Drug/Small Molecule:

sertraline

A selective serotonin uptake inhibitor that is used in the treatment of depression. PubChem (source: Drug Bank)

For the treatment of posttraumatic stress disorder, depression, obsessive-compulsive disorder and panic disorder (source: Drug Bank)

It is believed that sertraline inhibits reuptake of serotonin at the neuronal membrane. SSRIs have less sedative, anticholinergic, and cardiovascular effects than the tricyclic antidepressant drugs because of decreased binding to histamine, acetylcholine, and norepinephrine receptors. (source: Drug Bank)

Sertraline, an antidepressant drug similar to citalopram, fluoxetine, and paroxetine, is of the selective serotonin reuptake inhibitor (SSRI) type. Sertraline has one active metabolite and is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, and post-traumatic stress disorder. (source: Drug Bank)

Avoid St.John's Wort.
Avoid alcohol.
Avoid taking with grapefruit juice.
Take with food. (source: Drug Bank)

Hepatic (source: Drug Bank)

98% (source: Drug Bank)

The effects of food on the bioavailability of the sertraline tablet and oral concentrate were studied in subjects administered a single dose with and without food. For the tablet, AUC was slightly increased when drug was administered with food but the Cmax was 25% greater, while the time to reach peak plasma concentration (Tmax) decreased from 8 hours post-dosing to 5.5 hours. For the oral concentrate, Tmax was slightly prolonged from 5.9 hours to 7.0 hours with food. (source: Drug Bank)

Symptoms of toxicity include alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, somnolence and serotonin syndrome. (source: Drug Bank)

CN[C@H]1CC[C@H](c2c1cccc2)c3ccc(c(c3)Cl)Cl (source: Drug Bank)