NT_167247.1:g.2828760C=, NT_167247.1:g.2828760C>A, NT_167247.2:g.2823175C=, NT_167247.2:g.2823175C>A, NT_167248.1:g.2742682C=, NT_167248.1:g.2742682C>A, NT_167248.2:g.2737086C=, NT_167248.2:g.2737086C>A, NT_167249.1:g.2779748C=, NT_167249.1:g.2779748C>A, NT_167249.2:g.2780450C=, NT_167249.2:g.2780450C>A, XR_926693.1:n.701G=, XR_926693.1:n.701G>T, XR_953042.1:n.531G=, XR_953042.1:n.531G>T, rs116662199, rs116841198, rs58471066, rs7757186 
C > A

SNP  
rs3211371  NC_000019.10:g.41016810C>T, NC_000019.9:g.41522715C>T, NG_007929.1:g.30512C>T, NM_000767.4:c.1459C>T, NP_000758.1:p.Arg487Cys, XM_005258569.1:c.*48C>T, XM_005258569.3:c.*48C>T, XM_005258570.1:c.*214C>T, XM_005258571.1:c.859C>T, XM_006723050.2:c.*143C>T, XM_011526547.1:c.*214C>T, XM_011526548.1:c.979C>T, XM_011526549.1:c.868C>T, XM_011526550.1:c.859C>T, XP_005258628.1:p.Arg287Cys, XP_011524850.1:p.Arg327Cys, XP_011524851.1:p.Arg290Cys, XP_011524852.1:p.Arg287Cys, rs12721654, rs28399500, rs33995163, rs58951873 
C > T

SNP 
R487C


rs35979566  NC_000019.10:g.41012693T>A, NC_000019.9:g.41518598T>A, NG_007929.1:g.26395T>A, NM_000767.4:c.1172T>A, NP_000758.1:p.Ile391Asn, XM_005258569.1:c.1152+208T>A, XM_005258569.3:c.1152+208T>A, XM_005258570.1:c.1152+208T>A, XM_005258571.1:c.572T>A, XM_006723050.2:c.1172T>A, XM_011526546.1:c.1153123T>A, XM_011526547.1:c.1152+208T>A, XM_011526548.1:c.692T>A, XM_011526549.1:c.581T>A, XM_011526550.1:c.572T>A, XP_005258628.1:p.Ile191Asn, XP_006723113.1:p.Ile391Asn, XP_011524850.1:p.Ile231Asn, XP_011524851.1:p.Ile194Asn, XP_011524852.1:p.Ile191Asn, rs57682077 
T > A

SNP 
I391N


rs3745274  NC_000019.10:g.41006936G>T, NC_000019.9:g.41512841G>T, NG_007929.1:g.20638G>T, NM_000767.4:c.516G>T, NP_000758.1:p.Gln172His, XM_005258569.1:c.516G>T, XM_005258569.3:c.516G>T, XM_005258570.1:c.516G>T, XM_005258571.1:c.364+2490G>T, XM_006723050.2:c.516G>T, XM_011526546.1:c.516G>T, XM_011526547.1:c.516G>T, XM_011526548.1:c.484+2490G>T, XM_011526549.1:c.751G>T, XM_011526550.1:c.364+2490G>T, XP_005258626.1:p.Gln172His, XP_005258627.1:p.Gln172His, XP_006723113.1:p.Gln172His, XP_011524848.1:p.Gln172His, XP_011524849.1:p.Gln172His, rs56308434, rs57685583 
G > T

SNP 
Q172H


rs3786547  NC_000019.10:g.41000286T>C, NC_000019.9:g.41506191T>C, NG_007929.1:g.13988T>C, NM_000767.4:c.1723715T>C, XM_005258569.1:c.1723715T>C, XM_005258569.3:c.1723715T>C, XM_005258570.1:c.1723715T>C, XM_006723050.2:c.1723715T>C, XM_011526546.1:c.1723715T>C, XM_011526547.1:c.1723715T>C, XM_011526548.1:c.1723715T>C 
T > C

