Chemical: Drug
telithromycin

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last updated 09/16/2014

1. Annotation of EMA Label for telithromycin and CYP3A4

Informative PGx

Summary

The EMA European Public Assessment Report (EPAR) for telithromycin (Ketek) does not contain pharmacogenetic information. It contains information regarding metabolism by CYP3A4 and contains information regarding use of concomitant drugs that are CYP3A4 substrates, inhibitors or inducers.

Annotation

The EMA-approved drug telithromycin is tagged with CYP3A4 in [Article:24433361].

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the telithromycin EMA drug label.

*Disclaimer: The contents of this page have not been endorsed by the EMA and are the sole responsibility of PharmGKB.

Genes and/or phenotypes found in this label

  • CYP3A4
    • metabolism/PK, Contraindications section, Drug interactions section, Warnings and precautions section
    • source: European Medicines Agency

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for telithromycin

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
VIP No Clinical Annotations available No Variant Annotations available
rs776746 NC_000007.13:g.99270539C>T, NC_000007.14:g.99672916T>C, NG_007938.1:g.12083G=, NG_007938.1:g.12083G>A, NM_000777.4:c.219-237A>G, NM_000777.4:c.219-237G>A, NM_001190484.2:c.219-237A>G, NM_001190484.2:c.219-237G>A, NM_001291829.1:c.-253-1A>G, NM_001291829.1:c.-253-1G>A, NM_001291830.1:c.189-237A>G, NM_001291830.1:c.189-237G>A, NR_033807.2:n.717-1A>G, NR_033807.2:n.717-1G>A, NR_033808.1:n.689-1G>A, NR_033809.1:n.581-237G>A, NR_033810.1:n.689-1G>A, NR_033811.1:n.321-1G>A, NR_033812.1:n.321-1G>A, XM_005250169.1:c.189-237G>A, XM_005250170.1:c.-357-1G>A, XM_005250171.1:c.-253-1G>A, XM_005250172.1:c.-254G>A, XM_005250173.1:c.-331-237G>A, XM_005250198.1:c.806-4288C>T, XM_006715859.2:c.219-237A>G, XM_011515843.1:c.-254A>G, XM_011515844.1:c.-229-237A>G, XM_011515845.1:c.-463-1A>G, XM_011515846.1:c.-331-237A>G, XM_011515847.1:c.-571-1A>G, XR_927383.1:n.344-237A>G, XR_927402.1:n.1466+48736T>C, rs10361242, rs11266830, rs386613022, rs58244770
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • telithromycin
Trade Names
  • Ketek
Brand Mixture Names

PharmGKB Accession Id

PA10202

Type(s):

Drug

Description

Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.

Source: Drug Bank

Indication

For the treatment of _Pneumococcal_ infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Telithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positive cocci (e.g. Streptococcus pneumoniae) in the presence of resistance mediated by methylases (erm genes) that alter the binding site at domain V. Telithromycin may also inhibit the assembly of nascent ribosomal units. Compared to erythromycin A, telithromycin binds to the 23S rRNA with 10 times greater affinity in erythromycin-susceptible organisms and 25 times greater affinity in macrolide-resistant strains. This increased binding affinity may be conferred by the C11-12 carbamate side chain of telithromycin. The side chain appears to maintain binding at domain II in the presence of resistance mediated by alterations in domain V.

Source: Drug Bank

Pharmacology

Telithromycin is a ketolide antibiotic which has an antimicrobial spectrum similar or slightly broader than that of penicillin. It is often used as an alternative in patients who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. Telithromycin prevents bacterial growth by binding to bacterial 50S ribosomal subunits and interfering with bacterial peptide translocation and elongation.

Source: Drug Bank

Food Interaction

Take without regard to meals.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic - estimated 50% metabolized by CYP3A4 and 50% metabolized independent of cytochrome P450

Source: Drug Bank

Protein Binding

60 - 70% bound primarily to human serum albumin

Source: Drug Bank

Absorption

Absolute bioavailability is approximately 57%. Maximal concentrations are reached 0.5 - 4 hours following oral administration. Food intake does not affected absorption.

