Chemical: Drug
methotrexate

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB annotates drug labels containing pharmacogenetic information approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the PGx in the label, an excerpt from the label and a downloadable highlighted label PDF file. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the "PGx Level" tag.

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1. FDA Label for methotrexate

Full label available at DailyMed

Genes and/or phenotypes found in this label


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Clinical Annotation for rs1801133 (MTHFR), methotrexate, Arthritis, Juvenile Rheumatoid, Arthritis, Psoriatic, Arthritis, Rheumatoid and Drug Toxicity (level 3 Toxicity/ADR)

Level of Evidence
Level 3
Type
Toxicity/ADR
Genes
MTHFR
Phenotypes
Arthritis, Juvenile Rheumatoid, Arthritis, Psoriatic, Arthritis, Rheumatoid, Drug Toxicity
OMB Race
Mixed Population
Race Notes
White pediatric group, Asian group, and an unknown group, several mixed populations, Black or African American, White.

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Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for methotrexate

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA SLCO1B1 *1A N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *1B N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *5 N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *14 N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *15 N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *23 N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *31 N/A N/A N/A
No VIP available No VIP available VA SLCO1B1 *35 N/A N/A N/A
No VIP available No VIP available VA TPMT *1 N/A N/A N/A
No VIP available No VIP available VA TPMT *2 N/A N/A N/A
No VIP available No VIP available VA TPMT *3A N/A N/A N/A
No VIP available No VIP available VA TPMT *3B N/A N/A N/A
No VIP available No VIP available VA TPMT *3C N/A N/A N/A
No VIP available No VIP available VA TPMT *12 N/A N/A N/A
No VIP available No Clinical Annotations available TPMT intermediate metabolizer phenotype
TPMT intermediate metabolizer phenotype N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs10035440 31529463T>C, 31539463T>C, 807+667T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs10061133 -94T>C, 126+1872T>C, 27T>C, 5060903A>G, 54466544A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs10072026 10661A>G, 242+68A>G, 30539499T>C, 79945140T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs10106 *192T>C, 130576075T>C, 15922T>C, 45973A>G, 59740607T>C
T > C
3' UTR
No VIP available No Clinical Annotations available VA
rs1017860 -191+15855T>C, 1187+705T>C, 1226+705T>C, 21435T>C, 24963070T>C, 77172206T>C
T > C
Intronic
No VIP available CA VA
rs10197559 14147C>T, 216185825C>T, 290+1371C>T, 66395243C>T
C > T
Intronic
No VIP available CA VA
rs10276036 1000-44G>A, 167367G>A, 25213041C>T, 87180198C>T, ABCB1: IVS9 ¿44a>G
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs10280623 145021A>G, 25235387T>C, 287-3005A>G, 87202544T>C
T > C
Intronic
rs1045642 208920T>A, 208920T>C, 25171488A>G, 25171488A>T, 3435T>A, 3435T>C, 87138645A>G, 87138645A>T, ABCB1*6, ABCB1: 3435C>T, ABCB1: C3435T, ABCB1: c.3435C>T, ABCB1:3435C>T, Ile1145=, Ile1145Ile, MDR1 3435C>T, MDR1 C3435T, PGP C3435T, c.3435C>T, mRNA 3853C>T
A > T
A > G
Synonymous
Ile1145Ile
No VIP available No Clinical Annotations available VA
rs10505168 113655752T>C, 26929301T>C, 2998+1586A>G, 3190+1586A>G, 31T>C, 3310+1586A>G
T > C
Intronic
rs1051266 3952235T>C, 46957794T>C, 80A>G, 9592A>G, : 80A>G, His27Arg, RFC-1, SCL19A1:80G>A, SLC19A1:Arg27His, SLC19A1:G80A, mRNA 199A>G
T > C
Missense
His27Arg
No VIP available CA VA
rs1053129 *2186G>T, *2244G>T, 3065G>T, 33081G>T, 79922720C>A, 80626901C>A
C > -
C > A
3' UTR
No VIP available No Clinical Annotations available VA
rs1054774 130554998T>A, 59719530T>A
T > A
Not Available
No VIP available No Clinical Annotations available VA
rs1059150 27801531T>G, 523A>C, 57605439T>G, 6984A>C, 782A>C, 78A>C, Ala26=
A > T
A > G
Synonymous
Ala26Ala
No VIP available No Clinical Annotations available VA
rs10760502 -429A>G, 130565267A>G, 5114A>G, 59729799A>G, 64A>G, Ile22Val
A > G
5' Flanking
Ile22Val
No VIP available CA VA
rs10821936 14528041C>T, 502+23410C>T, 63723577C>T, 67565C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs10868138 16081833T>C, 338A>G, 660A>G, 86917301T>C, Tyr113Cys
T > C
Not Available
Tyr113Cys
No VIP available No Clinical Annotations available VA
rs10994982 14514568A>G, 502+9937A>G, 54092A>G, 63710104A>G
A > G
Intronic
No VIP available CA VA
rs11045821 14092547G>A, 21332423G>A, 53296G>A, 727+469G>A
G > A
Intronic
No VIP available CA VA
rs11045872 14132468A>G, 1682+2107A>G, 21372344A>G, 93217A>G
