Chemical: Drug
donepezil

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.



PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for donepezil

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA APOE E2 N/A N/A N/A
No VIP available No VIP available VA APOE E3 N/A N/A N/A
No VIP available No VIP available VA APOE E4 N/A N/A N/A
No VIP available CA VA CYP2D6 *1 N/A N/A N/A
No VIP available CA VA CYP2D6 *1xN N/A N/A N/A
No VIP available CA No VIP available CYP2D6 *3 N/A N/A N/A
No VIP available CA VA CYP2D6 *4 N/A N/A N/A
No VIP available CA VA CYP2D6 *5 N/A N/A N/A
No VIP available CA No VIP available CYP2D6 *6 N/A N/A N/A
No VIP available No VIP available VA CYP3A7 *1A N/A N/A N/A
No VIP available No VIP available VA CYP3A7 *1C N/A N/A N/A
No VIP available No Clinical Annotations available VA
CYP2D6 poor metabolizer N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs1045642 NC_000007.13:g.87138645A>G, NC_000007.14:g.87509329A>G, NG_011513.1:g.208920T>C, NM_000927.4:c.3435T>C, NP_000918.2:p.Ile1145=, rs10239679, rs11568726, rs117328163, rs17210003, rs2229108, rs386513066, rs60023214, rs9690664
A > G
SNP
I1145I
No VIP available No Clinical Annotations available VA
rs1057868 NC_000007.13:g.75615006C>T, NC_000007.14:g.75985688C>T, NG_008930.1:g.75587C>T, NM_000941.2:c.1508C>T, NP_000932.3:p.Ala503Val, NW_003871064.1:g.3514924C>T, XM_005250459.1:c.1508C>T, XM_005250460.1:c.1205C>T, XM_005250461.1:c.932C>T, XM_005277600.1:c.1508C>T, XM_005277601.1:c.1205C>T, XM_005277602.1:c.932C>T, XP_005250516.1:p.Ala503Val, XP_005250517.1:p.Ala402Val, XP_005250518.1:p.Ala311Val, XP_005277657.1:p.Ala503Val, XP_005277658.1:p.Ala402Val, XP_005277659.1:p.Ala311Val, rs17840495, rs17846082, rs17859083, rs3198400, rs57699079
C > T
SNP
A503V
No VIP available No Clinical Annotations available VA
rs10776586 NC_000010.10:g.50858346T>C, NC_000010.11:g.49650300T>C, NG_011797.1:g.46206T>C, NM_001142929.1:c.1157+664T>C, NM_001142933.1:c.1265+664T>C, NM_001142934.1:c.1157+664T>C, NM_020549.4:c.1511+664T>C, NM_020984.3:c.1157+664T>C, NM_020985.3:c.1157+664T>C, NM_020986.3:c.1157+664T>C, rs17775728, rs56990565
T > C
SNP
No VIP available No Clinical Annotations available VA
rs11101187 NC_000010.10:g.50837033C>T, NC_000010.11:g.49628987C>T, NG_011797.1:g.24893C>T, NM_001142929.1:c.757+1202C>T, NM_001142933.1:c.865+1202C>T, NM_001142934.1:c.757+1202C>T, NM_020549.4:c.1111+1202C>T, NM_020984.3:c.757+1202C>T, NM_020985.3:c.757+1202C>T, NM_020986.3:c.757+1202C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs11101192 NC_000010.10:g.50854767G>A, NC_000010.11:g.49646721G>A, NG_011797.1:g.42627G>A, NM_001142929.1:c.927+47G>A, NM_001142933.1:c.1035+47G>A, NM_001142934.1:c.927+47G>A, NM_020549.4:c.1281+47G>A, NM_020984.3:c.927+47G>A, NM_020985.3:c.927+47G>A, NM_020986.3:c.927+47G>A, rs57573103
G > A
SNP
No VIP available No Clinical Annotations available VA
rs11101193 NC_000010.10:g.50856138G>T, NC_000010.11:g.49648092G>T, NG_011797.1:g.43998G>T, NM_001142929.1:c.928-415G>T, NM_001142933.1:c.1036-415G>T, NM_001142934.1:c.928-415G>T, NM_020549.4:c.1282-415G>T, NM_020984.3:c.928-415G>T, NM_020985.3:c.928-415G>T, NM_020986.3:c.928-415G>T, rs58391990
G > T
SNP
No VIP available No Clinical Annotations available VA
rs1128503 NC_000007.13:g.87179601A>G, NC_000007.14:g.87550285A>G, NG_011513.1:g.167964T>C, NM_000927.4:c.1236T>C, NP_000918.2:p.Gly412=, rs116989428, rs17276907, rs2032587, rs2229105, rs28365046, rs386518005, rs58257317
A > G
SNP
G412G
No VIP available No Clinical Annotations available VA
rs11685873 NC_000002.11:g.108611519G>A, NC_000002.12:g.107995063G>A, NG_042267.1:g.13550G>A, NM_001305005.2:c.448+1936G>A, NM_001305006.2:c.133+1936G>A, NM_001305007.2:c.-257+1936G>A, NM_021815.4:c.448+1936G>A, XM_005264008.1:c.448+1936G>A, XM_005264009.1:c.133+1936G>A, XM_011511579.1:c.334+1936G>A, XM_011511580.1:c.196+1936G>A, XM_011511581.1:c.133+1936G>A, rs61375312
G > A
SNP
No VIP available No Clinical Annotations available VA
rs12246528 NC_000010.10:g.50835264G>A, NC_000010.11:g.49627218G>A, NG_011797.1:g.23124G>A, NM_001142929.1:c.580-390G>A, NM_001142933.1:c.688-390G>A, NM_001142934.1:c.580-390G>A, NM_020549.4:c.934-390G>A, NM_020984.3:c.580-390G>A, NM_020985.3:c.580-390G>A, NM_020986.3:c.580-390G>A, rs61498554
G > A
SNP
No VIP available No Clinical Annotations available VA
rs12264845 NC_000010.10:g.50863083A>C, NC_000010.11:g.49655037A>C, NG_011797.1:g.50943A>C, NM_001142929.1:c.1281-58A>C, NM_001142933.1:c.1389-58A>C, NM_001142934.1:c.1281-58A>C, NM_020549.4:c.1635-58A>C, NM_020984.3:c.1281-58A>C, NM_020985.3:c.1281-58A>C, NM_020986.3:c.1281-58A>C
A > C
SNP
No VIP available No Clinical Annotations available VA
rs12266458 NC_000010.10:g.50847997C>T, NC_000010.11:g.49639951C>T, NG_011797.1:g.35857C>T, NM_001142929.1:c.758-6554C>T, NM_001142933.1:c.866-6554C>T, NM_001142934.1:c.758-6554C>T, NM_020549.4:c.1112-6554C>T, NM_020984.3:c.758-6554C>T, NM_020985.3:c.758-6554C>T, NM_020986.3:c.758-6554C>T, rs57653614
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1355534 NC_000003.11:g.165505857T>C, NC_000003.12:g.165788069T>C, NG_009031.1:g.54397A>G, NM_000055.2:c.1518-1758A>G, XM_005247685.1:c.1641-1758A>G, rs36152929, rs59339069
T > C
SNP
No VIP available No Clinical Annotations available VA
rs1523130 NC_000003.11:g.119499507T>C, NC_000003.12:g.119780660T>C, NG_011856.1:g.5177T>C, NM_003889.3:c.-1663T>C, NM_033013.2:c.-1663T>C, XM_005247866.1:c.-1828T>C, rs118196528, rs3814054, rs59854583, rs61314694
T > C
SNP
No VIP available No Clinical Annotations available VA
rs17798800 NC_000013.10:g.34950527C>T, NC_000013.11:g.34376390C>T, XR_941846.1:n.182+28266C>T, XR_941847.1:n.182+28266C>T, XR_941848.1:n.180+28266C>T, rs57038156
