Chemical: Drug
erythromycin

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.


Annotated Labels

  1. Annotation of FDA Label for erythromycin,sulfisoxazole and G6PD
  2. Annotation of HCSC Label for erythromycin,sulfisoxazole and G6PD

last updated 03/17/2017

1. Annotation of FDA Label for erythromycin,sulfisoxazole and G6PD

Actionable PGx

Summary

Erythromycin ethylsuccinate and sulfisoxazole acetyl is used to treat acute otitis media in children caused by certain strains of Haemophilus influenzae. The label warns that hemolysis may occur in G6PD deficient patients on this drug.

Annotation

Although the sulfisoxazole drug label does not specifically mention genetic testing, the FDA highlight precaution labeling prior to initiating treatment with sulfisoxazole for G6PD deficient individuals due to a risk of hemolytic anemia.

Excerpt from the sulfisoxazole drug label:

In glucose-6-phosphate dehydrogenase-deficient individuals, hemolysis may occur; this reaction is frequently dose related.

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the sulfisoxazole drug label.

*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.

Genes and/or phenotypes found in this label

  • Arrhythmias, Cardiac
    • Adverse reactions section, Precautions section
    • source: PHONT
  • Death, Sudden, Cardiac
    • Indications & usage section, Precautions section
    • source: PHONT
  • Heart Arrest
    • Precautions section
    • source: PHONT
  • Otitis Media
    • Indications & usage section
    • source: U.S. Food and Drug Administration
  • Seizures
    • Adverse reactions section
    • source: PHONT
  • Syncope
    • Adverse reactions section
    • source: PHONT
  • Tachycardia, Ventricular
    • Adverse reactions section, Precautions section
    • source: PHONT
  • Torsades de Pointes
    • Adverse reactions section, Precautions section
    • source: PHONT
  • Ventricular Fibrillation
    • Precautions section
    • source: PHONT
  • ABCB1
    • metabolism/PK, Drug interactions section
    • source: U.S. Food and Drug Administration
  • G6PD
    • toxicity, Contraindications section, Warnings and precautions section
    • source: U.S. Food and Drug Administration

2. Annotation of HCSC Label for erythromycin,sulfisoxazole and G6PD

Actionable PGx

Summary

The product monograph for erythromycin and sulfisoxazole states that it is contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, due to the risk for hemolysis. However, the monograph does not discuss testing for G6PD deficiency prior to treatment.

Annotation

Erythromycin and sulfisoxazole (PEDIAZOLE) is indicated for treatment of children with acute otitis media caused by strains of Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes or Branhamella catarrhalis susceptible to this combination. Excerpts from the erythromycin and sulfisoxazole product monograph:

PEDIAZOLE(R) (erythromycin ethylsuccinate and sulfisoxazole acetyl for oral suspension USP) is contraindicated in:

  • Uremic patients, and patients with a deficiency of erythrocytic glucose-6-phosphate dehydrogenase (G-6-PD).

Hemolysis may occur in glucose-6-phosphate dehydrogenase deficient individuals.

For the complete product monograph text with sections containing pharmacogenetic information highlighted, see the erythromycin and sulfisoxazole product monograph.

*Disclaimer: The contents of this page have not been endorsed by HCSC and are the sole responsibility of PharmGKB.


