Chemical: Drug
chlorproguanil
PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.
Clinical Variants that meet the highest level of criteria, manually curated by PharmGKB, are shown below.
Clinical Annotation for rs1050828 (G6PD), chlorproguanil, dapsone and Malaria (level 1B Toxicity/ADR)
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Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Gene" column lead to PharmGKB Gene Pages.
List of all variant annotations for chlorproguanil
| Gene ? |
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|---|
| rs1050828 | NC_000023.10:g.153764217C>T, NC_000023.11:g.154536002C>T, NG_009015.2:g.16571G>A, NM_000402.4:c.292G>A, NM_001042351.2:c.202G>A, NP_000393.4:p.Val98Met, NP_001035810.1:p.Val68Met, NW_003871103.3:g.1969981C>T, XM_005274657.1:c.292G>A, XM_005274657.2:c.292G>A, XM_005274658.1:c.202G>A, XM_005274658.2:c.202G>A, XM_005277833.1:c.292G>A, XM_005277834.1:c.202G>A, XM_011531132.1:c.292G>A, XP_005274714.1:p.Val98Met, XP_005274715.1:p.Val68Met, XP_005277890.1:p.Val98Met, XP_005277891.1:p.Val68Met, XP_011529434.1:p.Val98Met, rs1894404, rs2230034, rs3191188 |
C > T
|
SNP |
V98M
|
Overview
PharmGKB Accession Id
PA165857067
Type(s):
Drug
Information pulled from DrugBank has not been reviewed by PharmGKB.
Chemical Properties
SMILES
CC(C)N=C(N)/N=C(\N)/NC1=CC(=C(C=C1)Cl)Cl
Source: PubChem
InChI String
InChI=1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18)
Source: PubChem
IUPAC Names
- (1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine
Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.
Curated Information ?
Curated Information ?
| Evidence | Disease |
|---|---|
| Malaria | |
| Malaria, Falciparum |