Source: Drug Bank

Half-Life

Main elimination half-life is 2-3 hours; terminal elimination half-life is 10 hours

Source: Drug Bank

Toxicity

LD50>2000 mg/kg (PO in rats). Adverse effects are similar to those of clarithormycin and erithromycin and include diarrhea, nausea, vomiting, loose stools, abdominal pain, flatulence and dyspepsia. It may also cause dizziness, headache and taste disturbances.

Source: Drug Bank

Route of Elimination

The systemically available telithromycin is eliminated by multiple pathways as follows: 7% of the dose is excreted unchanged in feces by biliary and/or intestinal secretion; 13% of the dose is excreted unchanged in urine by renal excretion; and 37% of the dose is metabolized by the liver.

Source: Drug Bank

Volume of Distribution

* 2.9 L/kg

Source: Drug Bank

Chemical Properties

Chemical Formula

C43H65N5O10

Source: Drug Bank

Average Molecular Weight

812.0037

Source: Drug Bank

Monoisotopic Molecular Weight

811.473143325

Source: Drug Bank

SMILES

CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C

Source: PubChem

InChI String

InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42+,43-/m1/s1

Source: PubChem

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
CYP3A4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
CYP3A5
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
KCNH2

Drug Interactions

Interaction Description
alprazolam - telithromycin Increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
alprazolam - telithromycin Increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
amiodarone - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
amiodarone - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
astemizole - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
astemizole - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
atorvastatin - telithromycin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
atorvastatin - telithromycin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
bromazepam - telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if telithromycin is initiated, discontinued or dose changed. Dosage adjustments may be required. (source: Drug Bank )
carbamazepine - telithromycin Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
carbamazepine - telithromycin Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
cisapride - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
cisapride - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
colchicine - telithromycin Severe colchicine toxicity can occur (source: Drug Bank )
colchicine - telithromycin Severe colchicine toxicity can occur (source: Drug Bank )
cyclosporine - telithromycin Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
cyclosporine - telithromycin Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
dantrolene - telithromycin Telithromycin may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
digoxin - telithromycin Telithromycin may increase levels of digoxin (source: Drug Bank )
digoxin - telithromycin Telithromycin may increase levels of digoxin (source: Drug Bank )
dihydroergotamine - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
dihydroergotamine - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
disopyramide - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
disopyramide - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
ergotamine - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
ergotamine - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
fosphenytoin - telithromycin Telithromycin may possibly increase this agent's effect/toxicity (source: Drug Bank )
lovastatin - telithromycin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
lovastatin - telithromycin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
methysergide - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
methysergide - telithromycin Risk of ergotism and severe ischemia with this association (source: Drug Bank )
metoprolol - telithromycin Telithromycin may possibly increase metoprolol effect (source: Drug Bank )
metoprolol - telithromycin Telithromycin may possibly increase metoprolol effect (source: Drug Bank )
midazolam - telithromycin Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
phenytoin - telithromycin Telithromycin may possibly increase the agent effect/toxicity (source: Drug Bank )
phenytoin - telithromycin Telithromycin may possibly increase the effect and toxicity of phenytoin. (source: Drug Bank )
pimozide - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
pimozide - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
quinidine - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
quinidine - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
ranolazine - telithromycin Increased levels of ranolazine - risk of toxicity (source: Drug Bank )
rifampin - telithromycin Rifampin decreases the effect of telithromycin (source: Drug Bank )
rifampin - telithromycin Rifampin decreases the effect of telithromycin (source: Drug Bank )
tadalafil - telithromycin Telithromycin may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity. (source: Drug Bank )
tamoxifen - telithromycin Telithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank )
tamoxifen - telithromycin Telithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank )
tamsulosin - telithromycin Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank )
tamsulosin - telithromycin Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank )
telithromycin - acenocoumarol Telithromycin increases the anticoagulant effect (source: Drug Bank )
telithromycin - acenocoumarol Telithromycin may increase the anticoagulant effect of acenocoumarol. (source: Drug Bank )
telithromycin - alfentanil Telithromycin may reduce clearance of Alfentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Alfentanil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - alfuzosin Telithromycin may reduce clearance of Alfuzosin. Consider alternate therapy. (source: Drug Bank )
telithromycin - alprazolam Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
telithromycin - alprazolam Telithromycin may reduce clearance of Alprazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Alprazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - aminoglutethimide Aminoglutethimide may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - amiodarone Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - amiodarone Telithromycin may reduce clearance of Amiodarone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amiodarone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - amlodipine Telithromycin may reduce clearance of Amlopidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amlopidine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - amprenavir Co-administration may result in altered plasma concentrations of Amprenavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - anisindione Telithromycin may increase the anticoagulant effect of anisindione. (source: Drug Bank )
telithromycin - aprepitant Telithromycin may reduce clearance of Aprepitant. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Aprepitant if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - aripiprazole Telithromycin may reduce clearance of Aripiprazole. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Aripiprazole if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - astemizole Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - astemizole Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - atazanavir Co-administration may result in altered plasma concentrations of Atazanavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - atorvastatin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
