Chemical: Drug
brompheniramine

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

Overview

Generic Names
  • Brompheniramine Maleate
Trade Names
  • Bromfed
  • Bromfenex
  • Dimetane
  • Veltane
Brand Mixture Names
  • Cold & Allergy (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Cold & Allergy Relief - Liq (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Cold Relief (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Cold Relief Dm (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride)
  • Cough, Cold & Allergy Relief (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Decongestant Antihistaminic Syrup (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetane Expectorant Liq (Brompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetane Expectorant-C Syr (Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetane Expectorant-C Syrup (Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride)
  • Dimetane Expectorant-Dc Syr (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetane Expectorant-Dc Syrup (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
  • Dimetapp (Brompheniramine Maleate + Phenylephrine Hydrochloride)
  • Dimetapp Chewable Tablets (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Dimetapp Children's Cold & Allergy Tablets (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Dimetapp Children's Cold & Fever (Acetaminophen + Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Dimetapp Clear (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Dimetapp Cough & Cold Liqui-Gels - Cap (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride)
  • Dimetapp Cough, Cold & Flu (Acetaminophen + Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine Hydrochloride)
  • Dimetapp Dm Cough & Cold Liquid (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride)
  • Dimetapp Dm Elixir (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp Dm Tab (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp Extentabs (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp Extra Strength (Brompheniramine Maleate + Phenylephrine Hydrochloride)
  • Dimetapp Extra Strength Dm Cough & Cold (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride)
  • Dimetapp Liqui-Gels Cap (Brompheniramine Maleate + Phenylpropanolamine Hydrochloride)
  • Dimetapp Oral Infant Cold Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride)
  • Dimetapp Oral Infant Cold and Fever Drops (Acetaminophen + Brompheniramine Maleate + Phenylephrine Hydrochloride)
  • Dimetapp Oral Infant Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp Tab (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp-C Syr (Brompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Dimetapp-C Syrup (Brompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride)
  • Pharmetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
  • Tantapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)

PharmGKB Accession Id

PA448675

Type(s):

Drug

Description

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Source: Drug Bank

Indication

For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Brompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.

Source: Drug Bank

Pharmacology

Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H 1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Brompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Source: Drug Bank

Food Interaction

Avoid alcohol.|Take with food.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic (cytochrome P-450 system), some renal.

Source: Drug Bank

Absorption

Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Source: Drug Bank

Toxicity

Oral, rat: LD 50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.

Source: Drug Bank

Chemical Properties

Chemical Formula

C16H19BrN2

Source: Drug Bank

Isomeric SMILES

CN(C)CC[C@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2

Source: Drug Bank

CN(C)CCC(C1=CC=C(Br)C=C1)C1=NC=CC=C1

Source: Drug Bank

Canonical SMILES

CN(C)CCC(C1=CC=C(Br)C=C1)C1=CC=CC=N1

Source: Drug Bank

Average Molecular Weight

319.239

Source: Drug Bank

Monoisotopic Molecular Weight

318.073161265

Source: Drug Bank

SMILES

CN(C)CCC(C1=CC=C(Br)C=C1)C1=CC=CC=N1

Source: Drug Bank

InChI String

InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
FMO1

Drug Targets

Gene Description
CHRM1 (source: Drug Bank )
CHRM2 (source: Drug Bank )
CHRM3 (source: Drug Bank )
CHRM4 (source: Drug Bank )
CHRM5 (source: Drug Bank )
HRH1 (source: Drug Bank )

Drug Interactions

Interaction Description
brompheniramine - donepezil Possible antagonism of action (source: Drug Bank )
brompheniramine - donepezil Possible antagonism of action (source: Drug Bank )
brompheniramine - galantamine Possible antagonism of action (source: Drug Bank )
brompheniramine - galantamine Possible antagonism of action (source: Drug Bank )
brompheniramine - rivastigmine Possible antagonism of action (source: Drug Bank )
brompheniramine - rivastigmine Possible antagonism of action (source: Drug Bank )
donepezil - brompheniramine Possible antagonism of action (source: Drug Bank )
donepezil - brompheniramine Possible antagonism of action (source: Drug Bank )
galantamine - brompheniramine Possible antagonism of action (source: Drug Bank )
galantamine - brompheniramine Possible antagonism of action (source: Drug Bank )
tacrine - brompheniramine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Brompheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents. (source: Drug Bank )
tacrine - brompheniramine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Brompheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents. (source: Drug Bank )
trimethobenzamide - brompheniramine Trimethobenzamide and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects. (source: Drug Bank )
triprolidine - brompheniramine Triprolidine and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects. (source: Drug Bank )
triprolidine - brompheniramine Triprolidine and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects. (source: Drug Bank )
trospium - brompheniramine Trospium and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects. (source: Drug Bank )

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to brompheniramine: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). The Journal of pharmacology and experimental therapeutics. 2003. Hines Ronald N, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00835
ChEBI:
3183
KEGG Compound:
C06857
PubChem Compound:
6834
PubChem Substance:
46508137
9075
Drugs Product Database (DPD):
2244079
BindingDB:
50017666
ChemSpider:
6573
Therapeutic Targets Database:
DAP001066

Clinical Trials

These are trials that mention brompheniramine and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

Common Searches

Search PubMed
Search Medline Plus
Search PubChem
Search CTD

Sources for PharmGKB drug information: DrugBank, PubChem.