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for erythromycin

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP3A5 *1A N/A N/A N/A
No VIP available No VIP available VA CYP3A5 *3A N/A N/A N/A
No VIP available CA VA
rs35599367 NC_000007.13:g.99366316G>A, NC_000007.14:g.99768693G>A, NG_008421.1:g.20493C>T, NM_001202855.2:c.522-191C>T, NM_017460.5:c.522-191C>T, XM_011515841.1:c.522-191C>T, XM_011515842.1:c.522-191C>T, rs45581939, rs62471940
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4149056 NC_000012.11:g.21331549T>C, NC_000012.12:g.21178615T>C, NG_011745.1:g.52422T>C, NM_006446.4:c.521T>C, NP_006437.3:p.Val174Ala, rs52816141, rs60037639
T > C
SNP
V174A
No VIP available CA VA
rs717620 NC_000010.10:g.101542578C>T, NC_000010.11:g.99782821C>T, NG_011798.1:g.5116C>T, NM_000392.4:c.-24C>T, XM_005269536.1:c.-24C>T, XM_006717631.2:c.-24C>T, XM_011539291.1:c.-24C>T, XR_945604.1:n.166C>T, XR_945605.1:n.168C>T, rs17216163, rs386485129, rs58371376
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • EM
  • Erythrocin
  • Erythrocin Stearate
  • Erythromycin Stearate
  • Erythromycin estolate
  • Erythromycin ethylsuccinate
  • Erythromycin glucoheptonate
  • Erythromycin lactobionate
  • Erythromycin oxime
Trade Names
  • Abboticin
  • Abomacetin
  • Ak-mycin
  • Akne-Mycin
  • Aknin
  • Benzamycin
  • Benzamycin Pak
  • Bristamycin
  • Dotycin
  • Dumotrycin
  • E-Base
  • E-Glades
  • E-Mycin
  • E-Solve 2
  • EMU
  • ETS
  • Emgel
  • Eritrocina
  • Ermycin
  • Ery-Sol
  • Ery-Tab
  • Eryc
  • Eryc 125
  • Eryc Sprinkles
  • Erycen
  • Erycette
  • Erycin
  • Erycinum
  • Eryderm
  • Erygel
  • Erymax
  • Erypar
  • Erythra-Derm
  • Erythro
  • Erythro-Statin
  • Erythrogran
  • Erythroguent
  • Erythromast 36
  • Erythromid
  • Erythromycin A
  • Erythromycin B
  • Ethril 250
  • Ilocaps
  • Ilosone
  • Ilotycin
  • Ilotycin Gluceptate
  • IndermRetcin
  • Kesso-Mycin
  • Mephamycin
  • Pantomicina
  • Pce
  • Pfizer-e
  • Propiocine
  • R-P Mycin
  • Robimycin
  • Sansac
  • Serp-AFD
  • Stiemycin
  • Taimoxin-F
  • Theramycin Z
  • Torlamicina
  • Wemid
  • Wyamycin S
Brand Mixture Names
  • Sans-Acne Solution (Alcohol Anhydrous + Erythromycin)
  • Staticin Lot (Alcohol Anhydrous + Erythromycin + Laureth 4)
  • Stievamycin Forte Gel (Erythromycin + Tretinoin)
  • Stievamycin Gel (Erythromycin + Tretinoin)
  • T-Stat Lot (Alcohol Anhydrous + Erythromycin)
  • T-Stat Pad-Lot (Alcohol Anhydrous + Erythromycin)

PharmGKB Accession Id

PA449493

Type(s):

Drug

Description

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

Source: Drug Bank

Indication

For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to _Corynebacterium diphtheriae_, in the treatment of infections due to _Corynebacterium minutissimum_, intestinal amebiasis caused by _Entamoeba histolytica_, acute pelvic inflammatory disease caused by _Neisseria gonorrhoeae_, skin and soft tissue infections of mild to moderate severity caused by _Streptococcus pyogenes_ and _Staphylococcus aureus_, primary syphilis caused by _Treponema pallidum_, infections caused by _Chlamydia trachomatis_, nongonococcal urethritis caused by _Ureaplasma urealyticum_, and Legionnaires' disease caused by _Legionella pneumophila_.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

Source: Drug Bank

Pharmacology

Erythromycin is produced by a strain of Streptomyces erythraeus and belongs to the macrolide group of antibiotics. After absorption, erythromycin diffuses readily into most body fluids. In the absence of meningeal inflammation, low concentrations are normally achieved in the spinal fluid, but the passage of the drug across the blood-brain barrier increases in meningitis. Erythromycin is excreted in breast milk. The drug crosses the placental barrier with fetal serum drug levels reaching 5 - 20% of maternal serum concentrations. Erythromycin is not removed by peritoneal dialysis or hemodialysis.

Source: Drug Bank

Food Interaction

Avoid alcohol.|Take on empty stomach: 1 hour before or 2 hours after meals.|Take with a full glass of water Avoid taking with grapefruit juice.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin is partially metabolized by CYP3A4 resulting in numerous drug interactions.

Source: Drug Bank

Protein Binding

Erythromycin is largely bound to plasma proteins, ranging from 75 - 95% binding depending on the form.

Source: Drug Bank

Absorption

Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.

Source: Drug Bank

Half-Life

0.8 - 3 hours

Source: Drug Bank

Toxicity

Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.

Source: Drug Bank

Chemical Properties

Chemical Formula

C37H67NO13

Source: Drug Bank

Average Molecular Weight

733.9268

Source: Drug Bank

Monoisotopic Molecular Weight

733.461241235

Source: Drug Bank

SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O

Source: PubChem

InChI String

InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

Source: PubChem

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics
    Stylized depiction of the genes involved in the transport, metabolism and mechanism of action of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin.

