Chemical: Drug
adenosine triphosphate

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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Overview

Generic Names
  • 5'-ATP
  • ATP
  • Adenosine 5'-triphosphate
  • Adenosine 5'-triphosphoric acid
  • Adenosine, 5'-(tetrahydrogen triphosphate)
  • Adenosine-5'-triphosphate
  • Adenylpyrophosphoric acid
  • Triphosphoric acid adenosine ester
Trade Names
  • Adephos
  • Adetol
  • Adynol
  • Atipi
  • Atriphos
  • Cardenosine
  • Fosfobion
  • Glucobasin
  • Myotriphos
  • Phosphobion
  • Striadyne
  • Triadenyl
  • Triphosphaden
Brand Mixture Names

PharmGKB Accession Id

PA164743471

Type(s):

Drug

Description

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Source: Drug Bank

Indication

For nutritional supplementation, also for treating dietary shortage or imbalance

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. ATP can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase. The total quantity of ATP in the human body is about 0.1 mole. The energy used by human cells requires the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, hence its consumption must closely follow its synthesis.

Source: Drug Bank

Pharmacology

Adenosine triphosphate (ATP) is the nucleotide known in biochemistry as the "molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. The total quantity of ATP in the human body is about 0.1 mole. The energy used by human cells requires the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, hence its consumption must closely follow its synthesis.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Toxicity

Oral LD 50 in rats is > 2 g/kg.

Source: Drug Bank

Chemical Properties

Chemical Formula

C10H16N5O13P3

Source: Drug Bank

Isomeric SMILES

C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O)N

Source: Drug Bank

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

Source: Drug Bank

Canonical SMILES

NC1=C2N=CN([C@@H]3O[C@H]

Source: Drug Bank

Average Molecular Weight

507.181

Source: Drug Bank

Monoisotopic Molecular Weight

506.995745159

Source: Drug Bank

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

Source: Drug Bank

InChI String

InChI=1/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/s2

Source: Drug Bank

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this drug. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. activation of camp-dependent protein kinase pka - (BioCarta via Pathway Interaction Database)
  2. activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor - (BioCarta via Pathway Interaction Database)
  3. anthrax toxin mechanism of action - (BioCarta via Pathway Interaction Database)
  4. basic mechanisms of sumoylation - (BioCarta via Pathway Interaction Database)
  5. cardiac protection against ros - (BioCarta via Pathway Interaction Database)
  6. chrebp regulation by carbohydrates and camp - (BioCarta via Pathway Interaction Database)
  7. cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway - (BioCarta via Pathway Interaction Database)
  8. endocytotic role of ndk phosphins and dynamin - (BioCarta via Pathway Interaction Database)
  9. gata3 participate in activating the th2 cytokine genes expression - (BioCarta via Pathway Interaction Database)
  10. how progesterone initiates the oocyte maturation - (BioCarta via Pathway Interaction Database)
  11. hypoxia-inducible factor in the cardivascular system - (BioCarta via Pathway Interaction Database)
  12. ion channels and their functional role in vascular endothelium - (BioCarta via Pathway Interaction Database)
  13. phosphatidylcholine biosynthesis pathway - (BioCarta via Pathway Interaction Database)
  14. phospholipase c-epsilon pathway - (BioCarta via Pathway Interaction Database)
  15. polyadenylation of mrna - (BioCarta via Pathway Interaction Database)
  16. proteasome complex - (BioCarta via Pathway Interaction Database)
  17. regulation of ck1/cdk5 by type 1 glutamate receptors - (BioCarta via Pathway Interaction Database)
  18. regulation of spermatogenesis by crem - (BioCarta via Pathway Interaction Database)
  19. regulators of bone mineralization - (BioCarta via Pathway Interaction Database)
  20. role of parkin in ubiquitin-proteasomal pathway - (BioCarta via Pathway Interaction Database)
  21. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  22. sumoylation as a mechanism to modulate ctbp-dependent gene responses - (BioCarta via Pathway Interaction Database)
  23. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00171
PDB:
ATP
ChEBI:
15422
KEGG Compound:
C00002
PubChem Compound:
5957
PubChem Substance:
3304
46507614
IUPHAR Ligand:
1713
BindingDB:
2
ChemSpider:
5742
HET:
ATP
Therapeutic Targets Database:
DNC000262

Clinical Trials

These are trials that mention adenosine triphosphate and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, PubChem.