A > G
Intronic
No VIP available CA VA
rs11045879 103492T>C, 14142743T>C, 1865+4846T>C, 21382619T>C, OATP1B1: intronic C/T
T > C
Intronic
No VIP available CA VA
rs1105525 -200G>A, -39C>T, 30544867C>T, 5215C>T, 5293G>A, 79950508C>T
C > T
5' UTR
No VIP available CA VA
rs11231809 64302950T>A, 9608745T>A
T > A
Not Available
No VIP available CA VA
rs1127354 194C>A, 194C>G, 194C>T, 286C>A, 286C>G, 286C>T, 3133842C>A, 3133842C>G, 3133842C>T, 3193842C>A, 3193842C>G, 3193842C>T, 43C>A, 43C>G, 43C>T, 49-62C>A, 49-62C>G, 49-62C>T, 67-789C>A, 67-789C>G, 67-789C>T, 8787C>A, 8787C>G, 8787C>T, 94C>A, 94C>G, 94C>T, ITPA, ITPA: 94C>A, P32T, Pro15Ala, Pro15Ser, Pro15Thr, Pro32Ala, Pro32Ser, Pro32Thr
C > G
C > T
C > A
Not Available
Pro15Thr
No VIP available CA VA
rs1128503 1236T>C, 167964T>C, 87179601A>G, 87550285A>G, ABCB1 1236C>T, ABCB1*8, ABCB1: c.1236T>C, ABCB1:1236C>T, ABCB1:1236T>C, Gly412=, Gly412Gly, mRNA 1654T>C, p.Gly412Gly
A > G
Synonymous
Gly412Gly
No VIP available No Clinical Annotations available VA
rs1131596 -43C>A, -43C>G, -43C>T, 3952357G>A, 3952357G>C, 3952357G>T, 46957916G>A, 46957916G>C, 46957916G>T, 9470C>A, 9470C>G, 9470C>T
G > A
G > T
G > C
5' UTR
No VIP available No Clinical Annotations available VA
rs1142345 18070918T>C, 18130918T>C, 29457A>G, 719A>G, TPMT*3C, Tyr240Cys
T > C
Missense
Tyr240Cys
No VIP available CA VA
rs11545078 15803165G>A, 17847C>T, 452C>T, 63938764G>A, GGH: 452C>T, GGH: c.452C>T, Thr151Ile, p.Thr127Ile, p.Thr151Ile
G > A
Missense
Thr151Ile
No VIP available No Clinical Annotations available VA
rs11702425 1920T>C, 2460T>C, 3902796T>C, 46908355T>C, 88259T>C, Leu640=, Leu820=
T > C
Synonymous
Leu640Leu
No VIP available No Clinical Annotations available VA
rs117532069 23497160G>A, 53301068G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs11866002 12201936C>T, 2904G>A, 2919G>A, 3237G>A, 58587737C>T, Gln968=, Gln973=
G > T
G > C
Synonymous
Gln973Gln
No VIP available No Clinical Annotations available VA
rs1232027 30509379G>A, 79915020G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs12517451 30514432C>T, 35728G>A, 79920073C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs1264457 1750979A>A, 1751704A>A, 1790354A>A, 1806142G>A, 1839928G>A, 1970128A>A, 30398064G>A, 30458064G>A, 382G>A, Gly128Arg
G > A
Missense
Gly128Arg
No VIP available No Clinical Annotations available VA
rs12681874 14269G>A, 15806743C>T, 275+384G>A, 63942342C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs12894467 -1587C>T, 101507727C>T, 28C>T, 82507727C>T
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs12995526 216197971T>C, 26293T>C, 66407389T>C, 815-102T>C
T > C
Intronic
No VIP available CA VA
rs13120400 1194+928A>G, 13581248T>C, 51485A>G, 89033527T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs13181 *304T>G, 18123137T>G, 2251A>C, 23927A>C, 45854919T>G, ERCC2 Lys751Gln, ERCC2:2251A>C, ERCC2:Lys751Gln, Lys751Gln, rs13181:T>G
T > G
Missense
Lys751Gln
No VIP available No Clinical Annotations available VA
rs141059755 17972006A>C, 66107605A>C
A > C
A > G
Not Available
No VIP available CA VA
rs1476413 11852300C>T, 1632+35G>A, 18861G>A, 7857032C>T
C > T
Intronic
No VIP available CA VA
rs1544105 130562725C>T, 2572C>T, 59727257C>T
C > T
Not Available
No VIP available CA VA
rs1643650 15658A>G, 242+5065A>G, 30534502T>C, 79940143T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs1643657 19384A>G, 243-2589A>G, 30530776T>C, 79936417T>C
T > C
Intronic
No VIP available CA VA
rs1650723 *2876G>A, 30516389C>T, 33771G>A, 79922030C>T
C > T
3' Flanking
No VIP available CA VA
rs16853826 1227+1537G>A, 216205167G>A, 33489G>A, 66414585G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs16853834 1320+642C>T, 216210236C>T, 38558C>T, 66419654C>T
C > T
Intronic
No VIP available CA VA
rs1695 12658484A>G, 313A>G, 6624A>G, 67352689A>G, GSTP1*2, GSTP1*B, GSTP1: I105V, GSTP1:A313G, GSTP1:I105V, GSTP1:Ile105Val, Ile105Val, Part of haplotypes GSTP1*B and GSTP1*C, rs1695:A>G
A > G
Missense
Ile105Val
No VIP available No Clinical Annotations available VA
rs17021408 213943238T>C, 7461017T>C
T > C
Not Available
No VIP available CA VA
rs1703794 14578700T>C, 85897A>G, 99613173T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs17222723 101595996T>A, 2867T>A, 3284T>A, 3563T>A, 3752T>A, 3754T>A, 58534T>A, 99836239T>A, ABCC2 rs8187694, MRP2 Val1188Glu, Val1095Glu, Val1188Glu, Val956Glu
T > A
Not Available
Val956Glu
No VIP available No Clinical Annotations available VA
rs17264736 16056556G>T, 16116556G>T, 615+6078G>T, 78123G>T
G > T
Intronic
No VIP available CA VA
rs17421511 11857788G>A, 13373C>T, 587-1332C>T, 7862520G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs17514110 1227+1854C>T, 216205484C>T, 33806C>T, 66414902C>T
C > T
Intronic
