Chemical: Drug
adalimumab

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.



PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

List of all variant annotations for adalimumab

Gene ? Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA HLA-DRB1 *04:01:01 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:02 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:03 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:04 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:05 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:06 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:07 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *04:01:08 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *15:01:01:01 N/A N/A N/A
No VIP available No VIP available VA HLA-DRB1 *15:02:01 N/A N/A N/A
No VIP available CA VA
rs10210302 NC_000002.11:g.234158839C>T, NC_000002.12:g.233250193C>T, NG_023038.1:g.3623C>T, NM_001190266.1:c.-1885C>T, NM_001190267.1:c.-1979C>T, NM_017974.3:c.-1635C>T, NM_030803.6:c.-1635C>T, NM_198890.2:c.-1635C>T, NW_011332690.1:g.195531C>T, XM_005246082.1:c.-1635C>T, XM_005246083.1:c.-1979C>T, XM_005246084.1:c.-1635C>T, XM_005246085.1:c.-1979C>T, XM_005246086.1:c.-1635C>T, XM_005246087.1:c.-1635C>T, XM_006712608.1:c.-1635C>T, XM_011548853.1:c.-1635C>T, XM_011548854.1:c.-1635C>T, XM_011548855.1:c.-1635C>T, XM_011548856.1:c.-1635C>T, XR_241242.1:n.-1441C>T, XR_953240.1:n.-1441C>T, rs57072142
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1043879 NC_000001.10:g.25570081T>C, NC_000001.11:g.25243590T>C, NM_020317.4:c.716A>G, NP_064713.3:p.Glu239Gly, NR_135143.1:n.2509A>G, NR_135144.1:n.1584A>G, XM_011541797.1:c.716A>G, XM_011541798.1:c.*79A>G, XP_011540099.1:p.Glu239Gly, XR_241196.1:n.2280A>G, XR_241197.1:n.1962A>G, XR_241198.1:n.1689A>G, XR_241199.1:n.1858A>G, XR_241200.1:n.1629A>G, XR_241201.1:n.1038A>G, XR_946709.1:n.2280A>G, XR_946710.1:n.1962A>G, XR_946711.1:n.1689A>G, XR_946712.1:n.1858A>G, XR_946713.1:n.1584A>G, rs17844932, rs17857662, rs17859787, rs57469912
T > -
T > C
SNP
E239G
No VIP available No Clinical Annotations available VA
rs10499194 NC_000006.11:g.138002637C>T, NC_000006.12:g.137681500C>T
C > T
SNP
No VIP available No Clinical Annotations available VA
rs1050501 NC_000001.10:g.161643798T>C, NC_000001.11:g.161674008T>C, NG_023318.1:g.15894T>C, NM_001002273.2:c.692T>C, NM_001002274.2:c.695T>C, NM_001002275.2:c.692T>C, NM_001190828.1:c.674T>C, NM_004001.4:c.695T>C, NP_001002273.1:p.Ile231Thr, NP_001002274.1:p.Ile232Thr, NP_001002275.1:p.Ile231Thr, NP_001177757.1:p.Ile225Thr, NP_003992.3:p.Ile232Thr, XM_011509292.1:c.*486T>C, rs17416926, rs3171037, rs3818924, rs59522454
T > C
SNP
I231T
No VIP available No Clinical Annotations available VA
rs10512734 NC_000005.10:g.40393503A>G, NC_000005.9:g.40393605A>G, rs386514060, rs57228475
A > G
SNP
No VIP available CA VA
rs1059150 NC_000020.10:g.57605439T>G, NC_000020.11:g.59030384T>G, NG_031871.1:g.6984A>C, NM_006886.3:c.78A>C, NP_008817.1:p.Ala26=, NR_037929.1:n.782A>C, NR_037930.1:n.523A>C, rs3199795
T > -
T > G
SNP
A26A
No VIP available No Clinical Annotations available VA
rs1061622 NC_000001.10:g.12252955T>G, NC_000001.11:g.12192898T>G, NG_029791.1:g.30896T>G, NM_001066.2:c.587T>G, NP_001057.1:p.Met196Arg, XM_011542060.1:c.587T>G, XM_011542061.1:c.587T>G, XM_011542062.1:c.566T>G, XM_011542063.1:c.587T>G, XP_011540362.1:p.Met196Arg, XP_011540363.1:p.Met196Arg, XP_011540364.1:p.Met189Arg, XP_011540365.1:p.Met196Arg, XR_244793.1:n.692T>G, rs13306722, rs1681698, rs17037789, rs17883437, rs2228492, rs52797629, rs60195947
