Overview
| Generic Names: | Pyridine N-Oxide; Pyridostigmine Bromide; Pyridostigmine Bromine; Pyridostigminum |
|---|---|
| Trade Names: | Mestinon; Mestinon-SR; Regonol |
| PharmGKB Accession Id: | PA451185 |
Description
A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. PubChem (source: Drug Bank)
Indication
For the treatment of myasthenia gravis. (source: Drug Bank)
ATC Therapeutic Category
- N07AA:Anticholinesterases
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. (source: Drug Bank)
Pharmacology
Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. (source: Drug Bank)
Food Interactions
Take with food to decrease adverse effects. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hydrolysis by cholinesterases and by liver. (source: Drug Bank)
Absorption
Poorly absorbed from the GI tract with an oral bioavailability of 7.6 +/- 2.4%. (source: Drug Bank)
Isomeric SMILES Code:
C[n+]1cccc(c1)OC(=O)N(C)C (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ACHE |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| corticotropin |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| cortisone acetate |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| dexamethasone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| hydrocortisone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| methylprednisolone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| prednisolone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| prednisone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| succinylcholine |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| triamcinolone |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.