Chemical: Drug
dinoprost tromethamine

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Generic Names
  • Dinoprost, trometamol salt
  • PGF2-alpha THAM
  • PGF2alpha THAM
  • Prostaglandin F2-alpha THAM
  • Prostaglandin F2a tromethamine
  • Prostaglandin F2alpha tham
  • Prostin F2 Alpha
Trade Names
  • Dinolytic
  • Ensaprost
  • Lutalyse
  • Panacelan F tromethamine salt
  • Pronalgon F
  • Prostalmon F
  • Zinoprost
Brand Mixture Names

PharmGKB Accession Id





The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.

Source: Drug Bank


Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.

Source: Drug Bank


Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2 ~alpha~. Prostaglandin F2 ~alpha~ has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.

Source: Drug Bank


Slowly absorbed from the amniotic fluid into systemic circulation.

Source: Drug Bank


The half-life of dinoprost in amniotic fluid is 3 to 6 hours. The plasma half-life of dinoprost after intravenous administration is reported to be less than 1 minute.

Source: Drug Bank


Although overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: Drug Bank


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank



Source: Drug Bank

InChI String


Source: Drug Bank


KEGG Drug:
PubChem Compound:
PubChem Substance:
Drugs Product Database (DPD):
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Clinical Trials

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Sources for PharmGKB drug information: DrugBank, PubChem.