Chemical: Drug

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Generic Names
Trade Names
  • AT-7
  • Acigena
  • Almederm
  • Bilevon
  • Bivelon
  • Compound G-11
  • Cotofilm
  • Dermadex
  • Dial
  • Distodin
  • E-Z Scrub
  • Eleven
  • Exofene
  • Fascol
  • Fesia-Sin
  • Fomac
  • Fostril
  • G-Eleven
  • G-II
  • Gamophen
  • Gamophene
  • Germa-Medica
  • HCP
  • Hexa-Germ
  • Hexabalm
  • Hexachlorofen
  • Hexachlorophane
  • Hexachlorophen
  • Hexachlorophene, Pharma
  • Hexafen
  • Hexascrub
  • Hexazinone
  • Hexide
  • Hexophene
  • Hexosan
  • Isobac
  • Isobac 20
  • Nabac
  • Nabac 25 Ec
  • Neosept V
  • Phiso-Scrub
  • Phisodan
  • Phisohex
  • Pre-Op
  • Rcra Waste Number U132
  • Ritosept
  • Scrubteam Surgical Spongebrush
  • Septi-Soft
  • Septisol
  • Septofen
  • Soy-Dome
  • Ster-Zac
  • Steral
  • Steraskin
  • Surgi-Cen
  • Surgi-Cin
  • Surofene
  • Tersaseptic
  • Trichlorophene
  • Turgex
Brand Mixture Names
  • Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
  • Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)

PharmGKB Accession Id





A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)

Source: Drug Bank


For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The primary mechanism of action of hexachlorophene, based on studies with _Bacillus megatherium_, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.

Source: Drug Bank


Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding


Source: Drug Bank


Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.

Source: Drug Bank


Oral, rat LD ~50~: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: Drug Bank


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank



Source: Drug Bank

InChI String


Source: Drug Bank


Web Resource:
National Drug Code Directory:
KEGG Compound:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Drugs Product Database (DPD):
Therapeutic Targets Database:
FDA Drug Label at DailyMed:

Clinical Trials

These are trials that mention hexachlorophene and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

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No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.