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Interactions

Interaction Description
alprazolam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
alprazolam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
alprazolam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
aminophylline - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, aminophylline. (source: Drug Bank )
amiodarone - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
amiodarone - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
aprepitant - erythromycin The CYP3A4 inhibitor increases the effect and toxicity of aprepitant (source: Drug Bank )
astemizole - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
astemizole - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
atorvastatin - erythromycin The macrolide possibly increases the statin toxicity (source: Drug Bank )
atorvastatin - erythromycin The macrolide, erythromycin, may increase the toxicity of the statin, atorvastatin. (source: Drug Bank )
bromazepam - erythromycin Erythromcyin may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if erythromycin is initiated, discontinued or dose changed. Dosage adjustments may be required. (source: Drug Bank )
bromocriptine - erythromycin Erythromycin increases serum levels of bromocriptine (source: Drug Bank )
bromocriptine - erythromycin Erythromycin increases serum levels of bromocriptine (source: Drug Bank )
buspirone - erythromycin The macrolide increases the effect and toxicity of buspirone (source: Drug Bank )
buspirone - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of buspirone. (source: Drug Bank )
cabergoline - erythromycin Erythromycin increases serum levels and toxicity of cabergoline (source: Drug Bank )
cabergoline - erythromycin Erythromycin increases serum levels and toxicity of cabergoline (source: Drug Bank )
carbamazepine - erythromycin The macrolide increases the effect of carbamazepine (source: Drug Bank )
carbamazepine - erythromycin The macrolide, erythromycin, may increase the effect of carbamazepine. (source: Drug Bank )
cerivastatin - erythromycin The macrolide possibly increases the statin toxicity (source: Drug Bank )
cerivastatin - erythromycin The macrolide, erythromycin, may increase the toxicity of the statin, cerivastatin. (source: Drug Bank )
cilostazol - erythromycin Erythromycin increases the effect of cilostazol (source: Drug Bank )
cinacalcet - erythromycin The macrolide, erythromycin, may increase the serum concentration and toxicity of cinacalcet. (source: Drug Bank )
cisapride - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
cisapride - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
clozapine - erythromycin Erythromycin increases the effect of clozapine (source: Drug Bank )
clozapine - erythromycin Erythromycin increases the effect of clozapine (source: Drug Bank )
colchicine - erythromycin Severe colchicine toxicity can occur (source: Drug Bank )
colchicine - erythromycin Severe colchicine toxicity can occur (source: Drug Bank )
cyclosporine - erythromycin The macrolide increases the effect of cyclosporine (source: Drug Bank )
cyclosporine - erythromycin The macrolide, erythromycin, may increase the effect of cyclosporine. (source: Drug Bank )
diazepam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
diazepam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
digoxin - erythromycin The macrolide increases the effect of digoxin in 10% of patients (source: Drug Bank )
digoxin - erythromycin The macrolide, erythromycin, may increase the effect of digoxin in 10% of patients. (source: Drug Bank )
dihydroergotamine - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
dihydroergotamine - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
disopyramide - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
disopyramide - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
divalproex sodium - erythromycin Erythromycin increases the effect of valproic acid (source: Drug Bank )
docetaxel - erythromycin The agent increases the serum levels and toxicity of docetaxel (source: Drug Bank )
docetaxel - erythromycin Erythromycin may increase the serum levels and toxicity of docetaxel. (source: Drug Bank )
eletriptan - erythromycin This macrolide increases the effect and toxicity of eletriptan (source: Drug Bank )
eletriptan - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of eletriptan. (source: Drug Bank )
eplerenone - erythromycin This CYP3A4 inhibitor increases the effect and toxicity of eplerenone (source: Drug Bank )
ergotamine - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
ergotamine - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - acenocoumarol The macrolide increases anticoagulant effect (source: Drug Bank )
erythromycin - acenocoumarol The macrolide, erythromycin, may increase the anticoagulant effect of acenocoumarol. (source: Drug Bank )
erythromycin - alfentanil The macrolide increases the effect and toxicity of alfentanil (source: Drug Bank )
erythromycin - alfentanil The macrolide, erythromycin, may increase the effect and toxicity of alfentanil. (source: Drug Bank )
erythromycin - alprazolam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - alprazolam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - aminophylline The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, aminophylline. (source: Drug Bank )
erythromycin - amiodarone Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - amiodarone Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - anisindione The macrolide, erythromycin, may increase the anticoagulant effect of anisindione. (source: Drug Bank )
erythromycin - aprepitant This CYP3A4 inhibitor increases effect and toxicity of aprepitant (source: Drug Bank )
erythromycin - astemizole Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - astemizole Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - atorvastatin The macrolide possibly increases the statin toxicity (source: Drug Bank )
erythromycin - atorvastatin The macrolide, erythromycin, may increase the toxicity of the statin, atorvastatin. (source: Drug Bank )
erythromycin - bretylium Increased risk of cardiotoxicity and arryhthmias (source: Drug Bank )
erythromycin - bretylium Increased risk of cardiotoxicity and arryhthmias (source: Drug Bank )