T > G
SNP
M196R
No VIP available No Clinical Annotations available VA
rs10903129 NC_000001.10:g.25768937A>G, NC_000001.11:g.25442446A>G, NM_001282564.1:c.81-4316A>G, NM_018202.5:c.81-4316A>G, XM_005245931.1:c.81-4316A>G, XM_005245932.1:c.81-4316A>G, XM_005245933.1:c.80+11268A>G, XM_011541704.1:c.-531-4316A>G, rs17537348, rs56639081, rs60964820
A > G
SNP
No VIP available CA VA
rs10919563 NC_000001.10:g.198700442G>A, NC_000001.11:g.198731313G>A, NG_007730.1:g.97218G>A, NM_002838.4:c.1865-304G>A, NM_080921.3:c.1382-304G>A, XM_006711472.2:c.1721-304G>A, XM_006711473.2:c.1667-304G>A, XM_006711474.2:c.1523-304G>A, rs61716706
G > A
SNP
No VIP available CA VA
rs1130864 NC_000001.10:g.159683091G>A, NC_000001.11:g.159713301G>A, NG_013007.1:g.6289C>T, NM_000567.2:c.*224C>T, XM_005244904.1:c.*22+202C>T, XM_011509207.1:c.*22+202C>T, rs17860480
G > A
SNP
No VIP available No Clinical Annotations available VA
rs11586238 NC_000001.10:g.117263138C>G, NC_000001.11:g.116720516C>G, rs17377407, rs56747362
C > G
SNP
No VIP available CA VA
rs1264457 NC_000006.11:g.30458064G=, NC_000006.11:g.30458064G>A, NC_000006.12:g.30490287G=, NC_000006.12:g.30490287G>A, NM_005516.5:c.382G=, NM_005516.5:c.382G>A, NP_005507.3:p.Gly128=, NP_005507.3:p.Gly128Arg, NT_113891.2:g.1970128A=, NT_113891.2:g.1970128A>G, NT_113891.3:g.1970022A=, NT_113891.3:g.1970022A>G, NT_167245.1:g.1751704A=, NT_167245.1:g.1751704A>G, NT_167245.2:g.1746119A=, NT_167245.2:g.1746119A>G, NT_167246.1:g.1806142G=, NT_167246.1:g.1806142G>A, NT_167246.2:g.1800522G=, NT_167246.2:g.1800522G>A, NT_167247.1:g.1839928G=, NT_167247.1:g.1839928G>A, NT_167247.2:g.1834343G=, NT_167247.2:g.1834343G>A, NT_167248.1:g.1750979A=, NT_167248.1:g.1750979A>G, NT_167248.2:g.1745383A=, NT_167248.2:g.1745383A>G, NT_167249.1:g.1790354A=, NT_167249.1:g.1790354A>G, NT_167249.2:g.1791056A=, NT_167249.2:g.1791056A>G, rs115492845, rs117192178, rs17195355, rs7767992
G > A
SNP
G128R
No VIP available No Clinical Annotations available VA
rs12777960 NC_000010.10:g.35541026C>A, NC_000010.11:g.35252098C>A, NM_181698.3:c.-9+1472C>A, XM_011519358.1:c.-116+1472C>A, XM_011519359.1:c.-325+1472C>A, XM_011519360.1:c.-224+1472C>A, XM_011519361.1:c.-103+1472C>A, XM_011519362.1:c.-40+1472C>A, XM_011519363.1:c.-108+1472C>A, XM_011519364.1:c.-218+1472C>A, XM_011519365.1:c.-139+1472C>A, XM_011519366.1:c.-66+1472C>A, rs59091985
C > A
SNP
No VIP available No Clinical Annotations available VA
rs1295686 NC_000005.10:g.132660151T>C, NC_000005.9:g.131995843T>C, NG_012090.1:g.6979T>C, NM_002188.2:c.334-24T>C, rs386526750, rs58093005
T > C
SNP
No VIP available No Clinical Annotations available VA
rs13031237 NC_000002.11:g.61136129G>T, NC_000002.12:g.60908994G>T, NM_001291746.1:c.395-7883G>T, NM_002908.3:c.395-7883G>T, XM_005264470.1:c.395-7883G>T, XM_005264471.1:c.395-7883G>T, XM_005264472.1:c.395-7883G>T, XM_011533010.1:c.101-7883G>T, rs52833967, rs56896973
G > T
SNP
No VIP available No Clinical Annotations available VA
