Chemical: Drug
galantamine

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.


Annotated Labels

  1. FDA Label for galantamine and CYP2D6
  2. HCSC Label for galantamine and CYP2D6



PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for galantamine

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA APOE E2 N/A N/A N/A
No VIP available No VIP available VA APOE E3 N/A N/A N/A
No VIP available No VIP available VA APOE E4 N/A N/A N/A
No VIP available CA VA CYP2D6 *1 N/A N/A N/A
No VIP available CA VA CYP2D6 *1xN N/A N/A N/A
No VIP available CA VA CYP2D6 *3 N/A N/A N/A
No VIP available CA VA CYP2D6 *4 N/A N/A N/A
No VIP available CA VA CYP2D6 *5 N/A N/A N/A
No VIP available CA VA CYP2D6 *6 N/A N/A N/A
No VIP available CA VA CYP2D6 *41 N/A N/A N/A
No VIP available No VIP available VA CYP3A5 *1A N/A N/A N/A
No VIP available No VIP available VA CYP3A5 *3A N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs1045642 NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664
A > G
SNP
I1145I
No VIP available No Clinical Annotations available VA
rs1057868 NC_000007.13:g.75615006C>T, NC_000007.14:g.75985688C>T, NG_008930.1:g.75587C>T, NM_000941.2:c.1508C>T, NP_000932.3:p.Ala503Val, NW_003871064.1:g.3514924C>T, XM_005250459.1:c.1508C>T, XM_005250460.1:c.1205C>T, XM_005250461.1:c.932C>T, XM_005277600.1:c.1508C>T, XM_005277601.1:c.1205C>T, XM_005277602.1:c.932C>T, XP_005250516.1:p.Ala503Val, XP_005250517.1:p.Ala402Val, XP_005250518.1:p.Ala311Val, XP_005277657.1:p.Ala503Val, XP_005277658.1:p.Ala402Val, XP_005277659.1:p.Ala311Val, rs17840495, rs17846082, rs17859083, rs3198400, rs57699079
C > T
SNP
A503V
No VIP available No Clinical Annotations available VA
rs10776586 NC_000010.10:g.50858346T>C, NC_000010.11:g.49650300T>C, NG_011797.1:g.46206T>C, NM_001142929.1:c.1157+664T>C, NM_001142933.1:c.1265+664T>C, NM_001142934.1:c.1157+664T>C, NM_020549.4:c.1511+664T>C, NM_020984.3:c.1157+664T>C, NM_020985.3:c.1157+664T>C, NM_020986.3:c.1157+664T>C, rs17775728, rs56990565
T > C
SNP
No VIP available No Clinical Annotations available VA
rs11101187 NC_000010.10:g.50837033C>T, NC_000010.11:g.49628987C>T, NG_011797.1:g.24893C>T, NM_001142929.1:c.757+1202C>T, NM_001142933.1:c.865+1202C>T, NM_001142934.1:c.757+1202C>T, NM_020549.4:c.1111+1202C>T, NM_020984.3:c.757+1202C>T, NM_020985.3:c.757+1202C>T, NM_020986.3:c.757+1202C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs11101192 NC_000010.10:g.50854767G>A, NC_000010.11:g.49646721G>A, NG_011797.1:g.42627G>A, NM_001142929.1:c.927+47G>A, NM_001142933.1:c.1035+47G>A, NM_001142934.1:c.927+47G>A, NM_020549.4:c.1281+47G>A, NM_020984.3:c.927+47G>A, NM_020985.3:c.927+47G>A, NM_020986.3:c.927+47G>A, rs57573103
G > A
SNP
No VIP available No Clinical Annotations available VA
rs11101193 NC_000010.10:g.50856138G>T, NC_000010.11:g.49648092G>T, NG_011797.1:g.43998G>T, NM_001142929.1:c.928-415G>T, NM_001142933.1:c.1036-415G>T, NM_001142934.1:c.928-415G>T, NM_020549.4:c.1282-415G>T, NM_020984.3:c.928-415G>T, NM_020985.3:c.928-415G>T, NM_020986.3:c.928-415G>T, rs58391990
G > T
SNP
No VIP available No Clinical Annotations available VA
rs11685873 NC_000002.11:g.108611519G>A, NC_000002.12:g.107995063G>A, NG_042267.1:g.13550G>A, NM_001305005.2:c.448+1936G>A, NM_001305006.2:c.133+1936G>A, NM_001305007.2:c.-257+1936G>A, NM_021815.4:c.448+1936G>A, XM_005264008.1:c.448+1936G>A, XM_005264009.1:c.133+1936G>A, XM_011511579.1:c.334+1936G>A, XM_011511580.1:c.196+1936G>A, XM_011511581.1:c.133+1936G>A, rs61375312
G > A
SNP
No VIP available No Clinical Annotations available VA
rs12246528 NC_000010.10:g.50835264G>A, NC_000010.11:g.49627218G>A, NG_011797.1:g.23124G>A, NM_001142929.1:c.580-390G>A, NM_001142933.1:c.688-390G>A, NM_001142934.1:c.580-390G>A, NM_020549.4:c.934-390G>A, NM_020984.3:c.580-390G>A, NM_020985.3:c.580-390G>A, NM_020986.3:c.580-390G>A, rs61498554
G > A
SNP
No VIP available No Clinical Annotations available VA
rs12264845 NC_000010.10:g.50863083A>C, NC_000010.11:g.49655037A>C, NG_011797.1:g.50943A>C, NM_001142929.1:c.1281-58A>C, NM_001142933.1:c.1389-58A>C, NM_001142934.1:c.1281-58A>C, NM_020549.4:c.1635-58A>C, NM_020984.3:c.1281-58A>C, NM_020985.3:c.1281-58A>C, NM_020986.3:c.1281-58A>C
A > C
SNP
No VIP available No Clinical Annotations available VA
rs12266458 NC_000010.10:g.50847997C>T, NC_000010.11:g.49639951C>T, NG_011797.1:g.35857C>T, NM_001142929.1:c.758-6554C>T, NM_001142933.1:c.866-6554C>T, NM_001142934.1:c.758-6554C>T, NM_020549.4:c.1112-6554C>T, NM_020984.3:c.758-6554C>T, NM_020985.3:c.758-6554C>T, NM_020986.3:c.758-6554C>T, rs57653614