No VIP available CA VA
rs17602729 115236057G>A, 121+2014C>T, 133C>T, 7120C>T, 85207975G>A, Gln45Ter
G > A
Stop Codon
Gln45null
No VIP available CA VA
rs17731538 13603100G>A, 204-1592C>T, 29633C>T, 89055379G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs1799793 11587G>A, 18135477C>T, 45867259C>T, 862G>A, 934G>A, Asp288Asn, Asp312Asn, XPD Asp312Asn, XPD:Asp312Asn
C > T
Missense
Asp288Asn
No VIP available CA VA
rs1799983 11291734T>G, 12965T>G, 150696111T>G, 894T>G, Asp298Glu, NOS3:894G>T
T > G
Missense
Asp298Glu
No VIP available No Clinical Annotations available VA
rs1800460 18079228C>T, 18139228C>T, 21147G>A, 460G>A, Ala154Thr, TPMT*3B
C > T
Missense
Ala154Thr
No VIP available No Clinical Annotations available VA
rs1800566 20389C>T, 23359344G>A, 445C>T, 457C>T, 559C>T, 69745145G>A, NQO1*2, NQO1:C609T, NQO1:P187S, NQO1:c.558C>T, Pro149Ser, Pro153Ser, Pro187Ser, rs1800566 C>T
G > A
Missense
Pro149Ser
No VIP available CA VA
rs1800909 15815713A>G, 16T>C, 5299T>C, 63951312A>G, Cys6Arg, GGH: 16T>C, GGH: c.16T>C, p.Cys6Arg
A > G
Missense
Cys6Arg
rs1801131 1040A>C, 11208431T>G, 11794419T>G, 1286A>C, 1409A>C, 16685A>C, A1298C, Glu347Ala, Glu429Ala, Glu470Ala, MTHFR:1298A>C
T > G
Not Available
Glu347Ala
rs1801133 11210333G>A, 11796321G>A, 14783C>T, 419C>T, 665C>T, 677C>T, 788C>T, A222V, Ala140Val, Ala222Val, Ala263Val, C677T, MTHFR: c.677C>T, MTHFR:667C>T, p.A222V
G > A
Not Available
Ala140Val
No VIP available CA VA
rs1801394 -172-1823T>C, 1-1823T>C, 147A>G, 66A>G, 6757A>G, 7860973A>G, 7870973A>G, Ile22Met, Ile49Met, MTRR 66A>G, MTRR:66A>G
A > G
Missense
Ile22Met
No VIP available CA VA
rs1805087 237048500A>G, 2756A>G, 30566279A>G, 94920A>G, Asp919Gly, MS 2756A>G, MS D919G, MTR:2756A>G, MTR:Asp919Gly
A > G
Missense
Asp919Gly
No VIP available No Clinical Annotations available VA
rs1891059 213946009G>A, 7463788G>A
G > A
Not Available
No VIP available CA VA
rs1901633 4750561A>G, 4810561A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs197388 -1065A>T, 112297482A>T, 12+841T>A, 82269400A>T
A > T
5' Flanking
No VIP available CA VA
rs1979277 1303C>T, 1420C>T, 17835470G>A, 18232096G>A, 39761C>T, Leu435Phe, Leu474Phe, SHMT1 L435F
G > A
Missense
Leu435Phe
No VIP available No Clinical Annotations available VA
rs2032582 186947T>A, 186947T>G, 2677A, 2677G, 2677T, 2677T>A, 2677T>G, 3095G>T/A, 87160618A>C, 87160618A>T, 87531302A>C, 87531302A>T, 893 Ala, 893 Ser, 893 Thr, ABCB1*7, ABCB1: 2677G>T/A, ABCB1: 2677T/A>G, ABCB1: A893S, ABCB1: G2677T/A, ABCB1: c.2677G>T/A, ABCB1:2677G>A/T, ABCB1:2677G>T/A, ABCB1:A893T, Ala893Ser/Thr, MDR1, MDR1 G2677T/A, Ser893Ala, Ser893Thr, mRNA 3095G>T/A, p.Ala893Ser/Thr
A > T
A > C
Missense
Ser893Ala
Ser893Thr
No VIP available CA No Variant Annotations available
rs2070744 -51-762C>T, -786, -813C>T, 11285702C>T, 150690079C>T, 6933C>T, NOS3 -786T>C, NOS3:, T>C, eNOS -786T>C
C > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs2114358 129021179G>A, 36G>A, 42294728G>A, 971+19642G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs2177735 1228-1627G>A, 216207875G>A, 36197G>A, 66417293G>A
G > A
Intronic
No VIP available CA VA
rs2229109 1199G>A, 1199G>T, 167756G>A, 167756G>T, 25212652C>A, 25212652C>T, 87179809C>A, 87179809C>T, ABCB1: c.1199G>A, Ser400Asn, Ser400Ile, mRNA 1617G>A, p.Ser400Asn
C > T
C > A
Missense
Ser400Ile
Ser400Asn
No VIP available CA VA
rs2231135 -19-18828T>C, -476T>C, 13627715A>G, 5018T>C, 89079994A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2231137 13608835C>T, 23898G>A, 34G>A, 89061114C>T, ABCG2:V12M, Val12Met
C > T
Missense
Val12Met
No VIP available No Clinical Annotations available VA
rs2231142 13600044G>T, 32689C>A, 421C>A, 89052323G>T, ABCG2: Q141K, ABCG2:421C>A, ABCG2:Q141K, ABCG2:c.421C>A, Gln141Lys, rs2231142
G > T
Missense
Gln141Lys
No VIP available CA VA
rs2236225 1958G>A, 45908845G>A, 59087G>A, 64908845G>A, Arg653Gln, MTHFD1:1958G>A, MTHFD1:Arg653Gln, R653Q
G > A
Missense
Arg653Gln
No VIP available CA VA
rs2236624 1012-489A>G, 24836024T>C, 333-527T>C, 4226593T>C, 574+1936A>G, ADORA2A: g.4226593T>C
T > C
Intronic
No VIP available CA VA
rs2238476 16153872G>A, 16213872G>A, 175439G>A, 3391-1960G>A
G > A
Intronic
No VIP available CA VA
rs2267076 24830595T>C, 332+891T>C, 4221164T>C, 575-2193A>G, ADORA2A: g.4221164T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs2273697 101563815G>A, 1249G>A, 1438G>A, 1440G>A, 26353G>A, 553G>A, 99804058G>A, ABCC2: c.1249G>A, ABCC2:1249G>A, ABCC2:V417I, ABCC2:c.1249G>A, Val185Ile, Val417Ile, p.V417I
G > A
Not Available
Val417Ile
No VIP available No Clinical Annotations available VA
rs2274407 8948711C>A, 8948711C>G, 8948711C>T, 912G>A, 912G>C, 912G>T, 95859035C>A, 95859035C>G, 95859035C>T, Lys304=, Lys304Asn
C > G
C > T
C > A
Missense
Lys304Asn
Lys304Lys