rs1799724 NC_000006.11:g.31542482C>T, NC_000006.12:g.31574705C>T, NG_007462.1:g.4133C>T, NG_012010.1:g.7607C>T, NM_000594.3:c.-1037C>T, NM_000595.3:c.*1012C>T, NM_001159740.2:c.*1012C>T, NT_113891.2:g.3052098C>T, NT_113891.3:g.3051992C>T, NT_167245.1:g.2828023C>T, NT_167245.2:g.2822438C>T, NT_167246.1:g.2885366C>T, NT_167246.2:g.2879746C>T, NT_167247.1:g.2922188C>T, NT_167247.2:g.2916603C>T, NT_167248.1:g.2836120C>T, NT_167248.2:g.2830524C>T, NT_167249.1:g.2873283C>T, NT_167249.2:g.2873985C>T, XM_011514614.1:c.*1012C>T, XM_011514615.1:c.*1012C>T, XM_011514616.1:c.*1012C>T, XM_011514617.1:c.*1012C>T, XM_011514618.1:c.*1012C>T, XM_011547250.1:c.*1012C>T, XM_011547653.1:c.*1012C>T, XM_011547654.1:c.*1012C>T, XM_011547883.1:c.*1012C>T, XM_011547884.1:c.*1012C>T, XM_011547885.1:c.*1012C>T, XM_011547886.1:c.*1012C>T, XM_011547887.1:c.*1012C>T, XM_011548050.1:c.*1012C>T, XM_011548051.1:c.*1012C>T, XM_011548242.1:c.*1012C>T, XM_011548243.1:c.*1012C>T, XM_011548436.1:c.*1012C>T, XM_011548437.1:c.*1012C>T, XM_011548438.1:c.*1012C>T, XM_011548439.1:c.*1012C>T, XM_011548440.1:c.*1012C>T, XR_952245.1:n.-1983G>A, rs112098114, rs114464955, rs117934520, rs36205301, rs3807038, rs4151108
C > T
SNP
No VIP available CA VA
rs1799852 NC_000003.11:g.133475722C>T, NC_000003.12:g.133756878C>T, NG_013080.1:g.15746C>T, NM_001063.3:c.739C>T, NP_001054.1:p.Leu247=, XM_005247730.1:c.358C>T, XM_011513100.1:c.739C>T, XP_005247787.1:p.Leu120=, XP_011511402.1:p.Leu247=, rs56561776, rs56714894, rs8177231
C > T
SNP
L247L
No VIP available No Clinical Annotations available VA
rs1800471 NC_000019.10:g.41352971C>G, NC_000019.9:g.41858876C>G, NG_013091.1:g.16203G>C, NG_013364.1:g.5956G>C, NM_000660.5:c.74G>C, NP_000651.3:p.Arg25Pro, XM_005259150.1:c.-30+1769C>G, XM_005259187.1:c.74G>C, XM_011527242.1:c.74G>C, XP_005259244.1:p.Arg25Pro, XP_011525544.1:p.Arg25Pro, rs4987231
C > G
SNP
R25P
No VIP available CA VA
rs1800629 NC_000006.11:g.31543031G=, NC_000006.11:g.31543031G>A, NC_000006.12:g.31575254G=, NC_000006.12:g.31575254G>A, NG_007462.1:g.4682G=, NG_007462.1:g.4682G>A, NG_012010.1:g.8156G=, NG_012010.1:g.8156G>A, NM_000594.3:c.-488A>G, NM_000594.3:c.-488G>A, NT_113891.2:g.3052647A=, NT_113891.2:g.3052647A>G, NT_113891.3:g.3052541A=, NT_113891.3:g.3052541A>G, NT_167245.1:g.2828572G=, NT_167245.1:g.2828572G>A, NT_167245.2:g.2822987G=, NT_167245.2:g.2822987G>A, NT_167246.1:g.2885915G=, NT_167246.1:g.2885915G>A, NT_167246.2:g.2880295G=, NT_167246.2:g.2880295G>A, NT_167247.1:g.2922737G=, NT_167247.1:g.2922737G>A, NT_167247.2:g.2917152G=, NT_167247.2:g.2917152G>A, NT_167248.1:g.2836669G=, NT_167248.1:g.2836669G>A, NT_167248.2:g.2831073G=, NT_167248.2:g.2831073G>A, NT_167249.1:g.2873832G=, NT_167249.1:g.2873832G>A, NT_167249.2:g.2874534G=, NT_167249.2:g.2874534G>A, rs116610137, rs117441802, rs148958203, rs3091256, rs36205298, rs4134777, rs59729336
G > A
SNP
No VIP available CA VA
rs1800795 NC_000007.13:g.22766645C>G, NC_000007.14:g.22727026C>G, NG_011640.1:g.4880C>G, NM_000600.4:c.-237C>G, NM_001318095.1:c.-274C>G, NR_131935.1:n.54-321G>C, XM_005249745.1:c.-237C>G, XM_005249745.3:c.-237C>G, XM_005249746.1:c.-274C>G, XM_011515390.1:c.-84-153C>G, XM_011515391.1:c.-274C>G, rs17777058, rs36215460, rs56588968, rs58302852
C > G
SNP
No VIP available CA VA