C > T
SNP
No VIP available No Clinical Annotations available VA
rs17798800 NC_000013.10:g.34950527C>T, NC_000013.11:g.34376390C>T, XR_941846.1:n.182+28266C>T, XR_941847.1:n.182+28266C>T, XR_941848.1:n.180+28266C>T, rs57038156
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1917818 NC_000010.10:g.50849342T>G, NC_000010.11:g.49641296T>G, NG_011797.1:g.37202T>G, NM_001142929.1:c.758-5209T>G, NM_001142933.1:c.866-5209T>G, NM_001142934.1:c.758-5209T>G, NM_020549.4:c.1112-5209T>G, NM_020984.3:c.758-5209T>G, NM_020985.3:c.758-5209T>G, NM_020986.3:c.758-5209T>G, rs52822860, rs59761396
T > G
SNP
No VIP available No Clinical Annotations available VA
rs2032582 NC_000007.13:g.87160618A>C, NC_000007.13:g.87160618A>T, NC_000007.14:g.87531302A>C, NC_000007.14:g.87531302A>T, NG_011513.1:g.186947T>A, NG_011513.1:g.186947T>G, NM_000927.4:c.2677T>A, NM_000927.4:c.2677T>G, NP_000918.2:p.Ser893Ala, NP_000918.2:p.Ser893Thr, rs10228331, rs2229106, rs386553610, rs57135550, rs9641018
A > C
SNP
S893A
No VIP available CA VA
rs2177370 NC_000010.10:g.50838874A>G, NC_000010.11:g.49630828A>G, NG_011797.1:g.26734A>G, NM_001142929.1:c.757+3043A>G, NM_001142933.1:c.865+3043A>G, NM_001142934.1:c.757+3043A>G, NM_020549.4:c.1111+3043A>G, NM_020984.3:c.757+3043A>G, NM_020985.3:c.757+3043A>G, NM_020986.3:c.757+3043A>G, rs57851564
A > G
SNP
No VIP available No Clinical Annotations available VA
rs35599367 NC_000007.13:g.99366316G>A, NC_000007.14:g.99768693G>A, NG_008421.1:g.20493C>T, NM_001202855.2:c.522-191C>T, NM_017460.5:c.522-191C>T, XM_011515841.1:c.522-191C>T, XM_011515842.1:c.522-191C>T, rs45581939, rs62471940
G > A
SNP
No VIP available CA VA
rs3793790 NC_000010.10:g.50840736G>A, NC_000010.11:g.49632690G>A, NG_011797.1:g.28596G>A, NM_001142929.1:c.757+4905G>A, NM_001142933.1:c.865+4905G>A, NM_001142934.1:c.757+4905G>A, NM_020549.4:c.1111+4905G>A, NM_020984.3:c.757+4905G>A, NM_020985.3:c.757+4905G>A, NM_020986.3:c.757+4905G>A, rs59782324
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3793791 NC_000010.10:g.50841704C>T, NC_000010.11:g.49633658C>T, NG_011797.1:g.29564C>T, NM_001142929.1:c.757+5873C>T, NM_001142933.1:c.865+5873C>T, NM_001142934.1:c.757+5873C>T, NM_020549.4:c.1111+5873C>T, NM_020984.3:c.757+5873C>T, NM_020985.3:c.757+5873C>T, NM_020986.3:c.757+5873C>T, rs56496455, rs56687561
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3793797 NC_000010.10:g.50857849C>T, NC_000010.11:g.49649803C>T, NG_011797.1:g.45709C>T, NM_001142929.1:c.1157+167C>T, NM_001142933.1:c.1265+167C>T, NM_001142934.1:c.1157+167C>T, NM_020549.4:c.1511+167C>T, NM_020984.3:c.1157+167C>T, NM_020985.3:c.1157+167C>T, NM_020986.3:c.1157+167C>T, rs36154365, rs56811317
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3793798 NC_000010.10:g.50871466T>A, NC_000010.11:g.49663420T>A, NG_011797.1:g.59326T>A, NM_001142929.1:c.1623+638T>A, NM_001142933.1:c.1731+638T>A, NM_001142934.1:c.1623+638T>A, NM_020549.4:c.1977+638T>A, NM_020984.3:c.1623+638T>A, NM_020985.3:c.1623+638T>A, NM_020986.3:c.1623+638T>A, rs59172882
T > A
SNP
No VIP available No Clinical Annotations available VA
rs3793800 NC_000010.10:g.50871716A>G, NC_000010.11:g.49663670A>G, NG_011797.1:g.59576A>G, NM_001142929.1:c.1623+888A>G, NM_001142933.1:c.1731+888A>G, NM_001142934.1:c.1623+888A>G, NM_020549.4:c.1977+888A>G, NM_020984.3:c.1623+888A>G, NM_020985.3:c.1623+888A>G, NM_020986.3:c.1623+888A>G, rs17177963, rs58251637
A > G
SNP
No VIP available No Clinical Annotations available VA
rs3793801 NC_000010.10:g.50872912C>T, NC_000010.11:g.49664866C>T, NG_011797.1:g.60772C>T, NM_001142929.1:c.1713C>T, NM_001142933.1:c.1821C>T, NM_001142934.1:c.1713C>T, NM_020549.4:c.2067C>T, NM_020984.3:c.1713C>T, NM_020985.3:c.1713C>T, NM_020986.3:c.1713C>T, NP_001136401.1:p.Ile571=, NP_001136405.1:p.Ile607=, NP_001136406.1:p.Ile571=, NP_065574.3:p.Ile689=, NP_066264.3:p.Ile571=, NP_066265.3:p.Ile571=, NP_066266.3:p.Ile571=, rs17784428, rs58588938
C > T
SNP
I571I
No VIP available No Clinical Annotations available VA
rs3810950 NC_000010.10:g.50824619G>A, NC_000010.11:g.49616573G>A, NG_011797.1:g.12479G>A, NM_001142929.1:c.4G>A, NM_001142933.1:c.112G>A, NM_001142934.1:c.4G>A, NM_020549.4:c.358G>A, NM_020984.3:c.4G>A, NM_020985.3:c.4G>A, NM_020986.3:c.4G>A, NP_001136401.1:p.Ala2Thr, NP_001136405.1:p.Ala38Thr, NP_001136406.1:p.Ala2Thr, NP_065574.3:p.Ala120Thr, NP_066264.3:p.Ala2Thr, NP_066265.3:p.Ala2Thr, NP_066266.3:p.Ala2Thr, rs17775591, rs60084580
