Chemical: Drug
ethinyl estradiol

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB annotates drug labels containing pharmacogenetic information approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the PGx in the label, an excerpt from the label and a downloadable highlighted label PDF file. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the "PGx Level" tag.

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Annotated Labels

  1. FDA Label for drospirenone,ethinyl estradiol and CYP2C19
  2. EMA Label for ethinyl estradiol,norelgestromin and F5
  3. HCSC Label for drospirenone,ethinyl estradiol and F5,PROC,PROS1,SERPINC1
  4. HCSC Label for ethinyl estradiol,norelgestromin and F2,F5,MTHFR,PROC,PROS1,SERPINC1

last updated 07/14/2014

1. FDA Label for drospirenone,ethinyl estradiol and CYP2C19

Informative PGx

Summary

The FDA-approved drug label for drospirenone and ethinyl estradiol (Yaz) notes that in vitro studies showed an inhibitory effect of drospirenone on the turnover of model substrates of CYP1A1, CYP2C9, CYP2C19 and CYP3A4. However, in vivo studies using omeprazole as a marker substrate showed that drospirenone has little propensity to interact to a significant extent with cytochrome P450 enzymes at a clinical dose level.

There's more of this label. Read more.


last updated 05/08/2014

2. EMA Label for ethinyl estradiol,norelgestromin and F5

Genetic testing required

Summary

The EMA European Public Assessment Report (EPAR) for norelgestromin and ethinyl estradiol (Evra) contains information regarding its contraindication in women with known predisposition to venous thromboembolism (including Factor V Leiden, rs6025).

There's more of this label. Read more.


last updated 06/08/2015

3. HCSC Label for drospirenone,ethinyl estradiol and F5,PROC,PROS1,SERPINC1

Actionable PGx

Summary

The product monograph for drospirenone and ethinyl estradiol (YAZ) states that the drug is contraindicated in women with Factor V Leiden mutation, antithrombin-III-deficiency, protein C deficiency and protein S deficiency (among other contraindications), due to the risk for arterial or venous thrombosis.

There's more of this label. Read more.


last updated 06/08/2015

4. HCSC Label for ethinyl estradiol,norelgestromin and F2,F5,MTHFR,PROC,PROS1,SERPINC1

Actionable PGx

Summary

The product monograph for norelgestromin and ethinyl estradiol (EVRA) states that the drug is contraindicated in women with Factor V Leiden mutation, antithrombin-III-deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinaemia due to mutations in the MTHFR gene and prothrombin mutation G20210A (among other contraindications), due to the risk for arterial or venous thrombosis.

There's more of this label. Read more.