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1803274 NC_000003.11:g.165491280C>T, NC_000003.12:g.165773492C>T, NG_009031.1:g.68974G>A, NM_000055.2:c.1699G>A, NP_000046.1:p.Ala567Thr, XM_005247685.1:c.1822G>A, XP_005247742.1:p.Ala608Thr, rs17713328, rs17846898, rs3773869, rs52816414, rs60242395
C > T
SNP
A567T
No VIP available No Clinical Annotations available VA
rs1917818 NC_000010.10:g.50849342T>G, NC_000010.11:g.49641296T>G, NG_011797.1:g.37202T>G, NM_001142929.1:c.758-5209T>G, NM_001142933.1:c.866-5209T>G, NM_001142934.1:c.758-5209T>G, NM_020549.4:c.1112-5209T>G, NM_020984.3:c.758-5209T>G, NM_020985.3:c.758-5209T>G, NM_020986.3:c.758-5209T>G, rs52822860, rs59761396
T > G
SNP
No VIP available No Clinical Annotations available VA
rs2032582 NC_000007.13:g.87160618A>C, NC_000007.13:g.87160618A>T, NC_000007.14:g.87531302A>C, NC_000007.14:g.87531302A>T, NG_011513.1:g.186947T>A, NG_011513.1:g.186947T>G, NM_000927.4:c.2677T>A, NM_000927.4:c.2677T>G, NP_000918.2:p.Ser893Ala, NP_000918.2:p.Ser893Thr, rs10228331, rs2229106, rs386553610, rs57135550, rs9641018
A > C
SNP
S893A
No VIP available No Clinical Annotations available VA
rs2177369 NC_000010.10:g.50843729G>A, NC_000010.11:g.49635683G>A, NG_011797.1:g.31589G>A, NM_001142929.1:c.757+7898G>A, NM_001142933.1:c.865+7898G>A, NM_001142934.1:c.757+7898G>A, NM_020549.4:c.1111+7898G>A, NM_020984.3:c.757+7898G>A, NM_020985.3:c.757+7898G>A, NM_020986.3:c.757+7898G>A, rs58567404
G > A
SNP
No VIP available CA VA
rs2177370 NC_000010.10:g.50838874A>G, NC_000010.11:g.49630828A>G, NG_011797.1:g.26734A>G, NM_001142929.1:c.757+3043A>G, NM_001142933.1:c.865+3043A>G, NM_001142934.1:c.757+3043A>G, NM_020549.4:c.1111+3043A>G, NM_020984.3:c.757+3043A>G, NM_020985.3:c.757+3043A>G, NM_020986.3:c.757+3043A>G, rs57851564
A > G
SNP
No VIP available No Clinical Annotations available VA
rs2472677 NC_000003.11:g.119518417C>T, NC_000003.12:g.119799570C>T, NG_011856.1:g.24087C>T, NM_003889.3:c.-22-7659C>T, NM_022002.2:c.96-7659C>T, NM_033013.2:c.-22-7659C>T, XM_005247866.1:c.-187-7659C>T, rs57813967
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2571598 NC_000007.13:g.100489639C>T, NC_000007.14:g.100892018C>T, NG_007474.1:g.8903G>A, NM_000665.4:c.1553+316G>A, NM_001282449.1:c.1289+316G>A, NM_001302621.1:c.1553+316G>A, NM_001302622.1:c.1553+316G>A, NM_015831.2:c.1553+316G>A, XM_005250357.1:c.1553+316G>A, XM_005250358.1:c.1553+316G>A, XM_005250359.1:c.1289+316G>A, XM_006715995.2:c.1553+316G>A, XM_011516225.1:c.2051+316G>A, XM_011516226.1:c.1787+316G>A, XM_011516227.1:c.1553+316G>A, XM_011516228.1:c.1553+316G>A, XM_011516229.1:c.1553+316G>A, XR_927464.1:n.1924+316G>A, XR_927465.1:n.1615-680G>A, rs17880361, rs57627110
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2740574 NC_000007.13:g.99382096C>T, NC_000007.14:g.99784473C>T, NG_008421.1:g.4713G>A, NM_001202855.2:c.-392G>A, NM_017460.5:c.-392G>A, XM_011515841.1:c.-392G>A, XM_011515842.1:c.-392G>A, rs3176920, rs36231114, rs59393892
C > T
SNP
No VIP available No Clinical Annotations available VA
rs35599367 NC_000007.13:g.99366316G>A, NC_000007.14:g.99768693G>A, NG_008421.1:g.20493C>T, NM_001202855.2:c.522-191C>T, NM_017460.5:c.522-191C>T, XM_011515841.1:c.522-191C>T, XM_011515842.1:c.522-191C>T, rs45581939, rs62471940
G > A
SNP
No VIP available CA VA
rs3793790 NC_000010.10:g.50840736G>A, NC_000010.11:g.49632690G>A, NG_011797.1:g.28596G>A, NM_001142929.1:c.757+4905G>A, NM_001142933.1:c.865+4905G>A, NM_001142934.1:c.757+4905G>A, NM_020549.4:c.1111+4905G>A, NM_020984.3:c.757+4905G>A, NM_020985.3:c.757+4905G>A, NM_020986.3:c.757+4905G>A, rs59782324
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3793791 NC_000010.10:g.50841704C>T, NC_000010.11:g.49633658C>T, NG_011797.1:g.29564C>T, NM_001142929.1:c.757+5873C>T, NM_001142933.1:c.865+5873C>T, NM_001142934.1:c.757+5873C>T, NM_020549.4:c.1111+5873C>T, NM_020984.3:c.757+5873C>T, NM_020985.3:c.757+5873C>T, NM_020986.3:c.757+5873C>T, rs56496455, rs56687561
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3793797 NC_000010.10:g.50857849C>T, NC_000010.11:g.49649803C>T, NG_011797.1:g.45709C>T, NM_001142929.1:c.1157+167C>T, NM_001142933.1:c.1265+167C>T, NM_001142934.1:c.1157+167C>T, NM_020549.4:c.1511+167C>T, NM_020984.3:c.1157+167C>T, NM_020985.3:c.1157+167C>T, NM_020986.3:c.1157+167C>T, rs36154365, rs56811317
C > T
SNP
No VIP available No Clinical Annotations available VA
rs3793798 NC_000010.10:g.50871466T>A, NC_000010.11:g.49663420T>A, NG_011797.1:g.59326T>A, NM_001142929.1:c.1623+638T>A, NM_001142933.1:c.1731+638T>A, NM_001142934.1:c.1623+638T>A, NM_020549.4:c.1977+638T>A, NM_020984.3:c.1623+638T>A, NM_020985.3:c.1623+638T>A, NM_020986.3:c.1623+638T>A, rs59172882
T > A
SNP
No VIP available No Clinical Annotations available VA
rs3793800 NC_000010.10:g.50871716A>G, NC_000010.11:g.49663670A>G, NG_011797.1:g.59576A>G, NM_001142929.1:c.1623+888A>G, NM_001142933.1:c.1731+888A>G, NM_001142934.1:c.1623+888A>G, NM_020549.4:c.1977+888A>G, NM_020984.3:c.1623+888A>G, NM_020985.3:c.1623+888A>G, NM_020986.3:c.1623+888A>G, rs17177963, rs58251637
A > G
SNP
No VIP available No Clinical Annotations available VA
rs3793801 NC_000010.10:g.50872912C>T, NC_000010.11:g.49664866C>T, NG_011797.1:g.60772C>T, NM_001142929.1:c.1713C>T, NM_001142933.1:c.1821C>T, NM_001142934.1:c.1713C>T, NM_020549.4:c.2067C>T, NM_020984.3:c.1713C>T, NM_020985.3:c.1713C>T, NM_020986.3:c.1713C>T, NP_001136401.1:p.Ile571=, NP_001136405.1:p.Ile607=, NP_001136406.1:p.Ile571=, NP_065574.3:p.Ile689=, NP_066264.3:p.Ile571=, NP_066265.3:p.Ile571=, NP_066266.3:p.Ile571=, rs17784428, rs58588938
C > T
SNP
I571I
No VIP available No Clinical Annotations available VA
rs3810950 NC_000010.10:g.50824619G>A, NC_000010.11:g.49616573G>A, NG_011797.1:g.12479G>A, NM_001142929.1:c.4G>A, NM_001142933.1:c.112G>A, NM_001142934.1:c.4G>A, NM_020549.4:c.358G>A, NM_020984.3:c.4G>A, NM_020985.3:c.4G>A, NM_020986.3:c.4G>A, NP_001136401.1:p.Ala2Thr, NP_001136405.1:p.Ala38Thr, NP_001136406.1:p.Ala2Thr, NP_065574.3:p.Ala120Thr, NP_066264.3:p.Ala2Thr, NP_066265.3:p.Ala2Thr, NP_066266.3:p.Ala2Thr, rs17775591, rs60084580