No VIP available No Clinical Annotations available VA
rs2274808 1702-148C>T, 2242-148C>T, 3901068C>T, 46906627C>T, 86531C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs2274976 11850927C>T, 1781G>A, 20234G>A, 7855659C>T, Arg594Gln, G1793A, MTHFR:1793G>A, MTHFR:Arg594Gln
C > T
Missense
Arg594Gln
No VIP available No Clinical Annotations available VA
rs2278293 128040752C>T, 14285G>A, 250-159G>A, 309+134G>A, 324+119G>A, 471+119G>A, 480+119G>A, 549+119G>A, 579+119G>A, 66073595C>T, IMPDH1:IVS7+125G4A
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs2287584 31413007T>C, 31423007T>C, 3195A>G, 3306A>G, Pro1065=, Pro1102=
T > C
Synonymous
Pro1065Pro
No VIP available No Clinical Annotations available VA
rs2289030 113G>C, 57371592G>C, 57G>C, 95228286G>C
G > C
Not Available
No VIP available CA VA
rs2298383 -275+1797C>T, 2235A>A, 24825511C>T, 4216080C>T, ADORA2A: g.4216080C>T
C > T
Intronic
rs2306283 14089862A>G, 21329738A>G, 388A>G, 50611A>G, Asn130Asp, SLCO1B1*1B
A > G
Missense
Asn130Asp
No VIP available No Clinical Annotations available VA
rs2368393 29773998A>G, 29833998A>G, 29T>C, 827+5528T>C
A > G
Intronic
No VIP available CA VA
rs2372536 18342C>G, 216190020C>G, 347C>G, 66399438C>G, ATIC: 347C>G, ATIC:347C>G, Thr116Ser, mRNA 521C>G
C > G
Missense
Thr116Ser
No VIP available No Clinical Annotations available VA
rs2413739 -78+13991G>A, 22787605C>T, 43397036C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs2413775 -205T>A, 16334845T>A, 45544288T>A, SLC28A2: ¿146T>a
T > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs244076 13449007T>C, 32462A>G, 43252915T>C, 534A>G, Val178=
T > C
Synonymous
Val178Val
No VIP available CA VA
rs246240 16059024A>G, 16119024A>G, 616-7942A>G, 80591A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2476601 114377568A>A, 114377568A>G, 1693C>C, 1693C>T, 1858C>C, 1858C>T, 41808C>C, 41808C>T, 84349486A>A, 84349486A>G, Arg565=, Arg620=
A > G
Missense
Arg620Trp
No VIP available CA VA
rs2650972 6723274T>C, 6783274T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs2682818 43472842A>C, 77T>G, 81329536A>C, 82+1884T>G
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs2740574 -392G>A, 4713G>A, 5'-flanking region -392A>G, 99382096C>T, 99784473C>T, CYP3A4*1B, CYP3A4-V, CYP3A4:-392A>G
C > T
5' Flanking
No VIP available CA VA
rs28364006 16168249A>G, 16228249A>G, 189816A>G, 4009A>G, Thr1337Ala
A > G
Missense
Thr1337Ala
No VIP available No Clinical Annotations available VA
rs2838956 1173+707T>C, 1293+707T>C, 22362T>C, 3939465A>G, 46945024A>G
A > G
Intronic
No VIP available CA VA
rs2853539 -1582T>C, 279+115A>G, 649829A>G, 659829A>G, 7226A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs2910164 159912418C>G, 4723691C>G, 60C>G
C > G
Not Available
No VIP available No Clinical Annotations available VA
rs34115976 115577997C>G, 40125718C>G, 823-7154C>G, 83C>G
C > G
Intronic
No VIP available No Clinical Annotations available VA
rs34324334 43475018C>T, 43535018C>T, 722G>A, Ser241Asn
C > T
Missense
Ser241Asn
rs34489327 *145-370delT, *145-370delTinsCTTTAA, *449delA, *449delAinsTTAAAG, *859delT, *859delTinsCTTTAA, 20843delA, 20843delAinsTTAAAG, 6-basepair 3'UTR repeat, 663446delA, 663446delAinsTTAAAG, 673446delA, 673446delAinsTTAAAG, TYMS:-TTAAAG, TYMS:1494del, TYMS:1494del TTAAAG, ttaaag
T > -
T > TTAAAG
3' UTR
rs34743033 28-bp tandem repeats, CCGCGCCACTTGGCCTGCCTCCGTCCCG, TSER*2, TSER*3, TYMS: 28 bp tandem repeat, TYMS: 2R, TYMS: TSER *2/*3, TYMS:TSER 28-basepair 5'UTR enhancer region repeat
CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC > CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC
CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC > CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC
CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC > CCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCC
Not Available
No VIP available No Clinical Annotations available VA
rs34965641 13425C>T, 242+2832C>T, 30536735G>A, 79942376G>A
G > A
Intronic
No VIP available CA VA
rs351855 1058-90G>A, 11323G>A, 1162G>A, 176520243G>A, 21331516G>A, FGFR4:Arg388, FGFR4:GLY388ARG, Gly388Arg
G > A
Intronic
Gly388Arg
No VIP available CA VA
rs35592 103390T>C, 1219-176T>C, 16081823T>C, 16141823T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs3737967 *3288C>T, 11847449G>A, 1475G>A, 23712C>T, 7852181G>A, Arg492His
G > A
Missense
Arg492His
No VIP available CA VA
rs3740065 101605693A>G, 4146+154A>G, 52410157A>G, 68231A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs3740066 101604207C>T, 3972C>T, 52408671C>T, 66745C>T, ABCC2:3972C>T, I1324I, Ile1324=
C > T
Synonymous
Ile1324Ile
No VIP available No Clinical Annotations available VA
rs3744741 2051G>A, 252606C>T, 649232C>T, Arg684Gln
G > T
G > C
Missense
Arg684Gln
No VIP available CA VA