telithromycin - atorvastatin Telithromycin may reduce clearance of Atorvastatin. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - benzphetamine Telithromycin may reduce clearance of Benzphetamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Benzphetamine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - bisoprolol Telithromycin may reduce clearance of Bisoprolol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bisoprolol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - bortezomib Telithromycin may reduce clearance of Bortezomib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bortezomib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - bosentan Co-administration may cause decreased Telithromycin and increased Bosentan plasma concentrations. Consider alternate therapy. (source: Drug Bank )
telithromycin - bretylium Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - bretylium Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - bromazepam Telithromycin may reduce clearance of Bromazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bromazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - bromocriptine Telithromycin may reduce clearance of Bromocriptine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bromocriptine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - budesonide Telithromycin may reduce clearance of Budesonide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Budesonide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - buprenorphine Telithromycin may reduce clearance of Buprenorphine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Buprenorphine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - buspirone Telithromycin may reduce clearance of Buspirone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Buspirone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - busulfan Telithromycin may reduce clearance of Busulfan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Busulfan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - calcitriol Telithromycin may reduce clearance of Calcitriol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Calcitriol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - carbamazepine Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
telithromycin - carbamazepine Co-administration may cause decreased Telithromycin and increased Carbemazepine plasma concentrations. Consider alternate therapy. (source: Drug Bank )
telithromycin - chlordiazepoxide Telithromycin may reduce clearance of Chlordiazepoxide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chlordiazepoxide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - chloroquine Telithromycin may reduce clearance of Chloroquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chloroquine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - chlorpheniramine Telithromycin may reduce clearance of Chlorpheniramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chlorpheniramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ciclesonide Telithromycin may reduce clearance of Ciclesonide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ciclesonide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - cilostazol Telithromycin may reduce clearance of Cilostazol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cilostazol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - cinacalcet Telithromycin may reduce clearance of Cinacalcet. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cinacalcet if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - cisapride Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - cisapride Telithromycin may reduce clearance of Cisapride. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - citalopram Telithromycin may reduce clearance of Citalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Citalopram if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - clarithromycin Co-administration may result in altered plasma concentrations of Clarithromycin and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - clobazam Telithromycin may reduce clearance of Clobazam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clobazam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - clonazepam Telithromycin may reduce clearance of Clonazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clonazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - clorazepate Telithromycin may reduce clearance of Clorazepate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clorazepate if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - cocaine Telithromycin may reduce clearance of Cocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cocaine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - colchicine Severe colchicine toxicity can occur (source: Drug Bank )
telithromycin - colchicine Telithromycin may reduce clearance of Colchicine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Colchicine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - conivaptan Co-administration may result in altered plasma concentrations of Conivaptan and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - cyclosporine Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
telithromycin - cyclosporine Telithromycin may reduce clearance of Cyclosporine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cyclosporine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - dantrolene Telithromycin may reduce clearance of Dantrolene. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dantrolene if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - dapsone Telithromycin may reduce clearance of Dapsone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dapsone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - darifenacin Telithromycin may reduce clearance of Darifenacin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Darifenacin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - darunavir Co-administration may result in altered plasma concentrations of Darunavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - dasatinib Increased levels/toxicity of dasatinib (source: Drug Bank )
telithromycin - dasatinib Telithromycin may reduce clearance of Dasatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dasatinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - delavirdine Delavirdine may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - dexamethasone Co-administration may cause decreased Telithromycin and increased Dexamethasone plasma concentrations. Consider alternate therapy. (source: Drug Bank )
telithromycin - diazepam Telithromycin may reduce clearance of Diazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Diazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - dicumarol Telithromycin increases the anticoagulant effect (source: Drug Bank )
telithromycin - dicumarol Telithromycin may increase the anticoagulant effect of dicumarol. (source: Drug Bank )
telithromycin - digitoxin Telithromycin may reduce clearance of Digitoxin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Digitoxin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - digoxin Telithromycin may increase levels of digoxin (source: Drug Bank )
