Chemical: Drug
isoproterenol

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for isoproterenol

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
rs1042713 NC_000005.10:g.148826877G=, NC_000005.10:g.148826877G>A, NC_000005.9:g.148206440G=, NC_000005.9:g.148206440G>A, NG_016421.1:g.5285A=, NG_016421.1:g.5285A>G, NM_000024.5:c.46A=, NM_000024.5:c.46A>G, NP_000015.1:p.Arg16=, NP_000015.1:p.Arg16Gly, XM_005268382.1:c.46G=, XM_005268382.1:c.46G>A, XM_005268383.1:c.46G=, XM_005268383.1:c.46G>A, XP_005268439.1:p.Gly16=, XP_005268439.1:p.Gly16Arg, XP_005268440.1:p.Gly16=, XP_005268440.1:p.Gly16Arg, rs17287432, rs17334179, rs17334242, rs17721693, rs17839749, rs17846639, rs17859732, rs3182174, rs3729940, rs52812686, rs56964295
G > A
SNP
R16G
VIP No Clinical Annotations available No Variant Annotations available
rs1042714 NC_000005.10:g.148826910G=, NC_000005.10:g.148826910G>C, NC_000005.9:g.148206473G=, NC_000005.9:g.148206473G>C, NG_016421.1:g.5318C=, NG_016421.1:g.5318C>G, NM_000024.5:c.79C=, NM_000024.5:c.79C>G, NP_000015.1:p.Gln27=, NP_000015.1:p.Gln27Glu, XM_005268382.1:c.79G=, XM_005268382.1:c.79G>C, XM_005268383.1:c.79G=, XM_005268383.1:c.79G>C, XP_005268439.1:p.Glu27=, XP_005268439.1:p.Glu27Gln, XP_005268440.1:p.Glu27=, XP_005268440.1:p.Glu27Gln, rs17287411, rs17287474, rs17334200, rs17640526, rs17845338, rs17858183, rs17859733, rs3182175, rs3729941, rs52793394, rs60374884
G > C
G > T
SNP
Q27E
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • Epinephrine Isopropyl Homolog
  • IPA
  • Isoprenalin
  • Isoprenaline
  • Isopropydrin
  • Isopropyladrenaline
  • Isopropylarterenol
  • Isopropylnoradrenaline
  • Isopropylnorepinephrine
  • Isoproterenol Chloride
  • Isoproterenol HCl
  • L-Isopropylnoradrenaline
  • L-Isoproterenol
  • N-Isopropylnoradrenaline
  • N-Isopropylnorepinephrine
Trade Names
  • Aerolone
  • Aleudrin
  • Aleudrine
  • Aludrin
  • Aludrine
  • Asiprenol
  • Asmalar
  • Assiprenol
  • Bellasthman
  • Bronkephrine
  • Euspiran
  • Isadrine
  • Isonorene
  • Isonorin
  • Isorenin
  • Isuprel
  • Isuprel Mistometer
  • Isupren
  • Medihaler-Iso
  • Neo-Epinine
  • Neodrenal
  • Norisodrine
  • Norisodrine Aerotrol
  • Novodrin
  • Proternol
  • Respifral
  • Saventrine
  • Vapo-Iso
Brand Mixture Names

PharmGKB Accession Id

PA450121

Type(s):

Drug

Description

Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

Source: Drug Bank

Indication

For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Source: Drug Bank

Pharmacology

Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Route of Elimination

Excretion following inhalation administration is primarily renal and the major metabolite is the sulfate conjugate of isoproterenol.

Source: Drug Bank

Chemical Properties

Chemical Formula

C11H17NO3

Source: Drug Bank

Isomeric SMILES

CC(C)NCC(c1ccc(c(c1)O)O)O

Source: OpenEye

Canonical SMILES

CC(C)NCC(O)C1=CC(O)=C(O)C=C1

Source: Drug Bank

Average Molecular Weight

211.2576

Source: Drug Bank

Monoisotopic Molecular Weight

211.120843415

Source: Drug Bank

SMILES

CC(C)NCC(O)C1=CC(O)=C(O)C=C1

Source: Drug Bank

InChI String

InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3

Source: Drug Bank

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Sympathetic Nerve Pathway (Neuroeffector Junction)
    Simplified diagram of a sympathetic neuroeffector junction displaying genes which may be involved.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this drug. To report a pathway, click here.