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Generic Names
  • 17 alpha-Ethinylestradiol
  • 17 alpha-Ethynylestradiol
  • 17 alpha-Ethynyloestradiol
  • Aethinyloestradiolum
  • Aethinyoestradiol [German]
  • EE
  • EO
  • Ethinyl-Oestranol
  • Ethinylestradiolum [INN-Latin]
  • Ethinylestriol
  • Ethinyloestradiol
  • Ethynylestradiol
  • Ethynyloestradiol
  • Etinilestradiol [INN-Spanish]
  • ethynyl estradiol
Trade Names
  • Amenoron
  • Amenorone
  • Anovlar
  • Cyclosa
  • Dicromil
  • Diognat-E
  • Diogyn E
  • Diogyn-E
  • Diprol
  • Dyloform
  • Ertonyl
  • Esteed
  • Estigyn
  • Eston-E
  • Estopherol
  • Estoral
  • Estorals
  • Ethidol
  • Ethinoral
  • Ethy 11
  • Eticyclin
  • Eticyclol
  • Eticylol
  • Etinestrol
  • Etinestryl
  • Etinoestryl
  • Etistradiol
  • Etivex
  • Evra
  • Follicoral
  • Ginestrene
  • Gynolett
  • Halodrin
  • Inestra
  • Kolpolyn
  • Linoral
  • Marvelon
  • Menolyn
  • Mercilon
  • Microfollin
  • Neo-Estrone
  • Nogest-S
  • Novestrol
  • Oradiol
  • Orestralyn
  • Orestrayln
  • Ortho-Cyclen
  • Oviol
  • Primogyn
  • Primogyn C
  • Primogyn M
  • Progynon C
  • Progynon M
  • Prosexol
  • Spanestrin
  • Varnoline
  • Ylestrol
Brand Mixture Names
  • Alesse 21 Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Alesse 28 Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Brevicon (Ethinyl Estradiol + Norethindrone)
  • Cyclen (Ethinyl Estradiol + Norgestimate)
  • Demulen 30 (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Diane-35 (Cyproterone Acetate + Ethinyl Estradiol)
  • Evra (Ethinyl Estradiol + Norelgestromin)
  • Femhrt 1/5 (Ethinyl Estradiol + Norethindrone Acetate)
  • Geri Bons Tab (Calcium (Calcium Phosphate (Dibasic)) + Copper + Dl-Methionine + Ethinyl Estradiol + Fatty Acids + Folic Acid + Iodine + Iron Peptonized + Magnesium + Manganese + Methyltestosterone + Nicotinamide + Phosphorus (Calcium Phosphate (Dibasic)) + Pyridoxine Hydrochloride + Thiamine Hydrochloride + Thyroid + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D + Vitamin E)
  • Geri Tabs (Calcium (Calcium Phosphate (Dibasic)) + Copper Sulfate + Dl-Methionine + Ethinyl Estradiol + Folic Acid + Iodine + Iron Peptonized + Magnesium Oxide + Manganese Sulfate + Methyltestosterone + Nicotinamide + Phosphorus (Calcium Phosphate (Dibasic)) + Pyridoxine Hydrochloride + Thiamine Hydrochloride + Thyroid + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D + Vitamin E)
  • Lo-Femenal 21 Tablets (Ethinyl Estradiol + Norgestrel)
  • Loestrin 1.5/30 21day Pak (Ethinyl Estradiol + Norethindrone Acetate)
  • Loestrin 1.5/30 28day Pack (Ethinyl Estradiol + Norethindrone Acetate)
  • Marvelon 21 Tab (Desogestrel + Ethinyl Estradiol)
  • Marvelon 28 Tab (Desogestrel + Ethinyl Estradiol)
  • Min-Ovral 21 (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 28 (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Minestrin 1/20 21 (Ethinyl Estradiol + Norethindrone Acetate)
  • Minestrin 1/20 28 (Ethinyl Estradiol + Norethindrone Acetate)
  • Neo Mens Tab (Ethinyl Estradiol + Ethisterone)
  • Nuvaring (Ethinyl Estradiol + Etonogestrel)
  • Ortho Tablets (0.5/35, 1/35, 10/11, 7/7/7) (Ethinyl Estradiol + Norethindrone)
  • Ortho-Cept Tablets (Desogestrel + Ethinyl Estradiol)
  • Ovral 21 Tab (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 21 Tablets (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 28 Tablets (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 28tab (Ethinyl Estradiol + Norgestrel)
  • Preven Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Select 1/35 (Ethinyl Estradiol + Norethindrone)
  • Synphasic 21 Tablets (Ethinyl Estradiol + Norethindrone)
  • Synphasic 28 Tablets (Ethinyl Estradiol + Norethindrone)
  • Synphasic-28 Tablets (Ethinyl Estradiol + Norethindrone)
  • Tri-Cyclen Lo (Ethinyl Estradiol + Norgestimate)
  • Tri-Cyclen Tablets - 21-Day (Ethinyl Estradiol + Norgestimate)
  • Tri-Cyclen Tablets - 28-Day (Ethinyl Estradiol + Norgestimate)
  • Triphasil 21 (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 28 (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triquilar 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triquilar 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Yasmin 21 (Drospirenone + Ethinyl Estradiol)
  • Yasmin 28 (Drospirenone + Ethinyl Estradiol)

PharmGKB Accession Id

PA449527

Type(s):

Drug

Description

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives.

