Overview
| Trade Names: | Abbocillin; Ayercillin; Benzopenicillin; Benzylpenicillin; Benzylpenicillin G; Benzylpenicillinic Acid; Bicillin; Bicillin L-A; Cillora; Cilloral; Cilopen; Compocillin G; Cosmopen; Crysticillin 300 A.S.; Dropcillin; Free Benzylpenicillin; Free Penicillin G; Free Penicillin Ii; Galofak; Gelacillin; Liquacillin; Megacillin; Pencillin G; Penicillin; Penicillin G Potassium; Penicillin G Potassium in Plastic Container; Penicillin G Sodium; Penicillin-G Potassium; Penicillinic Acid, Benzyl-; Pentids; Pentids '200'; Permapen; Pfizerpen; Pfizerpen G; Pharmacillin; Phenylacetamidopenicillanic Acid; Pradupen; Specilline G; Ursopen; Wycillin |
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| PharmGKB Accession Id: | PA450842 |
Description
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on gamma-aminobutyric acid mediated synaptic transmission. PubChem (source: Drug Bank)
Indication
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required. (source: Drug Bank)
ATC Therapeutic Categories
- J01CE:Beta-lactamase sensitive penicillins
- S01AA:Antibiotics
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor. (source: Drug Bank)
Pharmacology
Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has <i>in vitro</i> activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Protein Binding
Bind to serum proteins, mainly albumin. (source: Drug Bank)
Absorption
Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient. (source: Drug Bank)
Toxicity
Oral LD<sub>50</sub> in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. (source: Drug Bank)
Isomeric SMILES Code:
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)Cc3ccccc3)C(=O)O)C (source: Drug Bank)
The following genes are in curated knowledge about this drug.
Primary phenotype data has been submitted and is available
| Gene | Relationship | Evidence | |
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IFNAR1 |
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Publications |
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SLCO1B1 |
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Publications |
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SLCO2B1 |
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Publications |
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SLCO3A1 |
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Publications |
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SLCO4A1 |
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Publications |
A list of non-curated publications that mention this drug along with other genes is available.
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
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The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| dicumarol |
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The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
| doxycycline |
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Possible antagonism of action (source: Drug Bank) |
| ethinyl estradiol |
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This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank) |
| mestranol |
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This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank) |
| methotrexate |
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The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank) |
| minocycline |
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Possible antagonism of action (source: Drug Bank) |
| oxytetracycline |
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Possible antagonism of action (source: Drug Bank) |
| tetracycline |
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Possible antagonism of action (source: Drug Bank) |
| warfarin |
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The IV penicillin increases the anticoagulant effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
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Drug Hypersensitivity |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.