Chemical: Drug

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Generic Names
  • Azlocilina [INN-Spanish]
  • Azlocillin sodium salt
  • Azlocilline [INN-French]
  • Azlocillinum [INN-Latin]
Trade Names
  • Azlin
  • Bayer Brand of Azlocillin
  • Securopen
Brand Mixture Names

PharmGKB Accession Id





A semisynthetic ampicillin-derived acylureido penicillin.

Source: Drug Bank


For the treatment of infections caused by _Pseudomonas aeruginosa_, _Escherichia coli_, and _Haemophilus influenzae_.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor.

Source: Drug Bank


Azlocillin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin demonstrates antibacterial activity against a broad spectrum of bacteria, including _Pseudomonas aeruginosa_, and, in contrast to most cephalosporins, exhibits activity against enterococci.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity


Eliminated predominantly by renal mechanisms, but also undergoes biotransformation within body tissues and intraintestinal degradation by bowel bacteria, with high concentrations found in bile.

Source: Drug Bank

Protein Binding

20 to 46% bound to plasma proteins

Source: Drug Bank


Not significantly absorbed from the gastrointestinal tract.

Source: Drug Bank


Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment.

Source: Drug Bank

Chemical Properties

Chemical Formula


Source: Drug Bank

Isomeric SMILES


Source: Drug Bank


Source: Drug Bank

Canonical SMILES


Source: Drug Bank

Average Molecular Weight


Source: Drug Bank

Monoisotopic Molecular Weight


Source: Drug Bank



Source: Drug Bank

InChI String


Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

No related genes are available.

Drug Interactions

Interaction Description
demeclocycline - azlocillin Possible antagonism of action (source: Drug Bank )
doxycycline - azlocillin Possible antagonism of action (source: Drug Bank )
ethinyl estradiol - azlocillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank )
minocycline - azlocillin Possible antagonism of action (source: Drug Bank )
tetracycline - azlocillin Possible antagonism of action (source: Drug Bank )
No related diseases are available


Web Resource:
KEGG Compound:
KEGG Drug:
PubChem Compound:
PubChem Substance:
Therapeutic Targets Database:

Clinical Trials

These are trials that mention azlocillin and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

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No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.