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ADRB1 (source: Drug Bank)
ADRB2 (source: Drug Bank)
ADRB3 (source: Drug Bank)
MAPK1 (source: Drug Bank)
MAPK3 (source: Drug Bank)
PIK3R1 (source: Drug Bank)
PIK3R2 (source: Drug Bank)
PIK3R3 (source: Drug Bank)

Drug Interactions

Interaction Description
acebutolol - isoproterenol Antagonism (source: Drug Bank)
acebutolol - isoproterenol Antagonism (source: Drug Bank)
amitriptyline - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
amitriptyline - isoproterenol The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
amoxapine - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
amoxapine - isoproterenol The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
atenolol - isoproterenol Antagonism (source: Drug Bank)
atenolol - isoproterenol Antagonism (source: Drug Bank)
bisoprolol - isoproterenol Antagonism (source: Drug Bank)
bisoprolol - isoproterenol Antagonism (source: Drug Bank)
carvedilol - isoproterenol Antagonism (source: Drug Bank)
carvedilol - isoproterenol Antagonism (source: Drug Bank)
clomipramine - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
clomipramine - isoproterenol The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
desipramine - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
desipramine - isoproterenol The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
doxepin - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
doxepin - isoproterenol The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
entacapone - isoproterenol Entacapone increases the effect and toxicity of the sympathomimetic, isoproterenol. (source: Drug Bank)
esmolol - isoproterenol Antagonism (source: Drug Bank)
esmolol - isoproterenol Antagonism (source: Drug Bank)
imipramine - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
imipramine - isoproterenol The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
isocarboxazid - isoproterenol Increased arterial pressure (source: Drug Bank)
isocarboxazid - isoproterenol Increased arterial pressure (source: Drug Bank)
l-methyldopa - isoproterenol Increased arterial pressure (source: Drug Bank)
l-methyldopa - isoproterenol Increased arterial pressure (source: Drug Bank)
labetalol - isoproterenol Antagonism (source: Drug Bank)
linezolid - isoproterenol Possible increase of arterial pressure (source: Drug Bank)
linezolid - isoproterenol Possible increase of arterial pressure (source: Drug Bank)
metoprolol - isoproterenol Antagonism (source: Drug Bank)
metoprolol - isoproterenol Antagonism (source: Drug Bank)
midodrine - isoproterenol Increased arterial pressure (source: Drug Bank)
moclobemide - isoproterenol Moclobemide increases the sympathomimetic effect (source: Drug Bank)
moclobemide - isoproterenol Moclobemide increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
nadolol - isoproterenol Antagonism (source: Drug Bank)
nadolol - isoproterenol Antagonism (source: Drug Bank)
nortriptyline - isoproterenol The tricyclic increases the sympathomimetic effect (source: Drug Bank)
nortriptyline - isoproterenol The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of isoproterenol. (source: Drug Bank)
oxprenolol - isoproterenol Antagonism (source: Drug Bank)
oxprenolol - isoproterenol Antagonism (source: Drug Bank)
phenelzine - isoproterenol Increased arterial pressure (source: Drug Bank)
phenelzine - isoproterenol Increased arterial pressure (source: Drug Bank)
pindolol - isoproterenol Antagonism (source: Drug Bank)
pindolol - isoproterenol Antagonism (source: Drug Bank)
propranolol - isoproterenol Antagonism (source: Drug Bank)
propranolol - isoproterenol Antagonism (source: Drug Bank)
rasagiline - isoproterenol Increased arterial pressure (source: Drug Bank)
reserpine - isoproterenol Increased arterial pressure (source: Drug Bank)
reserpine - isoproterenol Increased arterial pressure (source: Drug Bank)
timolol - isoproterenol Antagonism (source: Drug Bank)
timolol - isoproterenol Antagonism (source: Drug Bank)

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Diagnoses
Contraindicated With

Publications related to isoproterenol: 16

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and genomics. 2008. Wang Wayne C H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction between beta2 adrenergic receptor polymorphisms determines the extent of isoproterenol-induced vasodilatation ex vivo. Pharmacogenetics and genomics. 2007. Khalaila Jawad M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics. 2004. Dishy Victor, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. The Journal of biological chemistry. 2004. Huang Jianyun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 2003. Small Kersten M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Beta(2)-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans. The Journal of physiology. 2003. Garovic Vesna D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (New York, N.Y.). 2002. Perry Stephen J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 2002. B├╝scher Rainer, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. The New England journal of medicine. 2001. Dishy V, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). European journal of pharmacology. 2001. Green S A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans. Hypertension. 2000. Cockcroft J R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. Journal of receptor and signal transduction research. 2000. Tepe N M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 1997. Daaka Y, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 1994. Green S A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. The Journal of biological chemistry. 1993. Green S A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. The Journal of biological chemistry. 1989. Hausdorff W P, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0089-0785-21
DrugBank:
DB01064
ChEBI:
6046
KEGG Compound:
C07056
PubChem Compound:
3779
PubChem Substance:
46507323
9268
IUPHAR Ligand:
536
Drugs Product Database (DPD):
897639
BindingDB:
25392
ChemSpider:
3647
Therapeutic Targets Database:
DNC000819
FDA Drug Label at DailyMed:
394d3238-f763-4f67-bb9d-08751ec6ed31

Clinical Trials

These are trials that mention isoproterenol and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

Common Searches

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Sources for PharmGKB drug information: DrugBank, PubChem.