Chemical: Drug

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2D structure from PubChem
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Generic Names
Trade Names
  • Bantenol
  • Besantin
  • Equivurm Plus
  • Lomper
  • MBDZ
  • Mebendazole (JAN/USP)
  • Mebendazole(USAN)
  • Mebenoazole
  • Mebenvet
  • Mebex
  • Mebutar
  • Noverme
  • Ovitelmin
  • Pantelmin
  • Telmin
  • Vermicidin
  • Vermirax
  • Vermox
  • Vermox (TN)
  • Verpanyl
Brand Mixture Names
  • Bot-Plus Syringe Formula Equine Wormer (Mebendazole + Trichlorfon)
  • Equiverm B Pst (Mebendazole + Trichlorfon)
  • Telmin B Syringe Formula (Mebendazole + Trichlorfon)

PharmGKB Accession Id





A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules.

Source: Drug Bank


For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Source: Drug Bank


Mebendazole is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Mebendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Source: Drug Bank

Food Interaction

Lipid rich meals may improve absorption.|Take with food.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


Primarily hepatic. Primary metabolite is 2-amino-5-benzoylbenzimidazole, but also metabolized to inactive hydroxy and hydroxyamino metabolites. All metabolites are devoid of anthelmintic activity.

Source: Drug Bank

Protein Binding


Source: Drug Bank


Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Source: Drug Bank


2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).

Source: Drug Bank


Acute oral toxicity (LD 50): 620 mg/kg Mouse. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Source: Drug Bank

Route of Elimination

In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: OpenEye

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Drug Targets

Gene Description
TUBA1A (source: Drug Bank)
TUBB4B (source: Drug Bank)

Drug Interactions

Drug Description
mebendazole The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
ethotoin The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
fosphenytoin The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
mephenytoin The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
phenytoin The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
mebendazole The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)
mebendazole The hydantoin decreases the efficiency of mebendazole (source: Drug Bank)


Web Resource:
National Drug Code Directory:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Drugs Product Database (DPD):
Therapeutic Targets Database:
FDA Drug Label at DailyMed:

Clinical Trials

These are trials that mention mebendazole and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.