G > A
SNP
A2T
No VIP available No Clinical Annotations available VA
rs4646437 NC_000007.13:g.99365083G>A, NC_000007.14:g.99767460G>A, NG_008421.1:g.21726C>T, NM_001202855.2:c.671-205C>T, NM_017460.5:c.671-202C>T, XM_011515841.1:c.671-202C>T, XM_011515842.1:c.671-205C>T, rs386594232, rs57997883
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4838391 NC_000010.10:g.50832109C>T, NC_000010.11:g.49624063C>T, NG_011797.1:g.19969C>T, NM_001142929.1:c.399-1410C>T, NM_001142933.1:c.507-1410C>T, NM_001142934.1:c.399-1410C>T, NM_020549.4:c.753-1410C>T, NM_020984.3:c.399-1410C>T, NM_020985.3:c.399-1410C>T, NM_020986.3:c.399-1410C>T, rs56730446, rs57982792
C > T
SNP
No VIP available No Clinical Annotations available VA
rs4838392 NC_000010.10:g.50834978A>G, NC_000010.11:g.49626932A>G, NG_011797.1:g.22838A>G, NM_001142929.1:c.580-676A>G, NM_001142933.1:c.688-676A>G, NM_001142934.1:c.580-676A>G, NM_020549.4:c.934-676A>G, NM_020984.3:c.580-676A>G, NM_020985.3:c.580-676A>G, NM_020986.3:c.580-676A>G, rs60146256
A > G
SNP
No VIP available CA VA
rs6494223 NC_000015.10:g.32104256C>T, NC_000015.9:g.32396457C>T, NG_009216.1:g.78732C>T, NM_000746.5:c.240+2907C>T, NM_001190455.2:c.327+2907C>T, NR_046324.1:n.352+2907C>T, NT_187660.1:g.4389397C>T, NW_011332701.1:g.4276945C>T, XM_011521176.1:c.3+2909C>T, XM_011521178.1:c.240+2909C>T, XM_011521179.1:c.-194+2909C>T, XM_011547383.1:c.3+2908C>T, XM_011547386.1:c.240+2908C>T, XM_011547387.1:c.-194+2908C>T, XM_011548894.1:c.3+2908C>T, XM_011548896.1:c.240+2908C>T, XM_011548897.1:c.-194+2908C>T, rs57430710
C > T
SNP
No VIP available No Clinical Annotations available VA
rs6542746 NC_000002.11:g.108605836C>T, NC_000002.12:g.107989380C>T, NG_042267.1:g.7867C>T, NM_001305005.2:c.178+1047C>T, NM_001305006.2:c.-138+2617C>T, NM_001305007.2:c.-527+1047C>T, NM_021815.4:c.178+1047C>T, XM_005264008.1:c.178+1047C>T, XM_005264009.1:c.-138+2617C>T, XM_011511579.1:c.178+1047C>T, rs58317921, rs60571256
C > T
SNP
No VIP available No Clinical Annotations available VA
rs6720783 NC_000002.11:g.108623322T>G, NC_000002.12:g.108006866T>G, NG_042267.1:g.25353T>G, NM_001305005.2:c.895+664T>G, NM_001305006.2:c.580+664T>G, NM_001305007.2:c.154+664T>G, NM_021815.4:c.895+664T>G, XM_005264008.1:c.895+664T>G, XM_005264009.1:c.580+664T>G, XM_011511579.1:c.781+664T>G, XM_011511580.1:c.643+664T>G, XM_011511581.1:c.580+664T>G, rs58228354, rs58517179
T > G
SNP
No VIP available No Clinical Annotations available VA
rs6720975 NC_000002.11:g.46024212T>C, NC_000002.12:g.45797073T>C, NM_005400.2:c.349-45927T>C, XM_005264428.1:c.349-45927T>C, XM_005264429.1:c.349-45927T>C, XM_005264430.1:c.-102-45927T>C, XM_005264431.1:c.349-45927T>C, XM_005264431.2:c.349-45927T>C, XM_011532970.1:c.61-45927T>C, XM_011532971.1:c.61-45927T>C, XM_011532972.1:c.61-45927T>C, XM_011532973.1:c.61-45927T>C, XM_011532974.1:c.61-45927T>C, XM_011532975.1:c.61-45927T>C, XM_011532976.1:c.61-45927T>C, XM_011532977.1:c.7-45927T>C, XM_011532978.1:c.7-45927T>C, XM_011532979.1:c.4-45927T>C, XR_939695.1:n.1135-45927T>C, rs57219463
T > C
SNP
No VIP available No Clinical Annotations available VA
rs6942609 NC_000007.13:g.100895480G>A, NC_000007.14:g.101252199G>A, rs60593497
G > A
SNP
No VIP available No Clinical Annotations available VA
rs7076926 NC_000010.10:g.50863565C>T, NC_000010.11:g.49655519C>T, NG_011797.1:g.51425C>T, NM_001142929.1:c.1485+71C>T, NM_001142933.1:c.1593+71C>T, NM_001142934.1:c.1485+71C>T, NM_020549.4:c.1839+71C>T, NM_020984.3:c.1485+71C>T, NM_020985.3:c.1485+71C>T, NM_020986.3:c.1485+71C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs7094248 NC_000010.10:g.50855368C>G, NC_000010.11:g.49647322C>G, NG_011797.1:g.43228C>G, NM_001142929.1:c.927+648C>G, NM_001142933.1:c.1035+648C>G, NM_001142934.1:c.927+648C>G, NM_020549.4:c.1281+648C>G, NM_020984.3:c.927+648C>G, NM_020985.3:c.927+648C>G, NM_020986.3:c.927+648C>G, rs17719339, rs56640539, rs58948516
C > G
SNP
No VIP available No Clinical Annotations available VA
rs7094421 NC_000010.10:g.50863623A>G, NC_000010.11:g.49655577A>G, NG_011797.1:g.51483A>G, NM_001142929.1:c.1485+129A>G, NM_001142933.1:c.1593+129A>G, NM_001142934.1:c.1485+129A>G, NM_020549.4:c.1839+129A>G, NM_020984.3:c.1485+129A>G, NM_020985.3:c.1485+129A>G, NM_020986.3:c.1485+129A>G, rs17450574, rs58156562
A > G
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • (-)-Galanthamine
  • Galanthamine
  • Galanthamine hydrobromide
Trade Names
  • Galantamin
  • Jilkon
  • Lycoremin
  • Lycoremine
  • Reminyl
Brand Mixture Names