G > A
SNP
A2T
No VIP available No Clinical Annotations available VA
rs4646437 NC_000007.13:g.99365083G>A, NC_000007.14:g.99767460G>A, NG_008421.1:g.21726C>T, NM_001202855.2:c.671-205C>T, NM_017460.5:c.671-202C>T, XM_011515841.1:c.671-202C>T, XM_011515842.1:c.671-205C>T, rs386594232, rs57997883
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4838391 NC_000010.10:g.50832109C>T, NC_000010.11:g.49624063C>T, NG_011797.1:g.19969C>T, NM_001142929.1:c.399-1410C>T, NM_001142933.1:c.507-1410C>T, NM_001142934.1:c.399-1410C>T, NM_020549.4:c.753-1410C>T, NM_020984.3:c.399-1410C>T, NM_020985.3:c.399-1410C>T, NM_020986.3:c.399-1410C>T, rs56730446, rs57982792
C > T
SNP
No VIP available No Clinical Annotations available VA
rs4838392 NC_000010.10:g.50834978A>G, NC_000010.11:g.49626932A>G, NG_011797.1:g.22838A>G, NM_001142929.1:c.580-676A>G, NM_001142933.1:c.688-676A>G, NM_001142934.1:c.580-676A>G, NM_020549.4:c.934-676A>G, NM_020984.3:c.580-676A>G, NM_020985.3:c.580-676A>G, NM_020986.3:c.580-676A>G, rs60146256
A > G
SNP
No VIP available CA VA
rs6494223 NC_000015.10:g.32104256C>T, NC_000015.9:g.32396457C>T, NG_009216.1:g.78732C>T, NM_000746.5:c.240+2907C>T, NM_001190455.2:c.327+2907C>T, NR_046324.1:n.352+2907C>T, NT_187660.1:g.4389397C>T, NW_011332701.1:g.4276945C>T, XM_011521176.1:c.3+2909C>T, XM_011521178.1:c.240+2909C>T, XM_011521179.1:c.-194+2909C>T, XM_011547383.1:c.3+2908C>T, XM_011547386.1:c.240+2908C>T, XM_011547387.1:c.-194+2908C>T, XM_011548894.1:c.3+2908C>T, XM_011548896.1:c.240+2908C>T, XM_011548897.1:c.-194+2908C>T, rs57430710
C > T
SNP
No VIP available No Clinical Annotations available VA
rs6542746 NC_000002.11:g.108605836C>T, NC_000002.12:g.107989380C>T, NG_042267.1:g.7867C>T, NM_001305005.2:c.178+1047C>T, NM_001305006.2:c.-138+2617C>T, NM_001305007.2:c.-527+1047C>T, NM_021815.4:c.178+1047C>T, XM_005264008.1:c.178+1047C>T, XM_005264009.1:c.-138+2617C>T, XM_011511579.1:c.178+1047C>T, rs58317921, rs60571256
C > T
SNP
No VIP available No Clinical Annotations available VA
rs6720783 NC_000002.11:g.108623322T>G, NC_000002.12:g.108006866T>G, NG_042267.1:g.25353T>G, NM_001305005.2:c.895+664T>G, NM_001305006.2:c.580+664T>G, NM_001305007.2:c.154+664T>G, NM_021815.4:c.895+664T>G, XM_005264008.1:c.895+664T>G, XM_005264009.1:c.580+664T>G, XM_011511579.1:c.781+664T>G, XM_011511580.1:c.643+664T>G, XM_011511581.1:c.580+664T>G, rs58228354, rs58517179
T > G
SNP
No VIP available No Clinical Annotations available VA
rs6720975 NC_000002.11:g.46024212T>C, NC_000002.12:g.45797073T>C, NM_005400.2:c.349-45927T>C, XM_005264428.1:c.349-45927T>C, XM_005264429.1:c.349-45927T>C, XM_005264430.1:c.-102-45927T>C, XM_005264431.1:c.349-45927T>C, XM_005264431.2:c.349-45927T>C, XM_011532970.1:c.61-45927T>C, XM_011532971.1:c.61-45927T>C, XM_011532972.1:c.61-45927T>C, XM_011532973.1:c.61-45927T>C, XM_011532974.1:c.61-45927T>C, XM_011532975.1:c.61-45927T>C, XM_011532976.1:c.61-45927T>C, XM_011532977.1:c.7-45927T>C, XM_011532978.1:c.7-45927T>C, XM_011532979.1:c.4-45927T>C, XR_939695.1:n.1135-45927T>C, rs57219463
T > C
SNP
No VIP available No Clinical Annotations available VA
rs6942609 NC_000007.13:g.100895480G>A, NC_000007.14:g.101252199G>A, rs60593497
G > A
SNP
No VIP available No Clinical Annotations available VA
rs7076926 NC_000010.10:g.50863565C>T, NC_000010.11:g.49655519C>T, NG_011797.1:g.51425C>T, NM_001142929.1:c.1485+71C>T, NM_001142933.1:c.1593+71C>T, NM_001142934.1:c.1485+71C>T, NM_020549.4:c.1839+71C>T, NM_020984.3:c.1485+71C>T, NM_020985.3:c.1485+71C>T, NM_020986.3:c.1485+71C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs7094248 NC_000010.10:g.50855368C>G, NC_000010.11:g.49647322C>G, NG_011797.1:g.43228C>G, NM_001142929.1:c.927+648C>G, NM_001142933.1:c.1035+648C>G, NM_001142934.1:c.927+648C>G, NM_020549.4:c.1281+648C>G, NM_020984.3:c.927+648C>G, NM_020985.3:c.927+648C>G, NM_020986.3:c.927+648C>G, rs17719339, rs56640539, rs58948516
C > G
SNP
No VIP available No Clinical Annotations available VA
rs7094421 NC_000010.10:g.50863623A>G, NC_000010.11:g.49655577A>G, NG_011797.1:g.51483A>G, NM_001142929.1:c.1485+129A>G, NM_001142933.1:c.1593+129A>G, NM_001142934.1:c.1485+129A>G, NM_020549.4:c.1839+129A>G, NM_020984.3:c.1485+129A>G, NM_020985.3:c.1485+129A>G, NM_020986.3:c.1485+129A>G, rs17450574, rs58156562
A > G
SNP
No VIP available No Clinical Annotations available VA
rs7643645 NC_000003.11:g.119525497A>G, NC_000003.12:g.119806650A>G, NG_011856.1:g.31167A>G, NM_003889.3:c.-22-579A>G, NM_022002.2:c.96-579A>G, NM_033013.2:c.-22-579A>G, XM_005247866.1:c.-187-579A>G, rs57945460
A > G
SNP
No VIP available No Clinical Annotations available VA
rs776746 NC_000007.13:g.99270539C>T, NC_000007.14:g.99672916T>C, NG_007938.1:g.12083G=, NG_007938.1:g.12083G>A, NM_000777.4:c.219-237A>G, NM_000777.4:c.219-237G>A, NM_001190484.2:c.219-237A>G, NM_001190484.2:c.219-237G>A, NM_001291829.1:c.-253-1A>G, NM_001291829.1:c.-253-1G>A, NM_001291830.1:c.189-237A>G, NM_001291830.1:c.189-237G>A, NR_033807.2:n.717-1A>G, NR_033807.2:n.717-1G>A, NR_033808.1:n.689-1G>A, NR_033809.1:n.581-237G>A, NR_033810.1:n.689-1G>A, NR_033811.1:n.321-1G>A, NR_033812.1:n.321-1G>A, XM_005250169.1:c.189-237G>A, XM_005250170.1:c.-357-1G>A, XM_005250171.1:c.-253-1G>A, XM_005250172.1:c.-254G>A, XM_005250173.1:c.-331-237G>A, XM_005250198.1:c.806-4288C>T, XM_006715859.2:c.219-237A>G, XM_011515843.1:c.-254A>G, XM_011515844.1:c.-229-237A>G, XM_011515845.1:c.-463-1A>G, XM_011515846.1:c.-331-237A>G, XM_011515847.1:c.-571-1A>G, XR_927383.1:n.344-237A>G, XR_927402.1:n.1466+48736T>C, rs10361242, rs11266830, rs386613022, rs58244770
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
Trade Names
  • Aricept
  • Aricept ODT
  • Eranz
Brand Mixture Names