rs1801274 NC_000001.10:g.161479745A>G, NC_000001.11:g.161509955A>G, NG_012066.1:g.9541A>G, NM_001136219.1:c.500A>G, NM_021642.3:c.497A>G, NP_001129691.1:p.His167Arg, NP_067674.2:p.His166Arg, XM_005244960.1:c.500A>G, XM_011509287.1:c.500A>G, XM_011509288.1:c.497A>G, XM_011509289.1:c.500A>G, XM_011509290.1:c.500A>G, XM_011509291.1:c.500A>G, XP_005245017.1:p.His167Arg, XP_011507589.1:p.His167Arg, XP_011507590.1:p.His166Arg, XP_011507591.1:p.His167Arg, XP_011507592.1:p.His167Arg, XP_011507593.1:p.His167Arg, rs16830404, rs17851761, rs386545630, rs52796393, rs58440466
A > G
SNP
H167R
No VIP available No Clinical Annotations available VA
rs1980422 NC_000002.11:g.204610396C>T, NC_000002.12:g.203745673C>T, rs17246801, rs59734983, rs60654513
C > T
SNP
No VIP available No Clinical Annotations available VA
rs20575 NC_000008.10:g.23059324C>G, NC_000008.11:g.23201811C>G, NG_032107.1:g.28357G>C, NM_003844.3:c.626G>C, NP_003835.3:p.Arg209Thr, rs11550539, rs17398665, rs17759966, rs4871857, rs52835905, rs60716604
C > G
SNP
R209T
No VIP available CA VA
rs2071303 NC_000006.11:g.26091336T>C, NC_000006.12:g.26091108T>C, NG_008720.2:g.8828T>C, NM_000410.3:c.340+4T>C, NM_001300749.1:c.340+4T>C, NM_139003.2:c.340+4T>C, NM_139004.2:c.340+4T>C, NM_139006.2:c.340+4T>C, NM_139007.2:c.77-206T>C, NM_139008.2:c.77-206T>C, NM_139009.2:c.271+4T>C, NM_139010.2:c.77-1577T>C, NM_139011.2:c.77-2011T>C, XM_005249040.1:c.340+4T>C, XM_011514543.1:c.340+4T>C, XM_011514544.1:c.340+4T>C, XR_241893.1:n.462+4T>C, XR_241893.2:n.462+4T>C, XR_241894.1:n.587+4T>C, rs17515611, rs56518267, rs56939457, rs60682736
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2104286 NC_000010.10:g.6099045T>C, NC_000010.11:g.6057082T>C, NG_007403.1:g.10228A>G, NM_000417.2:c.64+5006A>G, NM_001308242.1:c.64+5006A>G, NM_001308243.1:c.64+5006A>G, XM_005252446.1:c.64+5006A>G, XM_005252447.1:c.64+5006A>G, rs56454393, rs57657975
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2228145 NC_000001.10:g.154426970A>C, NC_000001.11:g.154454494A>C, NG_012087.1:g.54302A>C, NM_000565.3:c.1073A>C, NM_181359.2:c.1066+4514A>C, NP_000556.1:p.Asp358Ala, XM_005245138.1:c.1010A>C, XM_005245139.1:c.924+4514A>C, XM_005245140.1:c.931A>C, XM_006711298.1:c.1121A>C, XM_006711299.2:c.1114+4514A>C, XP_005245195.1:p.Asp337Ala, XP_005245197.1:p.Ile311Leu, XP_006711361.1:p.Asp374Ala, rs117579727, rs52837205, rs58037860, rs8192284
A > C
SNP
D358A
No VIP available No Clinical Annotations available VA
rs2476601 NC_000001.10:g.114377568A=, NC_000001.10:g.114377568A>G, NC_000001.11:g.113834946A=, NC_000001.11:g.113834946A>G, NG_011432.1:g.41808C=, NG_011432.1:g.41808C>T, NM_001193431.2:c.1858C=, NM_001193431.2:c.1858C>T, NM_001308297.1:c.1786C=, NM_001308297.1:c.1786C>T, NM_012411.5:c.1693C=, NM_012411.5:c.1693C>T, NM_015967.5:c.1858C>T, NM_015967.6:c.1858C=, NM_015967.6:c.1858C>T, NP_001180360.1:p.Arg620=, NP_001180360.1:p.Arg620Trp, NP_001295226.1:p.Arg596=, NP_001295226.1:p.Arg596Trp, NP_036543.4:p.Arg565=, NP_036543.4:p.Arg565Trp, NP_057051.3:p.Arg620=, NP_057051.3:p.Arg620Trp, NR_125965.1:n.414+19474A>G, NR_125965.1:n.414+19474G>A, XM_005270738.1:c.1786T=, XM_005270738.1:c.1786T>C, XM_005270738.2:c.1786T=, XM_005270738.2:c.1786T>C, XM_011541221.1:c.1780T=, XM_011541221.1:c.1780T>C, XM_011541222.1:c.1858T=, XM_011541222.1:c.1858T>C, XM_011541223.1:c.1858T=, XM_011541223.1:c.1858T>C, XM_011541224.1:c.1414T=, XM_011541224.1:c.1414T>C, XM_011541225.1:c.1786T=, XM_011541225.1:c.1786T>C, XP_005270795.1:p.Trp596=, XP_005270795.1:p.Trp596Arg, XP_011539523.1:p.Trp594=, XP_011539523.1:p.Trp594Arg, XP_011539524.1:p.Trp620=, XP_011539524.1:p.Trp620Arg, XP_011539525.1:p.Trp620=, XP_011539525.1:p.Trp620Arg, XP_011539526.1:p.Trp472=, XP_011539526.1:p.Trp472Arg, XP_011539527.1:p.Trp596=, XP_011539527.1:p.Trp596Arg, rs117063937, rs52834763, rs60104027