rs3758149 -401C>T, 15816129G>A, 4883C>T, 63951728G>A, GGH: promoter -401C>T
G > A
5' Flanking
No VIP available CA VA
rs3761422 -274-2427T>C, 1398+208A>G, 24826672T>C, 4217241T>C, ADORA2A: g.4217241T>C
T > C
Intronic
No VIP available CA VA
rs3763980 1333A>T, 1634A>T, 1773A>T, 22316662A>T, 60173356A>T, Thr445Ser
A > T
Missense
Thr445Ser
No VIP available CA VA
rs3768142 237028564G>T, 2405+1710G>T, 30546343G>T, 74984G>T
G > T
Intronic
No VIP available No Clinical Annotations available VA
rs3784862 16050891G>A, 16110891G>A, 615+413G>A, 72458G>A
G > A
Intronic
No VIP available CA VA
rs3784864 16065325G>A, 16125325G>A, 616-1641G>A, 86892G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs3787186 -13-13209A>G, -14+5565A>G, 130+5565A>G, 20349436T>C, 50153344T>C, 71-12695A>G
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs3805500 2463+1366C>T, 2574+1366C>T, 31452977G>A, 31462977G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs3821353 216197779G>T, 26101G>T, 66407197G>T, 815-294G>T
G > T
Intronic
No VIP available CA VA
rs3824662 12542C>A, 779-1748C>A, 779-1751C>A, 8044208C>A, 8104208C>A
C > A
Intronic
No VIP available CA VA
rs408626 -825A>G, 237+350T>C, 30545492T>C, 4668A>G, 5840T>C, 79951133T>C
T > C
5' Flanking
No VIP available No Clinical Annotations available VA
rs4148396 101591944T>C, 3258+56T>C, 52396408T>C, 54482T>C
T > C
Intronic
No VIP available CA VA
rs4148416 14027575C>T, 3039C>T, 48753423C>T, Gly1013=
C > T
Synonymous
Gly1013Gly
No VIP available CA VA
rs4148737 176413A>G, 2212-372A>G, 25203995T>C, 87171152T>C
T > C
Intronic
VIP No Clinical Annotations available No Variant Annotations available
rs4149015 -910G>A, 14043446G>A, 21283322G>A, 4195G>A, SLCO1B1:11187G>A, SLCO1B1:G-11187A
G > A
5' Flanking
rs4149056 14091673T>C, 21331549T>C, 521T>C, 52422T>C, SLCO1B1*5, Val174Ala
T > C
Missense
Val174Ala
No VIP available CA VA
rs4149081 14138145G>A, 1865+248G>A, 21378021G>A, 98894G>A, OATP1B1: intronic A/G
G > A
Intronic
No VIP available CA VA
rs442767 -1188C>A, 237+713G>T, 30545855G>T, 4305C>A, 6203G>T, 79951496G>T
G > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs4451422 *714A>C, 130576597A>C, 16444A>C, 45451T>G, 59741129A>C
A > C
3' Flanking
No VIP available CA VA
rs45445694 *34+169_*34+196CGGGACGGAGGCAGGCCAAGTGGCGCGG[2][3][4][7][8][9], -97_-70CCGCGCCACTTGGCCTGCCTCCGTCCCG[2][3][4][7][8][9], 2, 28-bp tandem repeats located in the TS enhancer region of 5'UTR, 5043_5070CCGCGCCACTTGGCCTGCCTCCGTCCCG[2][3][4][7][8][9], 657646_657673CCGCGCCACTTGGCCTGCCTCCGTCCCG[2][3][4][7][8][9], TYMS:*2
CCGCGCCACTTGGCCTGCCTCCGTCCCG > (CCGCGCCACTTGGCCTGCCTCCGTCCCG)2
CCGCGCCACTTGGCCTGCCTCCGTCCCG > 4
CCGCGCCACTTGGCCTGCCTCCGTCCCG > 3
CCGCGCCACTTGGCCTGCCTCCGTCCCG > 8
CCGCGCCACTTGGCCTGCCTCCGTCCCG > 7
CCGCGCCACTTGGCCTGCCTCCGTCCCG > 9
5' UTR
No VIP available No Clinical Annotations available VA
rs45589337 246890A>G, 68116644T>C, 775A>G, 98144726T>C, Lys259Glu
T > C
Missense
Lys259Glu
No VIP available CA VA
rs4673993 1503+675T>C, 216212339T>C, 40661T>C, 66421757T>C
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs4781712 16043232A>G, 16103232A>G, 226-401A>G, 64799A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs4818789 1031+1857C>A, 1151+1857C>A, 18559C>A, 3943268G>T, 46948827G>T
G > T
Intronic
No VIP available No Clinical Annotations available VA
rs4819128 1031+1035G>A, 1151+1035G>A, 17737G>A, 3944090C>T, 46949649C>T
C > T
Intronic
No VIP available CA VA
rs4846051 11854457G>A, 1305C>T, 16704C>T, 7859189G>A, MTHFR:1317T>C, MTHFR:Phe435PHE, Phe435=
G > A
Synonymous
Phe435Phe
No VIP available No Clinical Annotations available VA
rs4867329 2931+245T>G, 3042+245T>G, 31425627A>C, 31435627A>C
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs4880 160113872A>G, 47C-T, 47T>C, 5482T>C, 64283329A>G, Ala16Val, SOD1:Val16Ala, SOD2: Val16Ala, T47C, V16A
A > G
Missense
Val16Ala
No VIP available CA VA
rs4888024 33053573A>G, 79439374A>G
A > G
Not Available
No VIP available CA VA
rs4948496 14610081T>C, 149605T>C, 63805617T>C, 734-5030T>C
T > C
Intronic
No VIP available CA VA
rs4982133 15526819A>C, 34526819A>C
A > C
Not Available
No VIP available CA VA
rs4986790 1020A>G, 120475302A>G, 1307A>G, 13843A>G, 296A>G, 49639834A>G, 776A>G, 896A>G, Asp259Gly, Asp299Gly, Asp99Gly, TLR4: D299G
A > G
Missense
Asp99Gly
No VIP available No Clinical Annotations available VA
rs56103835 101522556T>C, 1T>C, 82522556T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs5751876 1011+659A>G, 1083T>C, 24837301T>C, 4227870T>C, 574+659A>G, ADORA2A:1083T>C, ADORA2A:1976T>C, Tyr361=
T > C
Synonymous
Tyr361Tyr
No VIP available CA VA
rs5760410 153617G>A, 24815406G>A, 4205975G>A, ADORA2A: g.4205975G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs595961 1264-25A>G, 36367780A>G, 6339698A>G
A > G
Intronic