Source: Drug Bank

Pharmacogenetics

ORTHO EVRA (norelgestromin/ethinyl estradiol)

ORTHO EVRA is a transdermal contraceptive patch used to prevent ovulation and pregnancy. This medicine combines two types of female hormones, an estrogen (ethinyl estradiol) and a progestin (norelgestromin).

PK:

Since ORTHO EVRA® is applied transdermally, hormones from ORTHO EVRA get into the bloodstream and are processed by the body differently than hormones from birth control pills that are taken orally [Articles:17389559, 11849630, 11851637].The contraceptive patch delivers hormones (norelgestromin (NGMN) and ethinyl estradiol (EE)) transdermally into systemic circulation, bypassing the first-pass metabolism (via the gastrointestinal tract and/or liver). Patients will be exposed to about 60% more estrogen with ORTHO EVRA® than with a typical birth control pill containing 35 micrograms of estrogen (http://www.orthoevra.com/isi.html; [Article:16368722]). The increased estrogen concentration may increase the risk of venous thromboembolism and other estrogen-related adverse effects, although the degree of risk is still unclear. Norelgestromin undergoes hepatic metabolism and metabolites include norgestrel, which is highly bound to SHBG, and various hydroxylated and conjugated metabolites. Ethinyl estradiol is also metabolized to various hydroxylated products by cytochrome P450 (CYP) 2B1, 1A1, 1A2, 3A4, 3A5, 3A7 and 2C9 [Articles:9625734, 12865317, 14623547, 16024767, 14657266, 15784278]. Estradiol and its metabolites further undergo sulfation by sulfotransferases (SULTs) [Articles:12922923, 15860265, 10963623] and glucuronidation by glucoronyltransferases (UGTs) [Articles:17374650, 11457662, 9848110]. Studies showed that ethinyl estradiol inactivated purified, reconstituted rat hepatic cytochrome P450 (P450) 2B1 and human P450 2B6 in a mechanism-based manner [Article:11805216]. For graphical description of estrogen metabolism, please see estrogen metabolism pathway (https://www.pharmgkb.org/do/serve?objId=PA145011118&objCls=Pathway).

PD:

The ORTHO EVRA Patch is worn on the body to prevent pregnancy by delivering continuous levels of hormones (progestin and estrogen, respectively) into the bloodstream through the skin. Although the primary mechanism of action is inhibition of ovulation, other alterations occur, including changes in the cervical mucus (which increase the difficulty of sperm entry into the uterus) and the endometrium (which reduce the likelihood of implantation) [Articles:11849630, 11851637]. Norelgestromin is the active progestin largely responsible for the progestational activity that occurs in women following application of ORTHO EVRA®. Both progestins and estrogens exert their effect through binding to their receptors. Estrogens elicit their effects via estrogen receptors (ER/ESR1 and ESR2) [Articles:16876190, 18854778, 17986456, 17584965, 17673513, 14668813, 16033996]. Progestin affects both menstruation and gestation via the progesterone receptor (PGR) [Articles:17013809, 18321550]. The combination of an estrogen with a progestin in ORTHO EVRA suppresses the hypothalamic-pituitary system, decreases the secretion of gonadotropin-releasing hormone (GNRH1) from the hypothalamus and blunts the preovulatory LH (luteinizing hormone (LHB/CGA)) surge [Articles:17013809, 19434887]. In vitro studies showed that NGMN is a very potent inhibitory agent for sulfatase activity (STS) in the hormone-dependent breast cancer cells [Article:12711003]. The use of ORTHO EVRA Patch also increased the serum concentrations of estrogen-sensitive hepatic proteins such as sex hormone binding globulin (SHBG), corticosteroid binding globulin (SERPINA6/CBG), thyroid-binding globulin (SERPINA7/TBG), and affected biomarkers of vascular disease risk (increases in C-reactive protein (CRP) and fibrinogen (FGA, FGB), declines in free and total protein S (PROS1) and antithrombin (SERPINC1))[Articles:16982228, 18238963].

