Chemical: Drug
telithromycin
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1. Annotation of EMA Label for telithromycin and CYP3A4
Summary
The EMA European Public Assessment Report (EPAR) for telithromycin (Ketek) does not contain pharmacogenetic information. It contains information regarding metabolism by CYP3A4 and contains information regarding use of concomitant drugs that are CYP3A4 substrates, inhibitors or inducers.
Annotation
The EMA-approved drug telithromycin is tagged with CYP3A4 in [Article:24433361].
For the complete drug label text with sections containing pharmacogenetic information highlighted, see the telithromycin EMA drug label.
*Disclaimer: The contents of this page have not been endorsed by the EMA and are the sole responsibility of PharmGKB.
Genes and/or phenotypes found in this label
-
CYP3A4
- metabolism/PK, Contraindications section, Drug interactions section, Warnings and precautions section
- source: European Medicines Agency
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Gene" column lead to PharmGKB Gene Pages.
List of all variant annotations for telithromycin
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
| Gene ? |
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|---|
| rs776746 | NC_000007.13:g.99270539C>T, NC_000007.14:g.99672916T>C, NG_007938.1:g.12083G=, NG_007938.1:g.12083G>A, NM_000777.4:c.219-237A>G, NM_000777.4:c.219-237G>A, NM_001190484.2:c.219-237A>G, NM_001190484.2:c.219-237G>A, NM_001291829.1:c.-253-1A>G, NM_001291829.1:c.-253-1G>A, NM_001291830.1:c.189-237A>G, NM_001291830.1:c.189-237G>A, NR_033807.2:n.717-1A>G, NR_033807.2:n.717-1G>A, NR_033808.1:n.689-1G>A, NR_033809.1:n.581-237G>A, NR_033810.1:n.689-1G>A, NR_033811.1:n.321-1G>A, NR_033812.1:n.321-1G>A, XM_005250169.1:c.189-237G>A, XM_005250170.1:c.-357-1G>A, XM_005250171.1:c.-253-1G>A, XM_005250172.1:c.-254G>A, XM_005250173.1:c.-331-237G>A, XM_005250198.1:c.806-4288C>T, XM_006715859.2:c.219-237A>G, XM_011515843.1:c.-254A>G, XM_011515844.1:c.-229-237A>G, XM_011515845.1:c.-463-1A>G, XM_011515846.1:c.-331-237A>G, XM_011515847.1:c.-571-1A>G, XR_927383.1:n.344-237A>G, XR_927402.1:n.1466+48736T>C, rs10361242, rs11266830, rs386613022, rs58244770 |
C > T
|
SNP |
Overview
- telithromycin
- Ketek
PharmGKB Accession Id
PA10202
Type(s):
Drug
Description
Source: Drug Bank
Indication
Source: Drug Bank
Other Vocabularies
- ATC: Macrolides (J01FA)
- UMLS: telithromycin (C0907410)
- RxNorm: telithromycin (274786)
- NDFRT: TELITHROMYCIN (N0000148854)
Information pulled from DrugBank has not been reviewed by PharmGKB.
Pharmacology, Interactions, and Contraindications
Mechanism of Action
Source: Drug Bank
Pharmacology
Source: Drug Bank
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Source: Drug Bank
Absorption
Source: Drug Bank
Half-Life
Source: Drug Bank
Toxicity
Source: Drug Bank
Route of Elimination
Source: Drug Bank
Chemical Properties
SMILES
CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C
Source: PubChem
InChI String
InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42+,43-/m1/s1
Source: PubChem
Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.
Curated Information ?