PharmGKB Accession Id

PA449394

Type(s):

Drug

Description

Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.

Source: Drug Bank

Indication

For the palliative treatment of mild to moderate dementia of the Alzheimer's type.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Donepezil is a piperidine derivative that is a centerally active, reversible inhibitor of acetylcholinesterase. This drug is structurally unrelated to other anticholinesterase agents. Donepezil's proposed mechanism of action involves the reversible inhibition of cholinesterases (eg. acetylcholinesterase), which prevents the hydrolysis of acetycholine, and leads to an increased concentration of acetylcholine at cholinergic synapses. Evidence suggests that the anticholinesterase activity of donepezil is relatively specific for acetylcholinesterase in the brain.

Source: Drug Bank

Pharmacology

Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease progresses and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.

Source: Drug Bank

Food Interaction

Avoid alcohol.|Take without regard to meals.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 in the liver and also undergoes glucuronidation. The main metabolite, 6-O-desmethyl donepezil, has been reported to inhibit AChE to the same extent as donepezil in vitro.

Source: Drug Bank

Protein Binding

96%

Source: Drug Bank

Absorption

Donepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours.

Source: Drug Bank

Half-Life

70 hours

Source: Drug Bank

Toxicity

Symptoms of overdose include severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved.

Source: Drug Bank

Clearance

  • apparent plasma cl=0.13 L/hr/kg

Source: Drug Bank

Route of Elimination

Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified.

Source: Drug Bank

Volume of Distribution

  • 12 L/kg

Source: Drug Bank

Chemical Properties

Chemical Formula

C24H29NO3

Source: Drug Bank

Isomeric SMILES

COc1cc2c(cc1OC)C(=O)C(C2)CC3CCN(CC3)Cc4ccccc4

Source: OpenEye

Canonical SMILES

COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1

Source: Drug Bank

Average Molecular Weight

379.492

Source: Drug Bank

Monoisotopic Molecular Weight

379.214743799

Source: Drug Bank

SMILES

COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1

Source: Drug Bank

InChI String

InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ACHE (source: Drug Bank )
HTR2A (source: Drug Bank )

