Drug/Small Molecule:
penicillin g

2D structure

Overview

Trade Names: Abbocillin; Ayercillin; Benzopenicillin; Benzylpenicillin; Benzylpenicillin G; Benzylpenicillinic Acid; Bicillin; Bicillin L-A; Cillora; Cilloral; Cilopen; Compocillin G; Cosmopen; Crysticillin 300 A.S.; Dropcillin; Free Benzylpenicillin; Free Penicillin G; Free Penicillin Ii; Galofak; Gelacillin; Liquacillin; Megacillin; Pencillin G; Penicillin; Penicillin G Potassium; Penicillin G Potassium in Plastic Container; Penicillin G Sodium; Penicillin-G Potassium; Penicillinic Acid, Benzyl-; Pentids; Pentids '200'; Permapen; Pfizerpen; Pfizerpen G; Pharmacillin; Phenylacetamidopenicillanic Acid; Pradupen; Specilline G; Ursopen; Wycillin
PharmGKB Accession Id: PA450842

Description

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on gamma-aminobutyric acid mediated synaptic transmission. PubChem (source: Drug Bank)

Indication

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required. (source: Drug Bank)

ATC Therapeutic Categories

  • J01CE:Beta-lactamase sensitive penicillins
  • S01AA:Antibiotics

Pharmacology, Interactions, and Contraindications

Mechanism Of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor. (source: Drug Bank)

Pharmacology

Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has <i>in vitro</i> activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. (source: Drug Bank)

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

Bind to serum proteins, mainly albumin. (source: Drug Bank)

Absorption

Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient. (source: Drug Bank)

Toxicity

Oral LD<sub>50</sub> in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. (source: Drug Bank)

Isomeric SMILES Code:

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)Cc3ccccc3)C(=O)O)C (source: Drug Bank)

The following genes are in curated knowledge about this drug.

  Gene Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
IFNAR1
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  • GN
Publications
No phenotype data Genotype Data Available Literature annotations available Has annotations
SLCO1B1
  •   
  •   
  •   
  • FA
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Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
SLCO2B1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
SLCO3A1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
SLCO4A1
  •   
  •   
  •   
  • FA
  •   
Publications

A list of non-curated publications that mention this drug along with other genes is available.

A list of non-curated publications that mention this drug along with other drugs is available.

Drug Interactions

Drug Description
acenocoumarol Uncurated Annotation The IV penicillin increases the anticoagulant effect (source: Drug Bank)
dicumarol Uncurated Annotation The IV penicillin increases the anticoagulant effect (source: Drug Bank)
doxycycline Uncurated Annotation Possible antagonism of action (source: Drug Bank)
ethinyl estradiol Uncurated Annotation This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
mestranol Uncurated Annotation This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
methotrexate Uncurated Annotation The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank)
minocycline Uncurated Annotation Possible antagonism of action (source: Drug Bank)
oxytetracycline Uncurated Annotation Possible antagonism of action (source: Drug Bank)
tetracycline Uncurated Annotation Possible antagonism of action (source: Drug Bank)
warfarin Uncurated Annotation The IV penicillin increases the anticoagulant effect (source: Drug Bank)

Curated Information

The following diseases are in curated knowledge about this drug.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Drug Hypersensitivity
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  •   
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. Physicochemical determinants of human renal clearance

LinkOuts

DrugBank:
DB01053
ChEBI ID:
18208
KEGG Compound ID:
C05551
KEGG Drug ID:
D02336
PubChem Compound ID:
5904
PubChem Substance ID:
7885

Common Searches

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

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