Overview
| IUPAC Name: | (21E,23E,25E,27E,31E,33E)-20-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid |
|---|---|
| Trade Names: | Barstatin 100; Candex; Korostatin; Myco-Triacet Ii; Mycolog-Ii; Mycostatin; Mykacet; Mykinac; Mytrex F; Nadostine; Nilstat; Nyaderm; Nysert; Nystaform; Nystatin sodium; Nystatin, sodium salt; Nystatin-Triamcinolone Acetonide; Nystex; Nystop; PMS Nystatin; Pedi-Dri; Sodium nystatin; nystatin dihydrate |
| Brand Mixtures: | Derma-4 Ont (Neomycin Sulfate + Nystatin + Thiostrepton (Antibiotic of a Streptomyces Species) + Triamcinolone Acetonide); Flagystatin (Metronidazole + Nystatin); Kenacomb Cream (Gramicidin + Neomycin Sulfate + Nystatin + Triamcinolone Acetonide); Kenacomb Mild Cream (Gramicidin + Neomycin Sulfate + Nystatin + Triamcinolone Acetonide); Kenacomb Mild Ointment (Gramicidin + Neomycin Sulfate + Nystatin + Triamcinolone Acetonide); Kenacomb Ointment (Gramicidin + Neomycin Sulfate + Nystatin + Triamcinolone Acetonide); Kenacomb Ont (Gramicidin + Neomycin (Neomycin Sulfate) + Nystatin + Triamcinolone Acetonide); Lidecomb Cream (Fluocinonide + Gramicidin + Neomycin Sulfate + Nystatin); Mecomb Crm 0.1% (Gramicidin + Neomycin (Neomycin Sulfate) + Nystatin + Triamcinolone Acetonide); Solvaderm Ointment (Neomycin (Neomycin Sulfate) + Nystatin + Thiostrepton (Antibiotic of a Streptomyces Species) + Triamcinolone Acetonide) |
| PharmGKB Accession Id: | PA450666 |
Description
Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.
Indication
For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
ATC Therapeutic Categories
- A07AA:Antibiotics
- D01AA:Antibiotics
- G01AA:Antibiotics
Pharmacology and Interactions
Mechanism Of Action
Nystatin interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability.
Pharmacology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Food Interactions
Take without regard to meals.
Absorption, Distribution, Metabolism, Elimination & Toxicity
Absorption
Nystatin is not absorbed from intact skin or mucous membrane
Chemical Properties
Chemical Formula:
C47H75NO17
SMILES Code:
C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](C[C@@H]([C@H]([C@@H](CC(=O)C[C@@H]([C@H](CC[C@H](C[C@H](C[C @H](CC(=O)O[C@@H]([C@@H]([C@H]1O)C)C)O)O)O)O)O)O)C(=O)O)O)O[C@H]2[C@H]([C@H]([C@@H]([C@H](O2)C)O)N)O
(Format: OpenEye Isomeric)
Molecular Weight ( average / monoisotopic )
926.0949 / 925.5035
Non-Curated Information
A list of non-curated publications that mention this drug along with other genes is available.
Metabolizing Enzymes
Non-Curated Information
A list of non-curated publications that mention this drug along with other drugs is available.
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.