Drug Class
Dihydropyridine derivatives

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB annotates drug labels containing pharmacogenetic information approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the PGx in the label, an excerpt from the label and a downloadable highlighted label PDF file. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the "PGx Level" tag.

See the legend for more information about drug label sources and PGx Levels.

We welcome any information regarding drug labels containing PGx information approved by the FDA, EMA, PMDA, HCSC or other Medicine Agencies around the world - please contact feedback.


Annotated Labels

  1. FDA Label for amlodipine
  2. FDA Label for nifedipine

1. FDA Label for amlodipine

Full label available at DailyMed

Genes and/or phenotypes found in this label

  • Cardiomyopathies
    • Warnings section
    • source: PHONT
  • Cardiovascular Diseases
    • Indications & usage section
    • source: PHONT
  • Coronary Disease
    • Indications & usage section
    • source: PHONT
  • Death
    • Warnings section, Adverse reactions section, Precautions section
    • source: PHONT
  • Diabetes Mellitus
    • Indications & usage section, Warnings section, Adverse reactions section, Precautions section
    • source: PHONT
  • Heart Failure
    • Indications & usage section, Warnings section, Adverse reactions section
    • source: PHONT
  • Hypertension
    • Indications & usage section, Warnings section, Adverse reactions section, Precautions section
    • source: PHONT
  • Myocardial Infarction
    • Indications & usage section, Warnings section, Adverse reactions section, Precautions section
    • source: PHONT
  • Stroke
    • Indications & usage section, Warnings section, Adverse reactions section, Precautions section
    • source: PHONT


PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for Dihydropyridine derivatives

Gene ? Variant?
(144)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs10494366 106-38510G>T, 13574327G>T, 162085685G>T, 51105G>T
G > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 144

Overview

Generic Names
Trade Names
Brand Mixture Names

PharmGKB Accession Id

PA164712688

Other Vocabularies

Drugs And Small Molecules

The following have been classified under this therapeutic category:

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
NOS1AP
No related drugs are available.

Curated Information ?

EvidenceDisease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Death
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Hypertension

Publications related to Dihydropyridine derivatives: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers. British journal of clinical pharmacology. 2009. Becker Matthijs L, et al. PubMed

Clinical Trials

These are trials that mention Dihydropyridine derivatives and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

Common Searches

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.