Overview
| Generic Names: | procaine HCl |
|---|---|
| Trade Names: | Allocaine; Anticort; Chloroprocaine Hcl; Diethylaminoethyl P-Aminobenzoate; Duracaine; Duracillin A.S.; Gerovital; Gerovital H-3; Jenacain; Jenacaine; Neocaine; Nesacaine; Nissocaine; Norocaine; Novocain; Novocaine; P-Aminobenzoyldiethylaminoethanol; Penicillin G Procaine; Pfizerpen-As; Procain; Procaine Hcl; Procaine Hydrochloride; Procaine, Base; Scurocaine; Spinocaine; Vitamin H3 |
| PharmGKB Accession Id: | PA451110 |
Description
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). PubChem (source: Drug Bank)
Indication
Used as a local anesthetic primarily in oral surgery (source: Drug Bank)
ATC Therapeutic Categories
- C01BA:Antiarrhythmics, class Ia
- C05AD:Local anesthetics
- D04AB:Anesthetics for topical use
- J01CE:Beta-lactamase sensitive penicillins
- N01BA:Esters of aminobenzoic acid
- S01HA:Local anesthetics
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex. (source: Drug Bank)
Pharmacology
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hydrolysis by plasma esterases to PABA (source: Drug Bank)
Isomeric SMILES Code:
CCN(CC)CCOC(=O)c1ccc(cc1)N (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| HTR3A |
|
(source: Drug Bank) |
| CHRNA10 |
|
(source: Drug Bank) |
| GRIN3A |
|
(source: Drug Bank) |
| SCN10A |
|
(source: Drug Bank) |
| SLC6A3 |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.