telithromycin - digoxin Telithromycin may increase the plasma concentration of Digoxin. Monitor for changes in Digoxin efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - dihydroergotamine Telithromycin may reduce clearance of Dihydroergotamine. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - diltiazem Telithromycin may reduce clearance of Diltiazem. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Diltiazem if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - disopyramide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - disopyramide Telithromycin may reduce clearance of Disopyramide. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - docetaxel Telithromycin may reduce clearance of Docetaxel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Docetaxel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - dofetilide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - dofetilide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - doxepin Telithromycin may reduce clearance of Doxepin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxepin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - doxorubicin Telithromycin may reduce clearance of Doxorubicin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxorubicin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - efavirenz Efavirenz may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - eletriptan Telithromycin may reduce clearance of Eletriptan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eletriptan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - eplerenone Telithromycin may reduce clearance of Eplerenone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eplerenone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ergonovine Telithromycin may reduce clearance of Ergonovine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ergonivine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ergotamine Telithromycin may reduce clearance of Ergotamine. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank )
telithromycin - erlotinib Telithromycin may reduce clearance of Erlotinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erlotinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - erythromycin Telithromycin may reduce clearance of Erythromycin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erythromycin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - escitalopram Telithromycin may reduce clearance of Escitalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Escitalopram if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - eszopiclone Telithromycin may reduce clearance of Eszopiclone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eszopiclone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ethosuximide Telithromycin may reduce clearance of Ethosuximide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ethosuximide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - etoposide Telithromycin may reduce clearance of Etoposide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Etoposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - felbamate Telithromycin may reduce clearance of Felbamate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felbamate if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - felodipine Telithromycin may reduce clearance of Felodipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felodipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - fentanyl Telithromycin may reduce clearance of Fentanyl. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Fentanyl if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - flunisolide Telithromycin may reduce clearance of Flunisolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flunisolide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - flurazepam Telithromycin may reduce clearance of Flurazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flurazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - flutamide Telithromycin may reduce clearance of Flutamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flutamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - fosamprenavir Fosamprevavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - fosphenytoin Fosphenytoin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - gefitinib Telithromycin may reduce clearance of Gefitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Gefitinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - halofantrine Telithromycin may reduce clearance of Halofantrine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Halofantrine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - haloperidol Telithromycin may reduce clearance of Haloperidol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Haloperidol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ifosfamide Telithromycin may reduce clearance of Ifosfamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ifosfamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - imatinib Co-administration may result in altered plasma concentrations of Imatinib and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - indinavir Indinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - irinotecan Telithromycin may reduce clearance of Irinotecan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Irinotecan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - isoniazid Isoniazid may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - isradipine Telithromycin may reduce clearance of Isradipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Isradipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - itraconazole Itraconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - Ixabepilone Telithromycin may reduce clearance of Ixabepilone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ixabepilone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ketamine Telithromycin may reduce clearance of Ketamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ketamine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ketoconazole Ketoconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - lapatinib Telithromycin may reduce clearance of Lapatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lapatinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - lidocaine Telithromycin may reduce clearance of Lidocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lidocaine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - lopinavir Lopinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - lovastatin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
telithromycin - lovastatin Telithromycin may reduce clearance of Lovastatin. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - maraviroc Telithromycin may reduce clearance of Maraviroc. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Maraviroc if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - mefloquine Telithromycin may reduce clearance of Mefloquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mefloquine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - methadone Telithromycin may reduce clearance of Methadone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Methadone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - methylergonovine Telithromycin may reduce clearance of Methylergonovine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Methylergonovine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - methysergide Risk of ergotism and severe ischemia with this association (source: Drug Bank )