erythromycin - bromocriptine Erythromycin increases serum levels of bromocriptine (source: Drug Bank )
erythromycin - bromocriptine Erythromycin increases serum levels of bromocriptine (source: Drug Bank )
erythromycin - buspirone The macrolide increases the effect and toxicity of buspirone (source: Drug Bank )
erythromycin - buspirone The macrolide, erythromycin, may increase the effect and toxicity of buspirone. (source: Drug Bank )
erythromycin - cabergoline Erythromycin increases serum levels and toxicity of cabergoline (source: Drug Bank )
erythromycin - cabergoline Erythromycin increases serum levels and toxicity of cabergoline (source: Drug Bank )
erythromycin - carbamazepine The macrolide increases the effect of carbamazepine (source: Drug Bank )
erythromycin - carbamazepine The macrolide, erythromycin, may increase the effect of carbamazepine. (source: Drug Bank )
erythromycin - cerivastatin The macrolide possibly increases the statin toxicity (source: Drug Bank )
erythromycin - cerivastatin The macrolide, erythromycin, may increase the toxicity of the statin, cerivastatin. (source: Drug Bank )
erythromycin - cilostazol Erythromycin increases the effect of cilostazol (source: Drug Bank )
erythromycin - cinacalcet The macrolide, erythromycin, may increase the serum concentration and toxicity of cinacalcet. (source: Drug Bank )
erythromycin - cisapride Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - cisapride Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - citalopram Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - citalopram Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - clozapine Erythromycin increases the effect of clozapine (source: Drug Bank )
erythromycin - clozapine Erythromycin increases the effect of clozapine (source: Drug Bank )
erythromycin - colchicine Severe colchicine toxicity can occur (source: Drug Bank )
erythromycin - colchicine Severe colchicine toxicity can occur (source: Drug Bank )
erythromycin - cyclosporine The macrolide increases the effect of cyclosporine (source: Drug Bank )
erythromycin - cyclosporine The macrolide, erythromycin, may increase the effect of cyclosporine. (source: Drug Bank )
erythromycin - diazepam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - diazepam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - dicumarol The macrolide increases anticoagulant effect (source: Drug Bank )
erythromycin - dicumarol The macrolide, erythromycin, may increase the anticoagulant effect of dicumarol.. (source: Drug Bank )
erythromycin - digoxin The macrolide increases the effect of digoxin in 10% of patients (source: Drug Bank )
erythromycin - digoxin The macrolide, erythromycin, may increase the effect of digoxin in 10% of patients. (source: Drug Bank )
erythromycin - dihydroergotamine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - dihydroergotoxine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - disopyramide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - disopyramide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - docetaxel The agent increases the serum levels and toxicity of docetaxel (source: Drug Bank )
erythromycin - docetaxel Erythromycin may increase the serum levels and toxicity of docetaxel. (source: Drug Bank )
erythromycin - dofetilide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - dofetilide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - dyphylline The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, dyphylline. (source: Drug Bank )
erythromycin - eletriptan The macrolide increases the effect and toxicity of eletriptan (source: Drug Bank )
erythromycin - eletriptan The macrolide, erythromycin, may increase the effect and toxicity of eletriptan. (source: Drug Bank )
erythromycin - eplerenone This CYP3A4 inhibitor increases the effect and toxicity of eplerenone (source: Drug Bank )
erythromycin - ergonovine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - ergonovine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - ergotamine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank )
erythromycin - erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank )
erythromycin - everolimus The macrolide, erythromycin, may increase the serum concentration and toxicity of everolimus. (source: Drug Bank )
erythromycin - felodipine Erythromycin increases the effect of felodipine (source: Drug Bank )
erythromycin - felodipine Erythromycin increases the effect of felodipine (source: Drug Bank )
erythromycin - fluoxetine Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - fluoxetine Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - gefitinib This CYP3A4 inhibitor increases levels/toxicity of gefitinib (source: Drug Bank )
erythromycin - gefitinib This CYP3A4 inhibitor increases levels/toxicity of gefitinib (source: Drug Bank )
erythromycin - grepafloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - grepafloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - imatinib The macrolide increases levels of imatinib (source: Drug Bank )
erythromycin - imatinib The macrolide, erythromycin, may increase the serum concentration of imatinib. (source: Drug Bank )
erythromycin - itraconazole The macrolide increases the effect and toxicity of itraconazole (source: Drug Bank )
erythromycin - itraconazole The macrolide, erythromycin, may increase the effect and toxicity of itraconazole. (source: Drug Bank )
erythromycin - levofloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - levofloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - lincomycin Possible antagonism of action with this combination (source: Drug Bank )
erythromycin - lovastatin The macrolide possibly increases the statin toxicity (source: Drug Bank )
erythromycin - lovastatin The macrolide, erythromycin, may increase the toxicity of the statin, lovastatin. (source: Drug Bank )
erythromycin - mesoridazine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - mesoridazine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - methylergonovine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - methylergonovine Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - methylprednisolone The macrolide increases the effect of corticosteroid (source: Drug Bank )
