- Overview
- Properties
- Genetics
- Related Genes
- Pathways
- Related Drugs
- Related Diseases
- Datasets
- Downloads/LinkOuts
Overview
| Generic Names: | Oxazipam; Oxozepam; d-Oxazepam hemisuccinate |
|---|---|
| Trade Names: | Adumbran; Ansioxacepam; Anxiolit; Aplakil; Astress; Azutranquil; Bonare; Drimuel; Droxacepam; Durazepam; Enidrel; Hi-Long; Isodin; Lederpam; Limbial; Murelax; Nesontil; Noctazepam; Notaral; Oxa-puren; Oxanid; Pacienx; Praxiten; Propax; Psiquiwas; QUEN; Quilibrex; Rondar; Sedigoa; Serax; Serenal; Serenid; Serenid-D; Serepax; Seresta; Serpax; Sigacalm; Sobril; Tacepam; Tazepam; Uskan; Vaben; Wy-3498 stic; Zaxopam |
| PharmGKB Accession Id: | PA450731 |
Description
A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. PubChem (source: Drug Bank)
Indication
For the treatment of anxiety disorders. (source: Drug Bank)
ATC Therapeutic Category
- N05BA:Benzodiazepine derivatives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Oxazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation. (source: Drug Bank)
Pharmacology
Oxazepam is a drug which is a benzodiazepine derivative. It possesses relatively weak anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Avoid excessive quantities of coffee or tea (Caffeine).
Take with food.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Absorption
Well absorbed from the gastrointestinal tract following oral administration. (source: Drug Bank)
Toxicity
Symptoms of overdose include confusion, drowsiness, and lethargy. (source: Drug Bank)
Isomeric SMILES Code:
c1ccc(cc1)C2=NC(C(=O)Nc3c2cc(cc3)Cl)O (source: Drug Bank)
Curated Annotations (
)
-
rs1902023
at chr4:69218679
Study in human liver microsomes from 54 patients, primarily of Caucasian (n=48) descent: D85Y genotype showed a significant effect (p = 0.012) on S-oxazepam glucuronidation with lower median activities in 85Y/Y livers (49 pmol/min/mg protein) compared with 85D/D livers (131 pmol/min/mg), whereas 85D/Y livers were intermediate in activity (65 pmol/min/mg).- Variant Name:
- D85Y
- Related Drugs:
- oxazepam
- Evidence:
-
PMID:15044558
-
rs1902023
at chr4:69218679
Risk or phenotype-associated allele(s): T/T . Phenotype: Median oxazepam apparent oral clearance was significantly lower in 85YY subjects (1.62 ml min(-1) kg(-1)) compared with 85DD subjects (3.35 ml min(-1) kg(-1); P= 0.003, Student-Newman-Keuls test), whereas 85DY subjects were intermediate (2.34 ml min(-1) kg(-1); P= 0.018 vs. 85DD, P= 0.034 vs. 85YY). Regression analysis indicated that UGT2B15 D85Y genotype accounted for 34% of interindividual variability. Study size: 30. Study population/ethnicity: healthy male subjects.- Variant Name:
- 291G/T; D85Y
- Related Drugs:
- oxazepam
- Evidence:
-
PMID:19916996
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
GABRA1 |
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Publications |
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GABRB2 |
|
Publications |
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GABRG2 |
|
Publications |
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UGT1A9 |
|
Publications |
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UGT2B15 |
|
Publications |
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UGT2B17 |
|
Publications |
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UGT2B7 |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| clozapine |
|
Increased risk of toxicity (source: Drug Bank) |
| mephenytoin |
|
Possible increased levels of the hydantoin, decrease of benzodiazepine (source: Drug Bank) |
| phenytoin |
|
Possible increased levels of the hydantoin, decrease of benzodiazepine (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.