A > G
SNP
R620W
No VIP available No Clinical Annotations available VA
rs2736340 NC_000008.10:g.11343973C>T, NC_000008.11:g.11486464C>T, rs58684812
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2812378 NC_000009.11:g.34710260G>A, NC_000009.12:g.34710263G>A, NM_002989.3:c.-197C>T, XM_011518004.1:c.-197C>T, XR_242544.1:n.124+7225G>A, rs16931795, rs386574189, rs57427236
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3087243 NC_000002.11:g.204738919G>A, NC_000002.12:g.203874196G>A, NG_011502.1:g.11411G>A, NM_001037631.2:c.*1421G>A, NM_005214.4:c.*1384G>A, XR_241294.1:n.2154G>A, rs56520936, rs57552006, rs57994510
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3218253 NC_000022.10:g.37544810G>A, NC_000022.11:g.37148770G>A, NM_000878.3:c.-34+1055C>T, XM_005261599.1:c.-33-4565C>T, rs57212492, rs58893919
G > A
SNP
No VIP available No Clinical Annotations available VA
rs361525 NC_000006.11:g.31543101G=, NC_000006.11:g.31543101G>A, NC_000006.12:g.31575324G=, NC_000006.12:g.31575324G>A, NG_007462.1:g.4752G=, NG_007462.1:g.4752G>A, NG_012010.1:g.8226G=, NG_012010.1:g.8226G>A, NM_000594.3:c.-418A>G, NM_000594.3:c.-418G>A, NT_113891.2:g.3052717G=, NT_113891.2:g.3052717G>A, NT_113891.3:g.3052611G=, NT_113891.3:g.3052611G>A, NT_167245.1:g.2828642A=, NT_167245.1:g.2828642A>G, NT_167245.2:g.2823057A=, NT_167245.2:g.2823057A>G, NT_167246.1:g.2885985G=, NT_167246.1:g.2885985G>A, NT_167246.2:g.2880365G=, NT_167246.2:g.2880365G>A, NT_167247.1:g.2922807G=, NT_167247.1:g.2922807G>A, NT_167247.2:g.2917222G=, NT_167247.2:g.2917222G>A, NT_167248.1:g.2836739A=, NT_167248.1:g.2836739A>G, NT_167248.2:g.2831143A=, NT_167248.2:g.2831143A>G, NT_167249.1:g.2873902G=, NT_167249.1:g.2873902G>A, NT_167249.2:g.2874604G=, NT_167249.2:g.2874604G>A, rs139679880, rs36205296, rs4134778
G > A
SNP
No VIP available CA VA
rs3761847 NC_000009.11:g.123690239G>A, NC_000009.12:g.120927961G>A, NG_023346.1:g.6213C>T, NM_001190945.1:c.-366+1153C>T, NM_005658.4:c.-1638C>T, rs57231462
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3794271 NC_000012.11:g.20860093G>A, NC_000012.12:g.20707159G>A, NM_001145944.1:c.50+1078G>A, NM_001145945.1:c.404+1078G>A, NM_001145946.1:c.404+1078G>A, NM_017435.4:c.404+1078G>A, XM_005253394.1:c.404+1078G>A, XM_005253395.1:c.404+1078G>A, XM_005253396.1:c.50+1078G>A, XM_005253397.1:c.404+1078G>A, XM_005253397.2:c.404+1078G>A, XM_011520703.1:c.404+1078G>A, XM_011520704.1:c.404+1078G>A, XM_011520705.1:c.404+1078G>A, XM_011520706.1:c.50+1078G>A, XM_011520707.1:c.50+1078G>A, XM_011520708.1:c.50+1078G>A, XM_011520709.1:c.50+1078G>A, XM_011520710.1:c.404+1078G>A, XM_011520711.1:c.-150+1078G>A, XR_931308.1:n.759+1078G>A, rs57295874
G > A
SNP
No VIP available No Clinical Annotations available VA
rs3814057 NC_000003.11:g.119537254A>C, NC_000003.12:g.119818407A>C, NG_011856.1:g.42924A>C, NM_003889.3:c.*1195A>C, NM_022002.2:c.*1195A>C, NM_033013.2:c.*1195A>C, XM_005247866.1:c.995+2576A>C
A > C
SNP
No VIP available No Clinical Annotations available VA
rs394581 NC_000006.11:g.159482521C>T, NC_000006.12:g.159061489C>T, XM_011536288.1:c.621+2092G>A, XM_011536289.1:c.507+2092G>A, rs56472775, rs59212643, rs59433113, rs9456369