Drug Interactions

Interaction Description
amantadine - donepezil Possible antagonism of action (source: Drug Bank )
amantadine - donepezil Possible antagonism of action (source: Drug Bank )
amitriptyline - donepezil Possible antagonism of action (source: Drug Bank )
amitriptyline - donepezil Possible antagonism of action (source: Drug Bank )
amoxapine - donepezil Possible antagonism of action (source: Drug Bank )
amoxapine - donepezil Possible antagonism of action (source: Drug Bank )
azatadine - donepezil Possible antagonism of action (source: Drug Bank )
benztropine - donepezil Possible antagonism of action (source: Drug Bank )
benztropine - donepezil Possible antagonism of action (source: Drug Bank )
biperiden - donepezil Possible antagonism of action (source: Drug Bank )
biperiden - donepezil Possible antagonism of action (source: Drug Bank )
brompheniramine - donepezil Possible antagonism of action (source: Drug Bank )
brompheniramine - donepezil Possible antagonism of action (source: Drug Bank )
chlorpheniramine - donepezil Possible antagonism of action (source: Drug Bank )
chlorpheniramine - donepezil Possible antagonism of action (source: Drug Bank )
chlorpromazine - donepezil Possible antagonism of action (source: Drug Bank )
chlorpromazine - donepezil Possible antagonism of action (source: Drug Bank )
chlorprothixene - donepezil Possible antagonism of action (source: Drug Bank )
cimetidine - donepezil Possible antagonism of action (source: Drug Bank )
cimetidine - donepezil Possible antagonism of action (source: Drug Bank )
clemastine - donepezil Possible antagonism of action (source: Drug Bank )
clomipramine - donepezil Possible antagonism of action (source: Drug Bank )
clomipramine - donepezil Possible antagonism of action (source: Drug Bank )
clozapine - donepezil Possible antagonism of action (source: Drug Bank )
clozapine - donepezil Possible antagonism of action (source: Drug Bank )
cyclizine - donepezil Possible antagonism of action (source: Drug Bank )
cyclobenzaprine - donepezil Possible antagonism of action (source: Drug Bank )
cyclobenzaprine - donepezil Possible antagonism of action (source: Drug Bank )
cyproheptadine - donepezil Possible antagonism of action (source: Drug Bank )
cyproheptadine - donepezil Possible antagonism of action (source: Drug Bank )
darifenacin - donepezil Possible antagonism of action (source: Drug Bank )
darifenacin - donepezil Possible antagonism of action (source: Drug Bank )
desipramine - donepezil Possible antagonism of action (source: Drug Bank )
desipramine - donepezil Possible antagonism of action (source: Drug Bank )
dicyclomine - donepezil Possible antagonism of action (source: Drug Bank )
dicyclomine - donepezil Possible antagonism of action (source: Drug Bank )
dimenhydrinate - donepezil Possible antagonism of action (source: Drug Bank )
dimenhydrinate - donepezil Possible antagonism of action (source: Drug Bank )
diphenhydramine - donepezil Possible antagonism of action (source: Drug Bank )
diphenhydramine - donepezil Possible antagonism of action (source: Drug Bank )
disopyramide - donepezil Possible antagonism of action (source: Drug Bank )
disopyramide - donepezil Possible antagonism of action (source: Drug Bank )
donepezil - acepromazine Possible antagonism of action (source: Drug Bank )
donepezil - aceprometazine Possible antagonism of action (source: Drug Bank )
donepezil - alverine Possible antagonism of action (source: Drug Bank )
donepezil - amantadine Possible antagonism of action (source: Drug Bank )
donepezil - amantadine Possible antagonism of action (source: Drug Bank )
donepezil - amitriptyline Possible antagonism of action (source: Drug Bank )
donepezil - amitriptyline Possible antagonism of action (source: Drug Bank )
donepezil - amoxapine Possible antagonism of action (source: Drug Bank )
donepezil - amoxapine Possible antagonism of action (source: Drug Bank )
donepezil - atropine Possible antagonism of action (source: Drug Bank )
donepezil - atropine Possible antagonism of action (source: Drug Bank )
donepezil - azatadine Possible antagonism of action (source: Drug Bank )
donepezil - benztropine Possible antagonism of action (source: Drug Bank )
donepezil - benztropine Possible antagonism of action (source: Drug Bank )
donepezil - biperiden Possible antagonism of action (source: Drug Bank )
donepezil - biperiden Possible antagonism of action (source: Drug Bank )
donepezil - brompheniramine Possible antagonism of action (source: Drug Bank )
donepezil - brompheniramine Possible antagonism of action (source: Drug Bank )
donepezil - carbinoxamine Possible antagonism of action (source: Drug Bank )
donepezil - chlorpheniramine Possible antagonism of action (source: Drug Bank )
donepezil - chlorpheniramine Possible antagonism of action (source: Drug Bank )
donepezil - chlorpromazine Possible antagonism of action (source: Drug Bank )
donepezil - chlorpromazine Possible antagonism of action (source: Drug Bank )
donepezil - chlorprothixene Possible antagonism of action (source: Drug Bank )
donepezil - cimetidine Possible antagonism of action (source: Drug Bank )
donepezil - cimetidine Possible antagonism of action (source: Drug Bank )
donepezil - clemastine Possible antagonism of action (source: Drug Bank )
donepezil - clidinium Possible antagonism of action (source: Drug Bank )
donepezil - clomipramine Possible antagonism of action (source: Drug Bank )
donepezil - clomipramine Possible antagonism of action (source: Drug Bank )
donepezil - clozapine Possible antagonism of action (source: Drug Bank )
donepezil - clozapine Possible antagonism of action (source: Drug Bank )
donepezil - cyclizine Possible antagonism of action (source: Drug Bank )
donepezil - cyclobenzaprine Possible antagonism of action (source: Drug Bank )
donepezil - cyclobenzaprine Possible antagonism of action (source: Drug Bank )
donepezil - cyproheptadine Possible antagonism of action (source: Drug Bank )
donepezil - darifenacin Possible antagonism of action (source: Drug Bank )
donepezil - desipramine Possible antagonism of action (source: Drug Bank )
donepezil - desipramine Possible antagonism of action (source: Drug Bank )
donepezil - dexbrompheniramine Possible antagonism of action (source: Drug Bank )
donepezil - dicyclomine Possible antagonism of action (source: Drug Bank )
donepezil - dimenhydrinate Possible antagonism of action (source: Drug Bank )
donepezil - dimenhydrinate Possible antagonism of action (source: Drug Bank )
donepezil - diphenhydramine Possible antagonism of action (source: Drug Bank )
donepezil - diphenhydramine Possible antagonism of action (source: Drug Bank )
donepezil - diphenoxylate Possible antagonism of action (source: Drug Bank )
donepezil - diphenylpyraline Possible antagonism of action (source: Drug Bank )