erythromycin - methylprednisolone The macrolide, erythromycin, may increase the effect of corticosteroid, methylprednisolone. (source: Drug Bank )
erythromycin - methysergide Possible ergotism and severe ischemia with this combination (source: Drug Bank )
erythromycin - midazolam The macrolide increases the efect of the benzodiazepine (source: Drug Bank )
erythromycin - midazolam The macrolide increases the efect of the benzodiazepine (source: Drug Bank )
erythromycin - moxifloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - moxifloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - oxtriphylline The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline. (source: Drug Bank )
erythromycin - pimozide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - pimozide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - quetiapine This macrolide increases the effect/toxicity of quetiapine (source: Drug Bank )
erythromycin - quetiapine The macrolide, erythromycin, may increase the effect and toxicity of quetiapine. (source: Drug Bank )
erythromycin - quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - quinupristin This combination presents an increased risk of toxicity (source: Drug Bank )
erythromycin - ranolazine Increased levels of ranolazine - risk of toxicity (source: Drug Bank )
erythromycin - repaglinide This macrolide increases effect of repaglinide (source: Drug Bank )
erythromycin - repaglinide The macrolide, erythromycin, may increase effect of repaglinide. (source: Drug Bank )
erythromycin - rifabutin The rifamycin decreases the effect of the macrolide (source: Drug Bank )
erythromycin - rifabutin The rifamycin, rifabutin, may decrease the effect of the macrolide, erythromycin. (source: Drug Bank )
erythromycin - rifampin The rifamycin decreases the effect of the macrolide (source: Drug Bank )
erythromycin - rifampin The rifamycin, rifampin, may decrease the effect of the macrolide, erythromycin. (source: Drug Bank )
erythromycin - ritonavir Increased toxicity of both agents (source: Drug Bank )
erythromycin - ritonavir Increased toxicity of both agents (source: Drug Bank )
erythromycin - sertraline Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - sertraline Possible serotoninergic syndrome with this combination (source: Drug Bank )
erythromycin - sibutramine Erythromycin increases the effect and toxicity of sibutramine (source: Drug Bank )
erythromycin - sibutramine Erythromycin increases the effect and toxicity of sibutramine (source: Drug Bank )
erythromycin - sildenafil The macrolide increases the effect and toxicity of sildenafil (source: Drug Bank )
erythromycin - sildenafil The macrolide, erythromycin, may increase the effect and toxicity of sildenafil. (source: Drug Bank )
erythromycin - simvastatin The macrolide possibly increases the statin toxicity (source: Drug Bank )
erythromycin - simvastatin The macrolide, erythromycin, may increase the toxicity of the statin, simvastatin. (source: Drug Bank )
erythromycin - sirolimus The macrolide increases sirolimus levels (source: Drug Bank )
erythromycin - sirolimus The macrolide, erythromycin, may increase the serum concentration of sirolimus. (source: Drug Bank )
erythromycin - sodium Erythromycin increases the effect of valproic acid (source: Drug Bank )
erythromycin - sotalol Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - sotalol Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - sparfloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - sparfloxacin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - tacrolimus Erythromycin increases the effect and toxicity of tacrolimus (source: Drug Bank )
erythromycin - tacrolimus Erythromycin increases the effect and toxicity of tacrolimus (source: Drug Bank )
erythromycin - terfenadine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - terfenadine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - theophylline The macrolide increases the effect and toxicity of theophylline (source: Drug Bank )
erythromycin - theophylline The macrolide, erythromycin, may increase the effect and toxicity of theophylline. (source: Drug Bank )
erythromycin - thioridazine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - thioridazine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - triazolam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - triazolam The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
erythromycin - vardenafil The macrolide increases the effect and toxicity of vardenafil (source: Drug Bank )
erythromycin - vardenafil The macrolide, erythromycin, may increase the effect and toxicity of vardenafil. (source: Drug Bank )
erythromycin - verapamil Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - verapamil Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
erythromycin - vinblastine Erythromycin increases vinblastine toxicity (source: Drug Bank )
erythromycin - vinblastine Erythromycin increases vinblastine toxicity (source: Drug Bank )
erythromycin - warfarin The macrolide increases anticoagulant effect (source: Drug Bank )
erythromycin - warfarin The macrolide, erythromycin, may increase the anticoagulant effect of warfarin. (source: Drug Bank )
erythromycin - zafirlukast Erythromycin decreases the effect of zafirlukast (source: Drug Bank )
erythromycin - zafirlukast Erythromycin decreases the effect of zafirlukast (source: Drug Bank )
felodipine - erythromycin Erythromycin increases the effect of felodipine (source: Drug Bank )
felodipine - erythromycin Erythromycin increases the effect of felodipine (source: Drug Bank )
fluoxetine - erythromycin Possible serotoninergic syndrome with this combination (source: Drug Bank )
fluoxetine - erythromycin Possible serotoninergic syndrome with this combination (source: Drug Bank )
gefitinib - erythromycin This CYP3A4 inhibitor increases levels/toxicity of gefitinib (source: Drug Bank )
gefitinib - erythromycin This CYP3A4 inhibitor increases levels/toxicity of gefitinib (source: Drug Bank )
grepafloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
grepafloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
imatinib - erythromycin The macrolide increases levels of imatinib (source: Drug Bank )
imatinib - erythromycin The macrolide, erythromycin, may increase the serum concentration of imatinib. (source: Drug Bank )
