Chemical: Drug
fluspirilene

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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Overview

Generic Names
  • Fluspirileno [inn-spanish]
  • Fluspirilenum [inn-latin]
Trade Names
  • Imap
  • Lopac-F-100
  • Redeptin
Brand Mixture Names

PharmGKB Accession Id

PA162565878

Type(s):

Drug

Description

A long-acting injectable antipsychotic agent used for chronic schizophrenia.

Source: Drug Bank

Indication

Used for the treatment of schizophrenia.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Pharmacology

Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot antipsychotics (fluphenazine decanoate, fluphenazine enathate, perphenazine onanthat, pipotiazine undecylenate) with respect to treatment efficacy, response or tolerability. Outcomes suggest that fluspirilene does not differ significantly from oral antipsychotics or in different weekly regimens, although much cannot be inferred because of the shortage of trials.

Source: Drug Bank

Food Interaction

Avoid alcohol.

Source: Drug Bank

Chemical Properties

Chemical Formula

C29H31F2N3O

Source: Drug Bank

Isomeric SMILES

c1ccc(cc1)N2CNC(=O)C23CCN(CC3)CCCC(c4ccc(cc4)F)c5ccc(cc5)F

Source: OpenEye

Canonical SMILES

FC1=CC=C(C=C1)C(CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1

Source: Drug Bank

Average Molecular Weight

475.5727

Source: Drug Bank

Monoisotopic Molecular Weight

475.243519039

Source: Drug Bank

SMILES

FC1=CC=C(C=C1)C(CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1)C1=CC=C(F)C=C1

Source: Drug Bank

InChI String

InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DRD4

Drug Targets

Gene Description
CACNG1 (source: Drug Bank)
DRD2 (source: Drug Bank)
HTR2A (source: Drug Bank)
No related drugs are available.

Curated Information ?

Publications related to fluspirilene: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
DRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gain. The pharmacogenomics journal. 2009. Popp J, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB04842
KEGG Drug:
D02629
PubChem Compound:
3396
PubChem Substance:
159093
46508202
IUPHAR Ligand:
85
BindingDB:
26948
ChemSpider:
3279
Therapeutic Targets Database:
DAP000980

Clinical Trials

These are trials that mention fluspirilene and are related to either pharmacogenetics or pharmacogenomics.

No trials found.

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Sources for PharmGKB drug information: DrugBank, PubChem.