PharmGKB Accession Id

PA449726

Type(s):

Drug

Description

A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Galantamine is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimer's disease and other central nervous system disorders.

Source: Drug Bank

Indication

For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor. It is not structurally related to other acetylcholinesterase inhibitors. Galantamine's proposed mechanism of action involves the reversible inhibition of acetylcholinesterase, which prevents the hydrolysis of acetycholine, leading to an increased concentration of acetylcholine at cholinergic synapses. Galantamine also binds allosterically with nicotinic acetylcholine receptors and may possibly potentiate the action of agonists (such as acetylcholine) at these receptors.

Source: Drug Bank

Pharmacology

Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. It is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process.

Source: Drug Bank

Food Interaction

Take with food.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

18%

Source: Drug Bank

Half-Life

7 hours

Source: Drug Bank

Toxicity

LD 50=75 mg/kg (rat)

Source: Drug Bank

Clearance

Source: Drug Bank

Route of Elimination

Galantamine is metabolized by hepatic cytochrome P450 enzymes, glucuronidated, and excreted unchanged in the urine.

Source: Drug Bank

Volume of Distribution

  • 175 L

Source: Drug Bank

Chemical Properties

Chemical Formula

C17H21NO3

Source: Drug Bank

Isomeric SMILES

CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O

Source: Drug Bank

[H][C@]12C[C@@H](O)C=C[C@]11CCN(C)CC3=CC=C(OC)C(O2)=C13

Source: Drug Bank

Canonical SMILES

COC1=C2O[C@H]3C[C@@H]

Source: Drug Bank

Average Molecular Weight

287.3535

Source: Drug Bank

Monoisotopic Molecular Weight

287.152143543

Source: Drug Bank

SMILES

[H][C@]12C[C@@H](O)C=C[C@]11CCN(C)CC3=C1C(O2)=C(OC)C=C3

Source: Drug Bank

InChI String

InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ACHE (source: Drug Bank )
CHRNA1 (source: Drug Bank )
CHRNA10 (source: Drug Bank )
CHRNA2 (source: Drug Bank )
CHRNA3 (source: Drug Bank )
CHRNA4 (source: Drug Bank )
CHRNA5 (source: Drug Bank )
CHRNA6 (source: Drug Bank )
CHRNA7 (source: Drug Bank )
CHRNA9 (source: Drug Bank )
CHRNB1 (source: Drug Bank )
CHRNB2 (source: Drug Bank )
CHRNB3 (source: Drug Bank )
CHRNB4 (source: Drug Bank )
CHRND (source: Drug Bank )
CHRNE (source: Drug Bank )
CHRNG (source: Drug Bank )