donepezil - disopyramide Possible antagonism of action (source: Drug Bank )
donepezil - disopyramide Possible antagonism of action (source: Drug Bank )
donepezil - doxepin Possible antagonism of action (source: Drug Bank )
donepezil - doxepin Possible antagonism of action (source: Drug Bank )
donepezil - doxylamine Possible antagonism of action (source: Drug Bank )
donepezil - doxylamine Possible antagonism of action (source: Drug Bank )
donepezil - ethopropazine Possible antagonism of action (source: Drug Bank )
donepezil - ethopropazine Possible antagonism of action (source: Drug Bank )
donepezil - flavoxate Possible antagonism of action (source: Drug Bank )
donepezil - flupenthixol Possible antagonism of action (source: Drug Bank )
donepezil - flupenthixol Possible antagonism of action (source: Drug Bank )
donepezil - glutethimide Possible antagonism of action (source: Drug Bank )
donepezil - glycopyrrolate Possible antagonism of action (source: Drug Bank )
donepezil - hydroxyzine Possible antagonism of action (source: Drug Bank )
donepezil - hydroxyzine Possible antagonism of action (source: Drug Bank )
donepezil - hyoscyamine Possible antagonism of action (source: Drug Bank )
donepezil - imipramine Possible antagonism of action (source: Drug Bank )
donepezil - imipramine Possible antagonism of action (source: Drug Bank )
donepezil - isocarboxazid Possible antagonism of action (source: Drug Bank )
donepezil - isocarboxazid Possible antagonism of action (source: Drug Bank )
donepezil - isopropamide Possible antagonism of action (source: Drug Bank )
donepezil - loxapine Possible antagonism of action (source: Drug Bank )
donepezil - loxapine Possible antagonism of action (source: Drug Bank )
donepezil - maprotiline Possible antagonism of action (source: Drug Bank )
donepezil - maprotiline Possible antagonism of action (source: Drug Bank )
donepezil - meclizine Possible antagonism of action (source: Drug Bank )
donepezil - meclizine Possible antagonism of action (source: Drug Bank )
donepezil - meperidine Possible antagonism of action (source: Drug Bank )
donepezil - meperidine Possible antagonism of action (source: Drug Bank )
donepezil - mesoridazine Possible antagonism of action (source: Drug Bank )
donepezil - mesoridazine Possible antagonism of action (source: Drug Bank )
donepezil - methdilazine Possible antagonism of action (source: Drug Bank )
donepezil - methotrimeprazine Possible antagonism of action (source: Drug Bank )
donepezil - methylscopolamine Possible antagonism of action (source: Drug Bank )
donepezil - mirtazapine Possible antagonism of action (source: Drug Bank )
donepezil - mirtazapine Possible antagonism of action (source: Drug Bank )
donepezil - moclobemide Possible antagonism of action (source: Drug Bank )
donepezil - moclobemide Possible antagonism of action (source: Drug Bank )
donepezil - molindone Possible antagonism of action (source: Drug Bank )
donepezil - nortriptyline Possible antagonism of action (source: Drug Bank )
donepezil - nortriptyline Possible antagonism of action (source: Drug Bank )
donepezil - olanzapine Possible antagonism of action (source: Drug Bank )
donepezil - olanzapine Possible antagonism of action (source: Drug Bank )
donepezil - orphenadrine Possible antagonism of action (source: Drug Bank )
donepezil - orphenadrine Possible antagonism of action (source: Drug Bank )
donepezil - oxybutynin Possible antagonism of action (source: Drug Bank )
donepezil - perphenazine Possible antagonism of action (source: Drug Bank )
donepezil - perphenazine Possible antagonism of action (source: Drug Bank )
donepezil - phenelzine Possible antagonism of action (source: Drug Bank )
donepezil - phenelzine Possible antagonism of action (source: Drug Bank )
donepezil - phenindamine Possible antagonism of action (source: Drug Bank )
donepezil - pheniramine Possible antagonism of action (source: Drug Bank )
donepezil - pimozide Possible antagonism of action (source: Drug Bank )
donepezil - pimozide Possible antagonism of action (source: Drug Bank )
donepezil - pipotiazine Possible antagonism of action (source: Drug Bank )
donepezil - pipotiazine Possible antagonism of action (source: Drug Bank )
donepezil - procainamide Possible antagonism of action (source: Drug Bank )
donepezil - procainamide Possible antagonism of action (source: Drug Bank )
donepezil - prochlorperazine Possible antagonism of action (source: Drug Bank )
donepezil - prochlorperazine Possible antagonism of action (source: Drug Bank )
donepezil - procyclidine Possible antagonism of action (source: Drug Bank )
donepezil - promazine Possible antagonism of action (source: Drug Bank )
donepezil - promazine Possible antagonism of action (source: Drug Bank )
donepezil - promethazine Possible antagonism of action (source: Drug Bank )
donepezil - promethazine Possible antagonism of action (source: Drug Bank )
donepezil - propantheline Possible antagonism of action (source: Drug Bank )
donepezil - propericiazine Possible antagonism of action (source: Drug Bank )
donepezil - protriptyline Possible antagonism of action (source: Drug Bank )
donepezil - protriptyline Possible antagonism of action (source: Drug Bank )
donepezil - quetiapine Possible antagonism of action (source: Drug Bank )
donepezil - quetiapine Possible antagonism of action (source: Drug Bank )
donepezil - quinidine Possible antagonism of action (source: Drug Bank )
donepezil - quinidine Possible antagonism of action (source: Drug Bank )
donepezil - risperidone Possible antagonism of action (source: Drug Bank )
donepezil - risperidone Possible antagonism of action (source: Drug Bank )
donepezil - scopolamine Possible antagonism of action (source: Drug Bank )
donepezil - scopolamine Possible antagonism of action (source: Drug Bank )
donepezil - scopolamine Possible antagonism of action (source: Drug Bank )
donepezil - sertraline Possible antagonism of action (source: Drug Bank )
donepezil - sertraline Possible antagonism of action (source: Drug Bank )
donepezil - solifenacin Possible antagonism of action (source: Drug Bank )
donepezil - thioproperazine Possible antagonism of action (source: Drug Bank )
donepezil - thioridazine Possible antagonism of action (source: Drug Bank )
donepezil - thioridazine Possible antagonism of action (source: Drug Bank )
donepezil - thiothixene Possible antagonism of action (source: Drug Bank )
donepezil - thiothixene Possible antagonism of action (source: Drug Bank )
donepezil - tizanidine Possible antagonism of action (source: Drug Bank )
donepezil - tizanidine Possible antagonism of action (source: Drug Bank )
donepezil - tolterodine Possible antagonism of action (source: Drug Bank )
donepezil - tranylcypromine Possible antagonism of action (source: Drug Bank )
donepezil - tranylcypromine Possible antagonism of action (source: Drug Bank )