SNP  
rs3842689  NC_000003.11:g.119501400_119501405delGAGAAG, NC_000003.12:g.119782553_119782558delGAGAAG, NG_011856.1:g.7070_7075delGAGAAG, NM_003889.3:c.23+253_23+258del, NM_003889.3:c.23+253_23+258delGAGAAG, NM_022002.2:c.205_200del, NM_022002.2:c.205_200delGAGAAG, NM_033013.2:c.23+253_23+258del, NM_033013.2:c.23+253_23+258delGAGAAG, XM_005247866.1:c.188+253_188+258delGAGAAG, rs58559376 
GAGAAG > 

indel  
rs3892097  NC_000022.10:g.42524947C=, NC_000022.10:g.42524947C>T, NC_000022.11:g.42128945C=, NC_000022.11:g.42128945C>T, NG_008376.3:g.6047G=, NG_008376.3:g.6047G>A, NM_000106.5:c.5061A>G, NM_000106.5:c.5061G>A, NM_001025161.2:c.3531A>G, NM_001025161.2:c.3531G>A, NT_187682.1:g.51286C=, NT_187682.1:g.51286C>T, NW_004504305.1:g.51272T=, NW_004504305.1:g.51272T>C, NW_009646208.1:g.14511C=, NW_009646208.1:g.14511C>T, XM_005278353.1:c.3632A>G, XM_005278353.1:c.3632G>A, XM_005278354.1:c.2072A>G, XM_005278354.1:c.2072G>A, XM_005278354.3:c.2072A>G, XM_005278354.3:c.2072G>A, XM_011529966.1:c.5061A>G, XM_011529966.1:c.5061G>A, XM_011529967.1:c.5061A>G, XM_011529967.1:c.5061G>A, XM_011529968.1:c.5061A>G, XM_011529968.1:c.5061G>A, XM_011529969.1:c.3632A>G, XM_011529969.1:c.3632G>A, XM_011529970.1:c.3531A>G, XM_011529970.1:c.3531G>A, XM_011529971.1:c.3632A>G, XM_011529971.1:c.3632G>A, XM_011529972.1:c.5061A>G, XM_011529972.1:c.5061G>A, XM_011547541.1:c.2072A>G, XM_011547541.1:c.2072G>A, XM_011547750.1:c.3632A>G, XM_011547750.1:c.3632G>A, XM_011547751.1:c.2901A>G, XM_011547751.1:c.2901G>A, XM_011547756.1:c.1090C>T, XM_011547756.1:c.1090T>C, XM_011548819.1:c.2072A>G, XM_011548819.1:c.2072G>A, XR_430455.2:n.926C>T, XR_430455.2:n.926T>C, XR_952745.1:n.16631A>G, XR_952745.1:n.16631G>A, rs1800716, rs28371711, rs60082401, rs606231227 
C > T

SNP  
rs58425034  NC_000019.10:g.41009060G>C, NC_000019.9:g.41514965G>C, NG_007929.1:g.22762G>C, NM_000767.4:c.646159G>C, XM_005258569.1:c.646159G>C, XM_005258569.3:c.646159G>C, XM_005258570.1:c.646159G>C, XM_005258571.1:c.3653238G>C, XM_006723050.2:c.646159G>C, XM_011526546.1:c.646159G>C, XM_011526547.1:c.646159G>C, XM_011526548.1:c.4853238G>C, XM_011526549.1:c.55159G>C, XM_011526550.1:c.3653238G>C 
G > C

SNP  
rs628031  NC_000006.11:g.160560845A>G, NC_000006.12:g.160139813A>G, NM_003057.2:c.1222A>G, NM_153187.1:c.1222A>G, NP_003048.1:p.Met408Val, NP_694857.1:p.Met408Val, XM_005267102.1:c.1222A>G, XM_005267102.3:c.1222A>G, XM_005267103.1:c.1222A>G, XM_005267104.1:c.646A>G, XM_005267104.3:c.646A>G, XM_005267105.1:c.646A>G, XM_005267105.3:c.646A>G, XM_006715552.1:c.1222A>G, XM_011536074.1:c.646A>G, XP_005267159.1:p.Met408Val, XP_005267160.1:p.Met408Val, XP_005267161.1:p.Met216Val, XP_005267162.1:p.Met216Val, XP_006715615.1:p.Met408Val, XP_011534376.1:p.Met216Val, rs1086277, rs17202481, rs60990824 
A > G

SNP 
M408V


rs6545803  NC_000002.11:g.60534199G>T, NC_000002.12:g.60307064G>T, rs60116865 
G > T