telithromycin - metoprolol Telithromycin may possibly increase metoprolol effect (source: Drug Bank )
telithromycin - miconazole Miconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - midazolam Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
telithromycin - midazolam Telithromycin may reduce clearance of Midazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Midazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - mirtazapine Telithromycin may reduce clearance of Mirtazapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mirtazapine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - modafinil Telithromycin may reduce clearance of Modafinil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Modafinil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - moricizine Telithromycin may reduce clearance of Moricizine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Moricizine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - nafcillin Nafcillin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - nateglinide Telithromycin may reduce clearance of Nateglenide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nateglenide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - nefazodone Co-administration may result in altered plasma concentrations of Nefazodone and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - nelfinavir Nelfinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - nevirapine Nevirapine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - nicardipine Co-administration may result in altered plasma concentrations of Nicardipine and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank )
telithromycin - nifedipine Telithromycin may reduce clearance of Nifedipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nifedipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - nilotinib Telithromycin may reduce clearance of Nilotinib. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - nimodipine Telithromycin may reduce clearance of Nimodipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nimodipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - nisoldipine Telithromycin may reduce clearance of Nisoldipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nisoldipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - nitrendipine Telithromycin may reduce clearance of Nitrendipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nitrendipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - oxcarbazepine Oxcarbazepine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - paclitaxel Telithromycin may reduce clearance of Paclitaxel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Paclitaxel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - pentobarbital Pentobarbital may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - pergolide Telithromycin may reduce clearance of Pergolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pergolide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - phencyclidine Telithromycin may reduce clearance of Phencyclidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Phencyclidine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - phenobarbital Phenobarbital may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - phenytoin Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank )
telithromycin - phenytoin Phenytoin may decrease the plasma concentration of Telithromycin by increasing its metabolism. Consider alternate therapy. (source: Drug Bank )
telithromycin - pimozide Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - pimozide Telithromycin may reduce clearance of Pimozide. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - pipotiazine Telithromycin may reduce clearance of Pipotiazine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pipotiazine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - posaconazole Posaconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - praziquantel Telithromycin may reduce clearance of Praziquantel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Praziquantel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - primidone Primidone may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - quetiapine Telithromycin may reduce clearance of Quetiapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quetiapine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - quinine Telithromycin may reduce clearance of Quinine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quinine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - ranolazine Telithromycin may reduce clearance of Ranolazine. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - repaglinide Telithromycin may reduce clearance of Repaglinide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Repaglinide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - rifabutin Rifabutin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - rifampin Rifampin decreases the effect of telithromycin (source: Drug Bank )
telithromycin - rifampin Rifampin may decrease the plasma concentration of Telithromycin. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - rifapentine Rifapentine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank )
telithromycin - ritonavir Ritonavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - salmeterol Telithromycin may reduce clearance of Salmeterol. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - saquinavir Saquinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - sibutramine Telithromycin may reduce clearance of Sibutramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sibutramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - sildenafil Telithromycin may reduce clearance of Sildenafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sildenafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - simvastatin Telithromycin may possibly increase statin toxicity (source: Drug Bank )
telithromycin - simvastatin Telithromycin may reduce clearance of Simvastatin. Concomitant therapy is contraindicated. (source: Drug Bank )
telithromycin - sirolimus Telithromycin may reduce clearance of Sirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sirolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - solifenacin Telithromycin may reduce clearance of Solifenacin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Solifenacin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - sotalol Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - sotalol Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. (source: Drug Bank )
telithromycin - sufentanil Telithromycin may reduce clearance of Sufentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sufentanil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - sunitinib Possible increase in sunitinib levels (source: Drug Bank )
telithromycin - sunitinib Telithromycin may reduce clearance of Sunitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sunitinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tacrolimus This antibiotic increases the effect and toxicity of tacrolimus (source: Drug Bank )
