Overview
| Generic Names: | Hydroxydiazepam; Methyloxazepam; N-Methyloxazepam; Oxydiazepam |
|---|---|
| Trade Names: | Apo-Temazepam; Cerepax; Crisonar; Euhypnos; Euipnos; Gelthix; Levanxene; Levanxol; Levanzene; Mabertin; Normison; Novo-Temazepam; Perdorm; Planum; Remestan; Restoril; Signopam; Temaz |
| PharmGKB Accession Id: | PA451608 |
Description
A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. PubChem (source: Drug Bank)
Indication
For the short-term treatment of insomnia (generally 7-10 days). (source: Drug Bank)
ATC Therapeutic Category
- N05CD:Benzodiazepine derivatives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA<sub>A</sub>) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. (source: Drug Bank)
Pharmacology
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Avoid avocado.
Avoid excessive quantities of coffee or tea (Caffeine).
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%). (source: Drug Bank)
Protein Binding
96% (source: Drug Bank)
Absorption
Well absorbed, minimal first-pass metabolism. (source: Drug Bank)
Isomeric SMILES Code:
CN1C2=C(C=C(C=C2)Cl)C(=N[C@@H](C1=O)O)C3=CC=CC=C3 (source: Drug Bank)
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
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CYP2C19 |
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Publications |
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CYP3A4 |
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GABRA1 |
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GABRB2 |
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Publications |
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GABRG2 |
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Publications |
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UGT2B7 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| TSPO |
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(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| clozapine |
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Increased risk of toxicity (source: Drug Bank) |
| mephenytoin |
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Possible increased levels of the hydantoin, decrease of benzodiazepine (source: Drug Bank) |
| phenytoin |
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Possible increased levels of the hydantoin, decrease of benzodiazepine (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.
