Chemical: Drug

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2D structure from PubChem
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Generic Names
Trade Names
  • Benzedrex
  • Dristan
  • Obesin
Brand Mixture Names

PharmGKB Accession Id





Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers.. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.

Source: Drug Bank


It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.

Source: Drug Bank


Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


The signs and symptoms that are produced after the acute overdosage of Propylhexidrine include Psychosis, Burning sensation.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank


KEGG Drug:
PubChem Compound:
PubChem Substance:

Clinical Trials

These are trials that mention propylhexedrine and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.