Drug Interactions

Interaction Description
amantadine - galantamine Possible antagonism of action (source: Drug Bank )
amantadine - galantamine Possible antagonism of action (source: Drug Bank )
amitriptyline - galantamine Possible antagonism of action (source: Drug Bank )
amitriptyline - galantamine Possible antagonism of action (source: Drug Bank )
amoxapine - galantamine Possible antagonism of action (source: Drug Bank )
amoxapine - galantamine Possible antagonism of action (source: Drug Bank )
azatadine - galantamine Possible antagonism of action (source: Drug Bank )
benztropine - galantamine Possible antagonism of action (source: Drug Bank )
benztropine - galantamine Possible antagonism of action (source: Drug Bank )
biperiden - galantamine Possible antagonism of action (source: Drug Bank )
biperiden - galantamine Possible antagonism of action (source: Drug Bank )
brompheniramine - galantamine Possible antagonism of action (source: Drug Bank )
brompheniramine - galantamine Possible antagonism of action (source: Drug Bank )
chlorpheniramine - galantamine Possible antagonism of action (source: Drug Bank )
chlorpheniramine - galantamine Possible antagonism of action (source: Drug Bank )
chlorpromazine - galantamine Possible antagonism of action (source: Drug Bank )
chlorpromazine - galantamine Possible antagonism of action (source: Drug Bank )
chlorprothixene - galantamine Possible antagonism of action (source: Drug Bank )
cimetidine - galantamine Possible antagonism of action (source: Drug Bank )
cimetidine - galantamine Possible antagonism of action (source: Drug Bank )
clemastine - galantamine Possible antagonism of action (source: Drug Bank )
clomipramine - galantamine Possible antagonism of action (source: Drug Bank )
clomipramine - galantamine Possible antagonism of action (source: Drug Bank )
clozapine - galantamine Possible antagonism of action (source: Drug Bank )
clozapine - galantamine Possible antagonism of action (source: Drug Bank )
cyclizine - galantamine Possible antagonism of action (source: Drug Bank )
cyclobenzaprine - galantamine Possible antagonism of action (source: Drug Bank )
cyclobenzaprine - galantamine Possible antagonism of action (source: Drug Bank )
cyproheptadine - galantamine Possible antagonism of action (source: Drug Bank )
cyproheptadine - galantamine Possible antagonism of action (source: Drug Bank )
darifenacin - galantamine Possible antagonism of action (source: Drug Bank )
darifenacin - galantamine Possible antagonism of action (source: Drug Bank )
desipramine - galantamine Possible antagonism of action (source: Drug Bank )
desipramine - galantamine Possible antagonism of action (source: Drug Bank )
dicyclomine - galantamine Possible antagonism of action (source: Drug Bank )
dicyclomine - galantamine Possible antagonism of action (source: Drug Bank )
dimenhydrinate - galantamine Possible antagonism of action (source: Drug Bank )
dimenhydrinate - galantamine Possible antagonism of action (source: Drug Bank )
diphenhydramine - galantamine Possible antagonism of action (source: Drug Bank )
diphenhydramine - galantamine Possible antagonism of action (source: Drug Bank )
disopyramide - galantamine Possible antagonism of action (source: Drug Bank )
disopyramide - galantamine Possible antagonism of action (source: Drug Bank )
doxepin - galantamine Possible antagonism of action (source: Drug Bank )
doxepin - galantamine Possible antagonism of action (source: Drug Bank )
flavoxate - galantamine Possible antagonism of action (source: Drug Bank )
flupenthixol - galantamine Possible antagonism of action (source: Drug Bank )
flupenthixol - galantamine Possible antagonism of action (source: Drug Bank )
galantamine - acepromazine Possible antagonism of action (source: Drug Bank )
galantamine - aceprometazine Possible antagonism of action (source: Drug Bank )
galantamine - alverine Possible antagonism of action (source: Drug Bank )
galantamine - amantadine Possible antagonism of action (source: Drug Bank )
galantamine - amantadine Possible antagonism of action (source: Drug Bank )
galantamine - amitriptyline Possible antagonism of action (source: Drug Bank )
galantamine - amitriptyline Possible antagonism of action (source: Drug Bank )
galantamine - amoxapine Possible antagonism of action (source: Drug Bank )
galantamine - amoxapine Possible antagonism of action (source: Drug Bank )
galantamine - atropine Possible antagonism of action (source: Drug Bank )
galantamine - atropine Possible antagonism of action (source: Drug Bank )
galantamine - azatadine Possible antagonism of action (source: Drug Bank )
galantamine - benztropine Possible antagonism of action (source: Drug Bank )
galantamine - benztropine Possible antagonism of action (source: Drug Bank )
galantamine - biperiden Possible antagonism of action (source: Drug Bank )
galantamine - biperiden Possible antagonism of action (source: Drug Bank )
galantamine - brompheniramine Possible antagonism of action (source: Drug Bank )
galantamine - brompheniramine Possible antagonism of action (source: Drug Bank )
galantamine - carbinoxamine Possible antagonism of action (source: Drug Bank )
galantamine - chlorpheniramine Possible antagonism of action (source: Drug Bank )
galantamine - chlorpheniramine Possible antagonism of action (source: Drug Bank )
galantamine - chlorpromazine Possible antagonism of action (source: Drug Bank )
galantamine - chlorpromazine Possible antagonism of action (source: Drug Bank )
galantamine - chlorprothixene Possible antagonism of action (source: Drug Bank )
galantamine - cimetidine Possible antagonism of action (source: Drug Bank )
galantamine - cimetidine Possible antagonism of action (source: Drug Bank )
galantamine - clemastine Possible antagonism of action (source: Drug Bank )
galantamine - clidinium Possible antagonism of action (source: Drug Bank )
galantamine - clomipramine Possible antagonism of action (source: Drug Bank )
galantamine - clomipramine Possible antagonism of action (source: Drug Bank )
galantamine - clozapine Possible antagonism of action (source: Drug Bank )
galantamine - clozapine Possible antagonism of action (source: Drug Bank )
galantamine - cyclizine Possible antagonism of action (source: Drug Bank )
galantamine - cyclobenzaprine Possible antagonism of action (source: Drug Bank )
galantamine - cyclobenzaprine Possible antagonism of action (source: Drug Bank )
galantamine - cyproheptadine Possible antagonism of action (source: Drug Bank )
galantamine - darifenacin Possible antagonism of action (source: Drug Bank )
galantamine - desipramine Possible antagonism of action (source: Drug Bank )
galantamine - desipramine Possible antagonism of action (source: Drug Bank )
galantamine - dexbrompheniramine Possible antagonism of action (source: Drug Bank )
galantamine - dicyclomine Possible antagonism of action (source: Drug Bank )
galantamine - dimenhydrinate Possible antagonism of action (source: Drug Bank )
galantamine - dimenhydrinate Possible antagonism of action (source: Drug Bank )
galantamine - diphenhydramine Possible antagonism of action (source: Drug Bank )
galantamine - diphenhydramine Possible antagonism of action (source: Drug Bank )