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
[ close ]
Drug Interactions
| Interaction | Description |
|---|---|
| alprazolam - telithromycin | Increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| alprazolam - telithromycin | Increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| amiodarone - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| amiodarone - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| astemizole - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| astemizole - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| atorvastatin - telithromycin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| atorvastatin - telithromycin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| bromazepam - telithromycin | Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if telithromycin is initiated, discontinued or dose changed. Dosage adjustments may be required. (source: Drug Bank ) |
| carbamazepine - telithromycin | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| carbamazepine - telithromycin | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| cisapride - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| cisapride - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| colchicine - telithromycin | Severe colchicine toxicity can occur (source: Drug Bank ) |
| colchicine - telithromycin | Severe colchicine toxicity can occur (source: Drug Bank ) |
| cyclosporine - telithromycin | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| cyclosporine - telithromycin | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| dantrolene - telithromycin | Telithromycin may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| digoxin - telithromycin | Telithromycin may increase levels of digoxin (source: Drug Bank ) |
| digoxin - telithromycin | Telithromycin may increase levels of digoxin (source: Drug Bank ) |
| dihydroergotamine - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| dihydroergotamine - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| disopyramide - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| disopyramide - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| ergotamine - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| ergotamine - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| fosphenytoin - telithromycin | Telithromycin may possibly increase this agent's effect/toxicity (source: Drug Bank ) |
| lovastatin - telithromycin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| lovastatin - telithromycin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| methysergide - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| methysergide - telithromycin | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| metoprolol - telithromycin | Telithromycin may possibly increase metoprolol effect (source: Drug Bank ) |
| metoprolol - telithromycin | Telithromycin may possibly increase metoprolol effect (source: Drug Bank ) |
| midazolam - telithromycin | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| phenytoin - telithromycin | Telithromycin may possibly increase the agent effect/toxicity (source: Drug Bank ) |
| phenytoin - telithromycin | Telithromycin may possibly increase the effect and toxicity of phenytoin. (source: Drug Bank ) |
| pimozide - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| pimozide - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| quinidine - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| quinidine - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| ranolazine - telithromycin | Increased levels of ranolazine - risk of toxicity (source: Drug Bank ) |
| rifampin - telithromycin | Rifampin decreases the effect of telithromycin (source: Drug Bank ) |
| rifampin - telithromycin | Rifampin decreases the effect of telithromycin (source: Drug Bank ) |
| tadalafil - telithromycin | Telithromycin may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity. (source: Drug Bank ) |
| tamoxifen - telithromycin | Telithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank ) |
| tamoxifen - telithromycin | Telithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank ) |
| tamsulosin - telithromycin | Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank ) |
| tamsulosin - telithromycin | Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank ) |
| telithromycin - acenocoumarol | Telithromycin increases the anticoagulant effect (source: Drug Bank ) |
| telithromycin - acenocoumarol | Telithromycin may increase the anticoagulant effect of acenocoumarol. (source: Drug Bank ) |
| telithromycin - alfentanil | Telithromycin may reduce clearance of Alfentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Alfentanil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - alfuzosin | Telithromycin may reduce clearance of Alfuzosin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - alprazolam | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| telithromycin - alprazolam | Telithromycin may reduce clearance of Alprazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Alprazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - aminoglutethimide | Aminoglutethimide may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - amiodarone | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - amiodarone | Telithromycin may reduce clearance of Amiodarone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amiodarone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - amlodipine | Telithromycin may reduce clearance of Amlopidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amlopidine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - amprenavir | Co-administration may result in altered plasma concentrations of Amprenavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - anisindione | Telithromycin may increase the anticoagulant effect of anisindione. (source: Drug Bank ) |
| telithromycin - aprepitant | Telithromycin may reduce clearance of Aprepitant. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Aprepitant if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - aripiprazole | Telithromycin may reduce clearance of Aripiprazole. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Aripiprazole if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - astemizole | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - astemizole | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - atazanavir | Co-administration may result in altered plasma concentrations of Atazanavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - atorvastatin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| telithromycin - atorvastatin | Telithromycin may reduce clearance of Atorvastatin. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - benzphetamine | Telithromycin may reduce clearance of Benzphetamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Benzphetamine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - bisoprolol | Telithromycin may reduce clearance of Bisoprolol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bisoprolol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - bortezomib | Telithromycin may reduce clearance of Bortezomib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bortezomib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - bosentan | Co-administration may cause decreased Telithromycin and increased Bosentan plasma concentrations. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - bretylium | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - bretylium | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - bromazepam | Telithromycin may reduce clearance of Bromazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bromazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - bromocriptine | Telithromycin may reduce clearance of Bromocriptine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Bromocriptine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - budesonide | Telithromycin may reduce clearance of Budesonide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Budesonide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - buprenorphine | Telithromycin may reduce clearance of Buprenorphine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Buprenorphine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - buspirone | Telithromycin may reduce clearance of Buspirone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Buspirone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - busulfan | Telithromycin may reduce clearance of Busulfan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Busulfan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - calcitriol | Telithromycin may reduce clearance of Calcitriol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Calcitriol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - carbamazepine | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| telithromycin - carbamazepine | Co-administration may cause decreased Telithromycin and increased Carbemazepine plasma concentrations. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - chlordiazepoxide | Telithromycin may reduce clearance of Chlordiazepoxide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chlordiazepoxide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - chloroquine | Telithromycin may reduce clearance of Chloroquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chloroquine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - chlorpheniramine | Telithromycin may reduce clearance of Chlorpheniramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chlorpheniramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ciclesonide | Telithromycin may reduce clearance of Ciclesonide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ciclesonide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - cilostazol | Telithromycin may reduce clearance of Cilostazol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cilostazol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - cinacalcet | Telithromycin may reduce clearance of Cinacalcet. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cinacalcet if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - cisapride | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - cisapride | Telithromycin may reduce clearance of Cisapride. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - citalopram | Telithromycin may reduce clearance of Citalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Citalopram if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - clarithromycin | Co-administration may result in altered plasma concentrations of Clarithromycin and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - clobazam | Telithromycin may reduce clearance of Clobazam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clobazam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - clonazepam | Telithromycin may reduce clearance of Clonazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clonazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - clorazepate | Telithromycin may reduce clearance of Clorazepate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clorazepate if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - cocaine | Telithromycin may reduce clearance of Cocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cocaine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - colchicine | Severe colchicine toxicity can occur (source: Drug Bank ) |
| telithromycin - colchicine | Telithromycin may reduce clearance of Colchicine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Colchicine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - conivaptan | Co-administration may result in altered plasma concentrations of Conivaptan and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - cyclosporine | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| telithromycin - cyclosporine | Telithromycin may reduce clearance of Cyclosporine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cyclosporine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - dantrolene | Telithromycin may reduce clearance of Dantrolene. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dantrolene if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - dapsone | Telithromycin may reduce clearance of Dapsone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dapsone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - darifenacin | Telithromycin may reduce clearance of Darifenacin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Darifenacin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - darunavir | Co-administration may result in altered plasma concentrations of Darunavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - dasatinib | Increased levels/toxicity of dasatinib (source: Drug Bank ) |
| telithromycin - dasatinib | Telithromycin may reduce clearance of Dasatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Dasatinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - delavirdine | Delavirdine may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - dexamethasone | Co-administration may cause decreased Telithromycin and increased Dexamethasone plasma concentrations. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - diazepam | Telithromycin may reduce clearance of Diazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Diazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - dicumarol | Telithromycin increases the anticoagulant effect (source: Drug Bank ) |
| telithromycin - dicumarol | Telithromycin may increase the anticoagulant effect of dicumarol. (source: Drug Bank ) |
| telithromycin - digitoxin | Telithromycin may reduce clearance of Digitoxin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Digitoxin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - digoxin | Telithromycin may increase levels of digoxin (source: Drug Bank ) |
| telithromycin - digoxin | Telithromycin may increase the plasma concentration of Digoxin. Monitor for changes in Digoxin efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - dihydroergotamine | Telithromycin may reduce clearance of Dihydroergotamine. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - diltiazem | Telithromycin may reduce clearance of Diltiazem. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Diltiazem if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - disopyramide | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - disopyramide | Telithromycin may reduce clearance of Disopyramide. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - docetaxel | Telithromycin may reduce clearance of Docetaxel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Docetaxel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - dofetilide | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - dofetilide | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - doxepin | Telithromycin may reduce clearance of Doxepin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxepin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - doxorubicin | Telithromycin may reduce clearance of Doxorubicin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Doxorubicin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - efavirenz | Efavirenz may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - eletriptan | Telithromycin may reduce clearance of Eletriptan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eletriptan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - eplerenone | Telithromycin may reduce clearance of Eplerenone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eplerenone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ergonovine | Telithromycin may reduce clearance of Ergonovine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ergonivine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ergotamine | Telithromycin may reduce clearance of Ergotamine. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - erlotinib | This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank ) |
