Overview
| Generic Names: | Piperacillin Anhydrous |
|---|---|
| Trade Names: | Pipracil |
| Brand Mixtures: | Tazocin (Piperacillin (Piperacillin Sodium) + Tazobactam (Tazobactam Sodium)) |
| PharmGKB Accession Id: | PA450975 |
Description
Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. PubChem (source: Drug Bank)
Indication
For the treatment of polymicrobial infections. (source: Drug Bank)
ATC Therapeutic Category
- J01CA:Penicillins with extended spectrum
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor. (source: Drug Bank)
Pharmacology
Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has <i>in vitro</i> activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Largely not metabolized. (source: Drug Bank)
Absorption
Not absorbed following oral administration. (source: Drug Bank)
Isomeric SMILES Code:
CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| doxycycline |
|
Possible antagonism of action (source: Drug Bank) |
| ethinyl estradiol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| mestranol |
|
This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank) |
| methotrexate |
|
The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank) |
| minocycline |
|
Possible antagonism of action (source: Drug Bank) |
| mivacurium |
|
The agent increases the effect of the muscle relaxant (source: Drug Bank) |
| oxytetracycline |
|
Possible antagonism of action (source: Drug Bank) |
| pancuronium |
|
The agent increases the effect of the muscle relaxant (source: Drug Bank) |
| succinylcholine |
|
The agent increases the effect of the muscle relaxant (source: Drug Bank) |
| tetracycline |
|
Possible antagonism of action (source: Drug Bank) |
| tubocurarine |
|
The agent increases the effect of the muscle relaxant (source: Drug Bank) |
| warfarin |
|
The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.