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Overview
| Generic Names: | Terbutalin; Terbutalina [Dcit]; Terbutaline Sulfate; Terbutalino [INN-Spanish]; Terbutalinum [INN-Latin] |
|---|---|
| Trade Names: | Brethaire; Brethine; Brican; Bricanyl; Bricar; Bricaril; Bricyn |
| PharmGKB Accession Id: | PA451616 |
Description
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. PubChem (source: Drug Bank)
Indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema. (source: Drug Bank)
ATC Therapeutic Categories
- R03AC:Selective beta-2-adrenoreceptor agonists
- R03CC:Selective beta-2-adrenoreceptor agonists
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (source: Drug Bank)
Pharmacology
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Toxicity
Terbutaline Sulfate: Oral LD<sub>50</sub>(rat) = 8.7 g/kg; Oral LD<sub>50</sub>(mouse) = 205 mg/kg; Oral LD<sub>50</sub>(dog) = 1.5 g/kg; IP LD<sub>50</sub>(rat)= 220 mg/kg ; IP LD<sub>50</sub>(mouse) = 130 mg/kg; Oral LD<sub>50</sub>(rabbit) = >8 g/kg; IV LD<sub>50</sub>(mouse) = 36 mg/kg; IV LD<sub>50</sub>(dog) = 116 mg/kg; IV LD<sub>50</sub>(rabbit) = 110 mg/kg (source: Drug Bank)
Isomeric SMILES Code:
CC(C)(C)NCC(c1cc(cc(c1)O)O)O (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
ADRB2 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ADRB2 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| Methyldopa |
|
Increased arterial pressure (source: Drug Bank) |
| acebutolol |
|
Antagonism (source: Drug Bank) |
| alseroxylon |
|
Increased arterial pressure (source: Drug Bank) |
| amitriptyline |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| amoxapine |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| atenolol |
|
Antagonism (source: Drug Bank) |
| betaxolol |
|
Antagonism (source: Drug Bank) |
| bevantolol |
|
Antagonism (source: Drug Bank) |
| bisoprolol |
|
Antagonism (source: Drug Bank) |
| carteolol |
|
Antagonism (source: Drug Bank) |
| carvedilol |
|
Antagonism (source: Drug Bank) |
| clomipramine |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| deserpidine |
|
Increased arterial pressure (source: Drug Bank) |
| desipramine |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| doxepin |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| esmolol |
|
Antagonism (source: Drug Bank) |
| imipramine |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| isocarboxazid |
|
Increased arterial pressure (source: Drug Bank) |
| l-methyldopa |
|
Increased arterial pressure (source: Drug Bank) |
| labetalol |
|
Antagonism (source: Drug Bank) |
| linezolid |
|
Possible increase of arterial pressure (source: Drug Bank) |
| metoprolol |
|
Antagonism (source: Drug Bank) |
| midodrine |
|
Increased arterial pressure (source: Drug Bank) |
| moclobemide |
|
Moclobemide increases the sympathomimetic effect (source: Drug Bank) |
| nadolol |
|
Antagonism (source: Drug Bank) |
| nortriptyline |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| oxprenolol |
|
Antagonism (source: Drug Bank) |
| pargyline |
|
Increased arterial pressure (source: Drug Bank) |
| penbutolol |
|
Antagonism (source: Drug Bank) |
| phenelzine |
|
Increased arterial pressure (source: Drug Bank) |
| pindolol |
|
Antagonism (source: Drug Bank) |
| practolol |
|
Antagonism (source: Drug Bank) |
| propranolol |
|
Antagonism (source: Drug Bank) |
| protriptyline |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
| rasagiline |
|
Increased arterial pressure (source: Drug Bank) |
| reserpine |
|
Increased arterial pressure (source: Drug Bank) |
| sotalol |
|
Antagonism (source: Drug Bank) |
| timolol |
|
Antagonism (source: Drug Bank) |
| tranylcypromine |
|
Increased arterial pressure (source: Drug Bank) |
| trimipramine |
|
The tricyclic increases the sympathomimetic effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
Asthma |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.