SNP  
rs746647  NC_000006.11:g.31114182A=, NC_000006.11:g.31114182A>G, NC_000006.12:g.31146405A=, NC_000006.12:g.31146405A>G, NM_001105563.1:c.1473597C>T, NM_001105563.1:c.1473597T>C, NM_001105564.1:c.1581597C>T, NM_001105564.1:c.1581597T>C, NM_019052.3:c.1314597C>T, NM_019052.3:c.1314597T>C, NT_113891.3:g.2628836G=, NT_113891.3:g.2628836G>A, NT_167245.2:g.2405727G=, NT_167245.2:g.2405727G>A, NT_167246.2:g.2456920A=, NT_167246.2:g.2456920A>G, NT_167247.2:g.2490533A=, NT_167247.2:g.2490533A>G, NT_167248.2:g.2404423A=, NT_167248.2:g.2404423A>G, XM_005272832.1:c.1314597C>T, XM_005272832.1:c.1314597T>C, XM_005272833.1:c.1314597C>T, XM_005272833.1:c.1314597T>C, XM_005272833.3:c.1314597C>T, XM_005272833.3:c.1314597T>C, XM_005272834.1:c.1314597C>T, XM_005272834.1:c.1314597T>C, XM_005272835.1:c.1314597C>T, XM_005272835.1:c.1314597T>C, XM_005272836.1:c.1314597C>T, XM_005272836.1:c.1314597T>C, XM_005272837.1:c.1314597C>T, XM_005272837.1:c.1314597T>C, XM_005272838.1:c.1206597C>T, XM_005272838.1:c.1206597T>C, XM_005272839.1:c.486597C>T, XM_005272839.1:c.486597T>C, XM_005272840.1:c.486597C>T, XM_005272840.1:c.486597T>C, XM_005274987.1:c.1314597C>T, XM_005274987.1:c.1314597T>C, XM_005274988.1:c.1314597C>T, XM_005274988.1:c.1314597T>C, XM_005274988.3:c.1314597C>T, XM_005274988.3:c.1314597T>C, XM_005274989.1:c.1314597C>T, XM_005274989.1:c.1314597T>C, XM_005274990.1:c.1314597C>T, XM_005274990.1:c.1314597T>C, XM_005274991.1:c.1314597C>T, XM_005274991.1:c.1314597T>C, XM_005274992.1:c.1314597C>T, XM_005274992.1:c.1314597T>C, XM_005274993.1:c.1206597C>T, XM_005274993.1:c.1206597T>C, XM_005274994.1:c.486597C>T, XM_005274994.1:c.486597T>C, XM_005274995.1:c.486597C>T, XM_005274995.1:c.486597T>C, XM_005275137.1:c.1314597C>T, XM_005275137.1:c.1314597T>C, XM_005275138.1:c.1314597C>T, XM_005275138.1:c.1314597T>C, XM_005275139.1:c.1314597C>T, XM_005275139.1:c.1314597T>C, XM_005275140.1:c.486597C>T, XM_005275140.1:c.486597T>C, XM_005275265.1:c.1314597C>T, XM_005275265.1:c.1314597T>C, XM_005275266.1:c.1314597C>T, XM_005275266.1:c.1314597T>C, XM_005275267.1:c.1314597C>T, XM_005275267.1:c.1314597T>C, XM_005275268.1:c.1206597C>T, XM_005275268.1:c.1206597T>C, XM_005275269.1:c.486597C>T, XM_005275269.1:c.486597T>C, XM_005275422.1:c.1581597C>T, XM_005275422.1:c.1581597T>C, XM_005275423.1:c.1314597C>T, XM_005275423.1:c.1314597T>C, XM_005275424.1:c.1314597C>T, XM_005275424.1:c.1314597T>C, XM_006725488.1:c.1314597C>T, XM_006725488.1:c.1314597T>C, XM_006725702.1:c.1314597C>T, XM_006725702.1:c.1314597T>C, XM_006726004.1:c.1314597C>T, XM_006726004.1:c.1314597T>C, XM_011514702.1:c.1500597C>T, XM_011514702.1:c.1500597T>C, XM_011514703.1:c.1314597C>T, XM_011514703.1:c.1314597T>C, XM_011