C > T
SNP
No VIP available CA VA
rs396991 NC_000001.10:g.161514542A>C, NC_000001.11:g.161544752A>C, NG_009066.1:g.10872T>G, NM_000569.6:c.634T>G, NM_001127592.1:c.631T>G, NM_001127593.1:c.526T>G, NM_001127595.1:c.526T>G, NM_001127596.1:c.523T>G, NP_000560.5:p.Phe212Val, NP_001121064.1:p.Phe211Val, NP_001121065.1:p.Phe176Val, NP_001121067.1:p.Phe176Val, NP_001121068.1:p.Phe175Val, XM_011509293.1:c.428-1553T>G, rs17857127, rs2229097, rs3171040, rs4151086, rs61228128
A > C
SNP
F212V
No VIP available No Clinical Annotations available VA
rs4645983 NC_000001.10:g.15850603G>A, NC_000001.11:g.15524108G>A, NG_029188.1:g.5683C>T, NM_001229.4:c.93C>T, NM_001278054.1:c.93C>T, NM_032996.3:c.-118+475C>T, NP_001220.2:p.Ser31=, NP_001264983.1:p.Ser31=, NR_102732.1:n.338C>T, NR_102733.1:n.338C>T, XM_005246013.1:c.93C>T, XM_005246014.1:c.-118+744C>T, XM_005246014.2:c.-118+744C>T, XM_005246015.1:c.-434C>T, XM_005246050.1:c.-102G>A, XM_011542270.1:c.93C>T, XM_011542271.1:c.-474C>T, XM_011542272.1:c.-118+2083C>T, XM_011542273.1:c.93C>T, XP_005246070.1:p.Ser31=, XP_011540572.1:p.Ser31=, XP_011540575.1:p.Ser31=, XR_946778.1:n.258C>T, rs386594200
G > -
G > A
SNP
S31S
No VIP available No Clinical Annotations available VA
rs4750316 NC_000010.10:g.6393260C>G, NC_000010.11:g.6351298C>G, XR_242715.1:n.1710C>G, XR_242715.2:n.3074C>G, rs56902976, rs61718694
C > G
SNP
No VIP available No Clinical Annotations available VA
rs4810485 NC_000020.10:g.44747947T>G, NC_000020.11:g.46119308T>G, NG_007279.1:g.6042T>G, NM_001250.4:c.51+914T>G, NM_001250.5:c.51+914T>G, NM_001302753.1:c.51+914T>G, NM_152854.3:c.51+914T>G, NR_126502.1:n.141+914T>G, XM_005260617.1:c.51+914T>G, XM_005260617.2:c.51+914T>G, XM_005260618.1:c.51+914T>G, XM_005260619.1:c.51+914T>G, XM_005260619.2:c.51+914T>G, XM_005260620.1:c.51+914T>G, XM_011529109.1:c.51+914T>G, XR_244157.1:n.130+914T>G, XR_244158.1:n.130+914T>G, XR_936660.1:n.145+914T>G, rs17841920, rs56530668, rs60204642
T > G
SNP
No VIP available CA VA
rs510432 NC_000006.11:g.106774030T>C, NC_000006.12:g.106326155T>C, NM_001286106.1:c.-938A>G, NM_001286107.1:c.-794A>G, NM_001286108.1:c.-688A>G, NM_001286111.1:c.-688A>G, NM_004849.3:c.-688A>G, XM_005267231.1:c.-794A>G, XM_011536263.1:c.-688A>G, rs3761794, rs386597641
T > C
SNP
No VIP available No Clinical Annotations available VA
rs548234 NC_000006.11:g.106568034C>T, NC_000006.12:g.106120159C>T, rs13220305, rs56922927
C > T
SNP
No VIP available No Clinical Annotations available VA
rs6691117 NC_000001.10:g.207782931A>G, NC_000001.11:g.207609586A>G, NG_007481.1:g.118459A>G, NM_000573.3:c.4843A>G, NM_000651.4:c.6193A>G, NP_000564.2:p.Ile1615Val, NP_000642.3:p.Ile2065Val, XM_005273064.1:c.5809A>G, XM_006711166.2:c.6208A>G, XM_011509205.1:c.6208A>G, XP_005273121.1:p.Ile1937Val, XP_006711229.1:p.Ile2070Val, XP_011507507.1:p.Ile2070Val, rs59510794
A > G
SNP
I1615V
No VIP available No Clinical Annotations available VA
rs6822844 NC_000004.11:g.123509421G>T, NC_000004.12:g.122588266G>T, rs61272394
G > T
SNP
No VIP available No Clinical Annotations available VA
rs6920220 NC_000006.11:g.138006504G>A, NC_000006.12:g.137685367G>A, rs17264367, rs56495515, rs57269942, rs58273351
G > A
SNP
No VIP available No Clinical Annotations available VA
rs7527798 NC_000001.10:g.207872290T>C, NC_000001.11:g.207698945T>C, NM_175710.1:c.1143-244T>C, rs17186918, rs57821295
