Overview
| Trade Names: | Akilen; Baccidal; Bactocin; Danoflox; Effexin; Exocin; Exocine; Flobacin; Flodemex; Flotavid; Flovid; Floxal; Floxil; Floxin; Floxstat; Fugacin; Inoflox; Kinflocin; Kinoxacin; Liflox; Loxinter; Marfloxacin; Medofloxine; Mergexin; Novecin; Nufafloqo; O-Flox; Obide; Occidal; Ofcin; Oflin; Oflocee; Oflocet; Oflocin; Oflodal; Oflodex; Oflodura; Oflox; Ofloxin; Ofus; Onexacin; Operan; Orocin; Otonil; Pharflox; Praxin; Puiritol; Qinolon; Qipro; Quinolon; Quotavil; Rilox; Sinflo; Tabrin; Taravid; Tariflox; Tarivid; Telbit; Tructum; Uro Tarivid; Viotisone; Zanocin |
|---|---|
| PharmGKB Accession Id: | PA450684 |
Description
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. PubChem (source: Drug Bank)
Indication
For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea. (source: Drug Bank)
ATC Therapeutic Categories
- J01MA:Fluoroquinolones
- S01AX:Other antiinfectives
- S02AA:Antiinfectives
- S03AA:Antiinfectives
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Ofloxacin acts on DNA gyrase, an enzyme which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. (source: Drug Bank)
Pharmacology
Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. (source: Drug Bank)
Food Interactions
Avoid high doses of caffeine.
Take without regard to meals.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic (source: Drug Bank)
Protein Binding
32% (source: Drug Bank)
Absorption
Bioavailability of ofloxacin in the tablet formulation is approximately 98% (source: Drug Bank)
Toxicity
LD<sub>50</sub>=5450 mg/kg (orally in mice) (source: Drug Bank)
Isomeric SMILES Code:
CC1COc2c3n1cc(c(=O)c3cc(c2N4CCN(CC4)C)F)C(=O)O (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| TOP2A |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The quinolone increases the anticoagulant effect (source: Drug Bank) |
| calcium |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| dicumarol |
|
The quinolone increases the anticoagulant effect (source: Drug Bank) |
| foscarnet |
|
Increased risk of convulsions (source: Drug Bank) |
| iron |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| magnesium |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| magnesium oxide |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| procainamide |
|
The quinolone increases the effect of procainamide (source: Drug Bank) |
| quinidine |
|
Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank) |
| sucralfate |
|
Formation of non-absorbable complexes (source: Drug Bank) |
| warfarin |
|
The quinolone increases the anticoagulant effect (source: Drug Bank) |
| zinc |
|
Formation of non-absorbable complexes (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.