514704.1:c.1206597C>T, XM_011514704.1:c.1206597T>C, XM_011514705.1:c.1206597C>T, XM_011514705.1:c.1206597T>C, XM_011514706.1:c.1314597C>T, XM_011514706.1:c.1314597T>C, XM_011547254.1:c.1314597C>T, XM_011547254.1:c.1314597T>C, XM_011547255.1:c.1314597C>T, XM_011547255.1:c.1314597T>C, XM_011547256.1:c.1314597C>T, XM_011547256.1:c.1314597T>C, XM_011547257.1:c.1206597C>T, XM_011547257.1:c.1206597T>C, XM_011547258.1:c.1206597C>T, XM_011547258.1:c.1206597T>C, XM_011547259.1:c.1314597C>T, XM_011547259.1:c.1314597T>C, XM_011547260.1:c.486597C>T, XM_011547260.1:c.486597T>C, XM_011547657.1:c.1314597C>T, XM_011547657.1:c.1314597T>C, XM_011547658.1:c.1314597C>T, XM_011547658.1:c.1314597T>C, XM_011547659.1:c.1314597C>T, XM_011547659.1:c.1314597T>C, XM_011547660.1:c.1206597C>T, XM_011547660.1:c.1206597T>C, XM_011547661.1:c.1206597C>T, XM_011547661.1:c.1206597T>C, XM_011547662.1:c.1314597C>T, XM_011547662.1:c.1314597T>C, XM_011547663.1:c.486597C>T, XM_011547663.1:c.486597T>C, XM_011547889.1:c.1314597C>T, XM_011547889.1:c.1314597T>C, XM_011547890.1:c.1314597C>T, XM_011547890.1:c.1314597T>C, XM_011547891.1:c.1314597C>T, XM_011547891.1:c.1314597T>C, XM_011547892.1:c.1314597C>T, XM_011547892.1:c.1314597T>C, XM_011547893.1:c.1314597C>T, XM_011547893.1:c.1314597T>C, XM_011547894.1:c.1206597C>T, XM_011547894.1:c.1206597T>C, XM_011547895.1:c.1206597C>T, XM_011547895.1:c.1206597T>C, XM_011548055.1:c.1314597C>T, XM_011548055.1:c.1314597T>C, XM_011548056.1:c.1314597C>T, XM_011548056.1:c.1314597T>C, XM_011548057.1:c.1314597C>T, XM_011548057.1:c.1314597T>C, XM_011548058.1:c.1314597C>T, XM_011548058.1:c.1314597T>C, XM_011548059.1:c.1314597C>T, XM_011548059.1:c.1314597T>C, XM_011548060.1:c.1206597C>T, XM_011548060.1:c.1206597T>C, XM_011548061.1:c.1206597C>T, XM_011548061.1:c.1206597T>C, XM_011548245.1:c.1608597C>T, XM_011548245.1:c.1608597T>C, XM_011548246.1:c.1608597C>T, XM_011548246.1:c.1608597T>C, XM_011548247.1:c.1500597C>T, XM_011548247.1:c.1500597T>C, XM_011548248.1:c.1314597C>T, XM_011548248.1:c.1314597T>C, XM_011548249.1:c.1314597C>T, XM_011548249.1:c.1314597T>C, XM_011548250.1:c.1206597C>T, XM_011548250.1:c.1206597T>C, XM_011548251.1:c.486597C>T, XM_011548251.1:c.486597T>C, XR_247374.1:n.1608597C>T, XR_247374.1:n.1608597T>C, XR_247390.1:n.1608597C>T, XR_247390.1:n.1608597T>C, XR_952828.1:n.1858597C>T, XR_952828.1:n.1858597T>C, XR_952829.1:n.1858597C>T, XR_952829.1:n.1858597T>C, XR_952943.1:n.1858597C>T, XR_952943.1:n.1858597T>C, XR_952944.1:n.1858597C>T, XR_952944.1:n.1858597T>C, XR_953005.1:n.1808597C>T, XR_953005.1:n.1808597T>C, XR_953006.1:n.1808597C>T, XR_953006.1:n.1808597T>C, rs115868860, rs118166432, rs1265072, rs17190659, rs59892691, rs9263747 
A > G