T > C
SNP
No VIP available No Clinical Annotations available VA
rs7574865 NC_000002.11:g.191964633T=, NC_000002.11:g.191964633T>G, NC_000002.12:g.191099907T=, NC_000002.12:g.191099907T>G, NG_012852.1:g.56293A=, NG_012852.1:g.56293A>C, NM_001243835.1:c.274-23582A=, NM_001243835.1:c.274-23582A>C, NM_003151.3:c.274-23582A=, NM_003151.3:c.274-23582A>C, XM_005246817.1:c.301-23582A=, XM_005246817.1:c.301-23582A>C, XM_005246817.3:c.301-23582A=, XM_005246817.3:c.301-23582A>C, XM_006712719.2:c.274-23582A=, XM_006712719.2:c.274-23582A>C, XM_011511704.1:c.301-23582A=, XM_011511704.1:c.301-23582A>C, XM_011511705.1:c.274-23582A=, XM_011511705.1:c.274-23582A>C, XM_011511706.1:c.301-23582A=, XM_011511706.1:c.301-23582A>C, rs52795984, rs57433953
T > G
SNP
No VIP available No Clinical Annotations available VA
rs763780 NC_000006.11:g.52101739T>C, NC_000006.12:g.52236941T>C, NG_031869.1:g.12560A>G, NM_052872.3:c.482A>G, NP_443104.1:p.His161Arg, XM_011514276.1:c.482A>G, XP_011512578.1:p.His161Arg, XR_926873.1:n.-173T>C, rs56499381, rs57501176
T > C
SNP
H161R
No VIP available CA VA
rs767455 NC_000012.11:g.6450945T>C, NC_000012.12:g.6341779T>C, NG_007506.1:g.5317A>G, NM_001065.3:c.36A>G, NP_001056.1:p.Pro12=, XM_005253758.1:c.-135A>G, XM_005253759.1:c.36A>G, XP_005253816.1:p.Pro12=, rs1139417, rs11546182, rs117779755, rs17404022, rs17847988, rs1800691, rs3179755, rs3203525
T > C
SNP
P12P
No VIP available No Clinical Annotations available VA
rs7927894 NC_000011.10:g.76590272C>T, NC_000011.9:g.76301316C>T, rs17749718, rs59482530
C > T
SNP
No VIP available No Clinical Annotations available VA
rs8049439 NC_000016.10:g.28826194T>C, NC_000016.9:g.28837515T>C, NM_001308230.1:c.466-46T>C, NM_001310136.1:c.121-359292A>G, NM_007245.3:c.466-46T>C, NM_017492.3:c.466-46T>C, NM_145714.2:c.466-46T>C, NM_148414.2:c.466-46T>C, NM_148415.2:c.466-46T>C, NM_148416.2:c.466-46T>C, XM_005255061.1:c.466-46T>C, XM_005255062.1:c.466-46T>C, XM_005255063.1:c.466-46T>C, XM_005255063.2:c.466-46T>C, XM_005255064.1:c.466-46T>C, XM_005255065.1:c.466-46T>C, XM_005255066.1:c.466-46T>C, XM_005255067.1:c.466-46T>C, XM_005255068.1:c.466-46T>C, XM_005255069.1:c.466-46T>C, XM_005255070.1:c.466-46T>C, XM_005255071.1:c.466-46T>C, XM_005255072.1:c.466-46T>C, XM_005255073.1:c.466-46T>C, XM_005255074.1:c.466-46T>C, XM_005255075.1:c.466-46T>C, XM_005255076.1:c.466-46T>C, XM_005255077.1:c.286-46T>C, XM_006721007.1:c.466-46T>C, XM_006721008.1:c.466-46T>C, XM_006721009.1:c.466-46T>C, XM_006721010.2:c.466-46T>C, XM_006721011.1:c.466-46T>C, XM_006721012.2:c.466-46T>C, XM_006721013.2:c.466-46T>C, XM_011545719.1:c.466-46T>C, XM_011545720.1:c.466-46T>C, XM_011545721.1:c.466-46T>C, XM_011545722.1:c.100-46T>C, XR_243256.1:n.678-46T>C, XR_243257.1:n.678-46T>C, rs56444343, rs60750573
T > C
SNP
No VIP available CA VA
rs9373839 NC_000006.11:g.106655617T>C, NC_000006.12:g.106207742T>C, NM_001286106.1:c.574-5653A>G, NM_001286107.1:c.340-5653A>G, NM_001286108.1:c.570-5653A>G, NM_001286111.1:c.204-5653A>G, NM_004849.3:c.574-5653A>G, NR_104402.1:n.537-5653A>G, NR_104403.1:n.409-5653A>G, XM_005267231.1:c.340-5653A>G, XM_011536263.1:c.*10-5653A>G, rs17441272
T > C
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Generic Names
  • Ig gamma-1 chain C region
Trade Names
  • Humira
  • Humira (Abbott Laboratories)
  • Humira Pen
Brand Mixture Names