No VIP available CA VA
rs6064463 25676369T>C, 55480277T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs6123048 -13-7265T>C, 131-6751T>C, 20343492A>G, 50147400A>G, 71-6751T>C
A > G
Intronic
No VIP available CA VA
rs61886492 1378C>T, 1423C>T, 48949C>T, 49126274G>A, 49186274G>A, 499C>T, His167Tyr, His460Tyr, His475Tyr
G > A
Missense
His167Tyr
No VIP available CA VA
rs639174 2932-1862G>A, 3043-1862G>A, 31423647C>T, 31433647C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs6497759 1774G>A, 24741737G>A, 24801737G>A, Ala592Thr
G > A
Missense
Ala592Thr
No VIP available No Clinical Annotations available VA
rs6505162 -49+302A>C, -5T>G, 20+302A>C, 28444183A>C, 3181177A>C, 87A>C
A > C
5' Flanking
No VIP available CA VA
rs6506569 2716-20509T>C, 2755-20509T>C, 8265857T>C, 8275857T>C
T > C
Intronic
No VIP available CA VA
rs66554220
T > -
T > ATTTGTTCATGCCT
Not Available
No VIP available CA VA
rs6920220 138006504G>A, 42175961G>A
G > A
Not Available
No VIP available CA VA
rs70991108 -384_-383insTGGCGCGTCCCGCCCAGGT, 30544522_30544523insTGGCGCGTCCCGCCCAGGT, 4870_4871insTGGCGCGTCCCGCCCAGGT, 5637_5638insACCTGGGCGGGACGCGCCA, 79950163_79950164insTGGCGCGTCCCGCCCAGGT, 86+59_86+60insACCTGGGCGGGACGCGCCA, DHFR 19 bp deletion, DHFR 19-bp deletion, DHFR c.86 + 60_78, DHFR:19bp deletion, DHFR:19bp deletion in intron 1
- > TGGCGCGTCCCGCCCAGGT
Intronic
No VIP available CA VA
rs7142143 12718A>G, 244-1628A>G, 32403531T>C, 345+923A>G, 51403531T>C
T > C
Intronic
No VIP available CA VA
rs717620 -24C>T, 101542578C>T, 5116C>T, 52347042C>T, ABCC2: 5'UTR, ABCC2:(-24)C>T, mRNA 118C>T
C > T
5' UTR
No VIP available CA VA
rs719235 -354G>T, 15816082C>A, 4930G>T, 63951681C>A
C > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs7270101 124+21A>C, 224+21A>C, 3133893A>C, 316+21A>C, 3193893A>C, 49-11A>C, 67-738A>C, 73+21A>C, 8838A>C
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs7279445 2683+2343C>T, 3223+2343C>T, 3914359C>T, 46919918C>T, 99822C>T
C > T
Intronic
No VIP available CA VA
rs7317112 75-23516T>C, 9013199A>G, 95923523A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs7387 *115A>T, 30519150T>A, 31010A>T, 79924791T>A
T > A
3' UTR
No VIP available No Clinical Annotations available VA
rs747199 -51-655G>C, -52+441G>C, -54-652G>C, -55+441G>C, 44134345G>C, 44194345G>C
G > C
Intronic
No VIP available No Clinical Annotations available VA
rs7499 *16G>A, 112223G>A, 3926769G>A, 46932328G>A
G > A
3' UTR
No VIP available No Clinical Annotations available VA
rs7563206 18976C>T, 216190654C>T, 380-56C>T, 66400072C>T
C > T
Intronic
No VIP available CA VA
rs7624766 160429869A>G, 66925015A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs79085477 25897307C>T, 55701215C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs7911488 -10+1414T>C, -143T>C, -9-1866T>C, 105154089A>G, 55958553A>G, 70T>C
A > G
Intronic
No VIP available CA VA
rs7992226 101797840A>G, 14887516A>G, 1840-593T>C
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs80223967 213943679A>G, 7461458A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs8058040 16047712A>G, 16107712A>G, 352-636A>G, 69279A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs8090560 1864+1339G>A, 1903+1339G>A, 25004019G>A, 487+1339G>A, 62384G>A, 77213155G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs8187710 101611294G>A, 4544G>A, 52415758G>A, 73832G>A, ABCC2 rs8187710, Cys1515Tyr, MRP2 Cys1515Tyr
G > A
Missense
Cys1515Tyr
No VIP available No Clinical Annotations available VA
rs868755 157635A>C, 25222773T>G, 827+649A>C, 87189930T>G
T > G
Intronic
No VIP available No Clinical Annotations available VA
rs868853 -1508G>A, 9044752C>T, 95955076C>T
C > T
5' Flanking
No VIP available CA VA
rs9344 *1365+4648C>T, 12038G>A, 14768705G>A, 69462910G>A, 723G>A, CCND1 (A870G), CCND1:870G>A, Pro241=, rs603965
G > A
Intronic
Pro241Pro
No VIP available CA VA
rs9345389 1869-5735A>G, 32560438A>G, 94440604A>G
A > G
Intronic
No VIP available CA VA
rs9516519 *1372A>C, 8762133T>G, 95672457T>G
T > G
3' UTR
No VIP available No Clinical Annotations available VA
rs9611280 19942688G>A, 40552119G>A, 46G>A, Val16Met
G > A
Missense
Val16Met
No VIP available CA VA
rs9895420 -260T>A, 13986190T>A, 48712038T>A
T > A
5' Flanking
No VIP available CA VA
rs9977268 1834-74C>T, 2374-74C>T, 3901728C>T, 46907287C>T, 87191C>T
C > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • Amethopterin
  • Amethopterine
  • HDMTX
  • L-Amethopterin
  • MTX
  • Methopterin
  • Methotextrate
  • Methotrexat
  • Methotrexate Sodium
  • Methylaminopterin
  • Methylaminopterinum
  • N-Bismethylpteroylglutamic Acid
Trade Names
  • Abitrexate
  • Antifolan
  • Arbitrexate
  • Emtexate
  • Folex
  • Ledertrexate
  • Metatrexan
  • Methotrate
  • Mexate
  • Rheumatrex
  • Trexall
Brand Mixture Names