| telithromycin - erlotinib | Telithromycin may reduce clearance of Erlotinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erlotinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - erythromycin | Telithromycin may reduce clearance of Erythromycin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Erythromycin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - escitalopram | Telithromycin may reduce clearance of Escitalopram. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Escitalopram if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - eszopiclone | Telithromycin may reduce clearance of Eszopiclone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Eszopiclone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ethosuximide | Telithromycin may reduce clearance of Ethosuximide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ethosuximide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - etoposide | Telithromycin may reduce clearance of Etoposide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Etoposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - felbamate | Telithromycin may reduce clearance of Felbamate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felbamate if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - felodipine | Telithromycin may reduce clearance of Felodipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Felodipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - fentanyl | Telithromycin may reduce clearance of Fentanyl. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Fentanyl if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - flunisolide | Telithromycin may reduce clearance of Flunisolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flunisolide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - flurazepam | Telithromycin may reduce clearance of Flurazepam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flurazepam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - flutamide | Telithromycin may reduce clearance of Flutamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flutamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - fosamprenavir | Fosamprevavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - fosphenytoin | Fosphenytoin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - gefitinib | Telithromycin may reduce clearance of Gefitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Gefitinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - halofantrine | Telithromycin may reduce clearance of Halofantrine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Halofantrine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - haloperidol | Telithromycin may reduce clearance of Haloperidol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Haloperidol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ifosfamide | Telithromycin may reduce clearance of Ifosfamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ifosfamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - imatinib | Co-administration may result in altered plasma concentrations of Imatinib and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - indinavir | Indinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - irinotecan | Telithromycin may reduce clearance of Irinotecan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Irinotecan if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - isoniazid | Isoniazid may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - isradipine | Telithromycin may reduce clearance of Isradipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Isradipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - itraconazole | Itraconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - Ixabepilone | Telithromycin may reduce clearance of Ixabepilone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ixabepilone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ketamine | Telithromycin may reduce clearance of Ketamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ketamine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ketoconazole | Ketoconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - lapatinib | Telithromycin may reduce clearance of Lapatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lapatinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - lidocaine | Telithromycin may reduce clearance of Lidocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lidocaine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - lopinavir | Lopinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - lovastatin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| telithromycin - lovastatin | Telithromycin may reduce clearance of Lovastatin. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - maraviroc | Telithromycin may reduce clearance of Maraviroc. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Maraviroc if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - mefloquine | Telithromycin may reduce clearance of Mefloquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mefloquine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - methadone | Telithromycin may reduce clearance of Methadone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Methadone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - methylergonovine | Telithromycin may reduce clearance of Methylergonovine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Methylergonovine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - methysergide | Risk of ergotism and severe ischemia with this association (source: Drug Bank ) |
| telithromycin - metoprolol | Telithromycin may possibly increase metoprolol effect (source: Drug Bank ) |
| telithromycin - miconazole | Miconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - midazolam | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| telithromycin - midazolam | Telithromycin may reduce clearance of Midazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Midazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - mirtazapine | Telithromycin may reduce clearance of Mirtazapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mirtazapine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - modafinil | Telithromycin may reduce clearance of Modafinil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Modafinil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - moricizine | Telithromycin may reduce clearance of Moricizine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Moricizine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - nafcillin | Nafcillin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - nateglinide | Telithromycin may reduce clearance of Nateglenide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nateglenide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - nefazodone | Co-administration may result in altered plasma concentrations of Nefazodone and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - nelfinavir | Nelfinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - nevirapine | Nevirapine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - nicardipine | Co-administration may result in altered plasma concentrations of Nicardipine and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank ) |
