Chemical: Drug
ethynodiol diacetate

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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Generic Names
  • Ethinodiol Diacetate
  • Ethynodiol
  • Etynodiol
Trade Names
  • Cervicundin
  • Continuin
  • Femulen
  • Luteonorm
  • Luto-Metrodiol
  • Metrodiol
  • Metrodiol Diacetate
  • Metrulen
  • Ovulen
  • Ovulen 50
Brand Mixture Names
  • Demulen 30 (21 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 30 (28 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (21 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (28 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)

PharmGKB Accession Id





A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.

Source: Drug Bank


For the prevention of pregnancy in women who elect to use this product as a method of contraception.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Ethynodiol Diacetate will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Source: Drug Bank


Ethynodiol Diacetate is used as a female contraceptive. Ethynodiol Diacetate is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Ethynodiol Diacetate tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding


Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: Drug Bank


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank



Source: Drug Bank

InChI String


Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Drug Targets

Gene Description
ESR1 (source: Drug Bank )
PGR (source: Drug Bank )

Drug Interactions

Interaction Description
thiopental - ethynodiol diacetate Thiopental may decrease the effect of Ethynodiol diacetate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy. (source: Drug Bank )
thiopental - ethynodiol diacetate Thiopental may decrease the effect of Ethynodiol diacetate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy. (source: Drug Bank )
warfarin - ethynodiol diacetate Ethynodiol diacetate may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if ethynodiol diacetate is initiated, discontinued or dose (source: Drug Bank )


Web Resource:
KEGG Compound:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Drugs Product Database (DPD):
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Clinical Trials

These are trials that mention ethynodiol diacetate and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

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Sources for PharmGKB drug information: DrugBank, PubChem.