donepezil - trazodone Possible antagonism of action (source: Drug Bank )
donepezil - trazodone Possible antagonism of action (source: Drug Bank )
donepezil - trifluoperazine Possible antagonism of action (source: Drug Bank )
donepezil - trifluoperazine Possible antagonism of action (source: Drug Bank )
donepezil - triflupromazine Possible antagonism of action (source: Drug Bank )
donepezil - triflupromazine Possible antagonism of action (source: Drug Bank )
donepezil - trihexyphenidyl Possible antagonism of action (source: Drug Bank )
donepezil - trimeprazine Possible antagonism of action (source: Drug Bank )
donepezil - trimethobenzamide Possible antagonism of action (source: Drug Bank )
donepezil - trimipramine Possible antagonism of action (source: Drug Bank )
donepezil - trimipramine Possible antagonism of action (source: Drug Bank )
donepezil - tripelennamine Possible antagonism of action (source: Drug Bank )
donepezil - triprolidine Possible antagonism of action (source: Drug Bank )
donepezil - triprolidine Possible antagonism of action (source: Drug Bank )
donepezil - trospium Possible antagonism of action (source: Drug Bank )
donepezil - ziprasidone Possible antagonism of action (source: Drug Bank )
donepezil - ziprasidone Possible antagonism of action (source: Drug Bank )
donepezil - zuclopenthixol Possible antagonism of action (source: Drug Bank )
donepezil - zuclopenthixol Possible antagonism of action (source: Drug Bank )
doxepin - donepezil Possible antagonism of action (source: Drug Bank )
doxepin - donepezil Possible antagonism of action (source: Drug Bank )
flavoxate - donepezil Possible antagonism of action (source: Drug Bank )
flupenthixol - donepezil Possible antagonism of action (source: Drug Bank )
flupenthixol - donepezil Possible antagonism of action (source: Drug Bank )
glutethimide - donepezil Possible antagonism of action (source: Drug Bank )
glycopyrrolate - donepezil Possible antagonism of action (source: Drug Bank )
hydroxyzine - donepezil Possible antagonism of action (source: Drug Bank )
hydroxyzine - donepezil Possible antagonism of action (source: Drug Bank )
hyoscyamine - donepezil Possible antagonism of action (source: Drug Bank )
hyoscyamine - donepezil Possible antagonism of action (source: Drug Bank )
imipramine - donepezil Possible antagonism of action (source: Drug Bank )
imipramine - donepezil Possible antagonism of action (source: Drug Bank )
isocarboxazid - donepezil Possible antagonism of action (source: Drug Bank )
isocarboxazid - donepezil Possible antagonism of action (source: Drug Bank )
loxapine - donepezil Possible antagonism of action (source: Drug Bank )
loxapine - donepezil Possible antagonism of action (source: Drug Bank )
maprotiline - donepezil Possible antagonism of action (source: Drug Bank )
maprotiline - donepezil Possible antagonism of action (source: Drug Bank )
meclizine - donepezil Possible antagonism of action (source: Drug Bank )
meclizine - donepezil Possible antagonism of action (source: Drug Bank )
meperidine - donepezil Possible antagonism of action (source: Drug Bank )
meperidine - donepezil Possible antagonism of action (source: Drug Bank )
mesoridazine - donepezil Possible antagonism of action (source: Drug Bank )
mesoridazine - donepezil Possible antagonism of action (source: Drug Bank )
methotrimeprazine - donepezil Possible antagonism of action (source: Drug Bank )
mirtazapine - donepezil Possible antagonism of action (source: Drug Bank )
mirtazapine - donepezil Possible antagonism of action (source: Drug Bank )
moclobemide - donepezil Possible antagonism of action (source: Drug Bank )
moclobemide - donepezil Possible antagonism of action (source: Drug Bank )
nortriptyline - donepezil Possible antagonism of action (source: Drug Bank )
nortriptyline - donepezil Possible antagonism of action (source: Drug Bank )
olanzapine - donepezil Possible antagonism of action (source: Drug Bank )
olanzapine - donepezil Possible antagonism of action (source: Drug Bank )
orphenadrine - donepezil Possible antagonism of action (source: Drug Bank )
orphenadrine - donepezil Possible antagonism of action (source: Drug Bank )
oxybutynin - donepezil Possible antagonism of action (source: Drug Bank )
oxybutynin - donepezil Possible antagonism of action (source: Drug Bank )
perphenazine - donepezil Possible antagonism of action (source: Drug Bank )
perphenazine - donepezil Possible antagonism of action (source: Drug Bank )
phenelzine - donepezil Possible antagonism of action (source: Drug Bank )
phenelzine - donepezil Possible antagonism of action (source: Drug Bank )
pimozide - donepezil Possible antagonism of action (source: Drug Bank )
pimozide - donepezil Possible antagonism of action (source: Drug Bank )
procainamide - donepezil Possible antagonism of action (source: Drug Bank )
procainamide - donepezil Possible antagonism of action (source: Drug Bank )
prochlorperazine - donepezil Possible antagonism of action (source: Drug Bank )
prochlorperazine - donepezil Possible antagonism of action (source: Drug Bank )
promethazine - donepezil Possible antagonism of action (source: Drug Bank )
promethazine - donepezil Possible antagonism of action (source: Drug Bank )
propericiazine - donepezil Possible antagonism of action (source: Drug Bank )
quetiapine - donepezil Possible antagonism of action (source: Drug Bank )
quetiapine - donepezil Possible antagonism of action (source: Drug Bank )
quinidine - donepezil Possible antagonism of action (source: Drug Bank )
quinidine - donepezil Possible antagonism of action (source: Drug Bank )
thioproperazine - donepezil Possible antagonism of action (source: Drug Bank )
thioridazine - donepezil Possible antagonism of action (source: Drug Bank )
thioridazine - donepezil Possible antagonism of action (source: Drug Bank )
tizanidine - donepezil Possible antagonism of action (source: Drug Bank )
tizanidine - donepezil Possible antagonism of action (source: Drug Bank )
trazodone - donepezil Possible antagonism of action (source: Drug Bank )
trazodone - donepezil Possible antagonism of action (source: Drug Bank )
trifluoperazine - donepezil Possible antagonism of action (source: Drug Bank )
trifluoperazine - donepezil Possible antagonism of action (source: Drug Bank )
trihexyphenidyl - donepezil Possible antagonism of action (source: Drug Bank )
trimethobenzamide - donepezil The therapeutic effects of the anticholinergic, Trimethobenzamide, and/or the acetylcholinesterase inhibitor (central), Donepezil, may be reduced due to antagonism. Monitor therapeutic effects of both agents. (source: Drug Bank )
trospium - donepezil The therapeutic effects of the anticholinergic, Trospium, and/or the acetylcholinesterase inhibitor (central), Donepezil, may be reduced due to antagonism. Monitor therapeutic effects of both agents. (source: Drug Bank )