| telithromycin - nifedipine | Telithromycin may reduce clearance of Nifedipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nifedipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - nilotinib | Telithromycin may reduce clearance of Nilotinib. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - nimodipine | Telithromycin may reduce clearance of Nimodipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nimodipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - nisoldipine | Telithromycin may reduce clearance of Nisoldipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nisoldipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - nitrendipine | Telithromycin may reduce clearance of Nitrendipine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Nitrendipine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - oxcarbazepine | Oxcarbazepine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - paclitaxel | Telithromycin may reduce clearance of Paclitaxel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Paclitaxel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - pentobarbital | Pentobarbital may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - pergolide | Telithromycin may reduce clearance of Pergolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pergolide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - phencyclidine | Telithromycin may reduce clearance of Phencyclidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Phencyclidine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - phenobarbital | Phenobarbital may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - phenytoin | Telithromycin may possibly increase this agent effect/toxicity (source: Drug Bank ) |
| telithromycin - phenytoin | Phenytoin may decrease the plasma concentration of Telithromycin by increasing its metabolism. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - pimozide | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - pimozide | Telithromycin may reduce clearance of Pimozide. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - pipotiazine | Telithromycin may reduce clearance of Pipotiazine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pipotiazine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - posaconazole | Posaconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - praziquantel | Telithromycin may reduce clearance of Praziquantel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Praziquantel if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - primidone | Primidone may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - quetiapine | Telithromycin may reduce clearance of Quetiapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quetiapine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - quinidine | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - quinidine | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - quinine | Telithromycin may reduce clearance of Quinine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quinine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - ranolazine | Telithromycin may reduce clearance of Ranolazine. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - repaglinide | Telithromycin may reduce clearance of Repaglinide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Repaglinide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - rifabutin | Rifabutin may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - rifampin | Rifampin decreases the effect of telithromycin (source: Drug Bank ) |
| telithromycin - rifampin | Rifampin may decrease the plasma concentration of Telithromycin. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - rifapentine | Rifapentine may decrease the plasma concentration of Telithromycin. Consider alternate therapy. (source: Drug Bank ) |
| telithromycin - ritonavir | Ritonavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - salmeterol | Telithromycin may reduce clearance of Salmeterol. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - saquinavir | Saquinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - sibutramine | Telithromycin may reduce clearance of Sibutramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sibutramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - sildenafil | Telithromycin may reduce clearance of Sildenafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sildenafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - simvastatin | Telithromycin may possibly increase statin toxicity (source: Drug Bank ) |
| telithromycin - simvastatin | Telithromycin may reduce clearance of Simvastatin. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| telithromycin - sirolimus | Telithromycin may reduce clearance of Sirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sirolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - solifenacin | Telithromycin may reduce clearance of Solifenacin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Solifenacin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - sotalol | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - sotalol | Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. (source: Drug Bank ) |
| telithromycin - sufentanil | Telithromycin may reduce clearance of Sufentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sufentanil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - sunitinib | Possible increase in sunitinib levels (source: Drug Bank ) |
| telithromycin - sunitinib | Telithromycin may reduce clearance of Sunitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sunitinib if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tacrolimus | This antibiotic increases the effect and toxicity of tacrolimus (source: Drug Bank ) |
| telithromycin - tacrolimus | Telithromycin may reduce clearance of Tacrolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tacrolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tadalafil | Telithromycin may reduce clearance of Tadalafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tadalafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tamoxifen | Telithromycin may reduce clearance of Tamoxifen. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tamoxifen if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tamsulosin | Telithromycin may reduce clearance of Tamsulosin. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tamsulosin if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - temsirolimus | Telithromycin may reduce clearance of Temsirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Temsirolimus if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - teniposide | Telithromycin may reduce clearance of Teniposide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - terfenadine | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - terfenadine | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| telithromycin - tetrabenazine | Telithromycin may increase the QTc-prolonging effect of Tetrabenazine. