Chemical: Drug
etodolac

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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Overview

Generic Names
  • etodolac
Trade Names
  • Etodolac [Usan:Ban:Inn]
  • Etodolacetodolic acid
  • Etodolaco [INN-Spanish]
  • Etodolacum [INN-Latin]
  • Etodolic Acid
  • Lodine
  • Lodine XL
  • Ultradol
Brand Mixture Names

PharmGKB Accession Id

PA449550

Type(s):

Drug

Other Vocabularies

Chemical Properties

SMILES

CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(=O)O

Source: PubChem

InChI String

InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)

Source: PubChem

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Drug Targets

Gene Description
ALB (source: Drug Bank )
PTGS1 (source: Drug Bank )
PTGS2 (source: Drug Bank )
RXRA (source: Drug Bank )

Drug Interactions

Interaction Description
cyclosporine - etodolac Monitor for nephrotoxicity (source: Drug Bank )
cyclosporine - etodolac Monitor for nephrotoxicity (source: Drug Bank )
etodolac - acenocoumarol The NSAID increases the anticoagulant effect (source: Drug Bank )
etodolac - acenocoumarol The NSAID, etodolac, may increase the anticoagulant effect or acenocoumarol. (source: Drug Bank )
etodolac - alendronate Increased risk of gastric toxicity (source: Drug Bank )
etodolac - alendronate Increased risk of gastric toxicity (source: Drug Bank )
etodolac - anisindione The NSAID, etodolac, may increase the anticoagulant effect of anisindione. (source: Drug Bank )
etodolac - cyclosporine Monitor for nephrotoxicity (source: Drug Bank )
etodolac - cyclosporine Monitor for nephrotoxicity (source: Drug Bank )
etodolac - dicumarol The NSAID increases the anticoagulant effect (source: Drug Bank )
etodolac - dicumarol The NSAID, etodolac, may increase the anticoagulant effect of dicumarol. (source: Drug Bank )
etodolac - methotrexate The NSAID increases the effect and toxicity of methotrexate (source: Drug Bank )
etodolac - methotrexate The NSAID, etodolac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity. (source: Drug Bank )
etodolac - warfarin The NSAID increases the anticoagulant effect (source: Drug Bank )
etodolac - warfarin The NSAID, etodolac, may increase the anticoagulant effect of warfarin. (source: Drug Bank )
ginkgo biloba - etodolac Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided. (source: Drug Bank )
methotrexate - etodolac The NSAID increases the effect and toxicity of methotrexate (source: Drug Bank )
methotrexate - etodolac The NSAID, etodolac, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity. (source: Drug Bank )
timolol - etodolac The NSAID, Etodolac, may antagonize the antihypertensive effect of Timolol. (source: Drug Bank )
timolol - etodolac The NSAID, Etodolac, may antagonize the antihypertensive effect of Timolol. (source: Drug Bank )
trandolapril - etodolac The NSAID, Etodolac, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Etodolac is initiated, discontinued or dose changed. (source: Drug Bank )
treprostinil - etodolac The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Etodolac. Monitor for increased bleeding during concomitant thearpy. (source: Drug Bank )
warfarin - etodolac The antiplatelet effects of etodolac may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy. (source: Drug Bank )

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to etodolac: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0228-2599-11
DrugBank:
DB00749
ChEBI:
4909
KEGG Drug:
D00315
PubChem Compound:
3308
PubChem Substance:
179980
46505184
Drugs Product Database (DPD):
2242915
BindingDB:
50016799
ChemSpider:
3192
Therapeutic Targets Database:
DAP000778
FDA Drug Label at DailyMed:
a8984705-a43a-4977-808a-44df42930de1

Clinical Trials

These are trials that mention etodolac and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.