Serious as well as minor side effects have been reported with the use of the ORTHO EVRA Patch. "Serious risks, which can be life threatening, include blood clots, stroke and heart attacks and are increased if you smoke cigarettes. Cigarette smoking increases the risk of serious cardiovascular side effects, especially if you are over 35. Women who use the Patch are strongly advised not to smoke. Some women should not use the Patch, including women who have blood clots, certain cancers, a history of heart attack, blood clots, or stroke, as well as those who are or may be pregnant" (http://www.orthoevra.com/isi.html).

Source: PharmGKB

Indication

For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Source: Drug Bank

Pharmacology

Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.

Source: Drug Bank

Protein Binding

97%

Source: Drug Bank

Absorption

Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Source: Drug Bank

Half-Life

36 +/- 13 hours

Source: Drug Bank

Toxicity

Oral, mouse LD 50: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.

Source: Drug Bank

Chemical Properties

Chemical Formula

C20H24O2

Source: Drug Bank

Isomeric SMILES

C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@]2(C#C)O)O

Source: OpenEye

Canonical SMILES

C[C@]12CC[C@H]

Source: Drug Bank

Average Molecular Weight

296.4034

Source: Drug Bank

Monoisotopic Molecular Weight

296.177630012

Source: Drug Bank

SMILES

[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3

Source: Drug Bank

InChI String

InChI=1/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/s2

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ESR1 (source: Drug Bank)
NR1I2 (source: Drug Bank)