telithromycin - tacrolimus Telithromycin may reduce clearance of Tacrolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tacrolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tadalafil Telithromycin may reduce clearance of Tadalafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tadalafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tamoxifen Telithromycin may reduce clearance of Tamoxifen. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tamoxifen if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tamsulosin Telithromycin may reduce clearance of Tamsulosin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - temsirolimus Telithromycin may reduce clearance of Temsirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Temsirolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - teniposide Telithromycin may reduce clearance of Teniposide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - terfenadine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - terfenadine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
telithromycin - tetrabenazine Telithromycin may increase the QTc-prolonging effect of Tetrabenazine. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - theophylline Telithromycin may reduce clearance of Theophylline. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Theophylline if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - thioridazine Telithromycin may increase the QTc-prolonging effect of Thioridazine. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - tiagabine Telithromycin may reduce clearance of Tiagabine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tolterodine Telithromycin may reduce clearance of Tolterodine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tolterodine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - tramadol Telithromycin may reduce clearance of Tramadol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tramadol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - trazodone Telithromycin may reduce clearance of Trazodone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Trazodone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - triazolam Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
telithromycin - triazolam Telithromycin may reduce clearance of Triazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Triazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - trimipramine Telithromycin may reduce clearance of Trimipramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Trimipramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - vardenafil Telithromycin may reduce clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vardenafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - venlafaxine Telithromycin may reduce clearance of Venlafaxine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Venlafaxine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - verapamil Telithromycin may possibly increase verapamil effect/toxicity (source: Drug Bank )
telithromycin - verapamil Telithromycin may reduce clearance of Verapamil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - vinblastine Telithromycin may reduce clearance of Vinblastine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - vincristine Telithromycin may reduce clearance of Vincristine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vincristine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - vinorelbine Telithromycin may reduce clearance of Vinorelbine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vinorelbine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - voriconazole Voriconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank )
telithromycin - warfarin Telithromycin increases the anticoagulant effect (source: Drug Bank )
telithromycin - warfarin Telithromycin may increase the anticoagulant effect of Warfarin. INR should be monitored and Warfarin dose adjusted accordingly during concomitant therapy. (source: Drug Bank )
telithromycin - ziprasidone Telithromycin may increase the QTc-prolonging effect of Ziprasidone. Concomitant therapy should be avoided. (source: Drug Bank )
telithromycin - zolpidem Telithromycin may reduce clearance of Zolpidem. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zolpidem if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - zonisamide Telithromycin may reduce clearance of Zonisamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zonisamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
telithromycin - zopiclone Telithromycin may reduce clearance of Zopiclone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zopiclone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
teniposide - telithromycin The strong CYP3A4 inhibitor, Telithromycin, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
terfenadine - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
terfenadine - telithromycin Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank )
thiothixene - telithromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
thiothixene - telithromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
tiagabine - telithromycin The strong CYP3A4 inhibitor, Telithromycin, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
tolterodine - telithromycin Telithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank )
tolterodine - telithromycin Telithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank )
toremifene - telithromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank )
tramadol - telithromycin Telithromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. (source: Drug Bank )
trazodone - telithromycin The CYP3A4 inhibitor, Telithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
trazodone - telithromycin The CYP3A4 inhibitor, Telithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
triazolam - telithromycin Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
triazolam - telithromycin Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank )
trimipramine - telithromycin Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Telithromycin, a strong CYP3A4 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Concomitant therapy should be used with caution. (source: Drug Bank )
valproic acid - telithromycin The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vardenafil - telithromycin Telithromycin, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil. (source: Drug Bank )
venlafaxine - telithromycin Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank )
verapamil - telithromycin Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vincristine - telithromycin Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
vinorelbine - telithromycin Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinorelbine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
voriconazole - telithromycin Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of telithromycin by decreasing its metabolism. Telithromycin may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed. QTc interval prolongation may also occur. (source: Drug Bank )
vorinostat - telithromycin Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank )
ziprasidone - telithromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated. (source: Drug Bank )
zolpidem - telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
zonisamide - telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
zopiclone - telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank )
zuclopenthixol - telithromycin Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank )
No related diseases are available

