Overview
| Generic Names: | Terbinafine HCl; Terbinafine hydrochloride; Ternbinafine HCl; terbinafine |
|---|---|
| Trade Names: | Bramazil; Lamasil; Lamisil; Lamisil AT; Terbifoam; Terbina |
| PharmGKB Accession Id: | PA451614 |
Description
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene epoxidase, an enzyme that is part of the fungal cell wall synthesis pathway. (source: Drug Bank)
Indication
For the treatment of interdigital tinea infections. (source: Drug Bank)
ATC Therapeutic Categories
- D01AE:Other antifungals for topical use
- D01BA:Antifungals for systemic use
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Terbinafine is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. (source: Drug Bank)
Pharmacology
Terbinafine is an allylamine antifungal agent and acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. <i>in vitro</i>, mammalian squalene epoxidase is only inhibited at higher (4000 fold) concentrations than is needed for inhibition of the dermatophyte enzyme. Depending on the concentration of the drug and the fungal species test <i>in vitro</i>, Terbinafine may be fungicidal. However, the clinical significance of <i>in vitro</i> data is unknown. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
>99% (source: Drug Bank)
Absorption
Readily absorbed from gastrointestinal tract. (source: Drug Bank)
Isomeric SMILES Code:
CC(C)(C)C#C/C=C/CN(C)Cc1cccc2c1cccc2 (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
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CYP2D6 |
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Publications |
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CYP3A |
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Publications |
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NR1I2 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| SQLE |
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(source: Drug Bank) |
The following drugs are in curated knowledge about this drug.
| Drug | Relationship | Evidence | |
|---|---|---|---|
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tamoxifen |
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Publications |
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venlafaxine |
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Publications |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
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Terbinafine decreases the anticoagulant effect (source: Drug Bank) |
| atomoxetine |
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The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine (source: Drug Bank) |
| cyclosporine |
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Terbinafine decreases the effect of cyclosporine (source: Drug Bank) |
| desipramine |
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Terbinafine increases the effect and toxicity of the tricyclic (source: Drug Bank) |
| dextromethorphan |
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Terbinafine increases dextromethorphan levels (source: Drug Bank) |
| dicumarol |
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Terbinafine decreases the anticoagulant effect (source: Drug Bank) |
| imipramine |
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Terbinafine increases the effect and toxicity of the tricyclic (source: Drug Bank) |
| nortriptyline |
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Terbinafine increases the effect and toxicity of the tricyclic (source: Drug Bank) |
| rifampin |
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Rifampin decreases the effect of terbinafine (source: Drug Bank) |
| theophylline |
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Terbinafine increases the effect and toxicity of theophylline (source: Drug Bank) |
| warfarin |
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Terbinafine decreases the anticoagulant effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
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Toxic liver disease |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.