itraconazole - erythromycin The macrolide increases the effect and toxicity of itraconazole (source: Drug Bank )
itraconazole - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of itraconazole. (source: Drug Bank )
levofloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
levofloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
lincomycin - erythromycin Possible antagonism of action (source: Drug Bank )
lovastatin - erythromycin The macrolide possibly increases the statin toxicity (source: Drug Bank )
lovastatin - erythromycin The macrolide, erythromycin, may increase the toxicity of the statin, lovastatin. (source: Drug Bank )
mesoridazine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
mesoridazine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
methysergide - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
methysergide - erythromycin Possible ergotism and severe ischemia with this combination (source: Drug Bank )
midazolam - erythromycin The macrolide increases the effect of benzodiazepine (source: Drug Bank )
midazolam - erythromycin The macrolide increases the effect of benzodiazepine (source: Drug Bank )
moxifloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
moxifloxacin - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
oxtriphylline - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline. (source: Drug Bank )
pimozide - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
pimozide - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
quetiapine - erythromycin This macrolide increases the effect/toxicity of quetiapine (source: Drug Bank )
quetiapine - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of quetiapine. (source: Drug Bank )
quinidine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
quinidine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
quinupristin - erythromycin This combination presents an increased risk of toxicity (source: Drug Bank )
ranolazine - erythromycin Increased levels of ranolazine - risk of toxicity (source: Drug Bank )
repaglinide - erythromycin The macrolide increases the effect of repaglinide (source: Drug Bank )
repaglinide - erythromycin The macrolide, erythromycin, may increase the effect of repaglinide. (source: Drug Bank )
rifabutin - erythromycin The rifamycin decreases the effect of the macrolide (source: Drug Bank )
rifabutin - erythromycin The rifamycin, rifabutin, may decrease the effect of the macrolide, erythromycin. (source: Drug Bank )
rifampin - erythromycin The rifamycin decreases the effect of the macrolide (source: Drug Bank )
rifampin - erythromycin The rifamycin, rifampin, may decrease the effect of the macrolide, erythromycin. (source: Drug Bank )
tamsulosin - erythromycin Erythromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Erythromycin is initiated, discontinued, or dose changed. (source: Drug Bank )
tamsulosin - erythromycin Erythromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Erythromycin is initiated, discontinued, or dose changed. (source: Drug Bank )
telithromycin - erythromycin Telithromycin may reduce clearance of Erythromycin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erythromycin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
terfenadine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
terfenadine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
theophylline - erythromycin The macrolide increases the effect and toxicity of theophylline (source: Drug Bank )
theophylline - erythromycin The macrolide, erythromycin, may increase the effect and toxicity of theophylline. (source: Drug Bank )
thioridazine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
thioridazine - erythromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
thiothixene - erythromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
thiothixene - erythromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
topotecan - erythromycin The p-glycoprotein inhibitor, Erythromycin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided. (source: Drug Bank )
toremifene - erythromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
tramadol - erythromycin Erythromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. (source: Drug Bank )
trazodone - erythromycin The CYP3A4 inhibitor, Erythromycin , may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
trazodone - erythromycin The CYP3A4 inhibitor, Erythromycin , may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
triazolam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
triazolam - erythromycin The macrolide increases the effect of the benzodiazepine (source: Drug Bank )
trimipramine - erythromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. (source: Drug Bank )
valproic acid - erythromycin The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vardenafil - erythromycin Erythromycin may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
verapamil - erythromycin Erythromycin, a moderate CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of Verapamil if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vincristine - erythromycin Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vinorelbine - erythromycin Erythromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinorelbine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
voriconazole - erythromycin Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of erythromycin by decreasing its metabolism. Erythromycin may increase the serum concentration of voriconazole by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed. (source: Drug Bank )
vorinostat - erythromycin Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank )
zafirlukast - erythromycin Zafirlukast serum concentrations may be decreased by Erythromycin. (source: Drug Bank )
ziprasidone - erythromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated. (source: Drug Bank )
zopiclone - erythromycin The macrolide antibiotic, erythromycin, may increase the serum concentration of zopiclone. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if erythromycin is initiated, discontinued or dose changed. (source: Drug Bank )
zuclopenthixol - erythromycin Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank )

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Publications related to erythromycin: 69

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Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis. Archives of biochemistry and biophysics. 2017. Yi Myeongjin, et al. PubMed
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PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. Pharmacogenetics and genomics. 2017. Fohner Alison E, et al. PubMed
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Interethnic differences in pharmacokinetics of antibacterials. Clinical pharmacokinetics. 2015. Tsai Danny, et al. PubMed
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Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity. British journal of clinical pharmacology. 2014. Carls Alexandra, et al. PubMed
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Mechanisms and assessment of statin-related muscular adverse effects. British journal of clinical pharmacology. 2014. Moßhammer Dirk, et al. PubMed
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The genetics of pro-arrhythmic adverse drug reactions. British journal of clinical pharmacology. 2014. Petropoulou Evmorfia, et al. PubMed
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A 30-years review on pharmacokinetics of antibiotics: is the right time for pharmacogenetics?. Current drug metabolism. 2014. Baietto Lorena, et al. PubMed
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CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin. Pharmacogenomics. 2013. Elens Laure, et al. PubMed
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OATP1B1 Polymorphism as a Determinant of Erythromycin Disposition. Clinical pharmacology and therapeutics. 2012. Lancaster C S, et al. PubMed
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Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. European journal of clinical pharmacology. 2012. Zarogoulidis P, et al. PubMed
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Hepatic safety of antibiotics used in primary care. The Journal of antimicrobial chemotherapy. 2011. Andrade Raúl J, et al. PubMed
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Effect of ABCC2 (MRP2) Transport Function on Erythromycin Metabolism. Clinical pharmacology and therapeutics. 2011. Franke R M, et al. PubMed
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Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenetics and genomics. 2011. Hodges Laura M, et al. PubMed
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KCNH2 pharmacogenomics summary. Pharmacogenetics and genomics. 2010. Oshiro Connie, et al. PubMed
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Drug-induced long QT syndrome. Pharmacological reviews. 2010. Kannankeril Prince, et al. PubMed
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Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1. British journal of pharmacology. 2010. Yang Tao, et al. PubMed
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Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Pharmacogenetics and genomics. 2010. Agrawal Vishal, et al. PubMed
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Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clinical pharmacology and therapeutics. 2010. Oswald S, et al. PubMed
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In vivo evaluation of drug-drug interaction via mechanism-based inhibition by macrolide antibiotics in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals. 2009. Ogasawara Akihito, et al. PubMed
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Macrolide-induced digoxin toxicity: a population-based study. Clinical pharmacology and therapeutics. 2009. Gomes T, et al. PubMed
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Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines. Biochemical pharmacology. 2009. Kühne Annett, et al. PubMed
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Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009. Hauswald Stefanie, et al. PubMed
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Genetic determinants of response to clopidogrel and cardiovascular events. The New England journal of medicine. 2009. Simon Tabassome, et al. PubMed
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Cost-effectiveness of 99mTc-sestamibi in predicting response to chemotherapy in patients with lung cancer: systematic review and meta-analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009. Mohan Hosahalli K, et al. PubMed
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Induction of multiple drug transporters by efavirenz. Journal of pharmacological sciences. 2009. Weiss Johanna, et al. PubMed
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Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxidants & redox signaling. 2009. Kuo Macus Tien. PubMed
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Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Clinical pharmacology and therapeutics. 2008. Franke R M, et al. PubMed
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Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008. Luna-Tortós Carlos, et al. PubMed
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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed
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Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels. Molecular pharmacology. 2008. Perrin Mark J, et al. PubMed
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A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug metabolism and disposition: the biological fate of chemicals. 2008. Yasuda Kazuto, et al. PubMed
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Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica; the fate of foreign compounds in biological systems. 2008. Zhou S-F. PubMed
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Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008. Uhr Manfred, et al. PubMed
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Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study. Pharmacological research : the official journal of the Italian Pharmacological Society. 2008. Nikisch Georg, et al. PubMed
