IWPC Profile

International Warfarin Pharmacogenetics Consortium

Abstract

A number of pharmacogenomics research centers have collected data sets relating warfarin dosing to a variety of clinical and genetic parameters including genotypes of CYP2C9 and VKORC1. There is an interest among these groups in sharing their data, in order to possibly arrive at a consensus model for dosing that is consistent with all data sets. For further information regarding the warfarin consortium, please send email to feedback@pharmgkb.org.

IWPC Team

Data Contributors

• Academic Sinica, Taiwan, ROC:
  Ming-Ta M. Lee, Yuan-Tsong Chen

• Chang Gung Memorial Hospital, Chang Gung University, Taiwan, ROC:
  Ming-Shien Wen

• China Medical University, Graduate Institute of Chinese Medical School, Taichung, Taiwan, ROC:
  Ming-Ta M. Lee

• Hadassah Medical Organization, Israel:
  Yoseph Caraco, Idit Achache, Simha Blotnick, Mordechai Muszkat

• Inje University, Korea:
  Jae-Gook Shin, Ho-Sook Kim

• Instituto Nacional de Câncer, Brazil:
  Guilherme Suarez-Kurtz, Jamila Alessandra Perini

• Instituto Nacional de Cardiologia Laranjeiras, Brazil:
  Edimilson Silva-Assunção

• Intermountain Healthcare, USA:
  Jeffrey L. Anderson, Benjamin D. Horne, John F. Carlquist

• Marshfield Clinic, USA:
  Michael D. Caldwell, Richard L. Berg, James K. Burmester

• National University Hospital, Singapore:
  Boon Cher Goh, Soo-Chin Lee

• Newcastle University, United Kingdom:
  Farhad Kamali, Elizabeth Sconce, Ann K. Daly

• University of Alabama, USA:
  Nita A. Limdi

• University of California, San Francisco, USA:
  Alan H.B. Wu

• University of Florida, USA:
  Julie A. Johnson, Taimour Y. Langaee, Hua Feng

• University of Illinois, Chicago, USA:
  Larisa Cavallari, Kathryn Momary

• University of Liverpool, United Kingdom:
  Munir Pirmohamed, Andrea Jorgensen, Cheng Hok Toh, Paula Williamson

• University of North Carolina, USA:
  Howard McLeod, James P. Evans, Karen E. Weck

• University of Pennsylvania, USA:
  Stephen E. Kimmel, Colleen Brensinger

• University of Tokyo and RIKEN, Japan:
  Yusuke Nakamura, Taisei Mushiroda

• University of Washington, USA:
  David Veenstra, Lisa Meckley, Mark J. Rieder, Allan E. Rettie

• Uppsala University, Sweden:
  Mia Wadelius, Niclas Eriksson, Håkan Melhus

• Vanderbilt University, USA:
  C. Michael Stein, Dan M. Roden, Ute Schwartz, Daniel Kurnik

• Washington University in St. Louis, USA:
  Brian F. Gage, Elena Deych, Petra Lenzini, Charles Eby

• Wellcome Trust Sanger Institute, United Kingdom:
  Leslie Y. Chen, Panos Deloukas

Statistical Analysis:

• University of Alabama, USA:
  Nita A. Limdi

• Marshfield Clinic, USA:
  Michael D. Caldwell

• North Carolina State University, USA:
  Alison Motsinger-Reif

• Stanford University, USA:
  Teri E. Klein, Russ B. Altman, Hersh Sagreiya, Balaji S. Srinivasan

• Uppsala University, Uppsala Clinical Research Center, Sweden:
  Niclas Eriksson

• University of California, San Francisco, USA:
  Alan H.B. Wu

• University of North Carolina, USA:
  Michael Wagner

• University of Florida, USA:
  Julie A. Johnson

• University of Pennsylvania, USA:
  Stephen E. Kimmel

• University of Wisconsin-Madison, USA:
  David Page, Eric Lantz, Tim Chang

• Vanderbilt University, USA:
  Marylyn Ritchie

• Washington University in St. Louis, USA:
  Brian F. Gage, Elena Deych

Genotyping QC of IWPC Samples:

• Academic Sinica, Taiwan, ROC:
  Ming-Ta M. Lee, Liang-Suei Lu

Data Curation:

• Stanford University, USA:
  Teri E. Klein, Russ B. Altman, Balaji S. Srinivasan

• University of North Carolina:
  Michael Wagner

• Washington University in St. Louis, USA:
  Elena Deych

Funding Acknowledgements:

• Academic Sinica, Taiwan, ROC:
  National Research Program for Genomic Medicine, National Science Council, Taiwan (National Clinical Core, NSC95-3112-B-001-010 and National Genotyping Center, NSC95-3112-B -001-011)

• Hadassah Medical Organization, Israel:
  Israeli Science Foundation (789/04), United States - Israel Binational Foundation (2003229), Chief Scientist, Ministry of Health (5745)

• Inje University, Korea:
  KOSEF / MOST (No. R13-2007-023-00000-0) and Korea Health 21 R&D Project, Ministry of Health and Welfare, Korea (A030001)

• Instituto Nacional de Câncer, Brazil:
  Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Financiadora de Estudos e Projetos (FINEP)

• Marshfield Clinic, USA:
  Marshfield Clinic Research Foundation

• Newcastle University, United Kingdom:
  National Health Service (NHS) Executive (Northern & Yorkshire)

• Stanford University, USA:
  NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM61374)

• University of Alabama, USA:
  NIH/NINDS (K23NS45598-01)

• University of Florida, USA:
  NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM074492) and NIH/NHLBI (HL068834)

• University of Illinois, Chicago, USA:
  The American Association of Colleges of Pharmacy and the American Foundation for Pharmaceutical Education

• University of Liverpool, United Kingdom:
  United Kingdom Department of Health

• University of North Carolina, USA:
  NIH/NIGMS Pharmacogenetics Research Network and Database (U01GM63340) and North Carolina Biotechnology Company Multidisciplinary Research Grant (2006-MRG-1117)

• University of Pennsylvania, USA:
  NIH (R01HL066176, P20RR020741 and K24HL070936)

• University of Washington, USA:
  NIH/NIGMS (GM68797 and GM32165), NIH/NINDS (NS053646), CDC National Office of Public Health Genomics (NOPHG) Seed Funding, University of Washington Drug Metabolism, Transport and Pharmacogenomics Research (DMTPR) Program

• Uppsala University, Sweden:
  Wellcome Trust, Swedish Funding agencies: the Society of Medicine, the Foundation for Strategic Research, the Heart and Lung Foundation, the Söderberg, Thuréus and Selander Foundations and the Clinical Research Support (ALF)

• Vanderbilt University, USA:
  NIH/NIGMS Pharmacogenetics Research Network and Database (U01HL65962)

• Washington University in St. Louis, USA:
  NIH (R01HL074724 and R01HL71083) and the American Heart Association