Drug Interactions

Interaction Description
amoxicillin - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ampicillin - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
amprenavir - ethinyl estradiol Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
bosentan - ethinyl estradiol Decreases the effect of contraceptive (source: Drug Bank)
carbamazepine - ethinyl estradiol This product might cause a slight decrease of contraceptive effect (source: Drug Bank)
carbenicillin - ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
cloxacillin - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
cyclosporine - ethinyl estradiol The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
doxycycline - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - acenocoumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - acenocoumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - aminophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol - amobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - amobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - amprenavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - amprenavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - anisindione Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - aprepitant Aprepitant could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - aprobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - azlocillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - bacampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - bosentan Bosentan decreases the effect of contraceptive (source: Drug Bank)
ethinyl estradiol - bosentan Bosentan decreases the effect of contraceptive (source: Drug Bank)
ethinyl estradiol - butabarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - butalbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - butalbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - butethal This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - carbamazepine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - carbamazepine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - carbenicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - carbenicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - clavulanate This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - cyclacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - cyclosporine The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
ethinyl estradiol - cyclosporine The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
ethinyl estradiol - demeclocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - dicloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - dicumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - dicumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - doxycycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - doxycycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - dyphylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol - ethotoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - etoricoxib Etoricoxib increases the levels of ethinyl estradiol (source: Drug Bank)
ethinyl estradiol - flucloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - fosphenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - griseofulvin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - griseofulvin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - heptabarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - hetacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - hexobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - hexobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - itraconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - itraconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - lamotrigine The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
ethinyl estradiol - lamotrigine The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
ethinyl estradiol - mephenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - mephenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - methacycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - methohexital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - methylphenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - methylphenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - meticillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - mezlocillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - minocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - minocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - modafinil Modafinil decreases the effect of contraceptive (source: Drug Bank)
ethinyl estradiol - modafinil Modafinil decreases the effect of contraceptive (source: Drug Bank)
ethinyl estradiol - nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - nelfinavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - nelfinavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - oxcarbazepine Oxcarbazepine decreases the effect of the contracepitve (source: Drug Bank)
ethinyl estradiol - oxcarbazepine Oxcarbazepine decreases the effect of the contracepitve (source: Drug Bank)
ethinyl estradiol - oxtriphylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol - oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - penicillin g This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - penicillin g This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - pentobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - pentobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - phenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - phenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - phenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - phenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - pioglitazone Possible loss of contracepitve effect (source: Drug Bank)
ethinyl estradiol - pioglitazone Possible loss of contracepitve effect (source: Drug Bank)
ethinyl estradiol - piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - pivampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - prednisolone The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
ethinyl estradiol - prednisolone The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisolone. (source: Drug Bank)
ethinyl estradiol - prednisone The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
ethinyl estradiol - prednisone The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisone. (source: Drug Bank)
ethinyl estradiol - primidone This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - primidone This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - raloxifene Association not recommended (source: Drug Bank)
ethinyl estradiol - raloxifene Association not recommended (source: Drug Bank)
ethinyl estradiol - rifabutin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - rifabutin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - rifampin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - rifampin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - rifapentine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - ritonavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - ritonavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol - rolitetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - secobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - talbutal This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol - tazobactam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - theophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol - theophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol - ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol - tizanidine The contraceptive increases the effect of tizanidine (source: Drug Bank)
ethinyl estradiol - tizanidine The contraceptive increases the effect of tizanidine (source: Drug Bank)
ethinyl estradiol - topiramate Topiramate decreases the effect of estrogen (source: Drug Bank)
ethinyl estradiol - topiramate Topiramate decreases the effect of estrogen (source: Drug Bank)
ethinyl estradiol - troglitazone Possible loss of contracepitve effect (source: Drug Bank)
ethinyl estradiol - troglitazone Possible loss of contracepitve effect (source: Drug Bank)
ethinyl estradiol - ursodeoxycholic acid Estrogens decreases the effect of ursodiol (source: Drug Bank)
ethinyl estradiol - warfarin Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol - warfarin Increased thrombotic risk due to estrogen (source: Drug Bank)
griseofulvin - ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
itraconazole - ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
ketoconazole - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
lamotrigine - ethinyl estradiol The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
minocycline - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
modafinil - ethinyl estradiol Modafinil decreases the effect of the contraceptive (source: Drug Bank)
nelfinavir - ethinyl estradiol Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
oxcarbazepine - ethinyl estradiol Oxcarbazepine decreases the effect of the contraceptive (source: Drug Bank)
penicillin g - ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
phenobarbital - ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
phenytoin - ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
pioglitazone - ethinyl estradiol Possible loss of contraceptive effect (source: Drug Bank)
piperacillin - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
prednisolone - ethinyl estradiol The estrogenic agent increases the effect of the corticosteroid (source: Drug Bank)
prednisone - ethinyl estradiol The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
primidone - ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
raloxifene - ethinyl estradiol Association not recommended (source: Drug Bank)
rifabutin - ethinyl estradiol This product may cause a slight decrease of the contraceptive effect (source: Drug Bank)
rifampin - ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
tetracycline - ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
theophylline - ethinyl estradiol The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
tizanidine - ethinyl estradiol The contraceptive increases the effect of tizanidine (source: Drug Bank)

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
May Prevent
Contraindicated With

Publications related to ethinyl estradiol: 7

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacokinetic interaction between the CYP3A4 inhibitor ketoconazole and the hormone drospirenone in combination with ethinylestradiol or estradiol. British journal of clinical pharmacology. 2015. Wiesinger Herbert, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
PharmGKB summary: very important pharmacogene information for CYP2B6. Pharmacogenetics and genomics. 2010. Thorn Caroline F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability. Archives of toxicology. 2008. Strassburg Christian P, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual review of pharmacology and toxicology. 2003. Ding Xinxin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clinical pharmacology and therapeutics. 2002. Robertson Philmore, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00977
ChEBI:
4903
KEGG Compound:
C07534
KEGG Drug:
D00554
PubChem Compound:
5991
PubChem Substance:
148835
46508618
Drugs Product Database (DPD):
28231
ChemSpider:
5770
Therapeutic Targets Database:
DAP001018

Clinical Trials

These are trials that mention ethinyl estradiol and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, PubChem.