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - theophylline | Telithromycin may reduce clearance of Theophylline. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Theophylline if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - thioridazine | Telithromycin may increase the QTc-prolonging effect of Thioridazine. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - tiagabine | Telithromycin may reduce clearance of Tiagabine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tolterodine | Telithromycin may reduce clearance of Tolterodine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tolterodine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - tramadol | Telithromycin may reduce clearance of Tramadol. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tramadol if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - trazodone | Telithromycin may reduce clearance of Trazodone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Trazodone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - triazolam | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| telithromycin - triazolam | Telithromycin may reduce clearance of Triazolam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Triazolam if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - trimipramine | Telithromycin may reduce clearance of Trimipramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Trimipramine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - vardenafil | Telithromycin may reduce clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vardenafil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - venlafaxine | Telithromycin may reduce clearance of Venlafaxine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Venlafaxine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - verapamil | Telithromycin may possibly increase verapamil effect/toxicity (source: Drug Bank ) |
| telithromycin - verapamil | Telithromycin may reduce clearance of Verapamil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - vinblastine | Telithromycin may reduce clearance of Vinblastine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - vincristine | Telithromycin may reduce clearance of Vincristine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vincristine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - vinorelbine | Telithromycin may reduce clearance of Vinorelbine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Vinorelbine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - voriconazole | Voriconazole may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects. (source: Drug Bank ) |
| telithromycin - warfarin | Telithromycin increases the anticoagulant effect (source: Drug Bank ) |
| telithromycin - warfarin | Telithromycin may increase the anticoagulant effect of Warfarin. INR should be monitored and Warfarin dose adjusted accordingly during concomitant therapy. (source: Drug Bank ) |
| telithromycin - ziprasidone | Telithromycin may increase the QTc-prolonging effect of Ziprasidone. Concomitant therapy should be avoided. (source: Drug Bank ) |
| telithromycin - zolpidem | Telithromycin may reduce clearance of Zolpidem. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zolpidem if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - zonisamide | Telithromycin may reduce clearance of Zonisamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zonisamide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| telithromycin - zopiclone | Telithromycin may reduce clearance of Zopiclone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Zopiclone if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| teniposide - telithromycin | The strong CYP3A4 inhibitor, Telithromycin, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| terfenadine - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| terfenadine - telithromycin | Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank ) |
| thiothixene - telithromycin | May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank ) |
| thiothixene - telithromycin | May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank ) |
| tiagabine - telithromycin | The strong CYP3A4 inhibitor, Telithromycin, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| tolterodine - telithromycin | Telithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank ) |
| tolterodine - telithromycin | Telithromycin may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank ) |
| toremifene - telithromycin | Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration. (source: Drug Bank ) |
| tramadol - telithromycin | Telithromycin may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. (source: Drug Bank ) |
| trazodone - telithromycin | The CYP3A4 inhibitor, Telithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| trazodone - telithromycin | The CYP3A4 inhibitor, Telithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| triazolam - telithromycin | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| triazolam - telithromycin | Telithromycin increases the effect/toxicity of the benzodiazepine (source: Drug Bank ) |
| trimipramine - telithromycin | Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Telithromycin, a strong CYP3A4 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Concomitant therapy should be used with caution. (source: Drug Bank ) |
| valproic acid - telithromycin | The macrolide antibiotic, Erythromycin, may increase the serum concentratin of Valproic acid. Consider alternate therapy or monitor for changes in Valproic acid therapeutic and adverse effects if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| vardenafil - telithromycin | Telithromycin, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil. (source: Drug Bank ) |
| venlafaxine - telithromycin | Telithromycin, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Telithromycin is initiated, discontinued, or dose changed. (source: Drug Bank ) |
| verapamil - telithromycin | Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| vincristine - telithromycin | Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vincristine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| vinorelbine - telithromycin | Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinorelbine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| voriconazole - telithromycin | Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of telithromycin by decreasing its metabolism. Telithromycin may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed. QTc interval prolongation may also occur. (source: Drug Bank ) |
| vorinostat - telithromycin | Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank ) |
| ziprasidone - telithromycin | Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated. (source: Drug Bank ) |
| zolpidem - telithromycin | Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| zonisamide - telithromycin | Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| zopiclone - telithromycin | Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if telithromycin is initiated, discontinued or dose changed. (source: Drug Bank ) |
| zuclopenthixol - telithromycin | Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). (source: Drug Bank ) |
Publications related to telithromycin: 10
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- DAP000109
- FDA Drug Label at DailyMed:
- 4471223e-9023-457e-be2e-8e4e0c2d94d1
Clinical Trials
These are trials that mention telithromycin and are related to either pharmacogenetics or pharmacogenomics.
NURSA Datasets
No NURSA datasets available.