galantamine - diphenoxylate Possible antagonism of action (source: Drug Bank )
galantamine - diphenylpyraline Possible antagonism of action (source: Drug Bank )
galantamine - disopyramide Possible antagonism of action (source: Drug Bank )
galantamine - disopyramide Possible antagonism of action (source: Drug Bank )
galantamine - doxepin Possible antagonism of action (source: Drug Bank )
galantamine - doxepin Possible antagonism of action (source: Drug Bank )
galantamine - doxylamine Possible antagonism of action (source: Drug Bank )
galantamine - doxylamine Possible antagonism of action (source: Drug Bank )
galantamine - ethopropazine Possible antagonism of action (source: Drug Bank )
galantamine - ethopropazine Possible antagonism of action (source: Drug Bank )
galantamine - flavoxate Possible antagonism of action (source: Drug Bank )
galantamine - flupenthixol Possible antagonism of action (source: Drug Bank )
galantamine - flupenthixol Possible antagonism of action (source: Drug Bank )
galantamine - glutethimide Possible antagonism of action (source: Drug Bank )
galantamine - glycopyrrolate Possible antagonism of action (source: Drug Bank )
galantamine - hydroxyzine Possible antagonism of action (source: Drug Bank )
galantamine - hydroxyzine Possible antagonism of action (source: Drug Bank )
galantamine - hyoscyamine Possible antagonism of action (source: Drug Bank )
galantamine - imipramine Possible antagonism of action (source: Drug Bank )
galantamine - imipramine Possible antagonism of action (source: Drug Bank )
galantamine - isocarboxazid Possible antagonism of action (source: Drug Bank )
galantamine - isocarboxazid Possible antagonism of action (source: Drug Bank )
galantamine - isopropamide Possible antagonism of action (source: Drug Bank )
galantamine - ketoconazole Ketoconazole increases the effect and toxicity of galantamine (source: Drug Bank )
galantamine - ketoconazole Ketoconazole increases the effect and toxicity of galantamine (source: Drug Bank )
galantamine - loxapine Possible antagonism of action (source: Drug Bank )
galantamine - loxapine Possible antagonism of action (source: Drug Bank )
galantamine - maprotiline Possible antagonism of action (source: Drug Bank )
galantamine - maprotiline Possible antagonism of action (source: Drug Bank )
galantamine - meclizine Possible antagonism of action (source: Drug Bank )
galantamine - meclizine Possible antagonism of action (source: Drug Bank )
galantamine - meperidine Possible antagonism of action (source: Drug Bank )
galantamine - meperidine Possible antagonism of action (source: Drug Bank )
galantamine - mesoridazine Possible antagonism of action (source: Drug Bank )
galantamine - mesoridazine Possible antagonism of action (source: Drug Bank )
galantamine - methdilazine Possible antagonism of action (source: Drug Bank )
galantamine - methotrimeprazine Possible antagonism of action (source: Drug Bank )
galantamine - methylscopolamine Possible antagonism of action (source: Drug Bank )
galantamine - mirtazapine Possible antagonism of action (source: Drug Bank )
galantamine - mirtazapine Possible antagonism of action (source: Drug Bank )
galantamine - moclobemide Possible antagonism of action (source: Drug Bank )
galantamine - moclobemide Possible antagonism of action (source: Drug Bank )
galantamine - molindone Possible antagonism of action (source: Drug Bank )
galantamine - nortriptyline Possible antagonism of action (source: Drug Bank )
galantamine - nortriptyline Possible antagonism of action (source: Drug Bank )
galantamine - olanzapine Possible antagonism of action (source: Drug Bank )
galantamine - olanzapine Possible antagonism of action (source: Drug Bank )
galantamine - orphenadrine Possible antagonism of action (source: Drug Bank )
galantamine - orphenadrine Possible antagonism of action (source: Drug Bank )
galantamine - oxybutynin Possible antagonism of action (source: Drug Bank )
galantamine - paroxetine Paroxetine increases the effect and toxicity of galantamine (source: Drug Bank )
galantamine - paroxetine Paroxetine increases the effect and toxicity of galantamine (source: Drug Bank )
galantamine - perphenazine Possible antagonism of action (source: Drug Bank )
galantamine - perphenazine Possible antagonism of action (source: Drug Bank )
galantamine - phenelzine Possible antagonism of action (source: Drug Bank )
galantamine - phenelzine Possible antagonism of action (source: Drug Bank )
galantamine - phenindamine Possible antagonism of action (source: Drug Bank )
galantamine - pheniramine Possible antagonism of action (source: Drug Bank )
galantamine - pimozide Possible antagonism of action (source: Drug Bank )
galantamine - pimozide Possible antagonism of action (source: Drug Bank )
galantamine - pipotiazine Possible antagonism of action (source: Drug Bank )
galantamine - pipotiazine Possible antagonism of action (source: Drug Bank )
galantamine - procainamide Possible antagonism of action (source: Drug Bank )
galantamine - procainamide Possible antagonism of action (source: Drug Bank )
galantamine - prochlorperazine Possible antagonism of action (source: Drug Bank )
galantamine - prochlorperazine Possible antagonism of action (source: Drug Bank )
galantamine - procyclidine Possible antagonism of action (source: Drug Bank )
galantamine - promazine Possible antagonism of action (source: Drug Bank )
galantamine - promazine Possible antagonism of action (source: Drug Bank )
galantamine - promethazine Possible antagonism of action (source: Drug Bank )
galantamine - promethazine Possible antagonism of action (source: Drug Bank )
galantamine - propantheline Possible antagonism of action (source: Drug Bank )
galantamine - propericiazine Possible antagonism of action (source: Drug Bank )
galantamine - protriptyline Possible antagonism of action (source: Drug Bank )
galantamine - protriptyline Possible antagonism of action (source: Drug Bank )
galantamine - quetiapine Possible antagonism of action (source: Drug Bank )
galantamine - quetiapine Possible antagonism of action (source: Drug Bank )
galantamine - quinidine Possible antagonism of action (source: Drug Bank )
galantamine - quinidine Possible antagonism of action (source: Drug Bank )
galantamine - risperidone Possible antagonism of action (source: Drug Bank )
galantamine - risperidone Possible antagonism of action (source: Drug Bank )
galantamine - scopolamine Possible antagonism of action (source: Drug Bank )
galantamine - scopolamine Possible antagonism of action (source: Drug Bank )
galantamine - sertraline Possible antagonism of action (source: Drug Bank )
galantamine - sertraline Possible antagonism of action (source: Drug Bank )
galantamine - solifenacin Possible antagonism of action (source: Drug Bank )
galantamine - thioproperazine Possible antagonism of action (source: Drug Bank )
galantamine - thioridazine Possible antagonism of action (source: Drug Bank )
galantamine - thioridazine Possible antagonism of action (source: Drug Bank )
galantamine - thiothixene Possible antagonism of action (source: Drug Bank )
galantamine - thiothixene Possible antagonism of action (source: Drug Bank )
galantamine - tizanidine Possible antagonism of action (source: Drug Bank )