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Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clinical pharmacology and therapeutics. 2007. Frassetto L A, et al. PubMed
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The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug metabolism and disposition: the biological fate of chemicals. 2007. Seithel Annick, et al. PubMed
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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert review of anticancer therapy. 2007. Fox Elizabeth, et al. PubMed
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Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2007. Marguerite Véronique, et al. PubMed
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Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Molecular pharmaceutics. 2007. Collnot Eva-Maria, et al. PubMed
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The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity. Clinical pharmacology and therapeutics. 2006. Kurnik Daniel, et al. PubMed
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Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability. The Journal of pharmacology and experimental therapeutics. 2006. Wisialowski Todd, et al. PubMed
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Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer research. 2006. Leggas Markos, et al. PubMed
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Impact of P-glycoprotein on clopidogrel absorption. Clinical pharmacology and therapeutics. 2006. Taubert Dirk, et al. PubMed
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Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. European journal of clinical pharmacology. 2006. Polasek Thomas M, et al. PubMed
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Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition. Expert opinion on drug delivery. 2006. Dey Surajit. PubMed
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Oral erythromycin and the risk of sudden death from cardiac causes. The New England journal of medicine. 2004. Ray Wayne A, et al. PubMed
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Influence of lipid lowering fibrates on P-glycoprotein activity in vitro. Biochemical pharmacology. 2004. Ehrhardt Manuela, et al. PubMed
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Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharmaceutical research. 2004. Hochman Jerome H, et al. PubMed
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Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clinical pharmacology and therapeutics. 2004. Marzolini Catia, et al. PubMed
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Genetic polymorphisms of the human MDR1 drug transporter. Annual review of pharmacology and toxicology. 2003. Schwab Matthias, et al. PubMed
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Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual review of pharmacology and toxicology. 2003. Ding Xinxin, et al. PubMed
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Clinical pharmacokinetics of galantamine. Clinical pharmacokinetics. 2003. Farlow Martin R. PubMed
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Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (New York, N.Y.). 2002. Splawski Igor, et al. PubMed
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Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed
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The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics. 2001. Zhang J, et al. PubMed
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Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn-Schmiedeberg's archives of pharmacology. 2001. Pauli-Magnus C, et al. PubMed
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Clinical pharmacokinetics of fluvastatin. Clinical pharmacokinetics. 2001. Scripture C D, et al. PubMed
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In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Clinical pharmacology and therapeutics. 2000. McCune J S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. The Journal of clinical investigation. 1999. Greiner B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo. Cancer letters. 1999. Szabó D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annual review of pharmacology and toxicology. 1999. Ambudkar S V, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Increased systemic toxicity of sarcoma chemotherapy due to combination with the P-glycoprotein inhibitor cyclosporin. International journal of clinical pharmacology and therapeutics. 1998. Theis J G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity. Biochimica et biophysica acta. 1997. Litman T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell. 1996. van Helvoort A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. The Journal of pharmacology and experimental therapeutics. 1994. Shimada T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL. Blood. 1994. Ross D D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
P-glycoprotein structure and evolutionary homologies. Cytotechnology. 1993. Croop J M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Comparison of the acid stability of azithromycin and erythromycin A. The Journal of antimicrobial chemotherapy. 1990. Fiese E F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). Clinical pharmacokinetics. 1989. Periti P, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0168-0215-01
DrugBank:
DB00199
PDB:
ERY
ChEBI:
48923
KEGG Compound:
C01912
KEGG Drug:
D00140
PubChem Compound:
12560
PubChem Substance:
46508487
5020
Drugs Product Database (DPD):
2237041
ChemSpider:
12041
HET:
ERY
Therapeutic Targets Database:
DAP000111
FDA Drug Label at DailyMed:
51709310-195d-4070-87fa-434e2e5e07bd

Clinical Trials

These are trials that mention erythromycin and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

provided by nursa.org

No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.