Overview
| Generic Names: | (e)-thiothixene; Cis-thiothixene; Thiothixine; Tiotixene; Tiotixeno [inn-spanish]; Tiotixenum [inn-latin] |
|---|---|
| IUPAC Name: | (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide |
| Trade Names: | Navan; Navane; Navaron; Orbinamon |
| PharmGKB Accession Id: | PA451669 |
Description
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem]
Indication
For the management of schizophrenia.
Pharmacology and Interactions
Pharmacology
Thiothixene is an antipsychotic of the thioxanthene series. Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic.
Half Life
10-20 hours
Toxicity
Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
Chemical Properties
Chemical Formula:
C23H29N3O2S2
SMILES Code:
CN1CCN(CC1)CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
(Format: OpenEye Isomeric)
Molecular Weight ( average / monoisotopic )
443.625 / 443.1701
Non-Curated Information
A list of non-curated publications that mention this drug along with other genes is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.