Publications related to telithromycin: 10

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Mechanisms and assessment of statin-related muscular adverse effects. British journal of clinical pharmacology. 2014. Moßhammer Dirk, et al. PubMed
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EMA Initiatives and Perspectives on Pharmacogenomics. British journal of clinical pharmacology. 2014. Ehmann Falk, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
PharmGKB summary: very important pharmacogene information for CYP3A5. Pharmacogenetics and genomics. 2012. Lamba Jatinder, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Review of macrolides (azithromycin, clarithromycin), ketolids (telithromycin) and glycylcyclines (tigecycline). The Medical clinics of North America. 2011. Zuckerman Jerry M, et al. PubMed
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KCNH2 pharmacogenomics summary. Pharmacogenetics and genomics. 2010. Oshiro Connie, et al. PubMed
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Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications. Clinical pharmacology and therapeutics. 2009. Zhang Y, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability. The Journal of pharmacology and experimental therapeutics. 2006. Wisialowski Todd, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide. Clinical pharmacology and therapeutics. 2006. Kajosaari Lauri I, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Macrolides and ketolides: azithromycin, clarithromycin, telithromycin. Infectious disease clinics of North America. 2004. Zuckerman Jerry M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
http://www.medscape.com/druginfo/monoinfobyid?cid=med&monotype=druginter&monoid=1697&mononame=CLARITHROMYCIN;+TELITHROMYCIN/IXABEPILONE&drugid=5030&drugname=Clarithromycin+Oral&intertype=server. [URL:http://www.medscape.com/druginfo/monoinfobyid?cid=med&monotype=druginter&monoid=1697&mononame=CLARITHROMYCIN;+TELITHROMYCIN/IXABEPILONE&drugid=5030&drugname=Clarithromycin+Oral&intertype=server]

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0088-2225-41
DrugBank:
DB00976
PDB:
TEL
KEGG Compound:
C12009
KEGG Drug:
D01078
PubChem Compound:
5462516
PubChem Substance:
14168
Drugs Product Database (DPD):
2247520
HET:
TEL
Therapeutic Targets Database:
DAP000109
FDA Drug Label at DailyMed:
4471223e-9023-457e-be2e-8e4e0c2d94d1

Clinical Trials

These are trials that mention telithromycin and are related to either pharmacogenetics or pharmacogenomics.

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NURSA Datasets

provided by nursa.org

No NURSA datasets available.

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Sources for PharmGKB drug information: DrugBank, PubChem.