Overview
| Generic Names: | Oxaprozina [INN-Spanish]; Oxaprozine [INN-French]; Oxaprozinum [INN-Latin] |
|---|---|
| Trade Names: | Alvo; Daypro; Daypro Alta; Deflam; Voir |
| PharmGKB Accession Id: | PA450730 |
Description
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. (source: Drug Bank)
Indication
Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis. (source: Drug Bank)
ATC Therapeutic Category
- M01AE:Propionic acid derivatives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Antiinflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. (source: Drug Bank)
Pharmacology
Oxaprozin is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. (source: Drug Bank)
Food Interactions
Take with food, usually once a day after breakfast. Food decreases the rate of absorption but not the amount absorbed. Avoid alcohol. (source: Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic. Ester and ether glucuronide are the major conjugated metabolites of oxaprozin, and do not have significant pharmacologic activity. (source: Drug Bank)
Protein Binding
99% (source: Drug Bank)
Absorption
Oxaprozin is 95% absorbed after oral administration. Food may reduce the rate of absorption of oxaprozin, but the extent of absorption is unchanged. Antacids do not significantly affect the extent and rate of oxaprozin absorption. (source: Drug Bank)
Toxicity
Oral, mouse: LD<sub>50</sub> = 1210 mg/kg; Oral, rabbit: LD<sub>50</sub> = 172 mg/kg; Oral, rat: LD<sub>50</sub> = 4470 mg/kg (source: Drug Bank)
Isomeric SMILES Code:
c1ccc(cc1)c2c(oc(n2)CCC(=O)O)c3ccccc3 (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| PTGS2 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| alendronate |
|
Increased risk of gastric toxicity (source: Drug Bank) |
| cyclosporine |
|
Monitor for nephrotoxicity (source: Drug Bank) |
| dicumarol |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
| methotrexate |
|
The NSAID increases the effect and toxicity of methotrexate (source: Drug Bank) |
| warfarin |
|
The NSAID increases the anticoagulant effect (source: Drug Bank) |
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.