galantamine - tizanidine Possible antagonism of action (source: Drug Bank )
galantamine - tolterodine Possible antagonism of action (source: Drug Bank )
galantamine - tranylcypromine Possible antagonism of action (source: Drug Bank )
galantamine - tranylcypromine Possible antagonism of action (source: Drug Bank )
galantamine - trazodone Possible antagonism of action (source: Drug Bank )
galantamine - trazodone Possible antagonism of action (source: Drug Bank )
galantamine - trifluoperazine Possible antagonism of action (source: Drug Bank )
galantamine - trifluoperazine Possible antagonism of action (source: Drug Bank )
galantamine - triflupromazine Possible antagonism of action (source: Drug Bank )
galantamine - triflupromazine Possible antagonism of action (source: Drug Bank )
galantamine - trihexyphenidyl Possible antagonism of action (source: Drug Bank )
galantamine - trimeprazine Possible antagonism of action (source: Drug Bank )
galantamine - trimethobenzamide Possible antagonism of action (source: Drug Bank )
galantamine - trimipramine Possible antagonism of action (source: Drug Bank )
galantamine - trimipramine Possible antagonism of action (source: Drug Bank )
galantamine - tripelennamine Possible antagonism of action (source: Drug Bank )
galantamine - triprolidine Possible antagonism of action (source: Drug Bank )
galantamine - triprolidine Possible antagonism of action (source: Drug Bank )
galantamine - trospium Possible antagonism of action (source: Drug Bank )
galantamine - ziprasidone Possible antagonism of action (source: Drug Bank )
galantamine - ziprasidone Possible antagonism of action (source: Drug Bank )
galantamine - zuclopenthixol Possible antagonism of action (source: Drug Bank )
galantamine - zuclopenthixol Possible antagonism of action (source: Drug Bank )
glutethimide - galantamine Possible antagonism of action (source: Drug Bank )
glycopyrrolate - galantamine Possible antagonism of action (source: Drug Bank )
hydroxyzine - galantamine Possible antagonism of action (source: Drug Bank )
hydroxyzine - galantamine Possible antagonism of action (source: Drug Bank )
hyoscyamine - galantamine Possible antagonism of action (source: Drug Bank )
hyoscyamine - galantamine Possible antagonism of action (source: Drug Bank )
imipramine - galantamine Possible antagonism of action (source: Drug Bank )
imipramine - galantamine Possible antagonism of action (source: Drug Bank )
isocarboxazid - galantamine Possible antagonism of action (source: Drug Bank )
isocarboxazid - galantamine Possible antagonism of action (source: Drug Bank )
ketoconazole - galantamine Ketoconazole increases the effect and toxicity of galantamine (source: Drug Bank )
ketoconazole - galantamine Ketoconazole increases the effect and toxicity of galantamine (source: Drug Bank )
loxapine - galantamine Possible antagonism of action (source: Drug Bank )
loxapine - galantamine Possible antagonism of action (source: Drug Bank )
maprotiline - galantamine Possible antagonism of action (source: Drug Bank )
maprotiline - galantamine Possible antagonism of action (source: Drug Bank )
meclizine - galantamine Possible antagonism of action (source: Drug Bank )
meclizine - galantamine Possible antagonism of action (source: Drug Bank )
meperidine - galantamine Possible antagonism of action (source: Drug Bank )
meperidine - galantamine Possible antagonism of action (source: Drug Bank )
mesoridazine - galantamine Possible antagonism of action (source: Drug Bank )
mesoridazine - galantamine Possible antagonism of action (source: Drug Bank )
methotrimeprazine - galantamine Possible antagonism of action (source: Drug Bank )
mirtazapine - galantamine Possible antagonism of action (source: Drug Bank )
mirtazapine - galantamine Possible antagonism of action (source: Drug Bank )
moclobemide - galantamine Possible antagonism of action (source: Drug Bank )
moclobemide - galantamine Possible antagonism of action (source: Drug Bank )
nortriptyline - galantamine Possible antagonism of action (source: Drug Bank )
nortriptyline - galantamine Possible antagonism of action (source: Drug Bank )
olanzapine - galantamine Possible antagonism of action (source: Drug Bank )
olanzapine - galantamine Possible antagonism of action (source: Drug Bank )
orphenadrine - galantamine Possible antagonism of action (source: Drug Bank )
orphenadrine - galantamine Possible antagonism of action (source: Drug Bank )
oxybutynin - galantamine Possible antagonism of action (source: Drug Bank )
oxybutynin - galantamine Possible antagonism of action (source: Drug Bank )
perphenazine - galantamine Possible antagonism of action (source: Drug Bank )
perphenazine - galantamine Possible antagonism of action (source: Drug Bank )
phenelzine - galantamine Possible antagonism of action (source: Drug Bank )
phenelzine - galantamine Possible antagonism of action (source: Drug Bank )
pimozide - galantamine Possible antagonism of action (source: Drug Bank )
pimozide - galantamine Possible antagonism of action (source: Drug Bank )
procainamide - galantamine Possible antagonism of action (source: Drug Bank )
procainamide - galantamine Possible antagonism of action (source: Drug Bank )
prochlorperazine - galantamine Possible antagonism of action (source: Drug Bank )
prochlorperazine - galantamine Possible antagonism of action (source: Drug Bank )
promethazine - galantamine Possible antagonism of action (source: Drug Bank )
promethazine - galantamine Possible antagonism of action (source: Drug Bank )
propericiazine - galantamine Possible antagonism of action (source: Drug Bank )
quetiapine - galantamine Possible antagonism of action (source: Drug Bank )
quetiapine - galantamine Possible antagonism of action (source: Drug Bank )
quinidine - galantamine Possible antagonism of action (source: Drug Bank )
quinidine - galantamine Possible antagonism of action (source: Drug Bank )
thioproperazine - galantamine Possible antagonism of action (source: Drug Bank )
thioridazine - galantamine Possible antagonism of action (source: Drug Bank )
thioridazine - galantamine Possible antagonism of action (source: Drug Bank )
tizanidine - galantamine Possible antagonism of action (source: Drug Bank )
tizanidine - galantamine Possible antagonism of action (source: Drug Bank )
trazodone - galantamine Possible antagonism of action (source: Drug Bank )
trazodone - galantamine Possible antagonism of action (source: Drug Bank )
trifluoperazine - galantamine Possible antagonism of action (source: Drug Bank )
trifluoperazine - galantamine Possible antagonism of action (source: Drug Bank )
trihexyphenidyl - galantamine Possible antagonism of action (source: Drug Bank )
trimethobenzamide - galantamine The therapeutic effects of the anticholinergic, Trimethobenzamide, and/or the acetylcholinesterase inhibitor (central), Galantamine, may be reduced due to antagonism. Monitor therapeutic effects of both agents. (source: Drug Bank )
trospium - galantamine The therapeutic effects of the anticholinergic, Trospium, and/or the acetylcholinesterase inhibitor (central), Galantamine, may be reduced due to antagonism. Monitor therapeutic effects of both agents. (source: Drug Bank )

