Chemical: Drug
adenosine triphosphate

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Overview

Generic Names
  • 5'-ATP
  • ATP
  • Adenosine 5'-triphosphate
  • Adenosine 5'-triphosphoric acid
  • Adenosine, 5'-(tetrahydrogen triphosphate)
  • Adenosine-5'-triphosphate
  • Adenylpyrophosphoric acid
  • Triphosphoric acid adenosine ester
Trade Names
  • Adephos
  • Adetol
  • Adynol
  • Atipi
  • Atriphos
  • Cardenosine
  • Fosfobion
  • Glucobasin
  • Myotriphos
  • Phosphobion
  • Striadyne
  • Triadenyl
  • Triphosphaden
Brand Mixture Names

PharmGKB Accession Id

PA164743471

Type(s):

Drug

Description

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Source: Drug Bank

Indication

For nutritional supplementation, also for treating dietary shortage or imbalance

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. ATP can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase. The total quantity of ATP in the human body is about 0.1 mole. The energy used by human cells requires the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, hence its consumption must closely follow its synthesis.

Source: Drug Bank

Pharmacology

Adenosine triphosphate (ATP) is the nucleotide known in biochemistry as the "molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. The total quantity of ATP in the human body is about 0.1 mole. The energy used by human cells requires the hydrolysis of 200 to 300 moles of ATP daily. This means that each ATP molecule is recycled 2000 to 3000 times during a single day. ATP cannot be stored, hence its consumption must closely follow its synthesis.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Toxicity

Oral LD 50 in rats is > 2 g/kg.

Source: Drug Bank

Chemical Properties

Chemical Formula

C10H16N5O13P3

Source: Drug Bank

Isomeric SMILES

C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O)N

Source: Drug Bank

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

Source: Drug Bank

Canonical SMILES

NC1=C2N=CN([C@@H]3O[C@H]

Source: Drug Bank

Average Molecular Weight

507.181

Source: Drug Bank

Monoisotopic Molecular Weight

506.995745159

Source: Drug Bank

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

Source: Drug Bank

InChI String

InChI=1/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/s2

Source: Drug Bank

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00171
PDB:
ATP
ChEBI:
15422
KEGG Compound:
C00002
PubChem Compound:
5957
PubChem Substance:
3304
46507614
IUPHAR Ligand:
1713
BindingDB:
2
ChemSpider:
5742
HET:
ATP
Therapeutic Targets Database:
DNC000262

Clinical Trials

These are trials that mention adenosine triphosphate and are related to either pharmacogenetics or pharmacogenomics.

No trials loaded.

NURSA Datasets

provided by nursa.org

No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.