SNP  
rs76228616  NC_000006.11:g.111922503G>C, NC_000006.12:g.111601300G>C, NG_032030.1:g.9975C>G, NM_001164281.2:c.9+4476C>G, NM_147200.2:c.86C>G, NM_147686.3:c.9+4476C>G, NR_028338.2:n.506C>G, NR_034108.1:n.3948G>C, NR_034109.1:n.3657G>C, XM_011535386.1:c.86C>G 
G > 
G > G

SNP  
rs762551  NC_000015.10:g.74749576C>A, NC_000015.9:g.75041917C>A, NG_008431.1:g.32035C>A, NM_000761.3:c.9154C>A, NM_000761.4:c.9154C>A, rs17861151, rs57172993 
C > A

SNP  
rs776746  NC_000007.13:g.99270539C>T, NC_000007.14:g.99672916T>C, NG_007938.1:g.12083G=, NG_007938.1:g.12083G>A, NM_000777.4:c.219237A>G, NM_000777.4:c.219237G>A, NM_001190484.2:c.219237A>G, NM_001190484.2:c.219237G>A, NM_001291829.1:c.2531A>G, NM_001291829.1:c.2531G>A, NM_001291830.1:c.189237A>G, NM_001291830.1:c.189237G>A, NR_033807.2:n.7171A>G, NR_033807.2:n.7171G>A, NR_033808.1:n.6891G>A, NR_033809.1:n.581237G>A, NR_033810.1:n.6891G>A, NR_033811.1:n.3211G>A, NR_033812.1:n.3211G>A, XM_005250169.1:c.189237G>A, XM_005250170.1:c.3571G>A, XM_005250171.1:c.2531G>A, XM_005250172.1:c.254G>A, XM_005250173.1:c.331237G>A, XM_005250198.1:c.8064288C>T, XM_006715859.2:c.219237A>G, XM_011515843.1:c.254A>G, XM_011515844.1:c.229237A>G, XM_011515845.1:c.4631A>G, XM_011515846.1:c.331237A>G, XM_011515847.1:c.5711A>G, XR_927383.1:n.344237A>G, XR_927402.1:n.1466+48736T>C, rs10361242, rs11266830, rs386613022, rs58244770 
C > T

SNP  
rs8192715  NC_000019.10:g.40941190G>A, NC_000019.9:g.41447095G>A, NR_001278.1:n.654106G>A, rs35989395 
G > A

SNP  
rs9461684  NC_000006.11:g.31253444C>T, NC_000006.12:g.31285667C>T, NT_113891.2:g.2766684C>T, NT_113891.3:g.2766578C>T, NT_167245.1:g.2548992C>T, NT_167245.2:g.2543407C>T, NT_167246.1:g.2600285C>T, NT_167246.2:g.2594665C>T, NT_167247.1:g.2633936C>T, NT_167247.2:g.2628351C>T, NT_167248.1:g.2546933C>T, NT_167248.2:g.2541337C>T, NT_167249.1:g.2587161C>T, NT_167249.2:g.2587863C>T, rs114017423, rs117266124, rs60686741 
C > T

SNP 
Overview
 NEV
 NVP
 Viramune
PharmGKB Accession Id
PA450616
Type(s):
Drug
Description
Source: Drug Bank
Indication
For use in combination with other antiretroviral drugs in the ongoing treatment of HIV1 infection.
Source: Drug Bank
Other Vocabularies
 ATC: Nonnucleoside reverse transcriptase inhibitors (J05AG)
 UMLS: Nevirapine (C0132326)
 RxNorm: Nevirapine (53654)
 NDFRT: NEVIRAPINE (N0000148461)
Information pulled from DrugBank has not been reviewed by PharmGKB.
Pharmacology, Interactions, and Contraindications
Mechanism of Action
Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNAdependent and DNAdependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
Source: Drug Bank
Pharmacology
Nevirapine is a nonnucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV1). HIV2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
Source: Drug Bank
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.
Source: Drug Bank
Toxicity
Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease.
Source: Drug Bank
Route of Elimination
Thus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.
Source: Drug Bank
Chemical Properties
SMILES
CC1=C2NC(=O)C3=C(N=CC=C3)N(C3CC3)C2=NC=C1
Source: Drug Bank
InChI String
InChI=1S/C15H14N4O/c1968171412(9)1815(20)113271613(11)19(14)104510/h23,68,10H,45H2,1H3,(H,18,20)
Source: Drug Bank
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.

Nevirapine Pathway, Pharmacokinetics
Representation of candidate genes involved in biotransformation of nevirapine and its mechanism of action in an infected liver cell.
Publications related to nevirapine: 71
LinkOuts
 Web Resource:
 Wikipedia
 National Drug Code Directory:
 0597004660
 DrugBank:
 DB00238
 PDB:
 NVP
 KEGG Compound:
 C07263
 ChemSpider:
 4308
 HET:
 NVP
 Therapeutic Targets Database:
 DAP000184
 FDA Drug Label at DailyMed:
 5ec0550063334bd0ac83464fad0d5162
Clinical Trials
These are trials that mention nevirapine and are related to either pharmacogenetics or pharmacogenomics.
NURSA Datasets
No NURSA datasets available.