Drug/Small Molecule:

sulfamethoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) (source: Drug Bank)

For the treatment of bronchitis, prostatitis and urinary tract infections. (source: Drug Bank)

Sulfonamides inhibit bacterial dihydrofolate synthetase, causing interference in the conversion of <i>p</i>-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, the immediate next step, and therefore act synergistically with the sulfonamides. (source: Drug Bank)

Sulfamethoxazole is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Sulfamethoxazole is normally given in combination with Trimethoprim (a dihydrofolate reductase inhibitor). Studies have shown that bacterial resistance develops more slowly with the combination of the two drugs than with either Trimethoprim or Sulfamethoxazole alone. (source: Drug Bank)

Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water. (source: Drug Bank)

Hepatic. The metabolism of sulfamethoxazole occurs predominately by N4-acetylation, although the glucuronide conjugate has been identified. (source: Drug Bank)

70% (source: Drug Bank)

Rapidly absorbed following oral administration. (source: Drug Bank)

c1cnc(nc1)NS(=O)(=O)c2ccc(cc2)N (source: Drug Bank)