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to donepezil: 19

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease. European journal of clinical pharmacology. 2016. Coin A, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacopsychiatry. 2015. Yoon H, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance. British journal of clinical pharmacology. 2014. Noetzli Muriel, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. 2014. Braga Ianna Lacerda Sampaio, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors. Neurobiology of aging. 2013. Martinelli-Boneschi Filippo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study. Drug and alcohol dependence. 2012. Ashare Rebecca L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease. Pharmacogenetics and genomics. 2011. Seripa Davide, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. The pharmacogenomics journal. 2010. Patterson C E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions. British journal of clinical pharmacology. 2010. Mannheimer Buster, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. Neurology. 2009. Pilotto Alberto, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009. Scacchi Renato, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug target identification using side-effect similarity. Science (New York, N.Y.). 2008. Campillos Monica, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease. Pharmacogenetics and genomics. 2006. Blesa Rafael, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
100 years and counting: prospects for defeating Alzheimer's disease. Science (New York, N.Y.). 2006. Roberson Erik D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics. 2006. Harold Denise, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. International journal of geriatric psychiatry. 2006. Takeda A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Pharmacogenetics. 2002. Rigaud Anne-Sophie, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
62856-851-30
DrugBank:
DB00843
ChEBI:
53289
KEGG Drug:
D00670
PubChem Compound:
3152
PubChem Substance:
207105
46504803
Drugs Product Database (DPD):
2232044
BindingDB:
8960
ChemSpider:
3040
Therapeutic Targets Database:
DAP000560
FDA Drug Label at DailyMed:
2b1b7b5f-2f20-418c-b1ac-794c2ef1ce5e

Clinical Trials

These are trials that mention donepezil and are related to either pharmacogenetics or pharmacogenomics.

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No NURSA datasets available.

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