Chemical: Drug

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Generic Names
  • gamma-benzene hexachloride
  • gamma-bhc
  • gamma-hch
  • gamma-hexachlorocyclohexane
  • gamma-hexachlorzyklohexan
  • gamma-lindane
  • lindan
Trade Names
  • Aalindan
  • Aficide
  • Agrocide
  • Agrocide III
  • Agrocide WP
  • Ameisenmittel merck
  • Ameisentod
  • Aparasin
  • Aphtiria
  • Aplidal
  • Arbitex
  • Atlas steward
  • BBH
  • Ben-Hex
  • Bentox 10
  • Benzene hexachloride
  • Bexol
  • Celanex
  • Chloresene
  • Codechine
  • DBH
  • Detmol-Extrakt
  • Devoran
  • Dol Granule
  • Drilltox-Spezial Aglukon
  • Entomoxan
  • Esoderm
  • Fumite lindane
  • Gamacid
  • Gamene
  • Gamma-BHC dust
  • Gamma-Col
  • Gamma-HCH dust
  • Gammalin
  • Gammalin 20
  • Gammasan
  • Gammaterr
  • Gammexane
  • Gexane
  • HCCH
  • HCH
  • HGI
  • Heclotox
  • Hexa
  • Hexachloran
  • Hexachlorane
  • Hexachlorocyclohexane
  • Hexatox
  • Hexaverm
  • Hexicide
  • Hexit
  • Hexyclan
  • Hortex
  • Indane
  • Isotox
  • Jacutin
  • Kokotine
  • Kwell
  • Lendine
  • Lentox
  • Lidenal
  • Lindafor
  • Lindatox
  • Lindex
  • Lindosep
  • Lintox
  • Linvur
  • Lorexane
  • Milbol 49
  • Mszycol
  • Murfume grain store smoke
  • Neo-Scabicidol
  • New kotol
  • Nexen FB
  • Nexit
  • Nexit-Stark
  • Nexol-E
  • Nicochloran
  • Omnitox
  • Ovadziak
  • Owadziak
  • PMS Lindane
  • Pedraczak
  • Pflanzol
  • Quellada
  • Sang-«gamma»
  • Scabene
  • Scabene lotion
  • Spritz-Rapidin
  • Spruehpflanzol
  • Streunex
  • TAP 85
  • Thionex
  • Tri-6
  • Viton
  • beta-BHC
  • beta-Hexachlorocyclohexane
  • beta-Lindane
Brand Mixture Names
  • Dermadex Crm (Benzoic Acid + Benzyl Benzoate + Lindane + Salicylic Acid + Zinc Oxide + Zinc Undecylenate)

PharmGKB Accession Id





An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment.

Source: Drug Bank


For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Lindane is an organochloride insecticide that has similar neurotoxic protperties to DDT. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lindane has very low ovicidal activity.

Source: Drug Bank


Scabies is a common, highly pruritic infestation of the skin caused by Sarcoptes scabiei (lice). It is a very contagious condition with specific lesions, such as burrows, and nonspecific lesions, such as papules, vesicles and excoriations. The typical areas of the body it affects are finger webs, scalp (hair), wrists, axillary folds, abdomen, buttocks, inframammary folds and genitalia (males). It is characterized by intense night-time itching. Scabies is spread through close personal contact (relatives, sexual partners, schoolchildren, chronically ill patients and crowded communities). Scabies infestations and the corresponding symptoms can be eliminated by killing the scabies with topical insecticides or scabicides. Lindane is a scabicide that is essentially an organochloride insecticide.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


Primarily hepatic through dechlorination leading to 2-chlorophenol, 0-chlorophenol, chlorocyclohexane, chlorocyclohexanol.

Source: Drug Bank

Protein Binding


Source: Drug Bank


Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies.

Source: Drug Bank


18 hours

Source: Drug Bank


Lindane is a moderately toxic compound via oral exposure, with a reported oral LD ~50~ of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD ~50~ values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: OpenEye

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank



Source: Drug Bank

InChI String


Source: Drug Bank


Web Resource:
National Drug Code Directory:
KEGG Compound:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Drugs Product Database (DPD):
Therapeutic Targets Database:
FDA Drug Label at DailyMed:

Clinical Trials

These are trials that mention lindane and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

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Sources for PharmGKB drug information: DrugBank, PubChem.