PharmGKB Accession Id

PA10004

Type(s):

Drug

Description

Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.

Source: Drug Bank

Indication

For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Source: Drug Bank

Pharmacology

Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Most likely removed by opsonization via the reticuloendothelial system.

Source: Drug Bank

Half-Life

10-20 days.

Source: Drug Bank

Clearance

Source: Drug Bank

Chemical Properties

Chemical Formula

C6428H9912N1694O1987S46

Source: Drug Bank

Canonical SMILES

Not Available

Source: Drug Bank

Average Molecular Weight

144190.3000

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
C1QA (source: Drug Bank)
C1QB (source: Drug Bank)
C1QC (source: Drug Bank)
C1R (source: Drug Bank)
C1S (source: Drug Bank)
FCGR1A (source: Drug Bank)
FCGR2A (source: Drug Bank)
FCGR2B (source: Drug Bank)
FCGR2C (source: Drug Bank)
FCGR3A (source: Drug Bank)
FCGR3B (source: Drug Bank)
TNF (source: Drug Bank)

Drug Interactions

Interaction Description
trastuzumab - adalimumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events. (source: Drug Bank)

Curated Information ?

Relationships from National Drug File - Reference Terminology (NDF-RT)

May Treat
Contraindicated With

Publications related to adalimumab: 49

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Transferrin Level Before Treatment and Genetic Polymorphism in HFE Gene as Predictive Markers for Response to Adalimumab in Crohn's Disease Patients. Biochemical genetics. 2016. Repnik Katja, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A Prospective Pharmacogenomic Study of Crohn's Disease Patients during Routine Therapy with Anti-TNF-alpha Drug Adalimumab: Contribution of ATG5, NFKB1, and CRP Genes to Pharmacodynamic Variability. Omics : a journal of integrative biology. 2016. Deželak Matjaž, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms within the human leucocyte antigen-E gene and their associations with susceptibility to rheumatoid arthritis as well as clinical outcome of anti-tumour necrosis factor therapy. Clinical and experimental immunology. 2015. Iwaszko M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis. Pharmacogenomics. 2015. Prieto-Pérez Rocío, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The TNFRSF1B rs1061622 polymorphism (p.M196R) is associated with biological drug outcome in Psoriasis patients. Archives of dermatological research. 2015. González-Lara Leire, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response. JAMA. 2015. Viatte Sebastien, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The Cw6 and late-cornified envelope genotype plays a significant role in anti-tumor necrosis factor response among psoriatic patients. Pharmacogenetics and genomics. 2015. Batalla Ana, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients. Pharmacogenomics. 2015. Koder Silvo, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy. BioMed research international. 2015. Canhão Helena, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association between TNF-alpha (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-alpha blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. Pharmacogenomics. 2015. Song Gwan Gyu, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors. Pharmacogenomics. 2015. Montes Ariana, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis. Pharmacogenomics. 2015. Dávila-Fajardo Cristina Lucía, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis. Pharmacogenetics and genomics. 2014. Montes Ariana, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Confirmation of -174G/C interleukin-6 gene promoter polymorphism as a genetic marker predicting antitumor necrosis factor treatment outcome. Pharmacogenetics and genomics. 2013. Dávila-Fajardo Cristina L, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of TNF-alpha polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis. Pharmacogenomics. 2013. Tong Qiang, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The role of Fcgamma receptor polymorphisms in the response to anti-tumor necrosis factor therapy in psoriasis A pharmacogenetic study. JAMA dermatology (Chicago, Ill.). 2013. Julià Marc, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. The pharmacogenomics journal. 2013. Bluett J, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between tumor necrosis factor-alpha (TNF-alpha) promoter -308 G/A and response to TNF-alpha blockers in rheumatoid arthritis: a meta-analysis. Modern rheumatology / the Japan Rheumatism Association. 2013. Zeng Zhen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics. 2013. Acosta-Colman Isabel, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring. Clinical reviews in allergy & immunology. 2013. Sivamani Raja K, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn's disease and ulcerative colitis. European journal of clinical pharmacology. 2013. Lacruz-Guzmán Diana, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis. PLoS genetics. 2013. Cui Jing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine. Pharmacogenomics. 2013. Umićević Mirkov Maša, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases. The pharmacogenomics journal. 2013. Prieto-Pérez R, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Effects of polymorphisms in TRAILR1 and TNFR1A on the response to anti-TNF therapies in patients with rheumatoid and psoriatic arthritis. Joint, bone, spine : revue du rhumatisme. 2012. Morales-Lara María José, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis. Joint, bone, spine : revue du rhumatisme. 2012. Daïen Claire Immediato, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
TNF-alpha -857 and -1031 polymorphisms predict good therapeutic response to TNF-alpha blockers in Chinese Han patients with ankylosing spondylitis. Pharmacogenomics. 2012. Tong Qiang, et al. PubMed
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Association of Rheumatoid Arthritis Risk Alleles with Response to Anti-TNF Biologics: Results from the CORRONA Registry and Meta-analysis. Inflammation. 2012. Pappas Dimitrios A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic and genomic predictors of anti-TNF response. Pharmacogenomics. 2011. Prajapati Rita, et al. PubMed
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Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis and rheumatism. 2010. Cui Jing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clinical pharmacology and therapeutics. 2010. Stuhlmüller B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford, England). 2010. Hassan Batool, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The TNF superfamily in 2009: new pathways, new indications, and new drugs. Drug discovery today. 2009. Tansey Malú G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. Arthritis and rheumatism. 2009. Varani Katia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study. Drug discovery today. 2009. Kooloos Wouter M, et al. PubMed
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TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. The pharmacogenomics journal. 2009. O'Rielly D D, et al. PubMed
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Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Human molecular genetics. 2008. Maxwell James R, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. Arthritis and rheumatism. 2008. Marotte Hubert, et al. PubMed
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A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis. Annals of the rheumatic diseases. 2008. Miceli-Richard C, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis. Arthritis and rheumatism. 2007. Guis Sandrine, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis. Pharmacogenomics. 2007. Coenen Marieke J H, et al. PubMed
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Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease. Drug discovery today. 2007. Kooloos Wouter M, et al. PubMed
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The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. Rheumatology (Oxford, England). 2007. Seitz M, et al. PubMed
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Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatology international. 2006. Lee Young Ho, et al. PubMed
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Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scandinavian journal of rheumatology. 2006. Cuchacovich M, et al. PubMed
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Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics. Annals of the rheumatic diseases. 2005. Fonseca J E, et al. PubMed
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Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Arthritis and rheumatism. 2003. Mugnier Benedicte, et al. PubMed
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Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. Annals of the rheumatic diseases. 2003. Padyukov L, et al. PubMed
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A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. Scandinavian journal of gastroenterology. 2002. Louis E, et al. PubMed

LinkOuts

GenBank:
J00228
Web Resource:
Wikipedia
UniProtKB:
P01857
National Drug Code Directory:
0074-3799-02
DrugBank:
DB00051
Drugs Product Database (DPD):
2258595
Therapeutic Targets Database:
DAP000392
FDA Drug Label at DailyMed:
608d4f0d-b19f-46d3-749a-7159aa5f933d

Clinical Trials

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