Drug/Small Molecule:
oxytocin

Overview

Generic Names: Pitocin; Syntocinon
Trade Names: Oxytocin (BAM Biotech); Pitocin (Parke-Davis); Syntocinon (Sandoz)
PharmGKB Accession Id: PA450760

Description

Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity. (source: Drug Bank)

Indication

To assist in labor, elective labor induction, uterine contraction induction (source: Drug Bank)

ATC Therapeutic Category

  • H01BB:Oxytocin and analogues

Pharmacology, Interactions, and Contraindications

Mechanism Of Action

Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. (source: Drug Bank)

Pharmacology

Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. (source: Drug Bank)

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

30% (source: Drug Bank)

Isomeric SMILES Code:

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N (source: Drug Bank)

A list of non-curated publications that mention this drug along with other genes is available.

Drug Targets

Gene Description
OXT Uncurated Annotation (source: Drug Bank)
PREP Uncurated Annotation (source: Drug Bank)

A list of non-curated publications that mention this drug along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00107
KEGG Compound ID:
C00746
KEGG Drug ID:
D00089
PubChem Compound ID:
439302
PubChem Substance ID:
4008

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

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