PharmGKB Accession Id

PA450428

Type(s):

Drug

Description

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Source: Drug Bank

Indication

For the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. Also for the treatment of severe psoriasis and severe, active, classical or definite rheumatoid arthritis.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Source: Drug Bank

Pharmacology

Methotrexate is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Methotrexate inhibits folic acid reductase which is responsible for the conversion of folic acid to tetrahydrofolic acid. At two stages in the biosynthesis of purines and at one stage in the synthesis of pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid. Tetrahydrofolic acid itself is synthesized in the cell from folic acid with the help of an enzyme, folic acid reductase. Methotrexate looks a lot like folic acid to the enzyme, so it binds to it quite strongly and inhibits the enzyme. Thus, DNA synthesis cannot proceed because the coenzymes needed for one-carbon transfer reactions are not produced from tetrahydrofolic acid because there is no tetrahydrofolic acid. Methotrexate selectively affects the most rapidly dividing cells (neoplastic and psoriatic cells). Methotrexate is also indicated in the management of severe, active, classical, or definite rheumatoid arthritis.

Source: Drug Bank

Food Interaction

Take without regard to meals. Limit caffeine intake.|Milk appears to reduce its absorption.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic.

Source: Drug Bank

Protein Binding

50%, primarily to albumin

Source: Drug Bank

Absorption

Generally well absorbed with a mean bioavailability of about 60%.

Source: Drug Bank

Half-Life

Low doses: 3 to 10 hours; High doses: 8 to 15 hours.

Source: Drug Bank

Toxicity

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD 50=43mg/kg(orally in rat).

Source: Drug Bank

Route of Elimination

With IV administration, 80% to 90% of the administered dose is excreted unchanged in the urine within 24 hours. There is limited biliary excretion amounting to 10% or less of the administered dose.

Source: Drug Bank

Volume of Distribution

  • 0.4 to 0.8 L/kg

Source: Drug Bank

Chemical Properties

Chemical Formula

C20H22N8O5

Source: Drug Bank

Isomeric SMILES

CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O

Source: OpenEye

Canonical SMILES

CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Source: Drug Bank

Average Molecular Weight

454.4393

Source: Drug Bank

Monoisotopic Molecular Weight

454.171315854

Source: Drug Bank

SMILES

CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Source: Drug Bank

InChI String

InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

Source: Drug Bank

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Model non-tissue specific cancer cell displaying candidate genes which may be involved in the pharmacodynamics of antimetabolite drugs acting on the folate cycle.
  1. Ibuprofen Pathway, Pharmacokinetics
    Stylized diagram of metabolism and transport of ibuprofen in the liver and kidney.
  1. Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Representation of transport and exchange of methotrexate in the brain.
  1. Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Methotrexate cellular disposition and effects.
  1. Methotrexate Pathway, Pharmacokinetics
    Diagramatic representation of uptake, transport and elimination of methotrexate.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this drug. To report a pathway, click here.