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to galantamine: 15

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Kynurenine pathway and cognitive impairments in schizophrenia: Pharmacogenetics of galantamine and memantine. Schizophrenia research. Cognition. 2016. Koola Maju Mathew. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacopsychiatry. 2015. Yoon H, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. 2014. Braga Ianna Lacerda Sampaio, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors. Neurobiology of aging. 2013. Martinelli-Boneschi Filippo, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Relationship of CYP2D6, CYP3A, POR, and ABCB1 genotypes with galantamine plasma concentrations. Therapeutic drug monitoring. 2013. Noetzli Muriel, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. The pharmacogenomics journal. 2010. Patterson C E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions. British journal of clinical pharmacology. 2010. Mannheimer Buster, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Galantamine in frontotemporal dementia and primary progressive aphasia. Dementia and geriatric cognitive disorders. 2008. Kertesz A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
100 years and counting: prospects for defeating Alzheimer's disease. Science (New York, N.Y.). 2006. Roberson Erik D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. International journal of geriatric psychiatry. 2006. Takeda A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy. Clinical neurology and neurosurgery. 2005. Kim Eunhee, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Galantamine: use in Alzheimer's disease and related disorders. Expert review of neurotherapeutics. 2004. Bullock Roger. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Clinical pharmacokinetics of galantamine. Clinical pharmacokinetics. 2003. Farlow Martin R. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS drug reviews. 2002. Lilienfeld Sean. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0378-8104-91
DrugBank:
DB00674
PDB:
GNT
ChEBI:
5264
KEGG Compound:
C08526
KEGG Drug:
D04292
PubChem Compound:
908828
9651
PubChem Substance:
10719
46505659
Drugs Product Database (DPD):
2266717
BindingDB:
10404
ChemSpider:
23175565
HET:
GNT
Therapeutic Targets Database:
DAP000559

Clinical Trials

These are trials that mention galantamine and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

Common Searches

Search PubMed
Search Medline Plus
Search PubChem
Search CTD

Sources for PharmGKB drug information: DrugBank, PubChem.