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
ABCB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ABCB11
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ABCC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ABCC11
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ABCC2
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ABCC3
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ABCC4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ABCC5
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ABCG2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ABL1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ABLIM1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ACE
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ACP1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ACP2
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ADA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADCY8
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADORA1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
ADORA2A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADORA2B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADORA3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADRA1D
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADRA2A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADRB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ADSL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AFF3
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
AGO1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AHCY
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ALDH1L1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ALPL
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
AMPD1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AMT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ANKRD12
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ANPEP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AOX1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AP1S2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AP2B1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
APEX1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
APOB
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
APOE
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
APP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ARF4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ARFGAP3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ARHGAP5
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
ARID5B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ARL4C
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ASNS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ATF1
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
ATIC
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ATM
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ATP5E
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ATRN
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
AZU1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
B2M
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BAX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BCL2L11
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BCR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BGLAP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BMI1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BMP1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
BMP7
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BRS3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BYSL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
C10orf11
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
C18orf56
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
C1orf167
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
C5orf22
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
C9orf47
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
C9orf72
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CA3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CAMP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CBR3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CBS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CCNA1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
CCND1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD14
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD1B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD226
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD33
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD52
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD97
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CDC20
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CDK1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CDK9
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CDKL1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CDKN1A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CEP72
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CGB
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CHST1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CKS2
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CLCN6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CLK1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CNOT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CNOT8
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CNTN5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CNTNAP2
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
COL18A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
COMT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CREB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CREBBP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CRHR1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CRYZ
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CSH2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CST7
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CTSG
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CTSL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CUL4B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CXCR1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CXCR2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CXCR4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP1A2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP1B1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2B6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2C19
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2C9
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2D6
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CYP3A4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP3A5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP3A7
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP4F2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DAPK1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DARS
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DDRGK1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DDX20
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DEFA3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DEFA4
No Dosing Guideline available No Drug Label available CA VA No VIP available PW
DHFR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DHPS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DNMT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DOK5
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DPYD
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DPYSL2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DRD4
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
DROSHA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DSG1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
E2F1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EFNB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EFR3A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EGFR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EIF4A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ELANE
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ENG
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
ENOSF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EPHA5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ERBB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ERCC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ERCC2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ERCC5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ETV5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ETV6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
EYA4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FAM168B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FAM175B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FAM3C
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
FASTKD3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FCGR2A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FCGR2B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FCGR3A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FCGR3B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FGD4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FGF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FGF9
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
FGFR4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FHOD3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FLNA
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
FOLH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
FOLR1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FOLR2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FOLR3
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
FPGS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FRK
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FTH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FZD2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FZD3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FZD6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
G6PD
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GALNT7
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
GART
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
GATA3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GBE1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GBF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GBP6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GCH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GCHFR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GDF10
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GDF11
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
GEMIN4
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
GGH
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GJA1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GMPS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GNG10
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GOLGA2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GPR137B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GRIA1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GSS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GSTM1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
GSTP1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GSTT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
GZMM
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
H3F3B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HAMP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HAS3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HAT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HDAC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HDAC4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HHEX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HIC2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HLA-A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HLA-B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HLA-C
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HLA-DQB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HLA-DRB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
HLA-E
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
HLA-G
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
HPRT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IAPP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ICAM3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IFNL3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IGFBP4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IKZF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL10
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL10RA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL10RB
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL15
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL17F
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL1B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL1R1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL1RL1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL1RN
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IL6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IMPA2
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
IMPDH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
IMPDH2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ITGAL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ITGAX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ITGB2
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
ITPA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
JRKL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
JUN
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KATNB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KDM5D
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KIAA1467
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KIF3A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KIR2DS4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KIT
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
KLC3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KMT2A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KRAS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
KRT83
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LCN2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LDLR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LEPR
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
LINC00251
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LRRC37A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LST1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
LTA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MAN2B2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MAP2K6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MAPT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MAX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MCCC2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MCPH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ME2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MGMT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MGST3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MICA
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR1206
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR1307
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR146A
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR2053
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR300
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR423
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR449B
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR492
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR577
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR604
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MIR618
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MOB3B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MPHOSPH9
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MPO
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MRPL33
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
MSH3
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
MTHFD1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MTHFD2
MTHFR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MTOR
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
MTR
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
MTRR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MUSK
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MYH15
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
MYLK
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NAIP
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
NALCN
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NAT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NAT2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NBPF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
NFATC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
NFATC2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NKG7
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NMT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NNMT
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
NOS3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NPFF
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
NQO1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NQO2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NR2F2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NR3C1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NRXN2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NT5E
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NTAN1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NUBPL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NUDT15
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NUP98
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
OLIG3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
OTC
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
PACSIN2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PAIP2B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PARG
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PCDH9
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PDE4B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PDGFA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PDZD2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PECAM1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PF4V1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PFDN6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PLS1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PMVK
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PNP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
POLE
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PON1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PPAT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PPP1CB
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRAM1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRDM2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRKCQ
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRKY
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PROC
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PTK7
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
PTPN22
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PTPRC
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PTPRG
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
PTPRM
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PTS
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
PYGL
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RAB31
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RAB5C
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RALBP1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RAPH1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RASSF4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RBBP8
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RBM19
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RBMX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RCC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RDX
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RFC1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RNASE6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RPL5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RRM1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RUNX1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
RUVBL2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
S100A12
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
S100A8
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
S100A9
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SACS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SAP18
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SEPT3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SERPINE1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
SHMT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC12A3
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
SLC16A7
SLC19A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC22A1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
SLC22A11
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC22A2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLC22A6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLC22A8
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLC22A9
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
SLC28A2
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
SLC28A3
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
SLC29A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC29A2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC39A6
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLC46A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC47A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC47A2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLC6A4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLCO1A2
SLCO1B1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
SLCO1B3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLCO1C1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLCO2B1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLCO3A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLCO4A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SLCO4C1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SMAD2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SMAD4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SMCHD1
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
SMCR8
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
SOD2
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
SPECC1L
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SPP1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SRGN
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SS18
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SSX1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ST18
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STK24
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STK38
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
SULT1A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TCEB3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TCN2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TCTN3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TEC
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TERF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TESK1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TGFB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TGIF1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
THOC5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TK1
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
TLR4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TM9SF2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TMEM45A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TNF
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
TNFAIP3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TNFRSF1A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TNFRSF1B
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
TNRC6A
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
TNRC6B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TOB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TOP2A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TP53
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
TPMT
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TRA
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TRB
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TUBA4A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TWIST2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TXK
TYMS
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
TYROBP
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
UCK2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
UGT1A1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
UGT2B15